Clinical trials: Sterility
Infertility, Male
NT-NOA - Novel Treatment of Some Men With Non-Obstructive Azoospermia
This clinical interventional study aims to assess whether treatment with denosumab in combination with letrozole can improve sperm production in infertile men with non-obstructive azoospermia selected by serum anti-mullerian…
- Trial name
- NT-NOA (NCT06706414)
- Testing
- Denosumab (Prolia), Letrozole (Aromatase Inhibitors)
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Martin Blomberg Jensen
Female Infertility Due to Nonimplantation of Ovum, Complications Associated With Artificial Fertilization
Comparing Ovarian Stimulation for Assisted Reproduction With Two Different Forms of Pituitary Suppression
The purpose of this study is to assess the non-inferiority of a multidose GnRH antagonist (cetrorelix) regimen to a GnRH agonist (triptorelin) long protocol in young infertile women undergoing ovarian stimulation with Pergoveris…
- Trial name
- Pergoveris (NCT01565265)
- Testing
- Pergoveris in long protocol with GnRH agonist, Pergoveris in GnRH antagonist protocol
- Where
- Switzerland
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Infertility
Comparison of Crinone 8% Intravaginal Gel and IM Progesterone Supplementation for In Vitro Fertilization (IVF)
The goal of this research study is to compare the pregnancy rates for two different types of progesterone supplementation after in-vitro fertilization (IVF).
- Trial name
- NCT00656201
- Testing
- Crinone 8% Vaginal Gel, Intramuscular Progesterone
- Where
- United States
- Volunteers
- 468 people
- Sponsor
- Brigham and Women's Hospital
Infertility
Optimizing Patient Analgesic Experience During IVF
This study is for patients undergoing In Vitro Fertilization (IVF). The investigators are studying the best way to control pain during the egg retrieval process.
- Trial name
- NCT01814657
- Testing
- Lidocaine hydrochloride (HCl) 1% solution, Sterile Normal Saline%
- Where
- Canada
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Infertility, Female
Improving Reproductive Fitness Through Pretreatment With Lifestyle Modification in Obese Women With Unexplained Infertility
A two-arm, multicenter, prospective, randomized clinical trial of a lifestyle modification program with tracked increased physical activity and weight loss (intensive) compared to recommendations to tracking of increased physical…
- Trial name
- FIT-PLESE (NCT02432209)
- Testing
- Caloric Restriction, Orlistat, Moderate physical activity
- Where
- 10 sites in United States
- Volunteers
- 379 people
- Sponsor
- Yale University
IVF, Infertility
Improvement of Fertilization Rate and Embryo Quality by Treating Calcium Ionophore in IVF Patients: a Sibling Oocyte Control Study
GM508 CultActive is a bicarbonate buffered reagent and ready-to-use designed to investigate oocytes of patients with failed fertilization after previous Intracytoplasmatic Sperm Injection cycles.
- Conditions
- IVF, Infertility, Artificial Oocyte Activation
- Trial name
- GM508 in IVF (NCT05722067)
- Testing
- calcium ionophore
- Where
- Taiwan
- Volunteers
- 68 people
- Sponsor
- Chang Gung Memorial Hospital
Infertility (IVF Patients)
Efficacy Study of the Embryo Transfer Catheter
A prospective randomized trial comparing Cook K-SOFT-5100 and Frydman classical catheter 4.5 for embryo transfer in human IVF/ICSI was performed.
- Trial name
- NCT00766714
- Testing
- Cook K-SOFT-5100 catheter, Frydman classical catheter
- Where
- Belgium
- Volunteers
- 1,446 people
- Sponsor
- University Hospital, Ghent
Infertility (IVF Patients), BMI
BMI Versus Body Fat Percentage - Which is the Better Predictor of Fertility Outcomes in IVF Cycles?
The goal of this prospective observational cohort study is to evaluate whether body composition measured using bioelectrical impedance analysis (BIA) (including measures of body fat% and visceral fat) serve as a better predictor…
- Conditions
- Infertility (IVF Patients), BMI, Bioelectrical Impedance Analysis, IVF Outcomes
- Trial name
- NCT07765368
- Testing
- Measurement of BIA (Body Fat and Visceral Fat Percentage)
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- IWK Health Centre
Infertility
Comparison of Two Embryo Transfer Catheters in Patients Undergoing in Vitro Fertilization and Embryo Transfer
In-vitro fertilization (IVF) treatment involves development of multiple follicles following ovarian stimulation, oocyte retrieval and embryo transfer (ET). ET is the final and most crucial step of IVF treatment.
