Clinical trials: Stenosis Coronary
Stenoses, Aortic
SAfe and Fast Discharge With Acurate Valve in Low Risk tavI Patients
Recent evidence from scientific literature supported the extension of TAVI procedures to lower risk populations. Despite its widespread usage, the expansion of TAVI into lower risk patient populations is still limited by…
- Trial name
- SAFARI (NCT05983458)
- Testing
- Transaortic valve replacement
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Maria Cecilia Hospital
CT Perfusion
Prognostic Value of CT dynamIc Myocardial Perfusion in Patients With Obstructive Coronary Artery Stenosis
VALIDITY is a prospective, open-label, multicenter, randomized controlled trial （ClinicalTrials.gov number）. The study was designed to evaluate the value of noninvasive anatomic CTA combined with functional CTP for the next…
- Trial name
- VALIDITY (NCT03250455)
- Testing
- CTA CTP, CTA
- Where
- 5 sites in China
- Volunteers
- 1,748 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Mitral Valve Stenosis and Insufficiency, Atrial Fibrillation
Dabigatran in Patients With Atrial Fibrillation and Mitral Biological Prostheses
The efficacy and safety of anticoagulation therapy using dabigatran in comparison with warfarin will be evaluated in patients with atrial fibrillation after mitral valve prosthetic replacement concomitant with Cox-Maze procedure.
- Trial name
- NCT03183843
- Testing
- Dabigatran Etexilate, Warfarin
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Research Institute for Complex Problems of Cardiovascular Diseases, Russia
Aortic Stenosis
Anatomical Determinants and Outcomes of Small Annulus Patients Undergoing TAVR in Different ASIAN Ethnicity
Transcatheter aortic valve implantation (TAVI) presents unique challenges for Asian patients compared to Caucasians, largely due to the prevalence of small aortic annulus (SAA) defined based on Caucasians' data (430 mm²)…
- Trial name
- NCT07240025
- Where
- Hong Kong
- Volunteers
- 31 people
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
Choreatic Disorder
Heart and Skeletal Muscle Problems in Neuroacanthocytosis
The purpose of this study is to learn about heart and skeletal muscle problems related to neuroacanthocytosis (also called Mcleod's syndrome and Levine-Critchley disease).
- Trial name
- NCT00007228
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease, Left Main Coronary Artery Stenosis
Concordance Between FFR and iFR for the Assessment of Intermediate Lesions in the Left Main Coronary Artery. A Prospective Validation of a Default Value for iFR
The assessment of Left Main Coronary Artery (LMCA) lesions by means of coronary angiography renders serious limitations. Studies with a limited number of patients have shown that a value of FFR (Fractional Flow Reserve) above…
- Conditions
- Coronary Artery Disease, Left Main Coronary Artery Stenosis, Left Main Coronary Artery Disease, Restenosis, Coronary
- Trial name
- iLITRO (NCT03767621)
- Testing
- Indication of revascularization
- Where
- 38 sites in Spain
- Volunteers
- 300 people
- Sponsor
- Fundación EPIC
Acquired Von Willebrand Disease Secondary to Severe Aortic Stenosis, Heye´s Syndrome
Severe Aortic Stenosis and Acquired Von Willebrand´s Disease: The Impact of Desmopressin in Valve-Replacement Surgery
Acquired Von Willebrand disease (type 2A) has been described in patients with severe aortic stenosis, the association of aortic stenosis and Digestive bleeding due to this phenomena has received the name of Heye´s syndrome.
- Conditions
- Acquired Von Willebrand Disease Secondary to Severe Aortic Stenosis, Heye´s Syndrome, Severe Aortic Stenosis
- Trial name
- NCT01994330
- Testing
- desmopressin
- Where
- Chile
- Volunteers
- 13 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Surgery, Survival, Prosthesis
15 Years Outcomes Following Bioprosthetic vs Mechanical Aortic Valve Replacement Between 50-65 Years
Currently there is an increase in the use of bioprosthesis worldwide (> 70% according to national data of the Spanish Society of Thoracic and Cardiovascular Surgery).
- Conditions
- Surgery, Survival, Prosthesis, Valve Heart Disease
- Trial name
- ANDALVALVE (NCT03239509)
- Testing
- bioprosthesis implantation between 2000-2015, mechanical prosthesis implantation between 2000-2015
- Where
- 7 sites in Spain
- Volunteers
- 1,200 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Low Flow, Low Gradient Aortic Stenosis
Transcatheter Aortic Valve Replacement in Severe Low Flow, Low Gradient Aortic Stenosis
LOW-TAVR is a real-world, retrospective and prospective, multicenter Italian registry aimed at evaluating the characteristics and clinical outcomes of patients with severe low flow, low gradient aortic stenosis undergoing…
- Trial name
- LOW-TAVR (NCT06589063)
- Testing
- Transcatheter aortic valve replacement
- Where
- Italy
- Volunteers
- 1,350 people
- Sponsor
- University of Salerno
Coronary Artery Stenosis
Coronary Non-slip Balloon Catheter in Patients With Coronary Artery Stenosis(CREST)
This is a prospective, multicenter, randomized controlled clinical investigation aiming to evaluate the safety and effectiveness of non-slip balloon catheter for the treatment of patients with coronary artery stenosis.
- Trial name
- NCT05606367
- Testing
- Non-slip Balloon Catheter of Shanghai MicroPort Rhythm, NSE Coronary Dilatation Catheter
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai MicroPort Rhythm MedTech Co., Ltd.
