Clinical trials: Staphylococcus Aureus Infections
Staphylococcus Aureus
The Causes and Interpretation of Low-level Resistance in Staphylococcus Aureus
The hypothesis of this investigation is that rate of isolation of resistant nosocomial pathogens can be explained by a combination of measures that include, among other things, antimicrobial drug use, infection control efforts…
- Trial name
- NCT01127516
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Virginia Commonwealth University
Staphylococcal Skin Infections
Daptomycin Versus Vancomycin in Participants With Skin Infections Due to MRSA
This was a real-world, prospective, open-label, multicenter study in which participants were randomized (1:1) to receive intravenous (IV) vancomycin or IV daptomycin.
- Trial name
- DAPHEOR1006 (NCT01419184)
- Testing
- Daptomycin, Vancomycin
- Where
- 26 sites in United States, Puerto Rico
- Volunteers
- 250 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Infections
Evaluation of Ceftaroline Fosamil Versus a Comparator in Adult Subjects With Community-acquired Bacterial Pneumonia (CABP) With Risk for Methicillin-resistant Staphylococcus Aureus
The purpose of this study is to determine whether ceftaroline is effective and safe for the treatment of patients with Community-acquired Bacterial Pneumonia (CABP) at risk for infection due to Methicillin-resistant…
- Trial name
- NCT01645735
- Testing
- Ceftaroline fosamil, Ceftriaxone plus vancomycin
- Where
- 31 sites in United States, Georgia and 6 more
- Volunteers
- 49 people
- Sponsor
- Forest Laboratories
Staphylococcus Aureus
Aurexis® in Cystic Fibrosis Subjects Chronically Colonized With Staphylococcus Aureus in Their Lungs
Patients who are at least 7 years old with stable Cystic Fibrosis who have Staphylococcus aureus in their Lungs will be enrolled into the study and receive one dose of Aurexis® intravenously on Study Day 1, and will be followed…
- Trial name
- NCT00198289
- Testing
- Aurexis® (tefibazumab)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Bristol-Myers Squibb
Skin Ulcers, Methicillin-resistant Staphylococcus Aureus Infection
Clinical Trial on the Reduction of Methicillin Resistant Staphylococcus Aureus (MRSA)
The purpose of the study is to determine if topically applied nitric oxide gas is effective in reducing the quantity of bacteria (including MRSA)in a wound.
- Trial name
- NCT00790608
- Testing
- Nitric Oxide
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Nitric BioTherapeutics, Inc
Staphylococcus Aureus Bacteraemia, Staphylococcal Bacteraemia
Comparison of Cloxacillin and Benzylpenicillin in Penicillin Susceptible S. Aureus Bacteraemia
The goal of this study is to investigate if benzylpenicillin is a better treatment option than cloxacillin in patients with penicillin-susceptible Staphylococcus aureus bacteraemia.
- Conditions
- Staphylococcus Aureus Bacteraemia, Staphylococcal Bacteraemia, Staphylococcus Aureus Bloodstream Infections (BSI; Bacteremia), Staphylococcus (S.) Aureus Infection
- Trial name
- COMeBAC (NCT06726395)
- Testing
- Penicillin G_1200mg, cloxacillin
- Where
- Sweden
- Volunteers
- 420 people
- Sponsor
- Region Skane
Staphylococcal Infections
Study of Staphylococcus Aureus Colonization of the Posterior Nasal Cavity in Patients Undergoing Otorhinolaryngologic Surgery
Staphylococcus aureus nasal carriage is a major risk factor of infection with this bacterium. Staphylococcus aureus colonization of the posterior nasal cavity is still misunderstood.
- Trial name
- SREENSTAPH2 (NCT02595112)
- Testing
- Staphylococcus aureus carriage
- Where
- France
- Volunteers
- 95 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Methicillin-Resistant Staphylococcus Aureus
Retapamulin for Reducing MRSA Nasal Carriage
The investigators will conduct a randomized placebo-controlled double-blinded study of nasal decolonization with retapamulin vs.
- Trial name
- NCT01461668
- Testing
- Retapamulin
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of California, Irvine
Clostridium Infections, Methicillin-resistant Staphylococcus Aureus (MRSA)
A Clinical Trial of Resistant Potato Starch for Gut MDRO Decolonization
Multidrug-resistant organisms (MDROs) cause serious infections that are difficult to treat, leading to increased morbidity and mortality, longer hospital stays, and increased healthcare costs.
