Clinical trials: Sterility
Infertility
Barusiban Subcutaneously for Reducing Implantation Failure Due to Uterine Contractions
This trial investigates the effects of FE 200440 compared to placebo on implantation rate in women undergoing IVF/ICSI treatment
- Trial name
- BASIC (NCT01723982)
- Testing
- Barusiban (FE 200440)
- Where
- 14 sites in Australia, Belgium and 4 more
- Volunteers
- 256 people
- Sponsor
- Ferring Pharmaceuticals
Female, Infertility
The Effect of Ovamax on Oocyte Quality
Oocyte quality is a basic parameter that affects embryo quality and therefore it influences the outcome of assisted reproduction. It has been suggested that oocyte quality is improved by the intake of vitamins and antioxidants.
- Trial name
- NCT06203223
- Testing
- Ova-max
- Where
- Greece
- Volunteers
- 97 people
- Sponsor
- Aristotle University Of Thessaloniki
Blepharitis
Sterile Plant-Based Gauze for Eyelid Hygiene in Anterior Blepharitis
The goal of this clinical trial is to learn whether a sterile gauze containing natural plant extracts can lower the number of bacteria on the eyelid margin in people with bilateral anterior blepharitis.
- Trial name
- BLEPH-GAUZE (NCT07759180)
- Testing
- Plant-Based Sterile Eyelid Gauze, Sterile Cotton Gauze Moistened with Saline Solution
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- Azienda Ospedaliera OO.RR. S. Giovanni di Dio e Ruggi D'Aragona
Endometriosis, Infertility Assisted Reproductive Technology
First Line Surgery or First Line Fertility Treatment Using Assisted Reproductive Technologies in Patients With Advanced Endometriosis
Endometriosis is a chronic disease affecting approximately 10% of women of reproductive age. It is strongly associated with pelvic pain and infertility.
- Trial name
- EndoSOFT (NCT07240363)
- Testing
- Endometriosis surgery
- Where
- 4 sites in Sweden
- Volunteers
- 350 people
- Sponsor
- Karolinska Institutet
Infertility, Female
Study on the Pharmacokinetics and Safety of QL1012D and Gonal-F® in Healthy Female Volunteers
The goal of this Interventional study is to Compare the Pharmacokinetics and Safety of Recombinant Human Follicle Stimulating Hormone Injection (QL1012D) and Gonal-F® in Healthy Female Volunteers.
- Trial name
- NCT06864793
- Testing
- QL1012D, Gonal-F®
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Female Infertility Due to Advanced Maternal Age
Mitochondrial Energy Production in ART (Assisted Reproductive Technology )
Oocyte maturation requires a lot of energy, which is provided by the mitochondria via the synthesis of ATP. The majority of patients with advanced maternal age (AMA) have poor egg quality.
- Trial name
- Mitenergy (NCT02727400)
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
IVF
FSH Followed by HMG vs FSH Plus HMG in IVF
The aim of this study is to compare the clinical outcomes of sequential administration of FSH and HP-hMG FSH alone versus concomitant administration of FSH and HP-hMG during controlled ovarian stimulation in IVF cycles.
- Trial name
- NCT04385342
- Testing
- FSH, HP-hMG
- Where
- 3 sites in Egypt
- Volunteers
- 530 people
- Sponsor
- Mansoura University
Infertility
Evaluation of the Luteolytic Effect of a Gonadotropin Releasing Hormone (GnRH) Agonist After the Administration of Human Chorionic Gonadotropin (hCG) in the Initial Follicular Phase a Its Influence on the Prognosis of in Vitro Fertilization Treatment
This study was designed to evaluate the ability of gonadotropin releasing hormone (GnRh) agonist to prevent the rise of progesterone during controlled ovarian stimulation for in vitro fertilization (IVF) after the administration…
- Trial name
- NCT00948805
- Testing
- GnRH agonist, Control
- Where
- Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Premature Ovarian Failure
Autologous Mesenchymal Stem Cells Transplantation In Women With Premature Ovarian Failure
Stem cells (SC) are the foundation cells for every organ, tissue and cell in the body. They are undifferentiated "blank" cells that do not yet have a specific function.
- Trial name
- NCT02062931
- Testing
- Stem Cell Preparation and Injection
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sayed Bakry
Fertility Issues
Lifestyle Care for Fertility Outcome Evaluation
An observational outcome evaluation of the Lifestyle Care for Fertility program.
- Trial name
- PROWESS (NCT06297070)
- Testing
- Whole Health Lifestyle Care for Reproductive Well-being pilot program
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Christine Kaiser, LAc, DACM
Male Infertility
Regulation of Stem Spermatogonia in the Mature Testis
Investigative trial to evaluate the role of a glial cell lined derived neurotrophic factor (GDNF) in regulation of spermatogonial renewal and testicular function.
