Clinical trials: Statin
Hyperlipidemia, Insulin Resistance
Relationship Between Insulin Resistance and Statin Induced Type 2 Diabetes, and Integrative Personal Omics Profiling
Background: There is general agreement that statin-treatment of patients to lower plasma cholesterol levels can increase the incidence of type 2 diabetes mellitus (T2D) in some individuals1-5.
- Conditions
- Hyperlipidemia, Insulin Resistance, Type 2 Diabetes
- Trial name
- NCT02437084
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Stanford University
Ischemic Stroke
Affect of Health Education on Statins Medication Persistence and ClinicaL Prognosis of Ischemic Stroke Patients (HELP)
The purpose of this study is to assess the affect of multiple health education interventions for statins medication Persistence and clinical prognosis of ischemic stroke patients at 3, 6 and 12 months.
- Trial name
- NCT02140658
- Testing
- multiple health education interventions, conventional health education
- Where
- China
- Volunteers
- 3,111 people
- Sponsor
- yongjun wang
Intracerebral Hemorrhage
Statins in Patients With Spontaneous Intracerebral Hemorrhage
The relation between improvement in results of treating spontaneous intracerebral hemorrhage (SICH) and the application of statins has been subject to numerous analyses, and yet still remains debatable.
- Trial name
- NCT06094244
- Testing
- Atorvastatin, Rosuvastatin, No drugs
- Where
- Poland
- Volunteers
- 153 people
- Sponsor
- Pomeranian Medical University Szczecin
Atherosclerosis
Single Ascending Dose Safety Study of BMS-962476 in Healthy Subjects and Patients With Elevated Cholesterol on Statins
To obtain safety and tolerability information in healthy subjects is administered as a single dose
- Trial name
- NCT01587365
- Testing
- BMS-962476
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Acute Coronary Syndrome
Low-dose PCSK9 Inhibitor Combined With Stains on Serum Lipids in Chinese Population With Acute Coronary Syndrome
A total of 100 patients aged 18-85 years old with a definite diagnosis of ACS were admitted to the Department of Cardiovascular, The First Affiliated Hospital of Nanjing Medical University.
- Trial name
- NCT05298475
- Testing
- Statin, PCSK9 inhibitor
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Focus of Study
Effect of Atorvastatin Versus Rosuvastatin Intensive Statin Regimens on Chinese Elderly Patients Undergoing PCI
This randomized, open label, parallel-group study is designed to investigate whether periprocedural intensive statin therapy with atorvastatin versus rosuvastatin administration before PCI and 30-day continuous intensive…
- Trial name
- ARISE (NCT01646307)
- Testing
- Atorvastatin, Rosuvastatin
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Anzhen Hospital
Asthma
Statin Treatment in Patients With Asthma
Asthma is a chronic respiratory condition characterized by bronchial hyper-responsiveness secondary to abnormal inflammation of the lung. Steroids remain the most effective treatment for this condition.
- Trial name
- NCT00292201
- Testing
- Atorvastatin
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Queen's University
Stroke, Rhabdomyolysis
Neuroprotection With Statin Therapy for Acute Recovery Trial Phase 2
This trial will be a phase 2 randomized safety study in which ischemic stroke patients will be randomly assigned within 24 hours of symptom onset to placebo or standard dose lovastatin versus short-term high-dose lovastatin 640…
- Conditions
- Stroke, Rhabdomyolysis, Jaundice
- Trial name
- NeuSTART2 (NCT01976936)
- Testing
- Low Dose Lovastatin, High Dose Lovastatin
- Where
- 7 sites in United States
- Volunteers
- 162 people
- Sponsor
- Columbia University
Dyslipidemias
Efficacy of Low-dose (10 mg) Rosuvastatin in Korean 4 Statin Benefit Groups Per 2013 ACC/AHA Guideline
This study aimed to evaluate the efficacy of low-dose rosuvastatin (10 mg) in the 4 statin benefit groups requiring high- or moderate-intensity statin therapy according to the 2013 American College of Cardiology/American Heart…
- Trial name
- NCT03903029
- Testing
- Low-dose (10mg) rosuvastatin
- Volunteers
- 242 people
- Sponsor
- Seoul National University Hospital
Hypertrophic Cardiomyopathy
Study to Determine if Atorvastatin Reduces Size and Stiffness of Muscle in the Left Ventricle of the Heart
The purpose of this study is to determine if a drug called atorvastatin will reduce the size and stiffness of the muscle in the left ventricle of the heart.
- Trial name
- NCT00317967
- Testing
- Atorvastatin
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University of Calgary
Early Gastric Cancer or Gastric Adenoma
Role of Statin on the Gastric Inflammation in Patients at High Risk of Gastric Cancer
Statins are commonly used as cholesterol-lowering medications and have shown effectiveness in the primary and secondary prevention of heart attack and stroke.
