Clinical trials: Statin Therapy
Non-ST Segment Elevation Myocardial Infarction, Unstable Angina Pectoris
Intensive Statin Treatment in Chinese Coronary Artery Disease Patients Undergoing PCI
This randomized, open label, controlled, parallel group study is designed to test whether 2-day high dose atorvastatin administration before PCI and 30-day continuous intensive atorvastatin treatment is superior to usual care, in…
- Conditions
- Non-ST Segment Elevation Myocardial Infarction, Unstable Angina Pectoris, Stable Angina Pectoris
- Trial name
- ISCAP (NCT01293097)
- Testing
- Atorvastatin, Statin
- Where
- China
- Volunteers
- 2,884 people
- Sponsor
- Peking University First Hospital
Coronary Heart Disease (CHD), CHD Risk-Equivalent Disease
Study to Assess the Tolerability and Efficacy of Anacetrapib in Patients With Coronary Heart Disease (CHD) or CHD Risk-Equivalent Disease (MK-0859-019)
This study will evaluate the efficacy of anacetrapib (100 mg) for 24 weeks relative to placebo, on plasma concentrations of Low Density Lipoprotein Cholesterol and assess the safety and tolerability of anacetrapib (100 mg) in…
- Trial name
- DEFINE (NCT00685776)
- Testing
- anacetrapib
- Volunteers
- 1,623 people
- Sponsor
- Merck Sharp & Dohme LLC
Acute Coronary Syndrome, Prevention
Cholesterol Self-testing in Patients Post Acute Coronary Syndrome
The pharmacological reduction of LDL-C lowers cardiovascular risk and is therefore a priority in cardiovascular secondary prevention.
- Conditions
- Acute Coronary Syndrome, Prevention, LDL Hyperlipoproteinemia, Therapeutic Adherence
- Trial name
- C-Check (NCT06526013)
- Testing
- Cholesterol self-measurement
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University of Leipzig
Hypercholesterolemia, HMG COA Reductase Inhibitor Adverse Reaction
Statin Therapy to Improve Medication Adherence
The purpose of this pilot study is to examine if using genetics can improve statin adherence in patients who should be taking statins but are not because of prior side effects with statins.
- Trial name
- NCT01894217
- Testing
- Genetic testing and reporting for SLCO1B1*5 allele
- Where
- 2 sites in United States
- Volunteers
- 63 people
- Sponsor
- Duke University
Coronary Heart Disease
The Alteration of HDL Protein Composition in Patients With Coronary Heart Disease Before and After Statins Treatment
The protein composition of HDL is complicated. The investigators have identified 40 distinct proteins associated with HDL by proteomics technology, and these proteins have been confirmed to be related to the function of…
- Trial name
- NCT01543308
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Neurocognitive Dysfunction
Statin Therapy To Limit Cognitive Dysfunction After Cardiac Surgery
The primary aim of our prospective, randomized, double-blind interventional clinical trial is to determine the effectiveness of high dose atorvastatin therapy to reduce post operative cognitive dysfunction (POCD) in patients…
- Trial name
- NCT01186289
- Testing
- atorvastatin
- Where
- United States
- Sponsor
- Duke University
Dyslipidemia, High Risk Coronary Artery Disease
Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With High Risk Coronary Artery Disease (FORWARD)
The primary objective was to evaluate the effect of treatment with evolocumab on the risk for cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization, whichever…
- Trial name
- FORWARD (NCT04087915)
- Testing
- Evolocumab
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Anzhen Hospital
Chronic Periodontitis
Short-term Effect of 2% Atorvastatin Dentifrice in Periodontal Status.
Periodontal disease (PD) is an inflammatory, infectious and destructive condition of the tissues surrounding the teeth. However, even if bacteria are required to initiate periodontal disease, the immune response is responsible…
- Trial name
- NCT01929135
- Testing
- Medicated 2% atorvastatin dentifrice, Non-medicated dentifrice
- Where
- 2 sites in Chile
- Volunteers
- 38 people
- Sponsor
- Universidad de los Andes, Chile
STEMI, Dyslipidemias
The Safety and Long-Term Clinical Benefit of PCSK9i in STEMI Patients
Patients with acute coronary syndromes (ACS) have an increased risk of recurrent ischemic events, particularly during the first year following the index event, which is mainly due to unattended risk factors and/ or poor…
- Trial name
- NCT05579418
- Testing
- Evolocumab
- Volunteers
- 350 people
- Sponsor
- Hamad Medical Corporation
Kawasaki Disease, Coronary Artery Abnormalities
Statins Study in Children of Acute Kawasaki Disease With Coronary Artery Abnormalities
The goal of this observational study is to learn about the safety and effects of atorvastatin in treatment of Chinese Kawasaki disease (KD) children complicated with coronary artery abnormalities (CAA) in acute phase.
