Clinical trials: Statin Dose
Dyslipidemias
Efficacy of Low-dose (10 mg) Rosuvastatin in Korean 4 Statin Benefit Groups Per 2013 ACC/AHA Guideline
This study aimed to evaluate the efficacy of low-dose rosuvastatin (10 mg) in the 4 statin benefit groups requiring high- or moderate-intensity statin therapy according to the 2013 American College of Cardiology/American Heart…
- Trial name
- NCT03903029
- Testing
- Low-dose (10mg) rosuvastatin
- Volunteers
- 242 people
- Sponsor
- Seoul National University Hospital
Atheroscleroses, Coronary
Effects of Statin for Elderly Patients With Atherosclerotic Cardiovascular Disease
High-dose statins can reduce mortality and cardiovascular events in patients with established atherosclerotic cardiovascular disease (ASCVD).
- Trial name
- NCT04826354
- Testing
- Rosuvastatin and Ezetimibe, Rosuvastatin
- Where
- 2 sites in South Korea
- Volunteers
- 582 people
- Sponsor
- Korea University Anam Hospital
Hyperlipidemia
LAPLACE-TIMI 57: Low-density Lipoprotein Cholesterol (LDL-C) Assessment With PCSK9 monoclonaL Antibody Inhibition Combined With Statin thErapy
To evaluate the effect of 12 weeks of subcutaneous (SC) evolocumab (AMG 145) administered every 2 weeks (Q2W) or every 4 weeks (Q4W), compared with placebo, on percent change from baseline in LDL-C when used in addition to a…
- Trial name
- LAPLACE (NCT01380730)
- Testing
- Evolocumab
- Where
- 100 sites in United States, Canada and 3 more
- Volunteers
- 631 people
- Sponsor
- Amgen
Aortic Valve Stenosis, Ventricular Hypertrophy
Effects of High Dose Atorvastatin in Patients With Surgical Aortic Stenosis
The purpose of the study is to see if statin therapy will optimize myocardial response to cardiopulmonary bypass during aortic valve replacement (AVR) for aortic valve stenosis (AVS) (Phase I) and optimize left ventricular…
- Trial name
- NCT00811330
- Testing
- Atorvastatin 80 mg
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Strasbourg, France
Thrombosis, Prevention
Re-STOP DVT: Reload of High Dose Atorvastatin for Preventing Deep Vein Thrombosis in Statin Users
Reload of high dose statin may have potential for preventing deep vein thrombosis (DVT) in patients on statin undergoing total knee replacement arthroplasty.
- Conditions
- Thrombosis, Prevention, Surgery
- Trial name
- Re-STOP DVT (NCT01063426)
- Testing
- High dose Atorvastatin+enoxaparin, Enoxaparin
- Where
- South Korea
- Volunteers
- 180 people
- Sponsor
- Hallym University Medical Center
Hypercholesterolemia, Dyslipidemia
A Multiple Dose Study Of PF-04950615 (RN316) In Subjects On Maximum Doses Of Statins
PF-04950615 is a new investigational hypercholesterolemic agent that is being tested in this study to evaluate if it can lower LDL cholesterol.
- Trial name
- NCT01350141
- Testing
- PF-04950615 (RN316)
- Where
- 35 sites in United States, Canada
- Volunteers
- 46 people
- Sponsor
- Pfizer
Liver Cirrhosis, Portal Hypertension Related to Cirrhosis
Clinical Evaluation of Simcyp-Guided Simvastatin Dosing in Patients With Liver Cirrhosis
This prospective open-label parallel pilot clinical study evaluated the efficacy and safety of physiologically based pharmacokinetic (PBPK)-guided simvastatin dosing in Child-Pugh A and B cirrhotic patients with portal…
- Trial name
- NCT07459972
- Testing
- Simvastatin 15 mg, Simvastatin 5 mg
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Kafrelsheikh University
Dyslipidaemias, Dyslipidemias
A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Administering Multiple Oral Doses of GSK1292263 Alone and With Atorvastatin
This study investigates the safety, pharmacokinetics and effects of GSK1292263 when taken alone or when co-dosed with atorvastatin to subjects with dyslipidemia.
- Trial name
- NCT01218204
- Testing
- 10mg atorvastatin, 80mg atorvastatin, 100mg GSK1292263
- Where
- 21 sites in United States
- Volunteers
- 287 people
- Sponsor
- GlaxoSmithKline
Hyperlipidemia
Ascending Multiple Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Evolocumab (AMG 145) in Adults With Hyperlipidemia on Stable Doses of a Statin
The purpose of the study is to evaluate the safety and tolerability of multiple doses of evolocumab when given as an add-on to stable statin therapy.