- Trial name
- NCT01813994
- Testing
- Arm1: Statin
- Where
- South Korea
- Volunteers
- 96 people
- Sponsor
- Yonsei University
Atherosclerosis, Thromboembolism
Aspirin and Statins for Prevention of Atherosclerosis and Arterial Thromboembolism in Systemic Lupus Erythematosus
The purpose of this trial is to study if aspirin and statins (lipid-lowering agents) can reduce the progression of subclinical atherosclerosis in patients with systemic lupus erythematosus (SLE).
- Conditions
- Atherosclerosis, Thromboembolism, Systemic Lupus Erythematosus
- Trial name
- NCT00371501
- Testing
- Rosuvastatin, aspirin
- Where
- Hong Kong
- Volunteers
- 72 people
- Sponsor
- Tuen Mun Hospital
Acute Kidney Injury
The Effects of Statin on Postoperative Renal Function in Valvular Heart Surgery: a Randomized, Placebo-controlled Study
The aim of this study is to examine the association between preoperative statin treatment and the incidence of postoperative acute kidney injury(AKI) in patients undergoing valvular heart surgery.
- Trial name
- NCT01909739
- Testing
- atrovastatin
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Arterial Stiffness
Atorvastatin Effects On Arterial Stiffness In Hemodialysis
This research aims to assess effects of atorvastatin on arterial stiffness in hemodialysis patients
- Trial name
- NCT04472637
- Testing
- Atorvastatin
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Alexandria University
Chronic Nephropathy, Proteinuria
Statins in Proteinuric Nephropathies
End stage renal disease (ESRD) is rapidly growing worldwide. Patients with ESRD have increased morbidity and mortality mostly because of a dramatic excess of cardiovascular disease.
- Conditions
- Chronic Nephropathy, Proteinuria, Hypertension
- Trial name
- ESPLANADE (NCT00199927)
- Testing
- Fluvastatin, standard therapy
- Where
- 16 sites in Italy
- Volunteers
- 217 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Atrial Fibrillation
Coronary Computed Tomography AngioGraphy Prior to Catheter Ablation in Patients With Atrial FIBrillation
The purpose of this randomized, controlled trial is to investigate whether coronary computed tomography (CT) angiography prior to catheter ablation and derived treatment (medical anti-ischemic and multimodality treatment and/or…
- Trial name
- FIBCAG (NCT05978388)
- Testing
- Analysis of coronary CT Angiography and CAC scoring at the time of catheter ablation
- Where
- Denmark
- Volunteers
- 852 people
- Sponsor
- Tor Biering-Sørensen
Alzheimer's Disease
Statin Effects on Beta-Amyloid and Cerebral Perfusion in Adults at Risk for Alzheimer's Disease
The purpose of the research is to see how simvastatin affects a substance in the body called beta-amyloid. Beta-amyloid is found in the brain and in the liquid around the brain and spinal cord.
- Trial name
- SHARP (NCT00939822)
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Coronary Artery Disease, Statin Adverse Reaction
Barriers to Optimal LDL-C Targets in Patients With Atherosclerotic Cardiovascular Disease
In the present cross-sectional observational study, the investigators aimed to: Evaluate the prevalence of achievement of LDL-C targets among a sample of Egyptian ASCVD patients.
- Conditions
- Coronary Artery Disease, Statin Adverse Reaction, LDL Level
- Trial name
- BOLT (NCT06897566)
- Testing
- Fasting lipid profile
- Where
- 2 sites in Egypt
- Volunteers
- 1,000 people
- Sponsor
- Cairo University
Hypercholesterolemia
Combination Treatment With Green Tea Extract and Statins in Patients With Hypercholesterolemia
There is a positive correlation between serum's cholesterol levels and death from cardiovascular disease, especially coronary artery disease. The reduction of plasma lipids levels is one of the main goals of prevention.
- Trial name
- GTE-Stat (NCT00944827)
- Testing
- Green Tea Extract - Catechins
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- University of Thessaly
Coronary Artery Disease, Atherosclerosis of Coronary Artery
Comparison of Moderate-Intensity Statin Plus Ezetimibe vs. High-Intensity Statin for Coronary Plaque Stabilization
This study is a prospective, multicenter, randomized clinical trial aimed at comparing the effects of moderate-intensity statin plus ezetimibe combination therapy versus high-intensity statin monotherapy on coronary plaque…
- Conditions
- Coronary Artery Disease, Atherosclerosis of Coronary Artery, Plaque, Atherosclerotic
- Trial name
- NCT06767345
- Testing
- Rosuvastatin, Rosuvastatin/ezetimibe
- Where
- 7 sites in South Korea
- Volunteers
- 410 people
- Sponsor
- Korea University Anam Hospital