Clinical trials: Steroid
Muscle Health, Muscle Strength
Dose-Response Impact of Geranylgeraniol (GG) Supplementation on Muscle Health
This study will evaluate the effects of daily geranylgeraniol (GG) supplementation on muscular strength, body composition, and aerobic capacity in healthy, physically active men and women.
- Conditions
- Muscle Health, Muscle Strength, Body Composition
- Trial name
- GGE (NCT07502924)
- Testing
- Geranylgeraniol (150 mg), Geranylgeraniol (300 mg)
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Hand Injuries, Finger Injuries
Efficacy of Steroids on Functional Outcomes After Musculoskeletal Injuries of the Hand
Steroids are often prescribed for their anti-inflammatory effects in patients with musculoskeletal injuries. Studies have shown that steroids may reduce pain and swelling, but their effects on range of motion and functional…
- Trial name
- NCT05003596
- Testing
- Methylprednisolone Tablet, Standard Mobilization Treatment
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Robert Wood Johnson Barnabas Health
21-hydroxylase Deficiency
Examining Genetic Differences Among People With 21-Hydroxylase Deficiency
Congenital adrenal hyperplasia (CAH) is a genetic disorder that affects the amount of steroids that the body forms. The most common form of CAH is 21-hydroxylase deficiency (21OHD), which leads to cortisol deficiency.
- Trial name
- NCT00542841
- Testing
- Hydrocortisone withdrawal
- Where
- 3 sites in United States, Brazil
- Volunteers
- 99 people
- Sponsor
- Maria I. New
Migraine, Chronic Migraine, Headache
A Study Investigating the Efficacy of GON Blocks.
Greater occipital nerve block ("GON block") is carried out extensively in the treatment of chronic migraine, but more research is required to understand the effectiveness of the procedure.
- Trial name
- NCT04017741
- Testing
- Combined Depo-Medrone and Lidocaine, Sodium Chloride 0.9% Inj
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Barts & The London NHS Trust
Sleep Disorder; Breathing-Related, Snoring
Intranasal Steroid as Medical Therapy For Sleep-Disordered Breathing in Children
MIST+ is studying a nasal spray to see if it will reduce the need for surgery for snoring. Children aged 3-12 are invited to take part.
- Conditions
- Sleep Disorder; Breathing-Related, Snoring, Obstructive Sleep Apnea of Child, Sleep Disorders in Children
- Trial name
- MIST+ (NCT05382494)
- Testing
- Mometasone Furoate 50mcg Nasal Spray, Sodium Chloride 0.9 % Nasal Spray
- Where
- 2 sites in Australia
- Volunteers
- 130 people
- Sponsor
- Murdoch Childrens Research Institute
Dysphagia
Dysphagia Following Anterior Cervical Spine Surgery; Single Dose Steroid vs Saline (DysDexVSSal)
This prospective, randomized, double blind, controlled study evaluates the effect of a single dose of perioperative IV steroid versus saline on swallowing after anterior cervical spine surgery
- Trial name
- NCT03711474
- Testing
- Dexamethasone, Saline
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Graft vs Host Disease
Sirolimus as Treatment of Steroid-Refractory or Steroid-Dependent Chronic Graft-Versus-Host Disease
To study the effectiveness of an immunosuppressive drug sirolimus, in the treatment of chronic graft versus host disease in combination with prednisone.
- Trial name
- NCT00388362
- Testing
- Sirolimus, Prednisone
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Stanford University
Chronic Graft vs Host Disease
Donor Regulatory T-cells for cGVHD in Patients Who do Not Obtain Complete Remission With Ruxolitinib
Phase II clinical trial to assess the efficacy of donor regulatory enriched T cells in steroid-refractory chronic graft versus host disease patients who did not obtain complete remission under treatment with ruxolitinib
- Trial name
- Treg4GVHD (NCT05095649)
- Testing
- Regulatory T-cell enriched infusion
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Chronic Graft Versus Host Disease
Ruxolitinib Plus Fostamatinib for Steroid Refractory cGvHD
This is an open-label phase I study of fostamatinib in combination with ruxolitinib for the treatment of chronic GvHD with a suboptimal response to corticosteroids.
- Trial name
- NCT06233110
- Testing
- Fostamatinib, Ruxolitinib
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stefanie Sarantopoulos, MD, PhD.
FRNS/SDNS, Ripertamab
Study of Ripertamab in Children With Frequent Relapses or Steroid-Dependent Nephrotic Syndrome
This is an open-label randomized controlled trial to evaluate the efficacy and safety of one dose versus two doses of ripertamab in children with frequent relapses or steroid-dependent nephrotic syndrome (FRNS/SDNS).
