Clinical trials: Statin
Statin Therapy, Statin Adverse Reaction
DESIFOR-EXPAND (MHIF)
The DESIFOR pilot study was conducted to determine the feasibility of utilizing an n-of-1 trial to facilitate tolerance of unblinded rosuvastatin in patients with prior statin intolerance
- Conditions
- Statin Therapy, Statin Adverse Reaction, Statin
- Trial name
- NCT06804980
- Testing
- Rosuvastatin (Crestor)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Minneapolis Heart Institute Foundation
Dyslipidemias, Hyperlipidemias
Efficacy and Safety of Pitavastatin and PCSK9 Inhibitors in Liver Transplant Patients
To study the efficacy and safety of pitavastatin and PCSK9 inhibitors in liver transplant patients on ongoing immunosuppressive therapy.
- Conditions
- Dyslipidemias, Hyperlipidemias, Liver Transplant Disorder, Immunosuppression
- Trial name
- PINTL (NCT05537948)
- Testing
- Pitavastatin, PCSK9 inhibitor
- Where
- Russia
- Volunteers
- 59 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Statin, Cardiovascular Risk Factors
Role of Coronary CTA on Lipid Management and Risk Factors Control in an Asymptomatic Chinese Population
The primary objective of this study is to determine whether coronary computed tomography angiography (CCTA) -based coronary heart disease(CHD) prevention strategy improves lipid-lowering treatment and cardiovascular risk factor…
- Conditions
- Statin, Cardiovascular Risk Factors, Primary Prevention, Adherence, Medication
- Trial name
- RESPECT2 (NCT05725096)
- Testing
- Coronary Computed Tomography Angiography, Traditional cardiovascular risk stratification
- Where
- China
- Volunteers
- 3,400 people
- Sponsor
- Zhang longjiang,MD
Primary Aldosteronism, Statin
Statin Combined with Amlodipine Treats Primary Aldosteronism
The drug treatment for primary aldosteronism (PA) is limited and difficult to improve long-term cardiovascular outcomes. This study plans to enroll patients with primary aldosteronism and randomly divide into 3 groups: scheme 1…
- Conditions
- Primary Aldosteronism, Statin, Mineralocorticoid Receptor Antagonist, Hypertension
- Trial name
- STOP-PA (NCT06523465)
- Testing
- Simvastatin combined with Amlodipine besylate, Simvastatin combined with Spironolactone and Amlodipine besylate., Amlodipine besylate combined Spironolactone
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Third Military Medical University
Statin Adverse Reaction
Hepatic Safety of Statin Use in Neurology Inpatients
This research employs a cross-sectional study and a retrospective cohort study to analyze the liver safety of statin use among inpatients in the neurology department in China from different perspectives.
- Trial name
- NCT06592196
- Testing
- stain
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shanghai Yueyang Integrated Medicine Hospital
Dyslipidemias, Statin Adverse Reaction
Efficacy and Safety of Bempedoic Acid in Association With Anti-PCSK9 and Ezetimibe in Statin-intolerant Patients
Statin intolerance occurs in up to 15-20% of treated patients. The combined use of Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) inhibitors with ezetimibe is commonly performed in these patients, and has been associated…
- Conditions
- Dyslipidemias, Statin Adverse Reaction, Cardiovascular Diseases, Lipid Metabolism Disorders
- Trial name
- BESAFE (NCT06381947)
- Testing
- Lipid-lowering therapy combination with PCSK9 inhibitors, bempedoic acid and ezetimibe, Lipid-lowering therapy combination with PCSK9 inhibitors and ezetimibe
- Volunteers
- 130 people
- Sponsor
- University of Salerno
Cardiovascular Diseases, Dyslipidemias
Efficacy, Safety and Cost-efficacy of a Pre-emptive Genotyping Strategy in Patients Receiving Statins
This is a Phase IV multicentre adaptive single-blinded randomized clinical trial if preemptively genotyping populations at risk of cardiovascular disease susceptible of receiving high or moderate doses of statin therapy is…
- Conditions
- Cardiovascular Diseases, Dyslipidemias, Statin Adverse Reaction, Pharmacogenic Myopathy
- Trial name
- PREVESTATGx (NCT06262685)
- Testing
- Preemptive pharmacogenetic atorvastatin dose based on CPIC guidelines, Preemptive pharmacogenetic simvastatin dose based on CPIC guidelines, Preemptive pharmacogenetic pitavastatin dose based on CPIC guidelines
- Where
- Spain
- Volunteers
- 216 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Intracerebral Hemorrhage, Statins
Statin for Neuroprotection in Spontaneous Intracerebral Hemorrhage
Brain injury after spontaneous intracerebral hemorrhage results from pathophysiologic responses in the brain parenchyma due to hematoma formation, release of clot components, and surrounding edema.
- Trial name
- STATIC (NCT04857632)
- Testing
- Statin
- Where
- 3 sites in China
- Volunteers
- 98 people
- Sponsor
- Capital Medical University
Cardiovascular Diseases, Statin Adverse Reaction
Evaluation of Major Cardiovascular Events in Participants With, or at High Risk for, Cardiovascular Disease Who Are Statin Intolerant Treated With Bempedoic Acid (ETC-1002) or Placebo
The purpose of this study is to determine if treatment with bempedoic acid (ETC-1002) versus placebo decreases the risk of cardiovascular events in participants who have or are at high risk for cardiovascular disease and are…
- Trial name
- CLEAR Outcomes (NCT02993406)
- Testing
- Bempedoic acid 180 mg tablet
- Where
- 1,319 sites in United States, Argentina and 30 more
- Volunteers
- 13,970 people
- Sponsor
- Esperion Therapeutics, Inc.
