Clinical trials: Staphylococcus Aureus Infections
Methicillin-Resistant Staphylococcus Aureus
Retapamulin for Reducing MRSA Nasal Carriage
The investigators will conduct a randomized placebo-controlled double-blinded study of nasal decolonization with retapamulin vs.
- Trial name
- NCT01461668
- Testing
- Retapamulin
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of California, Irvine
Staphylococcal Skin Infections, Abscesses
Staphylococcus Aureus Decolonization Study
The purpose of this study is to determine whether measures to eliminate the Staph germ from the skin of the index patient (with a special ointment and soap) are more effective when performed by everyone in the household rather…
- Conditions
- Staphylococcal Skin Infections, Abscesses, Furunculosis, Staphylococcus Aureus
- Trial name
- SuDS (NCT00731783)
- Testing
- 2% Mupirocin Ointment, 4% Chlorhexidine liquid soap, Hygiene protocol
- Where
- United States
- Volunteers
- 183 people
- Sponsor
- Washington University School of Medicine
Methicillin-resistant Staphylococcus Aureus
Project CLEAR - Changing Lives by Eradicating Antibiotic Resistance
This randomized controlled trial will compare strategies to reduce the risk of methicillin-resistant Staphylococcus aureus (MRSA) infection and re-hospitalization in MRSA carriers.
- Trial name
- CLEAR (NCT01209234)
- Testing
- Standard-of-Care Education, MRSA Decolonization
- Where
- 24 sites in United States
- Volunteers
- 2,140 people
- Sponsor
- University of California, Irvine
MRSA, Cystic Fibrosis
AeroVanc in the Treatment of Methicillin-resistant Staphylococcus Aureus Infection in Patients With Cystic Fibrosis
This is a multi-center, randomized phase III study to evaluate the clinical effectiveness of AeroVanc in persistent methicillin-resistant Staphylococcus aureus (MRSA) infection in patients with cystic fibrosis (CF).
- Trial name
- NCT03181932
- Testing
- Vancomycin inhalation powder
- Where
- 71 sites in United States, Canada
- Volunteers
- 188 people
- Sponsor
- Savara Inc.
Staphylococcal Skin Infections
Daptomycin Versus Vancomycin in Participants With Skin Infections Due to MRSA
This was a real-world, prospective, open-label, multicenter study in which participants were randomized (1:1) to receive intravenous (IV) vancomycin or IV daptomycin.
- Trial name
- DAPHEOR1006 (NCT01419184)
- Testing
- Daptomycin, Vancomycin
- Where
- 26 sites in United States, Puerto Rico
- Volunteers
- 250 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Atopic Dermatitis (AD)
Targeted Microbiome Transplant in Atopic Dermatitis
The purpose of this study is to examine the safety and effectiveness of a new therapy, commensal lotion containing infection fighting bacteria, on decreasing or eliminating the infection causing bacteria found on the skin of…
- Trial name
- NCT03151148
- Testing
- TMT Lotion
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Staphylococcal Skin Infection
Comparison of Telavancin and Vancomycin for Complicated Skin and Skin Structure Infections With a Focus on Methicillin-resistant Staphylococcus Aureus
Study 0018 (NCT00107978) compares the safety and effectiveness of an investigational drug, telavancin, and an approved drug, vancomycin, for the treatment of complicated skin and skin structure infections.
- Trial name
- ATLAS2 (NCT00107978)
- Testing
- Telavancin, Vancomycin
- Where
- United States
- Volunteers
- 1,035 people
- Sponsor
- Cumberland Pharmaceuticals
Abscesses, Furunculosis
The Natural History of Community-Associated MRSA Infections and Decolonization Strategies
The purpose of this study is to determine the natural history of community-associated Staphylococcus aureus infections in both adult and pediatric patients by monitoring the rate of recurrent infections in those colonized with S.
- Conditions
- Abscesses, Furunculosis, Staphylococcus Aureus, Staphylococcal Skin Infections
- Trial name
- StLStaRS (NCT00513799)
- Testing
- Mupirocin ointment, Chlorhexidine showers, Bleach baths (dilute)
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Washington University School of Medicine
Methicillin-Resistant Staphylococcus Aureus, Bacterial Infections
Dalbavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections in Children, Known or Suspected to be Caused by Susceptible Gram-positive Organisms, Including MRSA
To determine the safety and descriptive efficacy of dalbavancin for the treatment of acute bacterial skin and skin structure infections in children, aged birth to 17 years (inclusive), known or suspected to be caused by…
- Conditions
- Methicillin-Resistant Staphylococcus Aureus, Bacterial Infections, Staphylococcal Skin Infections
- Trial name
- NCT02814916
- Testing
- Dalbavancin, Vancomycin, Oxacillin
- Where
- 84 sites in United States, Argentina and 18 more
- Volunteers
- 199 people
- Sponsor
- AbbVie
Abscess
Emergency Bedside Ultrasound for Pediatric Soft Tissue Infections
The purpose of this study is to determine if soft tissue infections in pediatric patients can be more accurately diagnosed (i.e.
