Clinical trials: Statin
Statin Dose
Effective Dose of Statin Post PCI
In this study post coronary stenting patients, were enrolled to receive moderate dose versus high dose statin for 1 year, and the result of major adverse cardiovascular events were recorded
- Trial name
- NCT04923152
- Testing
- moderate statin dose, high dose statin
- Where
- Iran
- Volunteers
- 582 people
- Sponsor
- Shiraz University of Medical Sciences
Hyperlipidemias
To Explore the Treatment Effect of Various Commercially Available Statins on Patients With Hyperlipidemia
The primary objective is to survey the efficacy of various commercially available statins (a class of lipid-lowering agents, for example, rosuvastatin, atorvastatin, simvastatin, lovastatin, pravastatin and fluvastatin) under…
- Trial name
- NCT00726362
- Where
- 8 sites in Taiwan
- Volunteers
- 3,270 people
- Sponsor
- AstraZeneca
Venous Thromboembolism, Blood Clot
Statins for Venous Event Reduction in Patients With Venous Thromboembolism
The standard or usual treatment for patients diagnosed with deep vein thrombosis or pulmonary embolism is treatment with blood thinners (called anticoagulants).
- Conditions
- Venous Thromboembolism, Blood Clot, Post Thrombotic Syndrome
- Trial name
- SAVER (NCT04319627)
- Testing
- Rosuvastatin Calcium
- Where
- 31 sites in Canada, France and 4 more
- Volunteers
- 2,700 people
- Sponsor
- Ottawa Hospital Research Institute
Dyslipidemia Associated With Type II Diabetes Mellitus
Type 2 Diabetic Patients Maintained on Statin Therapy
Patients with diabetes mellitus (DM) are at increased risk of atherosclerotic cardiovascular disease (ACVD). The achievement of the LDL-C target with statins for the reduction of ACVD risk is recommended.
- Trial name
- NCT03784703
- Testing
- Atorvastatin 40 Mg Oral Tablet, Rosuvastatin 10 Mg Oral Tablet
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Damanhour University
Impotence
Improvement of Erectile Dysfunction by Fluvastatin in Patients With Cardiovascular Risk Factors
The purpose of the study is to determine the effect of fluvastatin on penile arterial blood flow and erectile function in patients with arteriogenic ED and cardiovascular risk factors.
- Trial name
- NCT00382161
- Testing
- Fluvastatin-sodium
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital, Saarland
Acute Heart Failure
Study to Evaluate the Effectiveness of High Dose Statin Loading in Acute Heart Failure Patients
This is a prospective, single-center, randomized, controlled, open-label, pilot study to evaluate the effectiveness of high dose statin loading in acute heart failure patients.
- Trial name
- NCT01127945
- Testing
- statin
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Type II Diabetes Mellitus, Mixed Dyslipidemia
Diabetes and Combined Lipid Therapy Regimen (DIACOR) Study
The primary study hypothesis of this study is to determine whether there is a greater percentage of patients achieving a triglyceride level of <200 mg/dL with the combination of simvastatin 20 mg and fenofibrate 160mg than with…
- Trial name
- NCT00309712
- Testing
- fenofibrate 160 mg and simvastatin 20 mg
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Intermountain Health Care, Inc.
Dyslipidemia, Coronary Heart Disease
Comparative Efficacy Evaluation of Lipids When Treated With Niaspan & Statin or Other Lipid-Modifying Therapies-COMPELL
The purpose of this study is to evaluate the effectiveness of first-line treatment using Niaspan (an extended release version of niacin) and statins versus other drugs that lower lipid levels, in subjects with elevated fat levels…
- Conditions
- Dyslipidemia, Coronary Heart Disease, Atherosclerosis, Stroke
- Trial name
- NCT00079638
- Testing
- Niacin, Atorvastatin, Simvastatin
- Volunteers
- 300 people
- Sponsor
- Kos Pharmaceuticals
Dyslipidemia, Coronary Artery Disease
Characterization of Multi-dose RVX000222 in Combination With Statin Treatment in Dyslipidemia
This study is designed to characterize the pharmacokinetics of multi-dose RVX000222 and atorvastatin and rosuvastatin when either statin is administered in combination with RVX000222 in subjects with dyslipidemia.