- Conditions
- Clostridium Infections, Methicillin-resistant Staphylococcus Aureus (MRSA), Vancomycin-Resistant Enterococci, Carbapenem-Resistant Enterobacteriaceae
- Trial name
- MDRO-Fiber (NCT07792915)
- Testing
- Resistant Potato Starch, Maltodextrin
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- VA Office of Research and Development
Methicillin-resistant Staphylococcus Aureus
Cluster Randomized Trial of Hospitals to Assess Impact of Targeted Versus Universal Strategies to Reduce Methicillin-resistant Staphylococcus Aureus (MRSA) in Intensive Care Units (ICUs)
The Randomized Evaluation of Decolonization versus Universal Clearance to Eliminate MRSA (REDUCE MRSA) Trial is a cluster randomized trial of the comparative effectiveness of three strategies to prevent methicillin-resistant…
- Trial name
- REDUCE-MRSA (NCT00980980)
- Testing
- Chlorhexidine bath and nasal mupirocin
- Where
- 42 sites in United States
- Volunteers
- 74,256 people
- Sponsor
- Harvard Pilgrim Health Care
Staphylococcus Aureus Bacteraemia
Direct Thrombin Inhibitors Versus LMWH in Staphylococcus Aureus Bacteraemia
Safety and efficacy of direct thrombin inhibitors versus enoxaparin in patients with staphylococcus aureus bacteraemia. The study hypothesizes that inhibition of the coagulase-activity of S.
- Trial name
- NCT01911624
- Testing
- direct thrombin inhibition, enoxaparin
- Where
- Belgium
- Volunteers
- 94 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Staphylococcus Aureus, HIV Infections
Rifabutin Based Therapy for the Eradication of Staphylococcus Aureus Colonization in HIV Infected Adults
DESIGN: This single center, double-blinded, randomized phase II study is being conducted to assess the efficacy of a rifabutin based regimen to eliminate S. aureus colonization in HIV infected individuals.
- Trial name
- NCT00869518
- Testing
- rifabutin plus trimethoprim sulfamethoxazole
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Francisco
Methicillin-resistant Staphylococcus Aureus Infection
Incidence and Relationship of Positive Preoperative Methicillin Resistant Staphylococcus Aureus (MRSA) Screens and Post-operative Infections
The purpose of this study is to evaluate the prevalence of pre-surgical patients who are MRSA carriers. From an evidence-based practice perspective, findings from this study can be considered in the evaluation of the hospital SOP…
- Trial name
- MRSA (NCT01028105)
- Testing
- Preoperative MRSA screening
- Where
- 2 sites in United States
- Volunteers
- 975 people
- Sponsor
- Inova Health Care Services
Methicillin-resistant Staphylococcus Aureus
Comprehensive Strategy to Decolonize Methicillin-resistant Staphylococcus Aureus (MRSA) in the Outpatient Setting
The purpose of this study is to determine the effectiveness of topical and oral antibiotics in eliminating carriage of methicillin-resistant Staphylococcus aureus (MRSA) among those living in the community.
- Trial name
- NCT01232231
- Testing
- pharmacological decolonization treatment, Education
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Joseph Kim
MRSA
Retapamulin as a Decolonizing Agent for MRSA
The purpose of this study is to investigate the efficacy of retapamulin to reduce carriage of MRSA via a randomized, double-blind, placebo-controlled clinical study testing retapamulin among patients with confirmed…
- Trial name
- NCT03304873
- Testing
- Retapamulin
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- NYU Langone Health
Methicillin-resistant Staphylococcus Aureus
Efficacy Study of Altabax to Clear Methicillin-resistant Staphylococcus Aureus (MRSA) Nasal Colonization
The purpose of the study is to determine whether Altabax (retapamulin ointment, 1%) is effective in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) nasal colonization.
- Trial name
- NCT00856089
- Testing
- Retapamulin
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ochsner Health System
Emergencies
Staphylococcus Aureus Resistant to Methicillin (MRSA) Screening in Trauma
The main objective of this study and to know the incidence of healthy carriers of Staphylococcus aureus resistant méti- patients supported for fracture of the proximal femur .
- Trial name
- TRAUMASARM (NCT02842710)
- Testing
- GeneXpert®
- Sponsor
- University Hospital, Toulouse
Surgical Wound Infection, Cross Infection
Reducing Intraoperative ESKAPE Transmission Through Use of a Personal Hand Hygiene System
The investigators hypothesize that the use of a personal hand hygiene system (SafeHavenTM) by anesthesia providers in the adult operating room, combined with a novel infectious pathogen tracking system (OR PathTrac) will decrease…
- Trial name
- ESKAPE (NCT04900298)
- Testing
- SafeHaven Automated Hand Hygiene Device
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Oregon Health and Science University
Staphylococcus Aureus Pneumonia
Study of the Efficacy and Safety of MEDI4893
Clinical trial looking at safety and efficacy of MEDI4893 in prevention of pneumonia caused by Staphylococcus aureus in high-risk patients
- Trial name
- SAATELLITE (NCT02296320)
- Testing
- MEDI4893
- Where
- 49 sites in United States, Belgium and 8 more
- Volunteers
- 213 people
- Sponsor
- MedImmune LLC
Staphylococcus Aureus
Mupirocin-Iodophor ICU Decolonization Swap Out Trial
The Swap Out Trial is a cluster randomized controlled trial of HCA hospitals, evaluating the non-inferiority of two decolonization regimens: Arm 1 Routine Care: ICU nasal decolonization with mupirocin twice daily for 5 days in…
- Trial name
- NCT03140423
- Testing
- Arm 1. Routine Care (Mupirocin/CHG), Arm 2. Iodophor/CHG Decolonization
- Where
- 137 sites in United States
- Volunteers
- 353,323 people
- Sponsor
- Harvard Pilgrim Health Care