Clinical trials: Stenoses, Aortic
Aortic Valve Stenosis, Ventricular Outflow Obstruction, Left
Polish Registry of Common Carotid Artery Access for TAVI
Transcatheter aortic valve implantation (TAVI) is valuable treatment option for patients, who are at the high risk of surgical aortic valve replacement (AVR).
- Trial name
- POL-CAROTID (NCT03361007)
- Testing
- Transcatheter Aortic Valve Implantation (TAVI)
- Where
- 6 sites in Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Warsaw
Aortic Valve Stenosis, Cardiovascular Diseases
The Bicuspid Aortic Stenosis Following Transcatheter Aortic Valve Replacement Registry
The purpose of this study is to evaluate the clinical outcomes of transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic valve stenosis.
- Conditions
- Aortic Valve Stenosis, Cardiovascular Diseases, Heart Valve Diseases, Bicuspid
- Trial name
- Bicuspid TAVR (NCT02394184)
- Testing
- transcatheter aortic valve replacement
- Where
- South Korea
- Volunteers
- 102 people
- Sponsor
- Seung-Jung Park
Calcific Aortic Valve Disease, AORTIC VALVE DISEASES
Vericiguat for the Inhibition of Calcific Aortic Valve Stenosis Progression
Calcific aortic valve stenosis (CAVS) is a condition in which the aortic valve progressively narrows and stiffens due to calcium deposition, eventually impairing blood flow from the heart to the body.
- Conditions
- Calcific Aortic Valve Disease, AORTIC VALVE DISEASES, Aortic Valve Stenosis
- Trial name
- VERIFICATION (NCT07715279)
- Testing
- Vericiguat (BAY1021189)
- Where
- China
- Volunteers
- 238 people
- Sponsor
- West China Hospital
Aortic Stenosis
Correlation of Auscultatory Severity of Aortic Stenosis With Trans Thoracic Echocardiography
According to the 2006 ACC/AHA practice guidelines for valvular heart disease, patients with asymptomatic aortic stenosis(AS) should have screening transthoracic echocardiograms (TTE) performed annually for severe disease, every…
- Trial name
- Cassette (NCT01605669)
- Testing
- Tranthoracic Echocardiogram, Cardiac Ascultation Recordings with Electronic stethoscope
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- United States Naval Medical Center, San Diego
Aortic Stenosis
Regression in Left Ventricular Hypertrophy and Fibrosis in Aortic Stenosis
This trial aims to improve the heart health of people with a narrowed aortic valve called aortic stenosis (AS) who then have aortic valve replacement (AVR) by assessing the change in the mass of the left ventricle.
- Trial name
- RELIEF-AS (NCT07539259)
- Testing
- Dapagliflozin (DAPA), Spironolactone (drug), Spironolactone + Dapagliflozin
- Volunteers
- 445 people
- Sponsor
- University College, London
Aortic Stenosis
Does Cardiac REhabilitation Improve Functional, Independence, Frailty and Emotional outCOmes Following Trans Catheter Aortic ValvE Replacement?
The aim of this pilot study is to assess function, independence, frailty and emotional status in 30 patients who have been accepted for TAVI.
- Trial name
- RECOVER-TAVR (NCT02921880)
- Testing
- Cardiac Rehabilitation
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Heart Disease
4 Cities for Assessing CAlcification PRognostic Impact After TAVI
Transcatheter Aortic Valve Implantation (TAVI) indications are progressing rapidly as an alternative to conventional surgery for aortic stenosis cure.
- Trial name
- C4CAPRI (NCT02935491)
- Testing
- Transcatheter Aortic Valve Implantation (TAVI)
- Where
- France
- Volunteers
- 1,600 people
- Sponsor
- Hospices Civils de Lyon
Trachea Diseases, Tracheal Stenosis
Feasibility of Tracheobronchial Reconstruction Using Bioengineered Aortic Matrices
We used a segment of cryopreserved aorta as a graft for reconstruction for long segment tracheobronchial lesion in human.
- Conditions
- Trachea Diseases, Tracheal Stenosis, Lung Cancer, Tuberculosis; Tracheitis
- Trial name
- NCT04850742
- Testing
- Cryopreserved aorta
- Where
- Taiwan
- Volunteers
- 5 people
- Sponsor
- National Taiwan University Hospital
Quality of Life, Aortic Valve Stenosis
Frailty and Cognitive Function Assessment of TAVI Patients
Aortic stenosis (AS) is the most common valve disease among the adult population, in the majority of the cases it only requires treatment in advanced age.
- Conditions
- Quality of Life, Aortic Valve Stenosis, Heart Valve Disease
- Trial name
- NCT02650388
- Testing
- Cognitive fuction, quality of life
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- Hungarian Institute of Cardiology
Aortic Stenosis
PROVE ACURATE neo2™ - Post Market Safety and Performance Surveillance in Aortic Stenosis
Aortic valve sclerosis (aortic valve thickening and calcification without pressure gradient) is one of the most common valvular abnormalities in the Western world.