- Trial name
- NCT01863225
- Testing
- RVX000222, Rosuvastatin, Atorvastatin
- Where
- Australia
- Volunteers
- 13 people
- Sponsor
- Resverlogix Corp
Hypercholesterolemia
Evaluation of Alirocumab Versus Ezetimibe on Top of Statin in Asia in High Cardiovascular Risk Patients With Hypercholesterolemia
Primary Objective: To demonstrate the reduction of low-density lipoprotein cholesterol (LDL-C) by alirocumab as add-on therapy to stable maximally tolerated daily statin therapy in comparison to ezetimibe 10 mg daily after 24…
- Trial name
- ODYSSEY EAST (NCT02715726)
- Testing
- Alirocumab, ezetimibe, atorvastatin
- Where
- 62 sites in China, India and 1 more
- Volunteers
- 615 people
- Sponsor
- Sanofi
Ischemic Stroke, Acute
Safety and Efficacy of Evolocumab in Ischemic Stroke
The goal of this clinical trial is to evaluate the effect of evolocumab in combination with statin therapy (atorvastatin) in acute ischemic stroke (AIS).
- Trial name
- SEEIS (NCT05697185)
- Testing
- Evolocumab
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital of Guangxi Medical University
Cardiovascular Diseases, Statin Adverse Reaction
Evaluation of Major Cardiovascular Events in Participants With, or at High Risk for, Cardiovascular Disease Who Are Statin Intolerant Treated With Bempedoic Acid (ETC-1002) or Placebo
The purpose of this study is to determine if treatment with bempedoic acid (ETC-1002) versus placebo decreases the risk of cardiovascular events in participants who have or are at high risk for cardiovascular disease and are…
- Trial name
- CLEAR Outcomes (NCT02993406)
- Testing
- Bempedoic acid 180 mg tablet
- Where
- 1,319 sites in United States, Argentina and 30 more
- Volunteers
- 13,970 people
- Sponsor
- Esperion Therapeutics, Inc.
Heart Failure
Targeting Sympathetic Overactivity in Heart Failure Patients With Statins
Heart failure (HF) is a leading cause of morbidity and mortality in the United States with the incidence and prevalence of the disease on a continual rise.
- Trial name
- NCT01097785
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Pain, Weakness
Clinical Trial of CoQ10 for Mild-to-Moderate Statin-Associated Muscle Symptoms
This study will evaluate whether a dietary supplement, coenzyme Q10 (CoQ10), will improve muscle symptoms, such as muscle aches, pains, cramps, and/or weakness, which are experienced by some individuals who use statin medications.
- Conditions
- Pain, Weakness, Cramps, Myalgia or Myositis Nos
- Trial name
- NCT01032993
- Testing
- Coenzyme Q10
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Catherine Buettner
Sexual Dysfunction
Statin Lowering Testosterone and Sexual Function
Statins may decrease serum testosterone levels via decreasing cholesterol. This longitudinal study detected the effects of rosuvastatin on free testosterone levels and sexual function in men with type 2 diabetes.
- Trial name
- NCT02612714
- Testing
- Rosuvastatin
- Where
- Taiwan
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Postoperative Atrial Fibrillation
Post-Operative Atrial Fibrillation After Surgical Aortic Valve Replacement and the Influence of Statins
Statins have rapid and significant actions that have potentially important (but not yet proven) implications for postoperative atrial fibrillation and cardiac protection in patients undergoing cardiac surgery.
- Trial name
- NCT05062239
- Testing
- Discontinuance of treatment with statins 7 to 14 days prior to surgery until 30 days postoperative, No-intervention.
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Lars Peter Riber
Pain
Effect of Succinylcholine on Patients Using Statins
Based on available mechanistic and clinical information, the investigators propose a nonrandomized study to evaluate the effect of succinylcholine in patients taking statins.
- Trial name
- NCT00986583
- Testing
- Succinylcholine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- The Cleveland Clinic
Liver Cirrhoses
Statins for Prevention of Disease Progression and Hospitalization in Liver Cirrhosis
In a randomized, doubleblind and placebo-controlled trial we assess both clinical and cellular effects of atorvastatin in patients with liver cirrhosis.
- Trial name
- STATLiver (NCT04072601)
- Testing
- Atorvastatin 10mg
- Where
- Denmark
- Volunteers
- 78 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Contrast Induced Nephropathy
Statins for Prevention of Contrast Induced Nephropathy
In this randomized study the investigators wish to explore the role of pre-procedural statin therapy for the prevention of contrast induced nephropathy in patients with moderate-to-severe renal dysfunction, submitted to elective…
- Trial name
- NCT00770796
- Testing
- Atorvastatin
- Volunteers
- 304 people
- Sponsor
- Ospedale Misericordia e Dolce
ADPKD, Autosomal Dominant Polycystic Kidney
Statin Therapy in Patients With Early Stage ADPKD
This study plans to learn if pravastatin is helpful in slowing down the progression of kidney disease in adults with autosomal dominant polycystic kidney disease (ADPKD).
- Trial name
- NCT03273413
- Testing
- Pravastatin
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Colorado, Denver