Clinical trials: Steroid
Stenosis, Herniated Nucleus Pulposus
Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion
Neural injury is a well-known complication following extreme lateral lumbar interbody fusion (XLIF). It has been found that up to 9.4% of patients will have either temporary or persistent neurologic deficit.
- Conditions
- Stenosis, Herniated Nucleus Pulposus, Degenerative Disc Disease, Spondylosis
- Trial name
- NCT03327272
- Testing
- Methylprednisolone, Saline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Chronic Rhinosinusitis (CRS), Olfactory Dysfunction
Position-Directed Budesonide Nasal Drops for CRS-associated Olfactory Dysfunction
This single-center randomized controlled trial evaluates whether budesonide nasal drops delivered in the Wu's position (Wu's 45° Head-Hanging Reclination Position) improve olfactory function more effectively than conventional…
- Trial name
- NCT07386873
- Testing
- Nasal Drops, Nasal Spray
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Peking University Third Hospital
Bursitis
Steroid Injection for the Treatment of Greater Trochanteric Pain Syndrome
The objective of this study is to conduct a randomized, single-blinded placebo controlled trial comparing two modalities for the treatment of pain and mobility associated with trochanteric bursitis: (1) injection of…
- Trial name
- NCT00863889
- Testing
- Depomedrol injection, Lidocaine, Marcaine
- Where
- United States
- Sponsor
- Emory University
Hormone
HIIT, Steroid Hormones and Mental Health in Adolescents
The purpose of study was to investigate the effect of a high-intensity interval training (HIIT) intervention on cardiorespiratory fitness (CRF), hormonal, and mental health markers in male adolescents.
- Trial name
- NCT07311460
- Testing
- High-intensity interval training (HIIT) program
- Where
- Tunisia
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- High Institute of Sports and Physical Education of Kef
Trigger Point Pain, Myofascial, Lumbar Radiculopathy
The Effect of the Presence of Active Trigger Points in the Muscles Innervated by the Affected Nerve Roots on the Treatment Results of Transforaminal Epidural Steroid Injection in Patients With Lumbar Radiculopathy.
The association between lumbosacral radiculopathy and the ipsilateral gluteal trigger point has been demonstrated in 74% of previous studies in patients with chronic low back pain.
- Trial name
- NCT05535010
- Testing
- Transforaminal epidural steroid injection(TFESI)
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Marmara University
Barrett Esophagus, Esophageal Stenosis
Barretts oEsophageal Resection With Steroid Therapy Trial
Barretts mucosa is a premalignant condition of the oesophagus, which can progress to cancer. Oesophageal cancer is aggressive, with a 5 year survival of only ~15%.
- Trial name
- BERST (NCT02004782)
- Testing
- Prednisolone
- Where
- Australia
- Sponsor
- Professor Michael Bourke
Lupus Nephritis
A Study of Laquinimod in Participants With Systemic Lupus Erythematosus (SLE) Active Lupus Nephritis
The study aims to evaluate the safety and clinical effect of daily oral treatment with laquinimod capsules in active lupus nephritis participants.
- Trial name
- NCT01085097
- Testing
- Laquinimod, Mycophenolate Mofetil, Prednisolone/Prednisone
- Where
- 30 sites in United States, Canada and 3 more
- Volunteers
- 46 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Osteonecrosis, Acute Lymphoblastic Leukemia
Osteonecrosis in Children With Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia is the most common form of childhood cancer with current treatment survival rates approaching 80%. Improved outcomes show an increased number of survivors at risk for long-term treatment related side…
- Trial name
- NCT01104324
- Where
- 10 sites in Canada
- Volunteers
- 130 people
- Sponsor
- Halton, Jacqueline, M.D.
Psoriasis, Plaque Psoriasis
A Study to Determine the Efficacy and Safety of 122-0551 in Subjects With Plaque Psoriasis
Corticosteroids are one of the mainstays of treatment for subjects with corticosteroid-responsive dermatoses such as psoriasis. This study has been designed to determine and compare the efficacy and safety of a formulation of…
- Trial name
- NCT01700985
- Testing
- 122-0551, Vehicle
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- Therapeutics, Inc.
Eustachian Tube Dysfunction, Endolymphatic Hydrops
Refractory Eustachian Tube Dysfunction: Are the Symptoms Related to Endolymphatic Hydrops
The purpose of this study is to evaluate the benefit of treatment of refractory Eustachian tube dysfunction with standard treatment for endolymphatic hydrops.
- Trial name
- NCT01661777
- Testing
- Nasal steroid, Myringotomy tube placement, Diuretic
- Where
- United States
- Sponsor
- Vanderbilt University
T1DM, Hypersensitivity
The Use of Topical Nasal Steroids for Skin Reactions to Continuous Glucose Monitoring System, Among Children and Youth With Type 1 Diabetes Mellitus: Case Series
Background Type 1 diabetes mellitus is a chronic metabolic disorder that presents a significant set of challenges to the patient, their family and the physician.