- Trial name
- NCT01133522
- Testing
- Evolocumab
- Volunteers
- 60 people
- Sponsor
- Amgen
Gynecologic Oncological Pelvic/Abdominal Surgery
High-dose Periop Statins for Prevention of DVT
This study is designed to determine if the use of atorvastatin (Lipitor), a member of the HMG coA reductase inhibitor class of drugs referred to as statins, will reduce inflammatory responses and deep vein thrombosis formation…
- Trial name
- NCT00259662
- Testing
- atorvastatin
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Yale University
Hypercholesterolemia
Statin Interchange by Pharmacist Collaborative Practice Agreement (CPA)
A group of ~ 225 patients were switched from atorvastatin to an equivalent statin either by their physicians usual management or by an collaborative pharmacist coordinated process.
- Trial name
- NCT01222182
- Testing
- atorvastatin
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Drug-eluting Stent (DES)
Aspirin Mono Therapy 12-months After Drug-eluting Stents Implantation
The purpose of this study is to determine whether high dose statin therapy in patients with aspirin mono antiplatelet therapy who had received drug-eluting stent (DES) previously and were free of the adverse cardiac events during…
- Trial name
- statin (NCT01557075)
- Testing
- Atorvastatin (High dose statin treatment), Pravastatin (High dose statin treatment)
- Where
- South Korea
- Volunteers
- 2,000 people
- Sponsor
- Yonsei University
Telomere Shortening, Telomere Length, Mean Leukocyte
Rosuvastatin Effect on Telomere-telomerase System in ACS
Coronary heart disease (CHD) is one of the diseases characterised by biological aging as one of the important risk factors in several epidemiological studies.
- Conditions
- Telomere Shortening, Telomere Length, Mean Leukocyte, 22q Telomere Deletion Syndrome
- Trial name
- NCT02299245
- Testing
- rosuvastatin
- Volunteers
- 400 people
- Sponsor
- Xiao-dong Zhuang
Hypercholesterolemia
Study in High Risk Patients Switched From Higher Doses of Other Statins to Crestor on the Percentage of Patients Reaching the New LDL-C Target Goal
The purpose of this study is to determine the efficacy of Crestor in high risk patients switched from higher doses of other statins in obtaining the new European Atherosclerosis Society (EAS) low-density lipoprotein cholesterol…
- Trial name
- NCT00240344
- Where
- 75 sites in Netherlands
- Volunteers
- 2,650 people
- Sponsor
- AstraZeneca
Coronary Artery Disease
Statin and Atheroma Vulnerability Evaluation
The purpose of this study is to evaluate the effect of statin therapy on the modification of atherosclerotic plaque composition and vulnerability in non-intervened coronary arteries with mild to moderate stenosis using VH-IVUS…
- Trial name
- STABLE (NCT00997880)
- Testing
- Rosuvastatin calcium 40mg, Rosuvastatin calcium10mg
- Where
- South Korea
- Volunteers
- 312 people
- Sponsor
- Seung-Jung Park
Sleep Disorders
A Single-centre Open Label Study to Investigate the Effect of Repeat Doses of SB-649868 on the Pharmacokinetics of Simvastatin and Atorvastatin in Healthy Male Volunteers.
The present study will investigate in humans the enzyme inhibition effects of SB-649868 on CYP3A4, using Simvastatin and Atorvastatin as CYP3A4 probe substrates, administered as single doses: alone, and on two different occasions…
- Trial name
- NCT01299597
- Testing
- Atorvastatin, Simvastatin, SB649868
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Hypercholesterolemia, Diabetes
Does Simvastatin Affect Insulin Sensitivity in Dyslipidemic Type 2 Diabetic Patients?
We aimed to address the issue whether statins affect insulin resistance. To this end, we combined the available state-of-the art technology for detailed assessment of both whole-body and tissue specific insulin sensitivity in…
- Conditions
- Hypercholesterolemia, Diabetes, Cardiovascular Disease
- Trial name
- NCT00704314
- Testing
- Simvastatin
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Vienna
Hypercholesterolemia
Randomized Parallel Group Trial Of The Efficacy And Safety Of Ezetimibe With A Statin Versus Statin Dose Doubling In Patients With Persistent Primary Hypercholesterolemia (0653-152)(COMPLETED)
To compare the percent (%) change in plasma LDL-C concentration, after a six week course of treatment with ezetimibe 10 mg/day co-administered with an existing statin versus doubling of the existing statin dose
- Trial name
- NCT00652847
- Testing
- ezetimibe, statins
- Volunteers
- 1,140 people, healthy volunteers welcome
- Sponsor
- Organon and Co
Hypercholesterolemia
Comparison of the Effect of Vytorin 10/80 Tablet Split Into 4 and Simvastatin 20 Milligrams on Low-density Lipoprotein (LDL) Cholesterol
The purpose of this study is to compare the efficacy of a Vytorin 10/80 tablet, an approved agent for the treatment of elevated LDL cholesterol which combines the cholesterol absorption inhibitor Ezetimibe 10 mg and simvastatin…
- Trial name
- NCT00762164
- Testing
- Vytorin, Simvastatin
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Bronx VA Medical Center