Clinical trials: Status Epilepticus
Status Epilepticus
Safety and Efficacy Study of IV Ganaxolone as Adjuvant Therapy for Established Status Epilepticus (ESE)
This study is designed to optimize the dosing regimen and evaluate the preliminary safety and efficacy of Intravenous (IV) ganaxolone as adjuvant therapy for participants with ESE receiving initial IV antiepileptic drug (AED)…
- Trial name
- NCT05757544
- Testing
- IV Ganaxolone
- Sponsor
- Marinus Pharmaceuticals
Stroke, Guillain-Barre Syndrome
Artificial Intelligence-powered Virtual Assistant for Emergency Triage in Neurology
This study examines the use of an AI-powered virtual assistant for quickly identifying and handling neurological emergencies, particularly in places with limited medical resources.
- Conditions
- Stroke, Guillain-Barre Syndrome, Facial Palsy, Migraine
- Trial name
- AIDEN (NCT06334796)
- Testing
- Virtual Assistant
- Where
- Argentina
- Volunteers
- 10 people
- Sponsor
- Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia
Status Epilepticus, Refractory Status Epilepticus
Refractory Status Epilepticus Treatment: Quality and Efficacy of Coma Induction
This study is to investigate the effects of different treatment characteristics regarding the use of intravenous anesthetic drugs (IVADs) as a rescue treatment for refractory Status epilepticus (RSE) on course and outcome.
- Trial name
- RESET (NCT04333082)
- Testing
- Data collection
- Where
- Switzerland
- Volunteers
- 147 people
- Sponsor
- University Hospital, Basel, Switzerland
Status Epilepticus, Cardiac Arrest With Successful Resuscitation
VIGAB-BIOSTAT: Neuronal Injury Panel Substudy
The purpose of this substudy is to collect and analyze control data to characterize the degree of neuronal injury in PASE patients who have not received vigabatrin to later compare with patients who received this therapy and…
- Trial name
- NCT05000320
- Testing
- Neuronal Injury Panel
- Sponsor
- University of Florida
Epilepticus; Status, Focal Motor
Perampanel in Focal Status Epilepticus
Randomized controlled trial on focal motor status epilepticus (SE), studying the add-on efficacy of the enteral administration of perampanel (PER) to a conventional intravenous antiepileptic drug.
- Trial name
- PEPSI (NCT04309721)
- Testing
- Perampanel
- Where
- 10 sites in France
- Volunteers
- 1 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Convulsive Status EPILEPTICUS
Cardiac Injury With Convulsive Status Epilepticus
1. Determine the impact of cardiac injury on clinical profile, cardiac evaluation and outcome in patients hospitalized with convulsive status epilepticus (CSE). 2.
- Trial name
- NCT06119919
- Volunteers
- 50 people
- Sponsor
- Assiut University
Status Epilepticus
Efficacy of Phenytoin vs Levetiracetam in Status Epilepticus at Institute of Child Health,Faisalabad
Status epilepticus is the second most common neurologic emergency in children. Morbidity and mortality are considerable; thus, timely termination of convulsive status epilepticus is the primary goal of management to avoid these…
- Trial name
- NCT06067412
- Testing
- Levetiracetam, Phenytoin
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Epilepsy, Status Epilepticus
Repeated TMS at Low Frequencies to Reduce Seizure Occurrence
Perform non-invasive neuro-navigated repeated Transcranial Magnetic Stimulation (rTMS) at low frequencies (LF) with the intent to reduce the occurrence of seizures over time (long-term protocol).