- Trial name
- NCT03594565
- Testing
- Fluticasone Propionate
- Volunteers
- 13 people
- Sponsor
- Assaf-Harofeh Medical Center
Systemic Lupus Erythematosus (SLE), Repository Corticotropin Injection
Acthar SLE (Systemic Lupus Erythematosus)
This is a randomized study exploring the efficacy, safety and steroid sparing ability of two doses (40 U and 80 U) of Acthar in SLE patients with immune mediated hematologic manifestations requiring steroid use for a minimum of 2…
- Trial name
- Acthar SLE (NCT02779153)
- Testing
- Acthar low dose (40 U), Acthar high dose (80 U)
- Sponsor
- NYU Langone Health
Renal Transplant
Evaluation of Calcineurin-inhibitor Reduction With Conversion at 2 Months to Everolimus/Reduced Tacrolimus in Renal Transplant Recipients Following Campath® Induction
The purpose of this study is to evaluate whether conversion to everolimus (Zortress®), allowing the elimination or reduction of calcineurin inhibitors, will reduce nephrotoxicity (measured by increased creatinine clearance) and…
- Trial name
- NCT01935128
- Testing
- Arm 1 Everolimus/Reduced dose tacrolimus
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Toledo Health Science Campus
Postoperative Pain
Efficacy of Preoperative Intravenous Dexamethasone in Primary Total Knee Arthroplasty
To determine efficacy of preoperative IV dexamethasone for postoperative pain control after TKA.
- Trial name
- TKA (NCT02102815)
- Testing
- Dexamethasone, Normal saline
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Thammasat University
Multiple Sclerosis, Relapsing-remitting
Assessment of Lesion Activity Analysis in the Avonex- Steroid Azathioprine (ASA) Study
To examine short- and long-term value of appearance of new active lesions in predicting extent of cortical and subcortical deep gray matter (SDGM) atrophy over 5 years in ASA (Avonex- Steroid-Azathioprine)study.
- Trial name
- ASA (NCT01628315)
- Testing
- MRI
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- University at Buffalo
Sarcoma
Doxorubicin vs. Trabectedin Plus Doxorubicin in Non Operable and/or Metastatic STS
The proposed investigation intends to explore if the combination of trabectedin and doxorubicin in the first line of treatment of advanced sarcomas obtains better results than doxorubicin monotherapy
- Trial name
- NCT01104298
- Testing
- Doxorubicin, Trabectedin
- Where
- 20 sites in Spain
- Volunteers
- 115 people
- Sponsor
- Grupo Espanol de Investigacion en Sarcomas
Contraception, Female Contraception
A Study to Evaluate the Exposure of Norelgestromin and Ethinyl Estradiol From Commercial Lots of EVRA (a Transdermal Contraceptive Patch Manufactured by LOHMANN Therapie-Systeme) and CILEST (an Oral Contraceptive)
The objective of this study is to estimate exposure to the hormones norelgestromin, norgestrel, and ethinyl estradiol in healthy female volunteers across multiple commercial lots of EVRA® (a transdermal contraceptive patch…
- Trial name
- NCT00258063
- Testing
- EVRA® transdermal contraceptive patch containing 6 mg of norelgestromin and 0.60 mg of ethinyl estradiol (versus CILEST® tablets).
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Carpal Tunnel Syndrome
Acupuncture in Patients With Carpal Tunnel Syndrome ~ A Randomized Controlled Trial
To investigate the efficacy of acupuncture compared with steroid treatment in patients with mild-to-moderate carpal tunnel syndrome (CTS) as measured by objective changes in nerve conduction studies (NCS) and subjective symptoms…
- Trial name
- NCT01014221
- Testing
- Acupuncture, Prednisolone
- Where
- Taiwan
- Volunteers
- 77 people
- Sponsor
- Kuang Tien General Hospital
Myocarditis Acute
MYTHS - MYocarditis THerapy With Steroids
This is a phase III, multi-center international, single blind randomized controlled trial to test the efficacy of pulsed intravenous (IV) methylprednisolone versus standard therapy on top of maximal support in patients with Acute…
- Trial name
- MYTHS (NCT05150704)
- Testing
- Methylprednisolone, saline solution
- Where
- 49 sites in United States, Austria and 7 more
- Volunteers
- 288 people
- Sponsor
- Niguarda Hospital
Rotator Cuff Tendinopathy
IS'ECHO : Impact of Bursitis on the Efficacy of Subacromial Steroid Injection in Rotator Cuff Tendinopathy
Shoulder pain is a common reason for medical consultation affecting 6.7 % of the adults from 50 to 70 years old and until 21 % of the adults over 70.
- Trial name
- IS'ECHO (NCT03454321)
- Testing
- Infiltration
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Nantes University Hospital
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