Clinical trials: Steroid
Osteonecrosis, Osteonecrosis of the Femoral Head
A Phase II Trial of RAB001 (LLP2A-Alendronate) for Steroid-Induced Early-Stage Osteonecrosis of the Femoral Head
This is a multicenter, randomized (similar to drawing lots, where the treatment you receive is not chosen by you or the researchers), controlled, blinded (the three dose groups of the investigational drug are blinded, meaning…
- Trial name
- LLP2A-Ale (NCT07471880)
- Testing
- RAB001 high dose, RAB001 medium dose, RAB001 low dose
- Where
- China
- Volunteers
- 161 people
- Sponsor
- ZhongShan LaiBo RuiChen BioMedicine Co.,Ltd.
Drug Abuse, Harm Reduction
Harm Reduction Intervention for Anabolic-androgenic Steroids Users: a Randomized Controlled Trial
This clinical trial aims to investigate the short and long-term efficacy of a harm reduction intervention in reducing the use of non-clinical anabolic-androgenic steroids (AAS) in abusive users of AAS.
- Conditions
- Drug Abuse, Harm Reduction, Minimization, Harm, Anabolic Steroids Adverse Events
- Trial name
- SOS-RCT-HR (NCT07039539)
- Testing
- harm reduction intervention in non-clinical anabolic-androgenic steroids users
- Where
- Brazil
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Severe Alcoholic Hepatitis
Role of Extended Low Dose Prednisolone in Achieving Clinical and Biochemical Remission in Steroid Responsive Severe Alcoholic Hepatitis
Severity of alcoholic hepatitis is defined by Maddrey's discriminant function, value of 32 or higher indicates severe alcoholic hepatitis that carries an adverse prognosis with one month mortality of 30%-50%.
- Trial name
- NCT06155760
- Testing
- Prednisolone, Standard Medical therapy
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Lumbosacral Radiculopathy
Does Magnetic Resonance Imaging (MRI) Improve Interventional Outcomes for Lumbosacral Radiculopathy?
Epidural steroid injections (ESI) are the most frequently performed procedures in pain clinics. When performing ESI, there is no consensus about how to best select candidates for this intervention, and which level(s) to inject.
- Trial name
- NCT00826124
- Testing
- Epidural steroid injection, Magnetic Resonance Imaging (MRI)
- Where
- 2 sites in United States
- Volunteers
- 131 people
- Sponsor
- Johns Hopkins University
Exudative Retinal Detachment and Uveal Melanoma
Dexamethasone Implant for Retinal Detachment in Uveal Melanoma
This is an investigator-initiated Phase I study of a single dose of an intravitreally-administered dexamethasone implant (Ozurdex™) in subjects with uveal melanomas (UM) and exudative retinal detachments (ERD: build-up of fluid…
- Trial name
- NCT04082962
- Testing
- Dexamethasone intravitreal implant
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Ivana K. Kim
Multiple Myeloma and Plasma Cell Neoplasm
Chemotherapy Plus Steroid Therapy in Treating Patients With Multiple Myeloma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Trial name
- NCT00003603
- Testing
- cyclophosphamide, dexamethasone, idarubicin
- Where
- United Kingdom
- Volunteers
- 660 people
- Sponsor
- Riverside Haematology Group
Dry Eye
Topical Steroid Treatment For Dry Eye
Many patients refer to an oculoplastic or corneal clinic examination due to dry eye symptoms. epidemiologic studies estimate that as many as 15% of the population over 60 years suffer from dry eye.
- Trial name
- NCT02218827
- Testing
- Loteprednol Etabonate (FML)
- Where
- 2 sites in Israel
- Volunteers
- 30 people
- Sponsor
- Meir Medical Center
NAION( Non-arteritic Anterior Ischemic Optic Neuropathy)
Outcomes of Steroid and Oxygen Therapy Versus Placebo Therapy in Non-arteritic Anterior Ischemic Optic Neuropathy
Patients diagnosed with NAION within 14 days of onset were included. Patients were randomized into 3 groups. Group 1 or control consisted of 30 patients who received gelatinous capsules filled with sugar as placebo.
- Trial name
- NAION (NCT02439866)
- Testing
- Intravenous methylprednisolone, normobaric oxygen with face mask
- Where
- Iran
- Volunteers
- 90 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Inflammation, Vasculitis
Steroids and Methotrexate to Treat Systemic Vasculitis
This study will evaluate the safety and effectiveness of prednisone and methotrexate in treating severe Wegener's granulomatosis and other systemic vasculitides.
- Conditions
- Inflammation, Vasculitis, Wegener's Granulomatosis
- Trial name
- NCT00001256
- Testing
- prednisone and methotrexate
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Urethral Stricture
Holmium Laser Uretherotomy in Combination With Intralesional Steroids in Bulbar Uretheral Stricture
the purpose is to evaluate the outcome of visual internal uretherotomy with Holmium laser along with intralesional steroid injection.