Statin Adverse Reaction
The Association of Statins on Cardiorespiratory Fitness and Exercise Adaptation
Statins are part of one of the largest groups of drugs prescribed worldwide used in the treatment of dyslipidemia. Despite the good therapeutic results of statins and their good tolerance on the part of patients, some adverse…
- Trial name
- NCT04986241
- Testing
- Statin, Physical activity, Sedentary
- Where
- Brazil
- Volunteers
- 18,557 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Statin Treatment for Primary Prevention
STREAM Trial - Biomarker
Statins are among the most widely used drugs. While they were found to be effective for primary and secondary prevention of cardiovascular disease (CVD) in middle-aged subjects, their benefits for primary prevention in older…
- Trial name
- STREAM-Bio (NCT05482386)
- Testing
- Statin discontinuation
- Where
- Switzerland
- Volunteers
- 500 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Statin Treatment for Primary Prevention
STREAM Trial - Subclinical Atherosclerosis
Statins are among the most widely used drugs. While they were found to be effective for primary and secondary prevention of cardiovascular disease (CVD) in middle-aged subjects, their benefits for primary prevention in older…
- Trial name
- STREAM-SubATS (NCT05482399)
- Testing
- Statin discontinuation
- Where
- Switzerland
- Volunteers
- 500 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Metabolic Syndrome, Protection Against, Exercise Training
Interactions of Medicine and Exercise With Meal Timing
To analyze the effects of altering the time of ingestion of participants' habitual medication (i.e., metformin, statins, ARAII/IACE) and meals around the time of exercise training (exercise fasted or fed) on the improvement of…
- Conditions
- Metabolic Syndrome, Protection Against, Exercise Training, Metformin, Statins
- Trial name
- MMET (NCT04477590)
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION
- Where
- Spain
- Volunteers
- 160 people
- Sponsor
- University of Castilla-La Mancha
Diabetes Mellitus, Type 2, Dyslipidemia Associated With Type II Diabetes Mellitus
Effects of High Intensity Statin Therapy on Steroid Hormones and Vitamin D in Type 2 Diabetic Men
The aim of the study was to assess the effect of high intensity statin therapy on testicular and adrenal steroids and vitamin D levels in type 2 diabetes males.It is a prospective study, conducted between march 2021 and July…
- Conditions
- Diabetes Mellitus, Type 2, Dyslipidemia Associated With Type II Diabetes Mellitus, Statin Adverse Reaction, Hypogonadism, Male
- Trial name
- NCT05806723
- Testing
- Atorvastatin 40 Mg Oral Tablet
- Where
- Tunisia
- Volunteers
- 104 people
- Sponsor
- Hopital La Rabta
Muscle Cramp, Ache
7T Magnetic Resonance Spectroscopy and Skeletal Muscle Biopsy Findings in Statin Associated Adverse Muscle Events
Over 40 million Americans take statins to reduce their risk of atherosclerotic cardiovascular disease (ASCVD). Unfortunately, 10 to 20% stop taking them due to statin-associated muscle symptoms (e.g.
- Conditions
- Muscle Cramp, Ache, Weakness, Muscle, Statin Adverse Reaction
- Trial name
- NCT04507373
- Testing
- Simvastatin 40mg
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Texas Southwestern Medical Center
Statin-related Muscle Pain, Muscle Aches
7 Tesla MRI Study in Patients With Statin Related Muscle Complaints
Roughly 5-10% of statin-treated patients report muscle pain, aches, weakness, cramps, stiffness, or "heaviness" - typically occurring symmetrically in the legs.
- Conditions
- Statin-related Muscle Pain, Muscle Aches, Muscle Weakness, Muscle Cramp
- Trial name
- NCT04575090
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Adherence, Medication, Statin Adverse Reaction
Medicines Gaps Study
The adherence project aims to understand adherence rates and barriers to Direct oral anticoagulants (DOACs) and statins and improve awareness of healthcare professionals on adherence across Leeds.
- Conditions
- Adherence, Medication, Statin Adverse Reaction, Anticoagulant Adverse Reaction
- Trial name
- MeGa (NCT05332158)
- Testing
- Questionnaires to report barriers to medication adherence
- Where
- United Kingdom
- Volunteers
- 3,000 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Arterial Hypertension, Dyslipidemias
Study of Adherence to Antihypertensive Drugs and Statins by Hair Analysis
The problem of adherence to long-term therapies has been known for years and occurs substantially in all countries, although with greater severity in developing countries.
- Conditions
- Arterial Hypertension, Dyslipidemias, Antihypertensive Drugs, Statins
- Trial name
- INNOVA (NCT05347823)
- Testing
- Hair analysis for drug concentration
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Statin Dose
Effective Dose of Statin Post PCI
In this study post coronary stenting patients, were enrolled to receive moderate dose versus high dose statin for 1 year, and the result of major adverse cardiovascular events were recorded
- Trial name
- NCT04923152
- Testing
- moderate statin dose, high dose statin
- Where
- Iran
- Volunteers
- 582 people
- Sponsor
- Shiraz University of Medical Sciences
COVID, Statin
Statin Therapy and COVID-19 Infection
Considering that simvastatin, and probably statins in general, interfere with SARS-cov-2 cellular uptake and some inflammatory pathways activated by the virus, those patients on statin therapy should be less vulnerable to…
- Conditions
- COVID, Statin, Cardiovascular Diseases
- Trial name
- STACOV (NCT04407273)
- Testing
- observational
- Where
- Spain
- Volunteers
- 2,159 people
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili