Clinical trials: Staphylococcus Infections
Bone and Joint Infection, Staphylococcus
Clinical Relevance of Intracellular Staphylococci in BOne and Joint Infections
Different mechanisms have been proposed to explain the pathophysiology of chronic staphylococcal BJI, including biofilm formation and the ability of staphylococci to be internalized and to survive within cells.
- Trial name
- CRISBO (NCT04625478)
- Testing
- Patients having had an osteo-articular infection with Stahylococcus
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Staphylococcal Infections
Safety and Behavior of S. Aureus Immune Globulin Intravenous(Human), [Altastaph] in Patients With S. Aureus Bacteremia and Continuing Fever
Altastaph has been developed to help the removal of S. aureus from the bloodstream. The main objective of this study will be to test the safety and behavior of Altastaph in patients with S.aureus bacteremia and continuing fever
- Trial name
- NCT00063089
- Testing
- S. aureus Immune Globulin Intravenous (Human) 5%
- Volunteers
- 40 people
- Sponsor
- Nabi Biopharmaceuticals
Nosocomial Infections
Effect of Metallic Nanoparticles on Nosocomial Bacteria
This research aims to study the properties of metallic nanoparticles"MNPs" (silver nanoparticles "AgNps" and copper nanoparticles "CuNps") on the 2 most common nosocomial bacteria which are highly resistant to antibiotics…
- Trial name
- NCT04775238
- Testing
- Silver nanoparticles, Copper nanoparticles
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Atopic Dermatitis, Atopic Dermatitis Eczema
Staphylococcus Aureus and The Skin Microbiome During Flare And Resolution Of Atopic Dermatitis
The goal of this clinical trial is to compare and evaluate in patients with atopic dermatitis. The main questions it aims to answer are: Does the addition of systemic dicloxacillin to TCS treatment result in a more rapid and…
- Conditions
- Atopic Dermatitis, Atopic Dermatitis Eczema, Atopic Dermatitis Flare
- Trial name
- NCT05578482
- Testing
- Dicloxacillin Oral Capsule, Elocon 0.1 % Topical Cream
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Jacob Pontoppidan Thyssen
Staphylococcus Aureus, HIV Infections
Mupirocin Ointment to Eliminate Nasal Carriage of Staphylococcus Aureus in HIV Infection
Staphylococcus aureus is a bacteria that causes serious, often life threatening infections including pneumonia, wound, and bloodstream infections. Persons with AIDS are at high risk for S. aureus infections.
- Trial name
- NCT00801879
- Testing
- Mupirocin calcium ointment, 2%
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Columbia University
STAPHYLOCOCCAL INFECTIONS
Study of the Colonic Carriage of Staphylococcus Aureus in a Prospective Cohort of Patients Undergoing Endoscopic Screening for Digestive Cancer in the University Hospital of Saint-Etienne
Epidemiological study aiming to describe the carriage (nasal, throat, groin, rectal and colonic) of S. aureus in patients without chronic digestive disease who are going to have a colonoscopy for cancer screening.
- Trial name
- ColoStaph (NCT02502474)
- Testing
- Staphylococcus aureus carriage
- Where
- France
- Volunteers
- 112 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Staphylococcal Infection
Study to Assess Eradication of Nasal Carriage of Staphylococcus Aureus (SA) With Mupirocin (Bactroban 2% Nasal Ointment)
This study will assess the nasal eradication of SA in healthy subjects following treatment with mupirocin 2% (Bactroban 2% Nasal Ointment) twice daily for 5 days, by means of a broth enriched culture microbial assay.
- Trial name
- NCT02284555
- Testing
- Mupirocin
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Destiny Pharma Plc
Staphylococcal Infections
SA4Ag Safety, Tolerability, and Immunogenicity Study in Japanese Adults
The purpose of this study is to evaluate the safety, tolerability, and immunogenicity of a single dose of Staphylococcus aureus 4 antigen vaccine in Japanese adults aged 20 to <86 years.
- Trial name
- NCT02492958
- Testing
- Staphylococcus aureus 4-antigen vaccine
- Where
- 2 sites in Japan
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Pfizer
MRSA Bacteremia
A Phase 2a Study, Effect of Vancomycin With vs Without Delpazolid (LCB01-0371) in Patients With MRSA Bacteremia
The objectives of this study is to exploratory whether Vancomycin + Delpazolid is more effective to the standard of treatment (Vancomycin)/ for hospitalized adults with MRSA bacteraemia.
- Trial name
- NCT05225558
- Testing
- Delpazolid, Vancomycin
- Where
- 6 sites in South Korea
- Volunteers
- 40 people
- Sponsor
- LigaChem Biosciences, Inc.
Staphylococcus Aureus Infection
A Clinical Trial to Evaluate a Recombinant Staphylococcus Aureus Vaccine (Escherichia Coli) in Healthy Adults
Before this study, there will be an open-label, dose-escalation pilot study with a total of 30 participants with 10 per dosage group.
- Trial name
- NCT02804711
- Testing
- Low dosage of Staphylococcus aureus vaccine (15µg/0.6ml), Middle dosage of Staphylococcus aureus vaccine (30µg/0.6ml), High dosage of Staphylococcus aureus vaccine (60µg/0.6ml)
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Staphylococcus Aureus Infection, Surgical Site Infection
Serum Based Diagnosis of and Monitoring of Infection Recovery in Orthopedic Spine Implant Infections
The goal of this study is to test a new way to diagnose and track treatment of spine infections caused by the bacteria Staphylococcus aureus.
- Conditions
- Staphylococcus Aureus Infection, Surgical Site Infection, Orthopedic Procedures, Spine
- Trial name
- NCT04897971
- Testing
- Medium enriched for newly synthesized antibodies in spine infection
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Colorado, Denver
Methicillin-resistant Staphylococcus Aureus Infection
Incidence and Relationship of Positive Preoperative Methicillin Resistant Staphylococcus Aureus (MRSA) Screens and Post-operative Infections
The purpose of this study is to evaluate the prevalence of pre-surgical patients who are MRSA carriers. From an evidence-based practice perspective, findings from this study can be considered in the evaluation of the hospital SOP…
- Trial name
- MRSA (NCT01028105)
- Testing
- Preoperative MRSA screening
- Where
- 2 sites in United States
- Volunteers
- 975 people
- Sponsor
- Inova Health Care Services
MRSA - Methicillin Resistant Staphylococcus Aureus Infection
Epidemiology and Prevention of Methicillin Resistant Staphylococcus Aureus (MRSA) Transmission in the Community
The overall goal of this project is to elucidate the epidemiology of MRSA transmission in the community and test an intervention to prevent MRSA transmission in this setting.
- Trial name
- NCT00966446
- Testing
- Unsupervised Decolonization, Supervised Decolonization
- Where
- 4 sites in United States
- Volunteers
- 223 people
- Sponsor
- University of Pennsylvania
Methicillin-Resistant Staphylococcus Aureus (MRSA), Hospital-Acquired Pneumonia
Evaluation of Patients With Methicillin-Resistant Staphylococcus Aureus Hospital-Acquired Pneumonia Treated With Linezolid or Vancomycin
The objective of this study is to review the local management of patients with methicillin-resistant Staphylococcus aureus hospital-acquired pneumonia treated with vancomycin or linezolid with the goal to define if any difference…
- Trial name
- NCT01561469
- Testing
- Linezolid, Vancomycin
- Volunteers
- 188 people
- Sponsor
- Pfizer
Bacterial Infections, Gram-Positive Bacterial Infections
What is the Prevalence of Methicillin-Resistant Staphylococcus Aureus in Skin and Soft Tissue Infections Presenting to the Emergency Departments of a Canadian Academic Health Care Center?
Staphylococcus aureus is the most common bacteria responsible for skin, bone, and muscle infections. Recent studies from the United States have suggested that a type of this bacterium called methicillin resistant S.
- Conditions
- Bacterial Infections, Gram-Positive Bacterial Infections, Staphylococcal Infections
- Trial name
- CA-MRSA (NCT00736554)
- Where
- Canada
- Volunteers
- 152 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Pneumonia, Bloodstream Infection
Clinical Outcomes in Patients With Infection by Resistant Microorganism
The goal of this individual patient data meta-analysis is to estimate the attributed and the associated health burden related to bloodstream infections, pneumonia, skin and soft tissue infections, surgical site infections and…
- Conditions
- Pneumonia, Bloodstream Infection, Urinary Tract Infections, Skin Infection
- Trial name
- NCT05880069
- Testing
- Pathogen resistant phenotype
- Where
- Spain
- Volunteers
- 5,000 people
- Sponsor
- Hospital Universitario Virgen Macarena
Bacteremia
IL-10 Stratifying Tool for Towards Antibiotic Selection for MRSaB
Patients with MRSaB have high therapeutic failure rates and mortality rates. Recent studies have shown that an elevated IL-10 level is an independent risk factor of mortality.
- Trial name
- NCT02660346
- Testing
- Daptomycin, Vancomycin, Ceftaroline
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Sharp HealthCare
Staphylococcus Aureus, Staphylococcal Skin Infections
Rapid Test to Detect Staphylococcus Aureus in Blood and Wound Infections
The purpose of this study is to determine whether the Cepheid GeneXpert system accurately detects Methicillin-Resistant and -Susceptible Staphylococcus aureus in blood cultures and wound swabs.
- Conditions
- Staphylococcus Aureus, Staphylococcal Skin Infections, Bacteremia
- Trial name
- NCT01198262
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Michael E. DeBakey VA Medical Center
Staphylococcus Aureus Endocarditis, Staphylococcus Aureus Septicemia
Dabigatran vs. Oral Anti-Xa Inhibitors in S. Aureus Bacteremia
This is an open-label randomized controlled trial which will enroll patients with S. aureus bacteremia who are already taking oral anticoagulant medications (apixaban, edoxaban, or rivaroxaban) for an approved indication (stroke…
- Conditions
- Staphylococcus Aureus Endocarditis, Staphylococcus Aureus Septicemia, Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Bloodstream Infection
- Trial name
- DABI-SNAP (NCT06650501)
- Testing
- Dabigatran, Apixaban, edoxaban
- Where
- 3 sites in Canada
- Volunteers
- 300 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Staphylococcal Aureus Infection, Surgical Site Infection (SSI)
Gene Expression Analysis of Biofilm Formation and Antimicrobial Resistance in Clinical Methicillin-Resistant Staphylococcus Aureus
Staphylococcus aureus are Gram-positive cocci that asymptomatically colonize the skin and mucosal surfaces of approximately 20-30% of healthy individuals . Although they commonly exist as a harmless commensal organisms, S.
- Trial name
- NCT07796555
- Testing
- swab from lesion, Biochemical reactions, Antibiotic sensitivity
- Volunteers
- 100 people
- Sponsor
- Sohag University