Clinical trials: Stenosis, Aortic
Transcatheter Aortic Valve Implantation (TAVI), Blood Transfusion
Transfusion Requirements in Transcatheter Aortic Valve Implantation (TRITAVI) Study
Periprocedural bleeding events are frequent during transcatheter aortic valve implantation (TAVI), mainly driven by vascular complications and are associated to a worse prognosis.
- Conditions
- Transcatheter Aortic Valve Implantation (TAVI), Blood Transfusion, AKI, Prognosis
- Trial name
- TRITAVI (NCT03740425)
- Testing
- Blood Transfusion
- Where
- Italy
- Volunteers
- 3,235 people
- Sponsor
- G. d'Annunzio University
Aortic Stenosis
SecOnd-generation seLf-expandable Versus Balloon-expandable Valves and gEneral Versus Local Anesthesia in TAVI
Aim of the study is to demonstrate equivalence of second-generation self-expandable valves (CoreValve Evolut R) in comparison to second-generation balloon-expandable valves (Edwards Sapien 3) and of local anesthesia with…
- Trial name
- SOLVE-TAVI (NCT02737150)
- Testing
- CoreValve Evolut R, Edwards Sapien 3, Local anesthesia with conscious sedation
- Where
- Germany
- Volunteers
- 444 people
- Sponsor
- Helios Health Institute GmbH
Aortic Valve Stenosis, Postoperative Complications
Comparing Suture vs. Combined Closure Strategies for Large Blood Vessel Access in Patients Undergoing Transcatheter Aortic Valve Implantation (TAVI)
The goal of this clinical trial is to compare two strategies for closing the main artery access site in adult patients undergoing transcatheter aortic valve implantation (TAVI) through a blood vessel in the leg (transfemoral…
- Conditions
- Aortic Valve Stenosis, Postoperative Complications, Vascular System Injuries, Hemorrhage
- Trial name
- SEAL-TAVI (NCT07743697)
- Testing
- Single Suture-Based Vascular Closure Device, Extravascular Collagen Plug-Based Closure Device
- Where
- Switzerland
- Volunteers
- 705 people
- Sponsor
- University Hospital, Basel, Switzerland
Cardiomyopathy, Hypertrophic Obstructive
BHB-1893 Versus Metoprolol for Symptomatic Obstructive Hypertrophic Cardiomyopathy
The main purpose of this trial is to find out whether BHB-1893 works better than metoprolol in adults with symptoms of obstructive hypertrophic cardiomyopathy (oHCM).
- Trial name
- LIONHEART-HCM (NCT07755904)
- Testing
- BHB-1893, Metoprolol
- Where
- 3 sites in United States
- Volunteers
- 210 people
- Sponsor
- Braveheart Bio, Inc.
Cardiovascular Abnormalities
Novel Echocardiographic and Invasive Haemodynamic Measurements in the Assessment of Patients Low Flow Low Gradient Aortic Stenosis Undergoing TAVI
In this study the investigators will assess a variety of novel markers of heart strength (contractility) and assess whether they can give a clearer indication of how well patients with weak hearts respond to the TAVI procedure.
- Trial name
- LFLG (NCT05196815)
- Testing
- Ultrasound, Catheters, Soft study wire
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Aortic Stenosis, Severe
All Women Comparing Self-expanding ALLEGRA Valve to Any Other Balloon-expandable Valve
Study is aimed to demonstrate that the self-expandable Allegra TAVI system provides lower mean gradient assessed by TTE compared to balloon-expandable valve systems in a female patient population with symptomatic severe aortic…
- Trial name
- NCT05989074
- Testing
- ALLEGRA TAVI System TF, Ballon-expandable valve system
- Volunteers
- 130 people
- Sponsor
- Ceric Sàrl
Cardiovascular Diseases, Heart Diseases
Effects of Highly Active Anti-Retroviral Therapy on Cardiovascular Health in Infants of HIV-Infected Mothers
This study will determine the impact of highly active antiretroviral therapy (HAART) on the developing cardiovascular system, the evolution of HAART-associated cardiovascular changes over time, and the association between…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Atherosclerosis, HIV Infections
- Trial name
- CHAART-1 (NCT00253682)
- Where
- 5 sites in United States
- Volunteers
- 167 people
- Sponsor
- University of Miami
Aortic Valve Stenosis
Quality of Care in AS IMPULSE Study
The purpose of this study is to narrow the gap between patients being diagnosed with severe aortic stenosis and those being appropriately monitored and treated.
- Trial name
- IMPULSE (NCT02241447)
- Where
- 23 sites in Austria, Czechia and 7 more
- Volunteers
- 2,173 people
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
Heart Failure, Aortic Stenosis
Heart Failure and Aortic Stenosis Transcriptome
This study is aimed to investigate the global transcriptome in order to determine the expression profile of messenger RNAs (mRNAs), as well as long noncoding- (lncRNAs) and micro noncoding-RNAs (miRNAs) in heart failure (HF) and…
- Trial name
- RNA-HF-AS (NCT03268135)
- Testing
- measurement of RNAs
- Where
- 2 sites in Italy
- Volunteers
- 500 people
- Sponsor
- IRCCS Policlinico S. Donato
Hypertrophic Cardiomyopathy With Obstruction
Triple Chamber Pacing in Hypertrophic Obstructive Cardiomyopathy (HOCM) Patients - TRICHAMPION STUDY
This investigation is a prospective, randomized, single-blinded and multicenter design. The purpose of this study is to evaluate the benefit of atrial-synchronous biventricular (BiV) pacing in severely symptomatic hypertrophic…
- Trial name
- TRICHAMPION (NCT01614717)
- Testing
- CRT-P Implant
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Abbott Medical Devices
Aortic Valve Stenosis, Heart Valve Disease
Valve Leaflet Motion in Sutureless Bioprosthetic Aortic Valves
A single-center prospective interventional trial. Patients implanted with a sutureless bioprosthetic aortic valve at Karolinska University Hospital in Stockholm, Sweden from 2012 will be eligible.
