Clinical trials: Steroid
Kidney Transplantation
A Study to Evaluate the Safety and Efficacy of FK506E (MR4) in Patients Undergoing Primary Kidney Transplantation
The purpose of this study is to evaluate and to compare the efficacy and safety of a triple modified release tacrolimus FK506E (MR4) / MMF / steroid regimen with a triple standard tacrolimus FK506 / MMF / steroid regimen in…
- Trial name
- NCT00189839
- Testing
- tacrolimus
- Where
- 80 sites in Argentina, Australia and 21 more
- Volunteers
- 699 people
- Sponsor
- Astellas Pharma Inc
Major Depressive Disorder
Augmentation of Treatment-Resistant Depression With An Analog of the Neuroactive Steroid Allopregnanolone
Major depressive disorder (MDD) is highly prevalent and nearly 70% of individuals with MDD do not respond to standard antidepressant therapies despite adequate dosing.
- Trial name
- NCT02900092
- Testing
- Ganaxolone
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Autonomous Cortisol Secretion, Mild Autonomous Cortisol Secretion (MACS)
Metyrapone for Mild Autonomous Cortisol Secretion (MACS)
The purpose of this study is to find out whether the study drug, metyrapone, is safe and effective in treating participants with Mild Autonomous Cortisol Secretion (MACS).
- Trial name
- NCT06106295
- Testing
- Metyrapone
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Acute GVHD
A Study to Evaluate Steroid-free Treatment for Standard-Risk aGVHD (BMT CTN 1501)
The study is a Phase II randomized, open label, multicenter trial designed to identify whether sirolimus is a potential alternative to prednisone as an up-front treatment for patients with standard-risk acute GVHD defined…
- Trial name
- NCT02806947
- Testing
- Sirolimus, Prednisone
- Where
- 21 sites in United States
- Volunteers
- 127 people
- Sponsor
- Medical College of Wisconsin
Skin Diseases
Observational Study to Assess Safety and Utility Pattern of Topical Steroids
To assess incidence of adverse drug reactions and use pattern of topical steroids among patients who are prescribed or purchase over the counter (OTC) topical steroids for skin conditions in Korea
- Trial name
- NCT02377557
- Testing
- Topical Steroids
- Where
- South Korea
- Volunteers
- 1,175 people
- Sponsor
- Hanyang University
Graft vs Host Disease
Mesenchymal Stromal Cells (MSCs) for the Treatment of Graft Versus Host Disease (GVHD)
This is a bicentric, prospective, non randomized study. Pediatric and adult patients will be treated. Rationale: MSC have shown promising effects by reversal of severe therapy-resistant acute GvHD.
- Trial name
- MSC-GvHD (NCT01764100)
- Testing
- Mesenchymal stromal cells
- Where
- 3 sites in Italy
- Volunteers
- 10 people
- Sponsor
- Ettore Biagi, MD
Keratoconus
Dextenza Versus Topical Steroid Eye Drops for Postoperative Management Following Corneal Crosslinking
This study aims to compare the use of Dextenza, an FDA-approved intracanilular drug-eluting insert that is designed to deliver a tapered dose of dexamethasone to the ocular surface for 30 days, to the standard of care, or the use…
- Trial name
- NCT06235567
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, topical prednisolone acetate 1% (PredForte) eye drops
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Maanasa Indaram, MD
Uterine Fibroids, Adenomyosis
Effect of Addition of Steroids on Duration of Analgesia
The purpose of the study is to investigate the differences in post-procedural pain scores and narcotic use among patients who receive a Superior Hypogastric Nerve Block (SHNB) with and without corticosteroid performed as part of…
- Trial name
- NCT04126824
- Testing
- Triamcinolone, Bupivacaine, Iohexol contrast
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Piriformis Muscle Syndrome
Comparison of Ultrasound-guided Steroid Injection and Dry Needling in Piriformis Muscle Syndrome
The aim of this study is to to compare its effectiveness ultrasound-guided steroid injection, dry needling treatments and exercises in patients diagnosed with piriformis syndrome.