- Trial name
- NCT02756923
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- Weill Medical College of Cornell University
Anovulation, Amenorrhea
Effects of Gynecological Age on LH Sensitivity to Energy Availability
The purpose of this experiment is to investigate whether the dependence of luteinizing hormone pulsatility on energy availability declines during adolescence.
- Conditions
- Anovulation, Amenorrhea, Infertility, Starvation
- Trial name
- NCT00260286
- Testing
- Energy availability
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Ohio University
Polycystic Ovary Syndrome, Infertility, Female
Effect of Nitric Oxide Donors on Uterine and Subendometrial Blood Flow in Patients With Unexplained Infertility
The purpose of the study to evaluate effect of nitroglycerin trans-dermal patches on uterine and sub-endometrial blood flow in women with unexplained infertility.
- Trial name
- NCT03481582
- Testing
- Nitroglycerin, Three dimensional power doppler
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Infertility
Phase 3 Study to Evaluate the Efficacy and Safety of Pergoveris® in Assisted Reproductive Technology (ESPART)
This is a Phase 3, randomized, controlled, single-blind, multicenter, parallel-arm trial to assess the safety and efficacy of Pergoveris® (recombinant human follicle stimulating hormone [r-hFSH]/recombinant human luteinising…
- Trial name
- ESPART (NCT02047227)
- Testing
- Pergoveris®, GONAL-f®, Recombinant human chorionic gonadotrophin (r-hCG)
- Where
- Germany
- Volunteers
- 939 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Infertility Unexplained, Infertility, Male
Impact of DNA Fragmentation in Sperm on Pregnancy Outcome After Intra-uterine Insemination in a Spontaneous Cycle
Infertility affects about 10% of all couples and is defined by a failure to achieve a clinical pregnancy within a year of regular unprotected sexual intercourse.
- Conditions
- Infertility Unexplained, Infertility, Male, DNA Damage
- Trial name
- NCT03319654
- Testing
- DNA fragmentation by TUNEL assay
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Infertility
A Study to Compare the Efficacy and Safety of Follitropin Alfa/Lutropin Alfa Versus hMG in Japanese Participants With LH and FSH Deficiency Undergoing ART (HINATA)
The purpose of this study is to assess the efficacy and safety of follitropin alfa/lutropin alfa in Japanese participants with Luteinizing hormone (LH) and Follicle stimulating hormone (FSH) deficiency undergoing Assisted…
- Trial name
- NCT07340827
- Testing
- Follitropin alfa/lutropin alfa (MBJ-0011), hMG, Cetrorelix acetate
- Where
- 21 sites in Japan
- Volunteers
- 266 people
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Infertility
Variation in Serum Prolactin Levels During IntraCytoplasmic Sperm Injection
The purpose of the study is to determine whether or not stressful conditions such as ovum pick and awaiting Embryo Transfer is associated with significant increase in serum Prolactin (PRL) concentration in some…
- Trial name
- NCT02292953
- Testing
- Serum Prolactin levels
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Oligospermia
Seminal Fluid's Changes Over 20 Years
This is a cohort study including all the first seminal exams performed at the Fertility Center, Humanitas Research Hospital (Rozzano, Milan) between January 1998 and December 2018.
- Trial name
- NCT04349345
- Testing
- sperm count
- Volunteers
- 24,395 people
- Sponsor
- Istituto Clinico Humanitas
Infertility, Female
Analysis of TU-LESS by 3D Laparoscopy in the Treatment of Infertility
This study intends to carry out a prospective, randomized controlled trial to compare the trans-umbilical laparoendoscopic single-site surgery by 3D laparoscopy with normal laparoendoscopic surgery in the treatment of infertility…
- Trial name
- NCT02948205
- Testing
- 3D group, normal group
- Volunteers
- 500 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
Infertility, Male
The Aim of This Study is to Determine the Incidence of Alterations in Fluorescent In Situ Hybridisation (FISH) of Spermatozoa and to Evaluate the Efficacy of the Use of Annexin Columns (MACS®) in Patients With Altered FISH Undergoing In Vitro Fertilisation Techniques
250 petitions for FISH of spermatozoa were requested, determining the total and particular incidence in each of the indications collected. The effect of annexin columns was evaluated in 10 couples with altered FISH.
- Trial name
- NCT06524102
- Testing
- Magnetic Activated Cell Sorting
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Instituto de Investigación Sanitaria y Biomédica de Alicante