- Trial name
- NCT02671474
- Testing
- 4-dimensional volume-rendered computed tomography
- Where
- Sweden
- Volunteers
- 47 people
- Sponsor
- Karolinska University Hospital
Aortic Stenosis
Impact of Predilatation Between Self-expanding Valves
A Multicenter, prospective, non-randomized, trial evaluating the safety and clinical efficacy of the next-generation, self-expandable Boston Scientific ACURATE NEO/TF Transcatheter Heart Valves, implanted in patients with severe…
- Trial name
- DIRECTII (NCT04157920)
- Testing
- Transcatheter Aortic Valve Implantation with ACURATE NEO/TF, Transcatheter Aortic Valve Implantation with Medtronic CoreValve /Evolut R/Pro
- Where
- Greece
- Volunteers
- 78 people
- Sponsor
- National and Kapodistrian University of Athens
Acute Myocarditis, Dilated Cardiomyopathies
German Centre for Cardiovascular Research Cardiomyopathy Register
This is a joint project by Heidelberg University and Greifswald University. Our objective is to establish an unique national multi-center registry and biobank of well phenotyped patients with non-ischemic cardiomyopathies (CMP)…
- Conditions
- Acute Myocarditis, Dilated Cardiomyopathies, Hypertrophic Cardiomyopathies, Left Ventricular Myocardial Noncompaction Cardiomyopathy
- Trial name
- TORCH (NCT02187263)
- Where
- Germany
- Volunteers
- 2,300 people
- Sponsor
- Heidelberg University
Hypertrophic Cardiomyopathy
Role of Perhexiline in Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy (HCM) is the most common inherited heart muscle condition affecting up to 1 in 200 of the general population.
- Trial name
- RESOLVE-HCM (NCT04426578)
- Testing
- Perhexiline
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Flinders University
Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy
Non-Invasive Evaluation of Myocardial Stiffness by Elastography in Pediatric Cardiology (Elasto-Pédiatrie)
First, investigators must determine the physiological standards across age classes of myocardial stiffness estimated by Elastography in ultrafast (estimated right ventricular stiffness [VD] and left ventricular [LV]).
- Trial name
- NCT02619825
- Testing
- Echography, Elastography
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- French Cardiology Society
Hypertrophic Obstructive Cardiomyopathy \(HOCM\), Left Ventricular Outflow Tract Obstruction
Positron Emission Tomography to Assess the Effect of Camzyos on Ischaemia in HOCM: PEACH Trial
Hypertrophic obstructive cardiomyopathy (HOCM) is a heritable heart condition that leads to the thickening of the heart muscle and causes obstruction of blood flow, impeding it's ejection from the heart (LVOT obstruction).
- Conditions
- Hypertrophic Obstructive Cardiomyopathy \(HOCM\), Left Ventricular Outflow Tract Obstruction, Myocardial Ischaemia
- Trial name
- PEACH (NCT07120776)
- Testing
- Camzyos (Mavacamten)
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- University of Manchester
Aortic Valve Stenosis
RESPOND EDGE Post Market Study
The purpose of the RESPOND EDGE post market study is to collect real world clinical and device performance outcomes data with the Lotus Edge™ Valve System used in routine clinical practice to demonstrate that the commercially…
- Trial name
- RESPOND EDGE (NCT04009720)
- Testing
- Lotus Edge Device
- Where
- 13 sites in Denmark, Finland and 7 more
- Volunteers
- 200 people
- Sponsor
- Boston Scientific Corporation
Aortic Valve Stenosis
Exercise-based Cardiac Rehabilitation in Patients With Aortic Stenosis After Transcatheter Aortic Valve Implantation
Aortic valve stenosis (AS) is the most common valve disease among older individuals. In symptomatic AS, mortality is high, and the only treatment that improves prognosis and survival is transcatheter aortic valve implantation…
- Trial name
- TAVI (NCT06283940)
- Testing
- Physiotherapist-led exercise based cardiac rehabilitation (PT-X)
- Where
- Sweden
- Volunteers
- 135 people
- Sponsor
- Vastra Gotaland Region
Coarctation of Aorta, Aortic Stenosis
Cardiac Remodeling and Circulating Biomarkers in Pediatric Left Ventricular Pressure Loading Lesions
This study is designed to learn more about children who have blockage of the left side of their heart. The goal is to determine how much the heart muscle has thickened before surgery and how it changes in the months after…
- Conditions
- Coarctation of Aorta, Aortic Stenosis, Cardiac Hypertrophy
- Trial name
- LVOTO (NCT02545790)
- Testing
- Echocardiogram, Serology
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Colorado, Denver
Acute Myocardial Infarction, Coronary Artery Disease
Use of Intra-aortic Balloon Pump Before Surgery for Acute Myocardial Infarction
The optimal timing of surgery in patients with acute myocardial infarction (AMI) and the utilization of preoperative intra-aortic balloon pumps (IABP) in these patients are subjects of ongoing discussion and disagreement.
- Conditions
- Acute Myocardial Infarction, Coronary Artery Disease, Coronary Bypass Graft Stenosis of Autologous Vessel, Troponin
- Trial name
- NCT06468982
- Testing
- Intra-aortic Balloon Pump
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 156 people
- Sponsor
- Ataturk University
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