- Trial name
- NCT06095180
- Testing
- corticosteroid injection, dry needling, exercise
- Volunteers
- 60 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Acute Graft Versus Host Disease
Multicenter Study Of Natalizumab Plus Standard Steroid Treatment For High Risk Acute Graft-Versus-Host Disease
This research trial is designed to study the safety and effectiveness of combining the study drug, Natalizumab (Tysabri®) with the standard treatment, the use of steroids, as a new treatment for acute graft versus host disease…
- Trial name
- NCT02133924
- Testing
- natalizumab, steroids
- Where
- 12 sites in United States
- Volunteers
- 76 people
- Sponsor
- John Levine
Asthma Childhood
Ideal Steroids for Asthma Treatment in the PICU
Determine if differences in (1) pediatric intensive care unit length of stay, (2) continuous nebulized albuterol duration, and (3) a composite outcome of advanced asthma therapy incidence including use of non-invasive ventilation…
- Trial name
- iSTAT PICU (NCT03900624)
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Johns Hopkins All Children's Hospital
Dry Eye Disease
The Utility of IVCM to Assess Cellular Response and Efficacy of Long-term Topical Steroid Treatment in Patients With DED
This research study is looking to see if in vivo confocal microscopy (IVCM) imaging can be used to confirm clinical findings (which are noted by the doctor during an eye exam) and measure the immune response to the inflammation…
- Trial name
- NCT02120079
- Testing
- Lotemax, Soothe Tired Eyes Lubricant Eye Drop (Artificial Tears), In Vivo Confocal Microscopy (IVCM)
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Tufts Medical Center
Nephrotic Syndrome
Efficacy and Safety of Rituximab to That of Calcineurin Inhibitors in Children With Steroid Dependent Nephrotic Syndrome
Nephrotic syndrome in children is primarily caused by minimal change disease. Majority of these patients respond well to corticosteroids.
- Trial name
- NCT02438982
- Testing
- Tacrolimus, Rituximab
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Nilratan Sircar Medical College
Congenital Adrenal Hyperplasia, CAH - Congenital Adrenal Hyperplasia
Study of SPR001 in Adults With Classic Congenital Adrenal Hyperplasia
This is a multicenter Phase 2, multiple dose, dose escalation study to evaluate the safety, pharmacokinetics (PK), pharmacodynamics (PD), and efficacy of SPR001 in adult patients with classic congenital adrenal hyperplasia (CAH).
- Trial name
- NCT03257462
- Testing
- SPR001
- Where
- 9 sites in United States
- Volunteers
- 24 people
- Sponsor
- Spruce Biosciences
Covid-19, Hypoxia
Hydrocortisone for COVID-19 and Severe Hypoxia
We aim to assess the benefits and harms of low-dose hydrocortisone in patients with COVID-19 and severe hypoxia.
- Trial name
- COVID STEROID (NCT04348305)
- Testing
- Hydrocortisone, Sodium Chloride 9mg/mL
- Where
- 14 sites in Denmark
- Volunteers
- 30 people
- Sponsor
- Scandinavian Critical Care Trials Group
Asthma
Using Mobile Phones to Improve Adherence to Inhaled Steroids
This study has two main goals. The first goal is to test whether a mobile phone intervention can increase adherence to daily inhaled steroid medications in African American adolescents prescribed this type of medication by…
- Trial name
- ADEPT4 (NCT01710059)
- Testing
- Asthma Supervision, Mobile Phone, Inhaled Corticosteroid Mobile Phone Application
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Rush University Medical Center
Asthma, Status Asthmaticus
Steroids in Children Hospitalized With Asthma
Asthma is the most common chronic disease of children. A short (3-5 day) course of a short-acting steroid such as Prednisone or Prednisolone has long been the standard of care for asthma exacerbation.
- Conditions
- Asthma, Status Asthmaticus, Wheezes
- Trial name
- NCT02780479
- Testing
- Dexamethasone, Prednisone
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Florida
Graft vs Host Disease
Anti Cytokine Combination Therapy With Daclizumab and Infliximab for Treatment of Steroid Refractory Acute GVHD
The purpose of this study is to see whether serious graft versus host disease which is not well controlled with steroid treatment can be controlled with therapy with both daclizumab and infliximab.
- Trial name
- NCT00574470
- Testing
- daclizumab, infliximab
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Iowa
Congenital Adrenal Hyperplasia
Effects of Pioglitazone in Congenital Adrenal Hyperplasia
Congenital adrenal hyperplasia, an autosomal recessive condition, is mainly caused by mutations in the gene 21-hydroxylase and is treated with glucocorticoids in a slightly supraphysiological dose.
- Trial name
- NCT00151710
- Testing
- Pioglitazone
- Where
- Netherlands
- Sponsor
- Radboud University Medical Center
Lumbar Disc Herniation
Subjective Intraoperative Use of Epidural Steroid Administration Following Discectomy
The purpose of this study is to determine a grading system for inflammation in lumbar disc herniation and which groups, if any, benefit most from the administration of an intra-operative epidural steroid.
- Trial name
- Intra-Op (NCT04182997)
- Testing
- Dexamethasone, saline 0.9%
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Missouri-Columbia
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