Clinical trials: Stenoses, Aortic
Microvascular Dysfunction, Hypertrophic Obstructive Cardiomyopathy
Association Between Microvascular Resistance and Outcomes in Patients With Obstructive Hypertrophic Cardiomyopathy
About 60% of patients with hypertrophic cardiomyopathy have microvascular dysfunction. Microvascular dysfunction is directly related to prognosis in hypertrophic cardiomyopathy.
- Conditions
- Microvascular Dysfunction, Hypertrophic Obstructive Cardiomyopathy, Microcirculation Resistance
- Trial name
- NCT05671367
- Where
- China
- Volunteers
- 340 people
- Sponsor
- China National Center for Cardiovascular Diseases
Williams Beuren Syndrome
Efficacy of Minoxidil in Children With Williams-Beuren Syndrome
The Williams-Beuren syndrome (WBS) is a sporadic congenital disorder characterized by a multisystem developmental impairment. This syndrome is caused by a microdeletion in chromosome 7q11.23 that encompasses loss of the elastin…
- Trial name
- Williams (NCT00876200)
- Testing
- Minoxidil
- Where
- 18 sites in France
- Volunteers
- 21 people
- Sponsor
- Hospices Civils de Lyon
Aortic Valve Stenosis
A Study to Evaluate the Neuro-embolic Consequences of TAVR
A prospective, multi-center study to evaluate the neuro-embolic consequences of Transcatheter Aortic Valve Replacement (TAVR)
- Trial name
- NCT02073864
- Where
- 5 sites in United States
- Volunteers
- 46 people
- Sponsor
- Keystone Heart
Aortic Stenosis, Valvular Heart Disease
Severe Aortic Stenosis in Patients Referred for Valve Surgery
Our main hypothesis on the present study is that new parameters such as risk-taking behavior, patients motivation, health related quality of life, new biomarkers and more precise echocardiography measures in addition to…
- Conditions
- Aortic Stenosis, Valvular Heart Disease, Symptomatic Aortic Stenosis
- Trial name
- SAS (NCT01794832)
- Where
- Norway
- Volunteers
- 500 people
- Sponsor
- Oslo University Hospital
Hypertrophic Cardiomyopathy
A Biomarker and MRI Study on Troponin Release After Exercise in Hypertrophic Cardiomyopathy
Study population: 1) mutation carriers without the hypertrophic phenotype (pre-clinical Hypertrophic Cardiomyopathy (HCM)) and in 2) patients with clinically overt HCM (clinical HCM).
- Trial name
- BE STRONG HCM (NCT01559714)
- Where
- Netherlands
- Volunteers
- 81 people
- Sponsor
- Heartcenter, University Medical Center St. Radboud
Aortic Valve Stenosis
Protection by Remote Ischemic Preconditioning During Transcatheter Aortic Valve Implantation
Transcatheter aortic valve implantation (TAVI) has rapidly been adopted into clinical practice, but concerns have been raised regarding periprocedural complications like e.g. myocardial injury, stroke or acute kidney injury.
- Trial name
- NCT02080299
- Testing
- Remote ischemic preconditioning (RIPC)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University Hospital, Essen
Aortic Valve Stenosis
Sizing of the PERCEVAL® Sutureless Aortic Valve Prosthesis Using the CT: a Feasibility Study
This study is to analyse if the size of the valve can be determined with a preoperative CT scan of the heart in order to prepare the valve preoperatively to save time.
- Trial name
- NCT03667248
- Testing
- Sorin Perceval ® Sutureless Valve (Sorin Group Italia Srl, 13040 Saluggia, Italy), available in different sizes (S 19-21mm, M 21-23mm, L 23-25mm, XL 25-27mm)
- Where
- Switzerland
- Volunteers
- 7 people
- Sponsor
- University Hospital, Basel, Switzerland
Long QT Syndrome, Hypertrophic Cardiomyopathy
Molecular Genetic Screening and Identification of Congenital Arrhythmogenic Diseases
The aim of this study is the identification of familial congenital arrhythmogenic disorders and their clinical follow-up.
- Conditions
- Long QT Syndrome, Hypertrophic Cardiomyopathy, Arrhythmogenic Right Ventricular Dysplasia
- Trial name
- NCT00221832
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Heidelberg University
Cardiomyopathy, Hypertrophic
Pacemaker Therapy for Drug-refractory Symptoms in Mid-cavity Hypertrophic Cardiomyopathy
The main aim of this study is to assess the acute effects of a pacemaker on reducing abnormally high intracavity pressures in the hearts of patients with mid-cavity obstructive hypertrophic cardiomyopathy (HCM).
