Clinical trials: Stenosis, Spinal
Sciatica, Low Back Pain
Artificial Intelligence (AI)-Based Prediction of Treatment Response in Sciatica Patients Receiving Transforaminal Epidural Steroid Injection
This prospective observational study aims to develop artificial intelligence (AI)-based predictive models to estimate treatment response in patients with sciatica undergoing transforaminal epidural steroid injection (TFESI).
- Conditions
- Sciatica, Low Back Pain, Lumbar Spinal Stenosis, Radiculopathy
- Trial name
- NCT07080307
- Where
- Turkey (Türkiye)
- Volunteers
- 1,500 people
- Sponsor
- Marmara University
Lumbar Spinal Stenosis, Degenerative Lumbar Spinal Stenosis
Decompression Versus Instrumented Fusion for Lumbar Degenerative Disease. Clinical and Biomechanical Outcome Study
Identification of clinical and instrumental parameters that could predict the outcome of surgical decompression of lumbar degenerative stenosis.
- Trial name
- ARCHIMEDE (NCT06335511)
- Testing
- microsurgical decompression, decompression and instrumented fusion
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Azienda Usl di Bologna
Lumbar Spinal Stenosis
Comparative Effectiveness and Prognostic Factors of Surgical and Non-surgical Management of Lumbar Spinal Stenosis
Introduction: Lumbar spinal stenosis is a common cause of low back and leg pain in elderly impacting physical activity and quality of life. Initial treatments are non-surgical options. If unsuccessful, surgery is advocated.
- Trial name
- NCT03548441
- Testing
- Surgery, Non-surgical management
- Where
- Denmark
- Volunteers
- 600 people
- Sponsor
- Spine Centre of Southern Denmark
Degenerative Lumbar Spinal Stenosis
Efficacy and Safety of Acupuncture for Degenerative Lumbar Spinal Stenosis
Degenerative Lumbar spinal stenosis (DLSS) is a major problem for public health and the primary reason the older seek lumbar spine surgery. Acupuncture is safe and maybe effective for DLSS but the evidence is poor.
- Trial name
- NCT02644746
- Testing
- acupuncture
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Degenerative Lumbar Spinal Stenosis
Effectiveness and Safety of the Facet Fixation (FFX®) Implant in the Treatment of Degenerative Lumbar Spinal Stenosis
This is a prospective, multicentric, comparative, randomised-controlled study to evaluate the safety and efficacy of the Facet Fixation implant.
- Trial name
- FFX® RCT (NCT06106061)
- Testing
- Decompression + FFX®, Decompression alone
- Volunteers
- 320 people
- Sponsor
- SC Medica
Spinal Stenosis
A Study of the In-Space Device for Treatment of Moderate Spinal Stenosis
The purpose of this study is to evaluate the safety and effectiveness of the In-Space compared to the X STOP Interspinous Process Distraction (IPD) device ("X STOP") for the treatment of patients experiencing intermittent…
- Trial name
- In-Space (NCT00697827)
- Testing
- Interspinous Spacer device, Interspinous Process Distraction Device
- Where
- 10 sites in United States
- Volunteers
- 44 people
- Sponsor
- Synthes USA HQ, Inc.
Degenerative Lumbar Spinal Stenosis
Comparison of Bioactive Glass Ceramics Spacer and PEEK Cages in Posterior Lumbar Interbody Fusion: A Prospective, RCT
The authors aimed to compare the clinical efficacy and safety of CaO-SiO2-P2O5-B2O3 glass ceramics with PEEK cage that is widely used for posterior lumbar interbody fusion (PLIF) surgery in the clinical field.
- Trial name
- Novomax (NCT03302520)
- Testing
- NovoMax, BioAlpha Inc, Seong-nam, Korea, PEEK cage
- Where
- South Korea
- Volunteers
- 54 people
- Sponsor
- Seoul National University Hospital
Neuropathy; Radicular, Lumbar, Lumbosacral, Failed Back Surgery Syndrome
Efficacy of Pregabalin in Patients With Radicular Pain
The purpose of this study is to evaluate whether pregabalin is effective in reducing the pain in patients who present with radicular pain due to a herniated disc, spinal stenosis or failed back surgery syndrome.
- Conditions
- Neuropathy; Radicular, Lumbar, Lumbosacral, Failed Back Surgery Syndrome, Spinal Stenosis, Herniated Disc
- Trial name
- NCT00908375
- Testing
- Pregabalin, Sugar Pill
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Northwestern University
Lumbosacral Spinal Stenosis
Irrigation Endoscopic Decompressive Laminotomy
The classic laminectomy for surgical treatment of spinal stenosis has considerable morbidity .This is further magnified by the disease being more common in elderly with associated medical comorbidities and being usually global…
- Trial name
- NCT01991912
- Testing
- open lumbar decompression
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Spinal Stenosis, Low Back Pain
Spine Patient Outcomes Research Trial (SPORT): Spinal Stenosis
This study tests the effectiveness of different treatments for the three most commonly diagnosed conditions of the lower backbone (lumbar spine).
