Clinical trials: Staphylococcus Infections
Infection
Vitamin D and Staphylococcus Aureus in the Diabetes Study
There are indications that the vitamin D status of an individual is related to susceptibility to staphylococcal infections. In the present study we will examine nasal colonisation rate in subjects participating in an ongoing…
- Trial name
- NCT01395290
- Testing
- cholecalciferol
- Where
- Norway
- Volunteers
- 280 people
- Sponsor
- University of Tromso
Staphylococcus Aureus Bloodstream Infection
A Study to Evaluate the Safety and Pharmacokinetics of AZD7760 in Healthy Japanese Adults
The purpose of this study is to evaluate the safety and PK of AZD7760 when given as an intravenous (IV) infusion to healthy Japanese adult participants.
- Trial name
- NCT07612813
- Testing
- AZD7760
- Where
- Japan
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Methicillin Resistance in Staphylococcus Aureus (MRSA)
Farm-originated Antimicrobial Resistance Modeling: Exploring Humans-to-Animal Dissemination
Antimicrobial resistance is a major public health issue. Methicillin resistance in Staphylococcus aureus (MRSA) is one of the indicators that is monitored particularly closely.
- Trial name
- FARMHAND (NCT07898930)
- Testing
- Sample collection
- Where
- 2 sites in France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Saint-Brieuc
Staphylococcus
Mupirocin to Reduce Staphylococcus Aureus Colonization in Infants Hospitalized in a NICU
The purpose of this study is to determine whether or not mupirocin treatment results in S. aureus decolonization in affected NICU patients.
- Trial name
- NCT02967432
- Testing
- Mupirocin Topical Ointment, Petroleum Jelly
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Crouse Hospital
Staphylococcus Aureus
Staphylococcus Aureus Skin and Soft Tissue Infections
The purpose of this study is to evaluate strategies to prevent Staphylococcus aureus skin and soft tissue infections in soldiers during infantry training.
- Trial name
- NCT01385514
- Where
- Israel
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
Skin Disease, Bacterial, Abscess
Evaluation of 3 Versus 10 Days of Antibiotics in Skin Abscesses After Surgical Drainage
The objective of this study is to determine if there is a difference in treatment failures and recurrent skin infections when patients are given 3 or 10 days of antibiotics for uncomplicated skin abscesses after they have been…
- Trial name
- NCT02024867
- Testing
- Trimethoprim-Sulfamethoxazole
- Where
- United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Lucy Holmes, MD
Bone and Joint Infection, Antibiotic Resistant Staphylococcus Aureus Infection
Staphylococcal Acute Post-Operative PJI Treated With 'DAIR' And Impact Of Rifampin
S. aureus and coagulase-negative staphylococci are the most frequent bacteria responsible for PJI (prosthetic joint infection). The aim of this study is to describe the use of rifampicin.
- Trial name
- IPASTAPH (NCT03750721)
- Testing
- Role of rifampin in staphylococcal PJI
- Where
- France
- Volunteers
- 79 people
- Sponsor
- Hospices Civils de Lyon
Nasal Carriage of Staphylococcus Aureus
Staphylococcus Aureus Nasal Carriage
The repeated exposition to S. aureus is considered as a determining factor of acquisition of the nasal colonization. The healthcare professionals are regularly in touch with this pathogenic bacterium.
- Trial name
- SANAC (NCT02796690)
- Testing
- nasal swabs will be collected
- Where
- France
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Toxic Shock Syndrome Staphylococcal
Phase I STEBVax in Healthy Adults
The main purpose of this study is to test the safety of a new vaccine, STEBVax, which may lead to a useful treatment for toxic shock syndrome.
- Trial name
- NCT00974935
- Testing
- Aluminum hydroxide, STEBVax vaccine
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Staphylococcus Aureus Bloodstream Infections (BSI; Bacteremia)
Linezolid Plus Standard of Care
The aim of the study is to assess whether targeting virulence factors by administering linezolid in addition to standard antibiotic treatment improves outcomes in patients with Staphylococcus aureus bacteraemia.
- Trial name
- LIPS (NCT06958835)
- Testing
- Linezolid 600 mg
- Where
- 12 sites in Switzerland
- Volunteers
- 606 people
- Sponsor
- University Hospital, Basel, Switzerland
Ventilator Associated Pneumonia, Staphylococcus Aureus
A Human Monoclonal Antibody Against Staphylococcus Aureus Alpha Toxin in Mechanically Ventilated Adult Subjects - 2
Clinical trial looking at safety and efficacy of suvratoxumab in prevention of pneumonia caused by Staphylococcus aureus in high-risk patients
- Trial name
- SAATELLITE-2 (NCT05331885)
- Testing
- Suvratoxumab
- Where
- 27 sites in Belgium, France and 4 more
- Volunteers
- 24 people
- Sponsor
- Aridis Pharmaceuticals, Inc.