- Trial name
- NCT02024880
- Testing
- Protective catheter group, Conventional catheter group
- Where
- China
- Volunteers
- 600 people
- Sponsor
- The University of Hong Kong
Breast Cancer Female
FErtility, PrEgnancy, contRaceptIon After Breast Cancer in France
FErtility, PrEgnancy, contRaceptIon after breast Cancer in France
- Trial name
- FEERIC (NCT03884413)
- Testing
- questionnaires
- Where
- France
- Volunteers
- 517 people, healthy volunteers welcome
- Sponsor
- Institut Curie
Endometriosis
Biomarkers in the Endometrial Fluid, Tissue, and Follicular Fluid of Moderate/Severe Endometriosis Patients
This study aims to explore biomarkers in the endometrial fluid and tissue of women with moderate to severe endometriosis, with a specific focus on those involved in pre-receptive endometrium and embryo implantation.
- Trial name
- NCT07182643
- Testing
- Endometrial fluid, Endometrial biopsy, Follicular fluid
- Where
- Sweden
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
Infertility Assisted Reproductive Technology, Ovarian Aging
Epigenetic Clock to Predict Ovarian Aging and Live Birth in ART
Epigenetic clocks based on DNA methylation estimate biological age and are associated with age-related conditions, but they have not been validated for female fertility.
- Trial name
- ARTCLOCK (NCT07875140)
- Testing
- Peripheral blood sampling for epigenetic age estimation
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Subfertility
GnRH Agonist for Dual Trigger in IVF and for Luteal Phase Support in FET
The objectives of this study are to compare the efficacy of the dual trigger group vs the hCG trigger group on the live birth rate in women undergoing IVF and the efficacy of the agonist in LP group vs the placebo group on the…
- Trial name
- NCT04064840
- Testing
- IVF: Decapeptyl and hCG, FET: Decapeptyl, IVF: hCG and normal saline
- Where
- China
- Volunteers
- 784 people
- Sponsor
- The University of Hong Kong
Infertility
Testosterone Gel in Poor Responders Undergoing IVF
The main purpose of this study is to compare the number of oocytes retrieved after using transdermal testosterone gel 10 mg per day or Dehydroepiandrosterone (DHEA) 75mg per day for 6-8 weeks as pre-treatment for poor ovarian…
- Trial name
- NCT02549690
- Testing
- Testosterone gel, DHEA
- Where
- Vietnam
- Sponsor
- Vietnam National University
Infertility
The Presence of Microbes in the Sperm and Their Impact on Sperm Capacitation and IVF Treatment
Study Goals: 1. Finding the prevalence of bacteria of the sperm in an innovative and more accurate methode 2. Understanding the effect of microbes on the process of capacitation 3.
- Trial name
- NCT02585297
- Testing
- no intervention
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Mayer Rokitansky Kuster Hauser Syndrome, Absence of Uterus
Uterine Transplant for Women With Absolute Uterine Factor Infertility (AUFI)
Absolute Uterine Factor Infertility (AUFI) is due to congenital or surgical absence of a uterus or the presence of a nonfunctional uterus.
- Conditions
- Mayer Rokitansky Kuster Hauser Syndrome, Absence of Uterus, Infertility of Uterine Origin
- Trial name
- NCT05263076
- Testing
- Uterine Transplant
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- John Goss
Female Infertility Due to Diminished Ovarian Reserve
IVF/ICSI Protocols in Poor Responders With Growth Hormone
in this study, we are trying to monitor the effect of the addition of growth hormone on the different down regulation protocols ( long, short, antagonist and microflare).
- Trial name
- NCT01897324
- Testing
- Growth hormone (Norditropin, Novo nordisk)
- Where
- Egypt
- Volunteers
- 287 people
- Sponsor
- Woman's Health University Hospital, Egypt
Thin Endometrium, Infertility Female
Effectiveness of Intrauterine Growth Hormone Administration as an add-on Therapy to Conventional Hormone Therapy Compared to Placebo in Patients With Thin Endometrium Undergoing Frozen Thawed Embryo Transfer
The purpose of this clinical trial is to see if intrauterine growth hormone infusions can help subjects reach a suitable endometrial thickness in patients who are resistant to routine hormonal therapy for embryo transfer in the…
- Conditions
- Thin Endometrium, Infertility Female, Infertility
- Trial name
- NCT06379659
- Testing
- Growh hormone
- Where
- Iran
- Volunteers
- 54 people
- Sponsor
- Isfahan University of Medical Sciences
Asthenozoospermia
Epididymal U.S Findings in Asthenozoospermic &Correlation With L.Carnitine Level
To evaluate the epididymal findings by U.S and study its correlation with seminal parameters including L.carnitine level in infertile males
- Trial name
- NCT05436080
- Testing
- U/S
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Infertility
Handling Medium for ICSI With Ionomycin and Latrunculin A
Using Latrunculin A and Ionomycin would improve the outcome of ICSI if the handling medium during the ICSI procedure has them.
- Trial name
- NCT03678610
- Testing
- Doing ICSI I a medium supplemented with Ionomycin and Latrunculin A
- Where
- 3 sites in Egypt
- Volunteers
- 700 people
- Sponsor
- Ibn Sina Hospital