- Trial name
- NCT00595881
- Testing
- Bedside emergency ultrasound
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Healthy
Safety and Immunogenicity Study of V710 Lyophilized Formulation (V710-004)
This study is being performed to evaluate a single 60 Mcg dose of lyophilized formulation of Merck Staphylococcus aureus vaccine (V710) in healthy subjects.
- Trial name
- NCT00822757
- Testing
- Comparator: V710
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Staphylococcus Aureus Pneumonia
Study of the Efficacy and Safety of MEDI4893
Clinical trial looking at safety and efficacy of MEDI4893 in prevention of pneumonia caused by Staphylococcus aureus in high-risk patients
- Trial name
- SAATELLITE (NCT02296320)
- Testing
- MEDI4893
- Where
- 49 sites in United States, Belgium and 8 more
- Volunteers
- 213 people
- Sponsor
- MedImmune LLC
Staphylococcal Infection
V710 Clinical Study in Healthy Male Japanese Subjects (V710-006) (COMPLETED)
This study is to evaluate the safety and immunogenicity of V710 in Japanese male subjects.
- Trial name
- NCT00735839
- Testing
- V710
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Staphylococcal Infections
Preventing Staphylococcal (Staph) Infection
The purpose of this study is to determine if mupirocin 2% in polyethylene glycol (PEG) ointment [Treatment Arm] is effective in preventing moderate to severe re-infection with Staphylococcus aureus compared with treatment with…
- Trial name
- NCT00108160
- Testing
- Mupirocin Ointment [Treatment]
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- US Department of Veterans Affairs
Staphylococcus Aureus, HIV Infections
Rifabutin Based Therapy for the Eradication of Staphylococcus Aureus Colonization in HIV Infected Adults
DESIGN: This single center, double-blinded, randomized phase II study is being conducted to assess the efficacy of a rifabutin based regimen to eliminate S. aureus colonization in HIV infected individuals.
- Trial name
- NCT00869518
- Testing
- rifabutin plus trimethoprim sulfamethoxazole
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Francisco
Staphylococcus Aureus, Health Care Associated Infection
Reducing Perioperative S. Aureus Transmission
The purpose of this study is to prevent the spread of S. aureus, a dangerous bacterium, within the operating room and between patients undergoing surgery.
- Conditions
- Staphylococcus Aureus, Health Care Associated Infection, Health Care Worker Patient Transmission
- Trial name
- NCT03638947
- Testing
- Swab and decolonization using povidone-iodine cleansing
- Where
- United States
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Randy Loftus
Staphylococcus Aureus
Preventing the Spread of Infection in Nursing Homes
This study evaluates the feasibility of targeting more frequent gown and glove use for specific high risk moments of care in specific nursing home residents in order to prevent Staphylococcus aureus (SA) acquisition and infection.
- Trial name
- NCT03319368
- Testing
- Targeted gown and glove use
- Where
- 2 sites in United States
- Volunteers
- 367 people
- Sponsor
- University of Maryland, Baltimore
Skin Disease, Bacterial, Abscess
Evaluation of 3 Versus 10 Days of Antibiotics in Skin Abscesses After Surgical Drainage
The objective of this study is to determine if there is a difference in treatment failures and recurrent skin infections when patients are given 3 or 10 days of antibiotics for uncomplicated skin abscesses after they have been…
- Trial name
- NCT02024867
- Testing
- Trimethoprim-Sulfamethoxazole
- Where
- United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Lucy Holmes, MD
MRSA
Retapamulin as a Decolonizing Agent for MRSA
The purpose of this study is to investigate the efficacy of retapamulin to reduce carriage of MRSA via a randomized, double-blind, placebo-controlled clinical study testing retapamulin among patients with confirmed…
- Trial name
- NCT03304873
- Testing
- Retapamulin
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- NYU Langone Health
Pneumonia Due to Staphylococcus Aureus
Safety, Pharmacokinetics and Efficacy of KBSA301 in Severe Pneumonia (S. Aureus)
The objectives of this study are to assess the safety, tolerability, pharmacokinetics, pharmacodynamics and clinical outcome of patients who have severe pneumonia caused by Staphylococcus aureus (S.
- Trial name
- NCT01589185
- Testing
- KBSA301
- Where
- 18 sites in United States, Belgium and 2 more
- Volunteers
- 48 people
- Sponsor
- Aridis Pharmaceuticals, Inc.