- Trial name
- NCT00000411
- Testing
- Decompressive laminectomy, Non-surgical treatments
- Where
- 13 sites in United States
- Volunteers
- 289 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Posterior Cervical Spinal Surgery, Myelopathy Cervical
Cervical Orthosis Versus no Orthosis Following Multi-level Posterior Cervical Fusion
Use of cervical orthosis after instrumented posterior cervical spinal surgery is still widely practiced even though modern fusion techniques likely do not require additional stabilization from an external orthosis.
- Conditions
- Posterior Cervical Spinal Surgery, Myelopathy Cervical, Radiculopathy, Cervical, Spinal Stenosis Cervical
- Trial name
- NCT04308122
- Testing
- Cervical Orthosis (CO), No Orthosis
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Dr. Christopher Bailey
Degenerative Disk Disease, Spondylolisthesis
Prospective Study of Minimally Invasive Spine Surgery
The population of the US is aging. They remain more active and place greater demands on their musculoskeletal system. A key problem is that pain and disability of age related spinal disorders will increase.
- Conditions
- Degenerative Disk Disease, Spondylolisthesis, Spinal Stenosis, Degenerative Scoliosis
- Trial name
- NCT01045473
- Volunteers
- 450 people
- Sponsor
- Society for Minimally Invasive Spine Surgery
Spinal Stenosis
Automatic Diagnosis of Spinal Stenosis on CT
MRI is a common tool for radiographic diagnosis of spinal stenosis, but it is expensive and requires long scanning time. CT is also a useful tool to diagnose spinal stenosis, yet interpretation can be time-consuming with high…
- Trial name
- ASSIST (NCT03746561)
- Testing
- deep learning
- Volunteers
- 500 people
- Sponsor
- Shanghai 10th People's Hospital
Spinal Stenosis, Lumbar Region, Spondylolisthesis
Evaluation of 3D Machine-vision Image Guided Surgery Spine Navigation
This study assesses clinical outcomes following the use of the MvIGS spine navigation system for treatment of spinal stenosis and degenerative spondylolisthesis of the lumbar spine in adults.
- Trial name
- NCT03968965
- Testing
- 3D MvIGS Spine Navigation, 2D Fluoroscopy
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- 7D Surgical Inc.
Spinal Stenosis
Spinal Epidural Lipomatosis: a Case Report and Review of the Literature
Introduction Lumbar spinal epidural lipomatosis (SEL) is a rare condition defined by an excessive deposition of adipose tissue in the lumbar spinal canal.
- Trial name
- NCT04622501
- Testing
- posterior spinal decompression and posterior spinal instrumented fusion
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Canadian Memorial Chiropractic College
Spondylolisthesis
Vertebral Osteosynthesis in Degenerative Lumbar Stenosis With Spondylolisthesis
Study to evaluate the superiority of the osteosynthesis associated with a decompressive surgery in comparison with a simple decompressive surgery in the treatment of lumbar degenerative stenosis with spondylolisthesis
- Trial name
- CLEOS (NCT00252551)
- Testing
- Osteosynthesis, Simple surgery
- Where
- 9 sites in France
- Volunteers
- 11 people
- Sponsor
- University Hospital, Toulouse
Lumbar Spinal Stenosis
Effectiveness of Transcranial Direct Current Stimulation in Chronic Pain Related to Lumbar Spinal Stenosis
Transcranial Direct Current Stimulation (tDCS) is a promising non-invasive brain stimulation technique in chronic pain. There is no study investigating the effectiveness of tDCS in radiating chronic lower extremity pain related…
- Trial name
- NCT03958526
- Testing
- active tDCS
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Istanbul University
Drain Tube Influence the Postoperative Epidural Haematoma
Does a Drain Tube Influence the Postoperative Epidural Haematoma for Lumbar Biportal Endoscopic Surgery?
The purpose of this study was to evaluate if wound drains could influence postoperative spinal epidural hematoma (POSEH) in biportal endoscopic spinal surgery (BESS) procedures for decompression of lumbar spinal stenosis.
- Trial name
- NCT06290791
- Testing
- two level lumbar decompression with BESS procedure received one drain., two level lumbar decompression with BESS procedure received two drain.
- Where
- China
- Volunteers
- 89 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Intervertebral Disc Degeneration, Stenosis, Spinal
Intraoperative Monitoring for the Lateral Lumbar Interbody Fusion Procedure
This study is designed to evaluate the clinical utility of a known intraoperative neuromonitoring modality (SSEP) using saphenous nerve as the site of stimulation to identify changes to the lumbar nerves which may be at risk…
- Conditions
- Intervertebral Disc Degeneration, Stenosis, Spinal, Spondylolisthesis, Spinal Deformity
- Trial name
- NCT05648474
- Testing
- Somatosensory evoked potential [SSEP] intraoperative monitoring
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Alphatec Spine, Inc.
Spinal Cord Injury, Spinal Cord Involvement
Clinical Trial of a Serious Game for Individuals With SCI/D
This study will evaluate the efficacy of a newly developed serious game, SCI HARD, to enhance self-management skills, self-reported health behaviors, and quality of life among adolescents and young adults with spinal cord injury…
- Conditions
- Spinal Cord Injury, Spinal Cord Involvement, Spina Bifida, Transverse Myelitis
- Trial name
- NCT02341950
- Testing
- SCI Hard
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- University of Michigan