- Trial name
- PROVE (NCT05539573)
- Testing
- Planned TAVI with the ACURATE neo2™ aortic bioprosthesis and ACURATE neo2™ transfemoral delivery system.
- Where
- 27 sites in France, Germany and 2 more
- Volunteers
- 1,043 people
- Sponsor
- University of Leipzig
Aortic Stenosis, Severe
Predictive Value of Pre-TAVI Infrahissian Conduction Time in the Occurrence of Complete Atrioventricular Block
The purpose of the study is implantation of a Pacemaker at 30 days for occurrence of a high-grade conduction disorder per- or post-procedure (yes/no)
- Trial name
- TAVHIS (NCT05714579)
- Testing
- Transcatheter Aortic Valve Implantation
- Where
- France
- Volunteers
- 35 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Hypertrophic Cardiomyopathy (HCM)
Mavacamten to Aficamten Transition in Patients With Obstructive Hypertrophic Cardiomyopathy
This is an investigator-initiated two-center study. The goal of this study is to investigate the feasibility, safety and efficacy outcomes of a seamless transition from mavacamten to aficamten in patients with obstructive…
- Trial name
- CMI-SWITCH (NCT07600177)
- Testing
- Aficamten
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Oregon Health and Science University
Aortic Valve Stenosis
Morbidity and Mortality Due to Deferral of Aortic Valve Replacement in Patients With Severe Aortic Stenosis
Background and Project Rationale: Degenerative aortic valve stenosis affects 2% of the elderly population aged 70 years or older and progresses insidiously with advancing age [1] before manifesting with symptoms such as decreased…
- Trial name
- AS DEFER (NCT04333875)
- Testing
- TAVR or SAVR
- Where
- Switzerland
- Volunteers
- 71 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Aortic Valve Replacement, Aortic Stenosis
TAVI Protocol - Paravertebral Block Study
Trans-apical aortic valve replacement is a new treatment for severe aortic stenosis. It is offered to elderly patients with medical problems that would markedly increase the risk of conventional cardiac surgery.
- Trial name
- TAVI PVB (NCT01404975)
- Testing
- Thoracic paravertebral block (PVB)
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- University Health Network, Toronto
Cognitive Impairment, Older People--Abuse of
Pre- and Post TAVI Cognitive Functioning and Intraoperative Carotid Flow Measurements
Purpose: 1. Measuring and optimize the usability of the BAMCOG (games to measure cognitive functioning) 2. Concurrent validation of BAMCOG with MoCA to see if BAMCOG can serve as a monitoring instrument/screener 3.
- Conditions
- Cognitive Impairment, Older People--Abuse of, Aortic Stenosis, Severe
- Trial name
- NCT05813353
- Where
- Netherlands
- Volunteers
- 54 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Aortic Valve Stenosis
Preoperative Chest CT-imaging in Surgical Aortic Valve Replacement with or Without CABG
Rationale When determining the strategy for aortic valve replacement, echocardiography is still considered the golden standard (1).
- Trial name
- GUIDE-SAVR (NCT06603454)
- Testing
- Preoperative CT
- Where
- Netherlands
- Volunteers
- 380 people
- Sponsor
- Romy Hegeman
Aortic Valve Stenosis
RESPOND Post Market Study
The purpose of the RESPOND post market study is to collect real world clinical and device performance outcomes data with the Lotus Valve System used in routine clinical practice to demonstrate that the commercially available…
- Trial name
- RESPOND (NCT02031302)
- Testing
- Lotus Valve System
- Where
- 41 sites in Colombia, Finland and 11 more
- Volunteers
- 1,064 people
- Sponsor
- Boston Scientific Corporation
Valve Stenoses, Aortic, Amyloidosis Cardiac
Impact of Amyloidosis on TAVI Patients
To analyze the prevalence and impact on the prognosis of amyloidosis due to transthyretin in patients with severe aortic stenosis who undergo percutaneous aortic valve implantation.
- Trial name
- AMY-TAVI (NCT03984877)
- Testing
- Diagnosis of amyloidosis
- Where
- Spain
- Volunteers
- 320 people
- Sponsor
- Javier López Pais
Aortic Valve Stenosis
Hamburg AoRtic Valve cOhoRt
The primary aim of the study is to identify the optimal treatment modality for patients with aortic valve disease, incorporating the individual patient's risk profile and anticipated clinical outcomes.
- Trial name
- HARbOR (NCT04227002)
- Where
- Germany
- Volunteers
- 15,000 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Aortic Stenosis, Left Ventricle Hypertrophied
Effect of Dapagliflozin on Myocardial and Renal Function Following Aortic Valve Stenosis Intervention
Randomized, double-blinded, placebo-controlled study in AS patients with subclinical or clinical heart failure undergoing treatment with TAVR.
- Trial name
- DAPAS (NCT05241431)
- Testing
- SGLT2 inhibitor
- Where
- Denmark
- Volunteers
- 106 people
- Sponsor
- University of Aarhus
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.