- Trial name
- NCT07530640
- Testing
- atorvastatin of dose level 1, atorvastatin of dose level 2, atorvastatin of dose level 3
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Children's Hospital of Fudan University
Sexual Dysfunction
Statin Lowering Testosterone and Sexual Function
Statins may decrease serum testosterone levels via decreasing cholesterol. This longitudinal study detected the effects of rosuvastatin on free testosterone levels and sexual function in men with type 2 diabetes.
- Trial name
- NCT02612714
- Testing
- Rosuvastatin
- Where
- Taiwan
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Myopathic Symptoms
Is Treatment of Vitamin D Deficiency Associated With Resolution of Statin-Induced Muscular Symptoms
Statins are a class of drugs that are highly effective at lowering cholesterol levels. However, compliance is often limited by symptoms of muscle pain.
- Trial name
- NCT01568255
- Testing
- Ergocalciferol
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Sickle Cell Disease
Effect of Simvastatin Treatment on Vaso-occlusive Pain in Sickle Cell Disease
The purpose of this study is to determine whether simvastatin is effective in reducing the frequency and intensity of vaso-occlusive pain episodes in patients with sickle cell disease.
- Trial name
- NCT01702246
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Noonan Syndrome
Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome
This study evaluate the efficacy of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-COA) reductase inhibitors, also known as "statins" in the treatment of growth and skeletal abnormalities in children with Noonan syndrome.
- Trial name
- RASTAT (NCT02713945)
- Testing
- Simvastatin
- Where
- 12 sites in France
- Volunteers
- 53 people
- Sponsor
- University Hospital, Toulouse
Aggressive Non-Hodgkin Lymphoma, Blasts Under 5 Percent of Bone Marrow Nucleated Cells
Donor Atorvastatin Treatment in Preventing Severe Acute GVHD After Nonmyeloablative Peripheral Blood Stem Cell Transplant in Patients With Hematological Malignancies
This phase II trial studies how well donor atorvastatin treatment works in preventing severe graft-versus-host disease (GVHD) after nonmyeloablative peripheral blood stem cell (PBSC) transplant in patients with hematological…
- Conditions
- Aggressive Non-Hodgkin Lymphoma, Blasts Under 5 Percent of Bone Marrow Nucleated Cells, Chronic Lymphocytic Leukemia, Loss of Chromosome 17p
- Trial name
- NCT01527045
- Testing
- Atorvastatin Calcium, Cyclosporine, Fludarabine Phosphate
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- Fred Hutchinson Cancer Center
Atherosclerosis
The Effect of Statin Treatment on Trained Innate Immunity
The innate immune system plays a pivotal role in the development and progression of atherosclerosis. Recently, it was reported that monocytes can develop a long-lasting immunological memory after stimulation with various…
- Trial name
- SIMPEL (NCT03354156)
- Testing
- statin treatment
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Hypercholesterolemia
Comparison of Ezetimibe Added to Ongoing Statin Therapy Versus Doubling the Dose of Statin in the Treatment of Hypercholesterolemia (P04355)
This is a randomized, open label, parallel group comparison study. Following a 1-week screening period, patients will be randomized to 1 of 2 treatment groups: ezetimibe added to ongoing statin treatment (ezetimibe plus…
- Trial name
- NCT00652327
- Testing
- Ezetimibe + Statin (simvastatin, atorvastatin, or pravastatin), Double Statin (simvastatin, atorvastatin, or pravastatin)
- Volunteers
- 83 people
- Sponsor
- Organon and Co
HIV Infection
Prospective Evaluation of Etravirine for HIV-infected Patients in Need of Lipid-lowering Drugs
Dyslipidaemia, characterized by raised triglyceride and low-density lipoprotein (LDL) cholesterol and reduced high-density lipoprotein (HDL) cholesterol levels, is common in HIV-infected individuals, and has been associated with…
- Trial name
- ETRALL (NCT01543035)
- Testing
- stop statin and switch to an antiretroviral drug with less impact on lipid metabolism
- Where
- 7 sites in Switzerland
- Volunteers
- 34 people
- Sponsor
- Calmy Alexandra
Chronic Hepatitis C
Fluvastatin, Rosuvastatin Added to Pegylated Interferon and Ribavirin
Hypothesis: addition of fluvastatin will increase the cure rate of standard anti-HCV therapy. Summary: This trial is limited to veterans in Oklahoma who qualify for care with the Veterans Administration.
- Trial name
- NCT00487318
- Testing
- standard of care, fluvastatin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Bader, Ted, M.D.
Heart Failure, Congestive
Statin Therapy in Heart Failure: Potential Mechanisms of Benefit
The goal of the investigators' study is to further understand the potentially beneficial effects of statin therapy in patients with heart failure.
- Trial name
- NCT00233480
- Testing
- atorvastatin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of California, Los Angeles