- Trial name
- NCT07388810
- Testing
- ripertamab
- Where
- China
- Volunteers
- 312 people
- Sponsor
- Mao Jianhua
Post-surgical Cystoid Macular Edema (PSCME)
Treatment of Post-surgical Cystoid Macular Edema With Topical Steroids Trial (TEMPEST-1)
The purpose of this study is to compare the change in visual acuity of patients with post surgical cystoid macular edema who will be treated with two different regimens.
- Trial name
- TEMPEST (NCT01769352)
- Testing
- PredA + Kelac
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Johns Hopkins University
Herniated Disk Lumbar, Fibromyalgia
Effect of Fibromyalgia on Outcomes of Transforaminal Epidural Steroid Injection Treatment in Lumbar Radicular Pain
Lumbar radicular pain is defined as low back and leg pain caused by inflammation in the affected nerve root due to various etiological factors.
- Trial name
- NCT05053217
- Testing
- transforaminal epidural steroid injection
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Marmara University
Hematologic Neoplasms
Donor Lymphocyte Infusion After Allogeneic Hematopoietic Cell Transplantation for High-Risk Hematologic Malignancies
Background: People with blood cancers often receive blood or bone marrow transplants. But even with these treatments, the risk of relapse is high.
- Trial name
- NCT05327023
- Testing
- donor lymphocyte infusion, Cyclophosphamide, Busulfan
- Where
- United States
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Type 2 Diabetes (T2DM), Hyperglycemia
CGM-Based Glycemic Analysis After ESI
The goal of this clinical study is to learn how blood glucose levels change after an epidural steroid injection (ESI) with dexamethasone in adults.
- Conditions
- Type 2 Diabetes (T2DM), Hyperglycemia, Radicular Pain, Spinal Stenosis
- Trial name
- CGMSteroid (NCT07280780)
- Testing
- Epidural Steroid Injection, Continuous Glucose Monitoring
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- Korea University Anam Hospital
Covid19
Impact of Steroids on Inflammatory Response in Covid-19
we designed this study to observe the efficacy and safety of dexamethasone versus methylprednisolone in covid-19 diseased patients upon monitoring the inflammatory response and to compare the outcome when these steroids will be…
- Trial name
- NCT04909918
- Testing
- Dexamethasone, Methylprednisolone
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Graft vs Host Disease
Study of BEGEDINA® vs "Conventional Treatment" for Treating Steroid-Resistant Acute GvHD
The objectives of this study are to determine the efficacy and safety of BEGEDINA® in subjects with steroid resistant acute graft versus host disease (GvHD).
- Trial name
- NCT02411084
- Testing
- Begelomab, Conventional Second-line Treatment
- Where
- 27 sites in United States, France and 5 more
- Volunteers
- 36 people
- Sponsor
- Adienne SA
Steroid-Sensitive Nephrotic Syndrome
Comparison of Relapse Rate After 12 Weeks Verses 20 Weeks Steroid Therapy for the Management of First Episode of Steroid Sensitive Nephrotic Syndrome
All children from 1 to 8 years of age, diagnose with nephrotic syndrome for the first time will be divided into two groups. One group will be given steroids for 12 weeks and other group will receive steroid for 20 weeks.
- Trial name
- NCT04713410
- Testing
- Prednisolone
- Where
- Pakistan
- Volunteers
- 68 people
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Breast Neoplasm, Shoulder Capsulitis
Improvement of Range of Motion in Frozen Shoulder in Breast Cancer Survivors
The prevalence of shoulder joint disease is high in breast cancer patients. The cause of adhesive capsulitis is not clearly identified.
- Conditions
- Breast Neoplasm, Shoulder Capsulitis, Range of Motion
- Trial name
- NCT04640220
- Testing
- Intra-articular steroid injection
- Where
- South Korea
- Volunteers
- 28 people
- Sponsor
- Yeungnam University Hospital
Lumbar Radiculopathy Due to Spinal Nerve Compression
The Effects of Use of Mirror Image on Radiation Exposure During Fluoroscopically Guided Transforaminal Epidural Injection
Lumbar Transforaminal Epidural Injection is helpful for the treatment of lumbosacral radicular pain. Tunnel view technique is the basis of X-ray assisted intervention.
- Trial name
- NCT03341182
- Testing
- Fluoroscopically Guided Lumbar Transforaminal Epidural Injections, conventional manner
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Analgesia
Shoulder Anterior Capsular Block and Intraarticular Steroid Injection Versus Intraarticular Steroid Injection for Enhancing Pain Relief in Adhesive Capsulitis
Improving pain in the patients with adhesive capsulitis by comparing the effect of combined shoulder anterior capsular block and intraarticular steroid injection versus intraarticular steroid injection.
- Trial name
- NCT07235982
- Testing
- Group Group Shoulder anterior capsular block (SHAC), Group intraarticular steroid injection (IASI)
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Zagazig University
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