- Trial name
- NCT03450252
- Testing
- Active pacing, Back-up pacing
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- Barts & The London NHS Trust
Aortic Stenosis
Neuropsychological Testing in Patients Undergoing Transvascular Aortic Valve Implantation
The purpose of this study is to examine the neuropsychological effects of transvascular aortic valve implantation (TAVI). Patients undergoing TAVI usually suffer from congestive heart failure and low cardiac output which may…
- Trial name
- TAVIPSYCH (NCT01648309)
- Testing
- Neuropsychological testing
- Where
- Israel
- Sponsor
- Hadassah Medical Organization
Mental Disorders
Effects of Emotion on Episodic Memory in Typically Developing Children and Children With Williams-Beuren Syndrome
It's well established in the literature that emotional events are more likely to be remembered than neutral events. Although this Emotional Enhancement of Memory (EEM) has been well demonstrated in the adult literature, little is…
- Trial name
- EEM-TAdev (NCT03688516)
- Testing
- Manipulation of valence and modality, Spatial and recognition memory, Source and content memory
- Where
- France
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Aortic Valve Stenosis, Renal Insufficiency
Remote Ischemic Preconditioning for Renal Protection in TAVI
Severe aortic stenosis remains a major cause of morbidity and mortality of the elderly affecting approximately 3% of elderly patients with an increasing number of patients undergoing transcatheter aortic valve interventions.
- Conditions
- Aortic Valve Stenosis, Renal Insufficiency, Contrast-induced Nephropathy
- Trial name
- NCT03347032
- Testing
- Remote ischemic preconditioning, Control
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Henry Ford Health System
Aortic Valve Stenosis
Improving Echo Measurements in the Diagnosis of Aortic Stenosis
Aortic stenosis is a common valvular heart disease, affecting mainly people over age 60. It is characterized by years to decades of slow progression followed by rapid clinical deterioration and a high death rate once symptoms…
- Trial name
- NCT02146755
- Where
- 2 sites in United States
- Volunteers
- 396 people
- Sponsor
- Baylor Research Institute
Aortic Valve Stenosis
PREVAIL-20J - Transfemoral Placement of 20mm Aortic Balloon Expandable Transcatheter Valve Trial
A single arm, prospective multicenter non-randomized pivotal clinical trial evaluating the 20mm Edwards SAPIEN XT™ transcatheter heart valve (model 9300TFX), NovaFlex™ transfemoral delivery system, and crimper accessories.
- Trial name
- PREVAIL-20J (NCT01419015)
- Testing
- SAPIEN XT NovaFlex delivery system
- Where
- 4 sites in Japan
- Volunteers
- 17 people
- Sponsor
- Edwards Lifesciences
Hypertrophic Cardiomyopathy
Family Studies of Inherited Heart Disease
Hypertrophic cardiomyopathy (HCM) is a genetically inherited heart disease. It causes thickening of heart muscle, especially the chamber responsible for pumping blood out of the heart, the left ventricle.
- Trial name
- NCT00001225
- Where
- United States
- Volunteers
- 5,880 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
CAVD
Randomized, Open-label Trial of Inhibitory Effect of Evogliptin on Progression of CAVD
The purpose of this study is to assess an inhibitory effect of Evogliptin on the progression of mild-to-moderate aortic stenosis in patients with T2DM and calcific aortic stenosis.
- Trial name
- NCT04521452
- Testing
- Evogliptin
- Where
- South Korea
- Volunteers
- 218 people
- Sponsor
- Asan Medical Center
Aortic Stenosis
Effect of Steroids on Cerebral Inflammation and Neuronal Damage After Surgical Aortic Valve Replacement
The purpose of this study is to investigate if methylprednisolone is effective in reducing the cerebral inflammatory response after open heart surgery with cardiopulmonary bypass.
- Trial name
- NCT01755338
- Testing
- Methylprednisolone
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Sahlgrenska University Hospital
Hypertension, Renovascular
Drug-eluting Balloon for Treatment of Non-atherosclerotic Renal Artery Stenosis
Efficacy of drug eluting balloon(DEB) for non-atherosclerotic renal artery stenosis will be tested in this study. The intervention group will be treated with paclitaxel eluting balloon.
- Trial name
- NCT04366596
- Testing
- Angioplasty with paclitaxel eluting balloon, Angioplasty with plain old balloon
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Peking Union Medical College Hospital
Myocardial Infarction (MI), Hypertrophic Cardiomyopathy (HCM)
The Application of T1 Mapping in Real-World
The goal of this observational study is to create a comprehensive real-world spectrum of T1 mapping measurements across different heart conditions.
- Conditions
- Myocardial Infarction (MI), Hypertrophic Cardiomyopathy (HCM), Dilated Cardiomyopathy (DCM), Arrhythmogenic Cardiomyopathy
- Trial name
- NCT07354646
- Testing
- Magnetic Resonance Imaging with Contrast
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Heart Valve Prosthesis, Aortic Stenosis
Comparison of Sutureless Vs. Standard Biological Prostheses for Surgical Aortic Valve Replacement
Multicenter randomised study which aims to compare sutureless Vs. standard bio- prostheses (1:1) among patients undergoing surgical aortic valve replacement in terms of: 6 -month hemodynamic performance.
- Conditions
- Heart Valve Prosthesis, Aortic Stenosis, Hemodynamics
- Trial name
- COPERA (NCT03965065)
- Testing
- Sutureless aortic bioprosthesis, Conventional stented sutured aortic prosthesis
- Where
- Spain
- Volunteers
- 350 people
- Sponsor
- Hospital San Carlos, Madrid
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.