Acute Coronary Syndrome, Acute Myocardial Infarction
Coronary Computed Tomographic Angiography in Emergency Department Chest Pain Patients at Intermediate Risk of Acute Coronary Syndrome
The purpose of this study is to determine whether Coronary Computed Tomographic Angiography (CCTA) will increase patient safety by decreasing the rate of missed ACS and adverse events in patients who receive standard care plus…
- Conditions
- Acute Coronary Syndrome, Acute Myocardial Infarction, Unstable Angina, Coronary Disease
- Trial name
- CCTA (NCT00473863)
- Testing
- Coronary Computed Tomographic Angiography
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Vancouver General Hospital
Coronary Bifurcation Lesion, Coronary Artery Disease (CAD)
Crossover vs Accurate Ostial PCI for Medina 0.0.1 and 0.1.0 Left Main Bifurcation Lesions
Coronary artery disease is a leading cause of mortality and morbidity globally. The left coronary artery system is critically important due to its supply of a large area of myocardium.
- Conditions
- Coronary Bifurcation Lesion, Coronary Artery Disease (CAD), Left Main Coronary Artery Stenosis
- Trial name
- NCT07596706
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 1,000 people
- Sponsor
- Istanbul Mehmet Akif Ersoy Educational and Training Hospital
Aortic Valve Stenosis
Transcatheter Aortic Valve Implantation Registry at the National Research Center for Cardiac Surgery, Nur-Sultan, Kazakhstan
This study will analyze patients with aortic stenosis who have undergone transcatheter valve implantation and surgical aortic valve replacement.
- Trial name
- NCT06874465
- Testing
- Transcatheter aortic valve implantation
- Where
- Kazakhstan
- Volunteers
- 100 people
- Sponsor
- National Research Center for Cardiac Surgery, Kazakhstan
Aortic Stenosis
A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis
The purpose of this study is to evaluate the efficacy, safety and tolerability of pelacarsen (TQJ230) administered subcutaneously once monthly compared to placebo in slowing the progression of calcific aortic valve stenosis.
- Trial name
- NCT05646381
- Testing
- Pelacarsen (TQJ230) 80mg
- Where
- 140 sites in United States, Austria and 13 more
- Volunteers
- 502 people
- Sponsor
- Novartis Pharmaceuticals
Coronary Artery Disease
Effectiveness and Safety of Coronary Scoring Balloon Dilation Catheter in the Pretreatment of Coronary Stenosis Lesions
This trial adopts a prospective, multicenter, randomized controlled, and non-inferiority comparison trial design, and plans to recruit 200 eligible subjects who will be randomly assigned to the experimental group or the control…
- Trial name
- NCT06291545
- Testing
- Coronary artery scoring balloon dilation catheter（JW Medical Systems Ltd）, ScoreFlex NC Coronary Dilatation Catheter
- Volunteers
- 200 people
- Sponsor
- JW Medical Systems Ltd
Coronary Stenoses, Myocardial Ischemia
Coronary Revascularization Assessed by Stress PET
Regional absolute myocardial blood flow during stress (sMBF) as measured by Positron Emission Tomography (PET) improves post mechanical revascularization provided there is a baseline stress induced perfusion defect.
- Conditions
- Coronary Stenoses, Myocardial Ischemia, Coronary Artery Stenosis, Coronary Disease
- Trial name
- NCT02931331
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ochsner Health System
Coronary Artery Stenosis
FFR and Inducible Myocardial Ischemia During Adenosine Stress Testing
This is a prospective, single center study involving 150 patients with stable coronary artery disease undergoing coronary angiography for chest pain evaluation.
- Trial name
- NCT04401657
- Testing
- Fractional flow reserve with adenosine stress testing
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Asan Medical Center
Systemic Inflammatory Response, Aortic Valve Stenosis
Evaluation of Intraoperative Dexmedetomidine Use in Patients Undergoing Surgical Aortic Valve Replacement
Aim of this randomized prospective study is to investigate the immunomodulatory effects of dexmedetomidine on outcomes in patients with isolated aortic stenosis after surgical aortic valve replacement.
- Trial name
- NCT05641064
- Testing
- Dexmedetomidine 0.5mcg/kg/h, Dexmedetomidine 1 mcg/kg/h
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- University Hospital Dubrava
Ischemic Heart Disease, Coronary Artery Stenosis
A Clinical Evaluation of the MINI TREK RX 1.20 mm Coronary Dilatation Catheter in Stenotic Lesions
This is a prospective, single-arm, open-label, multi-center, observational study to assess the acute safety and efficacy of MINI TREK RX 1.20 mm for enlarging coronary luminal diameter during percutaneous coronary intervention…
- Conditions
- Ischemic Heart Disease, Coronary Artery Stenosis, Chronic Coronary Total Occlusion, Coronary Bypass Graft Stenosis
- Trial name
- CROSS (NCT01186198)
- Testing
- MINI TREK RX 1.20 mm Coronary Dilatation Catheter
- Where
- 4 sites in United States
- Volunteers
- 71 people
- Sponsor
- Abbott Medical Devices
Hypertrophic Cardiomyopathy, Arrhythmia
Impact of Liwen Procedure in Obstructive Hypertrophic Cardiomyopathy on Arrhythmias
The goal of this observational study is to learn about the occurrence of various arrhythmias ( tachyarrhythmia and bradyarrhythmia ) during or after Percutaneous Intramyocardial Septal Radiofrequency Ablation.
- Trial name
- NCT06031519
- Testing
- Percutaneous Intramyocardial Septal Radiofrequency Ablation for hypertrophic obstructive cardiomyopathy (Liwen Procedure)
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Xijing Hospital
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