Skin Diseases, Infectious
Effective Antibiotic Treatment of MRSA
To evaluate the effective duration (in days) to clinical improvement of outpatient antibiotic regimens in the treatment of superficial abscesses caused by MRSA in patients that present to the emergency department.
- Trial name
- NCT00388310
- Testing
- Culture
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
Nurse's Role, Surgical Site Infection
Effectiveness of the Decolonization Circuit of S. Aureus, Reducing Infection in Primary Arthroplasty of the Lower Limb
Lower limb joint replacement surgery is one of the most prevalent globally. In our center, more than 400 lower limb arthroplasties (LLA) are performed annually.
- Conditions
- Nurse's Role, Surgical Site Infection, Patient Satisfaction
- Trial name
- NCT05158322
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Corporacion Parc Tauli
Staphylococcus (S.) Aureus Infection
Staphylococcus Aureus Caught in Action at the Site of Infection
This study is to obtain a comprehensive view of S. aureus adaptations in the infected human host and (i) to improve the understanding of the interface between antibiotic therapy, resistance development and virulence factor…
- Trial name
- PROSA (NCT04781569)
- Testing
- data collection, blood draw, nose swabs
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Methicillin-resistant Staphylococcus Aureus, Sepsis
Cystatin-C C-guided Vancomycin Dosing in Critically Ill Patients: A Quality Improvement Project
Determine if a cystatin C-inclusive vancomycin dosing algorithm improved target trough achievement compared to creatinine clearance-guided vancomycin therapy in critically ill patients.
- Conditions
- Methicillin-resistant Staphylococcus Aureus, Sepsis, Critical Illness
- Trial name
- NCT02945241
- Testing
- Vancomycin, Cystatin C dosing algorithm, Creatine clearance dosing algorithm
- Volunteers
- 399 people
- Sponsor
- Mayo Clinic
HIV Infections, Staphylococcal Infections
Immunologic Predisposition of HIV Patients to Develop Methicillin-Resistant Staphylococcus Aureus (MRSA) Colonization and Infection
The purpose of this study is to investigate the role of T helper 17 cells (Th17) in the pathogenesis of MRSA infections.
- Trial name
- MRSA-2 (NCT00859677)
- Where
- 2 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Pneumonia Due to Staphylococcus Aureus
Safety, Pharmacokinetics and Efficacy of KBSA301 in Severe Pneumonia (S. Aureus)
The objectives of this study are to assess the safety, tolerability, pharmacokinetics, pharmacodynamics and clinical outcome of patients who have severe pneumonia caused by Staphylococcus aureus (S.
- Trial name
- NCT01589185
- Testing
- KBSA301
- Where
- 18 sites in United States, Belgium and 2 more
- Volunteers
- 48 people
- Sponsor
- Aridis Pharmaceuticals, Inc.
Methicillin-Resistant Staphylococcus Aureus, Cystic Fibrosis
Initial and Chronic Methicillin Resistant Staphylococcus Aureus (MRSA) Infection in Cystic Fibrosis (CF)
This study aims to examine features of MRSA that are associated with chronic MRSA infection and bacterial persistence despite IV antibiotic therapy.
- Trial name
- TRI-STAR (NCT02684422)
- Testing
- Intervention N/A. Observational study
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- University of North Carolina, Chapel Hill
Health Care Associated Infection, Antibiotic Resistant Strain
Linezolid-resistant Staphylococcus Epidermidis in ICU and Risk Factors Analysis
Understanding the emergence of linezolid-resistance in Staphylococci has been allowed in the past years through the discovery of the clonal dissemination of a chromosomal cassette carrying a modified crf gene.
- Conditions
- Health Care Associated Infection, Antibiotic Resistant Strain, Infection Transmission
- Trial name
- ELiCSIR (NCT03140410)
- Testing
- Antibiotic resistance
- Where
- France
- Volunteers
- 103 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Patients withInfections Caused by S.Aureus Like Skin Infections , Chest Infections , Surgical Site Infections , and Urinary Tract Infections
Detection of Efflux Pump Genes Mediating Ciprofloxacin Resistance in Staphylococcus Aureus Isolates in Sohag University Hospitals
Among multidrug-resistant bacteria, Methicillin-resistant Staphylococcus aureus (MRSA) isolates were recognized to be an important mortality factor in hospital infections and a major concern in health-care and community settings…
- Trial name
- NCT05828550
- Testing
- antibiotic sensitivity
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University