- Conditions
- Epilepsy, Status Epilepticus, Epilepsia Partialis Continua, Epilepsia Partialis Continua, Refractory (Medically)
- Trial name
- NCT03154307
- Testing
- Low frequency repeated TMS (LF-rTMS)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Baptist Health South Florida
Psychomotor Status, Schizophrenia
The Motor Neurological Soft Signs (MNSS) in Persons With Schizophrenia
The aim is to contribute to the knowledge of the relationship between Motor Neurological Soft Signs (MNSS) and schizophrenia, as well as to point out the implications and recommendations for clinical and rehabilitative practices…
- Conditions
- Psychomotor Status, Schizophrenia, Motor Skills Disorders
- Trial name
- MNSS (NCT04495998)
- Testing
- Brief Motor Scale_portuguese version (BMS_pt)
- Where
- Portugal
- Volunteers
- 103 people
- Sponsor
- Faculdade de Motricidade Humana
Anesthesia, Psychomotor Status
Driving Skills Recovery Following Procedural Sedation for Gastrointestinal Endoscopy
This is a prospective cohort study that will analyze psychomotoric recovery using a commercially available driving simulator following sedation for endoscopic procedures in subjects undergoing elective outpatient endoscopic…
- Trial name
- NCT04350424
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Status Epilepticus, Altered Level of Consciousness
eegCap Application in Paediatrics wiTh redUced GCS in REsus
Children frequently present with altered or reduced consciousness levels to emergency departments. By using EEG monitoring, subclinical seizure activity may be detected, leading to earlier pharmacological intervention and…
- Conditions
- Status Epilepticus, Altered Level of Consciousness, Non-epileptic Seizures, Epilepsy
- Trial name
- CAPTURE (NCT05259891)
- Where
- Ireland
- Volunteers
- 20 people
- Sponsor
- University College Cork
Status Epilepticus
Sustained Effort Network for Treatment of Status Epilepticus/European Academy of Neurology Registry on Refractory Status Epilepticus (SENSE-II/AROUSE)
SENSE-II/AROUSE is a prospective, multicenter registry for patients treated for SE. The primary objective is to document patients and SE characteristics, treatment modalities, EEG features, and outcome of consecutive adults…
- Trial name
- SENSEII/AROUSE (NCT05839418)
- Where
- 11 sites in Austria, Belgium and 6 more
- Volunteers
- 3,000 people
- Sponsor
- Erasme University Hospital
Status Epilepticus, Convulsive Status EPILEPTICUS
Intravenous Ganaxolone as Adjunctive Therapy to Treat Subjects With Status Epilepticus
This study will evaluate the effectiveness and safety of an investigational drug, IV ganaxolone, as adjunctive therapy to standard of care to treat subjects with status epilepticus.
- Conditions
- Status Epilepticus, Convulsive Status EPILEPTICUS, Non Convulsive Status Epilepticus, Epilepsy
- Trial name
- NCT03350035
- Testing
- IV Ganaxolone active
- Where
- 8 sites in United States
- Volunteers
- 17 people
- Sponsor
- Marinus Pharmaceuticals
Status Epilepticus
SURESTEP: Transcranial Direct Current Stimulation in Super Refractory Status Epilepticus
The purpose of this study is to determine whether transcranial direct current stimulation affects super refractory status epilepticus.
- Trial name
- SURESTEP (NCT03819543)
- Testing
- Transcranial Direct Current Stimulation
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Manitoba
Status Epilepticus, Ketogenic Dieting
Ketogenic Diet for Status Epilepticus in Children Post Cessation of Convulsive Status Epilepticus
Ketogenic diet being started early in those with status epilepticus and frequent or abundant discharges in EEG in comparison to just standard therapy is being evaluated here for efficacy and adverse effects.
- Trial name
- NCT05591508
- Testing
- Ketogenic Diet
- Where
- India
- Volunteers
- 50 people
- Sponsor
- All India Institute of Medical Sciences
Status Epilepticus
The Etiology of New-onset Status Epilepticus
This study will help to identify the causes of new epilepsy and provide a basis for the development of a rational and standardized diagnosis and treatment plan to reduce the rate of disability and death.
- Trial name
- NCT05647525
- Testing
- Perform autoimmune encephalitis titer tests
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Jie Liu
Status Epilepticus, Generalized Convulsive Status Epilepticus
Effectiveness of Combined Levetiracetam and Midazolam in Generalized Convulsive Status Epilepticus in Children
Generalized status epilepticus is a common pediatric neurological emergency with significant mortality and morbidity. Benzodiazepines remain the first anticonvulsive line but benzo-diazepines don't control seizures in about 30%…
- Conditions
- Status Epilepticus, Generalized Convulsive Status Epilepticus, Status Epilepticus, Generalized, Status Epilepticus, Generalized Convulsive
- Trial name
- NCT04926844
- Testing
- Levetiracetam, Midazolam
- Where
- Egypt
- Volunteers
- 144 people
- Sponsor
- Sohag University
Respiratory Failure, Status Epilepticus
Pilot Simulation RCT of Telemedical Support for Paramedics
This study evaluates the impact of video communication via telemedicine on the quality of emergency care provided to children by paramedic teams supported by a remote physician in a simulated out-of-hospital setting.
- Conditions
- Respiratory Failure, Status Epilepticus, Status Asthmaticus, Cardiopulmonary Arrest
- Trial name
- NCT03742167
- Testing
- Telemedicine
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Boston Medical Center
Epileptic Seizure
Epileptic Seizures in Intensive Care Units
This retrospective observational cohort study is to assess and analyze clinical, electroencephalographic, laboratory, comorbidity, and treatment characteristics of Intensive care unit (ICU)-patients with epileptic seizures and to…
- Trial name
- NCT03860467
- Testing
- collection of patient data
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland
Status Epilepticus
Study of Midazolam in Healthy Adults
This study is a phase 1, open-label, crossover, comparison study to evaluate the safety and pharmacokinetics (PK) of a single IM administration of 10 mg midazolam using Rafa's auto-injector compared with seizalam in healthy…
- Trial name
- NCT04679623
- Testing
- Midazolam, Seizalam
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rafa Laboratories