- Trial name
- NCT05078788
- Testing
- Laser uretherotomy, Laser uretherotomy with triamcinolone
- Where
- Egypt
- Volunteers
- 124 people
- Sponsor
- Ain Shams University
HEPATITIS
TO Compare the Triple Drug Therapy and Dual Therapy .
Study to Compare the Safety and Efficacy of Tacrolimus and Steroids in Combination With Mycophenolate Mofetil or Without Mycophenolate Mofetil in Liver Transplantation with Hepatitis B Virus(HBsAg) Positive
- Trial name
- OPTIMUS-A (NCT02075242)
- Testing
- Mycophenolate Mofetil, Tacrolimus
- Where
- South Korea
- Volunteers
- 170 people
- Sponsor
- Asan Medical Center
Pulmonary Sarcoidosis
Efficacy and Safety of Intravenous Efzofitimod in Patients With Pulmonary Sarcoidosis
This is a multicenter, randomized, double-blind, placebo-controlled, study comparing the efficacy and safety of intravenous (IV) efzofitimod 3 mg/kg and 5 mg/kg versus placebo after 48 weeks of treatment.
- Trial name
- NCT05415137
- Testing
- Efzofitimod 3 mg/kg, Efzofitimod 5 mg/kg
- Where
- 91 sites in United States, Brazil and 7 more
- Volunteers
- 268 people
- Sponsor
- aTyr Pharma, Inc.
Liver Transplantation
A Study to Compare the Efficacy and Safety of FK506MR vs Prograf® in Patients Undergoing Liver Transplantation
The patients about to undergo liver transplantation will be randomized to one of the following two group: Group FK506MR: FK506MR/steroid; Group Prograf® : Prograf® /steroid The treatment period is 3 months(12 weeks
- Trial name
- NCT00459719
- Testing
- Tacrolimus modified-release, Prograf
- Where
- 5 sites in China
- Volunteers
- 42 people
- Sponsor
- Astellas Pharma Inc
Multiple Sclerosis, Relapsing-Remitting
Development and Evaluation of a Web-based Programme on Relapse Management for People With Multiple Sclerosis
This randomized controlled trial will evaluate a web-based relapse management programme, which is easily accessible for people with multiple sclerosis.
- Trial name
- POWER@MS2 (NCT04233970)
- Testing
- web-based intervention programme, web-based information material offered via the same platform (broca®) in addition to usual care
- Where
- Germany
- Volunteers
- 160 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Acute Sciatica
A Comparative Effectiveness Randomised Placebo Controlled Pilot Trial of the Management of Acute Lumbar Radicular Pain
Aim: In subjects with acute sciatica (≤ 4 weeks duration), this is a pilot comparative effectiveness study to evaluate feasibility and to determine final sample size for a future adequately powered randomised controlled trial of…
- Trial name
- SCIATICA (NCT03240783)
- Testing
- Betamethasone OR Dexamethasone Injectable, Normal Saline Flush, 0.9% Injectable Solution, Dexamethasone Oral Tablet
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- St George Hospital, Australia
Polytrauma
Genderspecific Differences in Hormone Levels After Trauma
The goal of this prospective study with the aim to establish a registry is to learn about the role of steroid hormones in severely injured patients.
- Trial name
- SteroPoly (NCT05794256)
- Testing
- No interventions are planned
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Technical University of Munich
Asthma
Dose Response of Fractional Exhaled Nitric Oxide (FeNO) to Inhaled Steroids in Mild-to-moderate Asthma
Asthma is a chronic disease, which means that it cannot be cured, but the investigators can use inhalers and tablets to control the symptoms.
- Trial name
- NCT00995657
- Testing
- Fluticasone Propionate
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- University of Dundee
Mechanical Ventilation, Mortality
Septic Shock em Steroids
Septic shock is a frequent reason for admission on pediatric intensive care units. Interventions which can change morbidity and mortality of septic shock patients are of great interest.
- Trial name
- NCT01047670
- Testing
- Hydrocortisone
- Where
- Brazil
- Volunteers
- 160 people
- Sponsor
- Unidade de Terapia Intensiva
Nephrotic Syndrome
Transcriptome Analysis in Idiopathic Nephrotic Syndrome: Steroid Responsiveness
Idiopathic nephrotic syndrome (INS) affects the glomerular barrier by damaging the podocytes with foot process effacement, leading to a pathological increase of permeability and protein loss.
- Trial name
- NCT06325137
- Testing
- Transcriptome analyses
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Burlo Garofolo
Asthma
TNF Alpha in Refractory Asthma
The purpose of this study was to investigate whether the administration of etanercept to patients with severe asthma improved their asthma related quality of life and a measure of the degree of reactivity of the airways
- Trial name
- NCT00276029
- Testing
- Etanercept
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University Hospitals, Leicester
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