Clinical trials: Steroid
Acute-graft-versus-host Disease
Extracorporal Photopheresis With UVADEX Plus Standard Steroid Treatment for High Risk Acute Graft-versus-host Disease
This is a single arm phase 2 trial which includes patients with high risk acute GVHD defined as Ann Arbor score 2 or 3. The purpose of the study is to improve the outcome of these patients in terms of response to treatment and…
- Trial name
- NCT04291261
- Testing
- Uvadex
- Where
- 4 sites in Austria, Germany
- Volunteers
- 24 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Graft Versus Host Disease (cGvHD)
Ex Vivo-Expanded Regulatory T Cells Plus Low-Dose Interleukin-2 for Steroid-Refractory Chronic GVHD
Hematopoietic Stem Cell Transplant (HCT) has been used to treat children and adults who have leukemia, lymphoma and other cancers of blood and immune cells since the 1970s. For many of these forms of cancer, HCT works well.
- Trial name
- EVENT (NCT06991361)
- Testing
- EVE-Treg
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Sarah Nikiforow, MD
Herniated Disk Lumbar, Metabolic Syndrome
Effect of Metabolic Syndrome on Outcomes of Transforaminal Epidural Steroid Injection Treatment in Chronic Lumbar Radiculopathy
Transforaminal epidural steroid injection (TFESI) has been increasingly preferred in patients who can not benefit from conservative approach in the treatment of lumbosacral radiculopathic pain due to lumbar disc herniation.
- Trial name
- NCT05088954
- Testing
- transforaminal epidural steroid injection
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Marmara University
Alopecia Areata
Comparative Study for Treatment of Alopecia Areata Using Carboxytherapy and Intralesional Steroids
Patients with three lesions of alopecia areata are randomly recruited in this study. Each lesion is randomized in to receiving either carboxytherapy in one lesion, intralesional steroids in another lesion and combination of both…
- Trial name
- NCT04228029
- Testing
- Carboxytherapy, Intralesional Steroid Injection
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Kasr El Aini Hospital
Cmv Colitis
Cytomegalovirus Infection in Steroid-refractory Ulcerative Colitis
Aim of the work To identify the prevalence of CMV infection in patients with steroid-refractory ulcerative colitis. To assess the clinical and endoscopic conditions in these patients.
- Trial name
- NCT03467841
- Testing
- CMV IgM, IgG in blood real time PCR for serum CMV DNA .
- Volunteers
- 50 people
- Sponsor
- Dr mohammedRmadan hamad
Graft Versus Host Disease
Fludarabine in Treating Patients With Steroid-Resistant Chronic Graft- Versus-Host Disease
RATIONALE: Fludarabine may be an effective treatment for graft-versus-host disease caused by bone marrow transplantation. PURPOSE: Phase I/II trial to study the effectiveness of fludarabine in treating patients who have chronic…
- Trial name
- NCT00004194
- Testing
- fludarabine phosphate
- Sponsor
- Jonsson Comprehensive Cancer Center
Steroid-refractory aGvHD Subsequent to Allogeneic Hematopoietic Cell Transplantation
A Study Evaluating the Efficacy and Safety of Neihulizumab vs "Conventional Treatment" to Treat Sr-aGvHD
This study is to assess the efficacy of Neihulizumab versus "conventional therapy" and to evaluate safety, pharmacokinetics and immunogenicity in treating steroid-refractory acute Graft-vs-Host Disease
- Trial name
- NCT02694770
- Testing
- Neihulizumab Treatment, Conventional Treatment
- Where
- 2 sites in United States
- Sponsor
- AbGenomics B.V Taiwan Branch
Apical Periodontitis
Antibacterial Activity of Calcium Hydroxide and Betamethasone in Apical Periodontitis
Apical periodontitis is a chronic inflammatory disease caused by bacterial infection of the root canal system. Although mechanical cleaning and shaping reduce most microorganisms, bacteria may persist in areas that are difficult…
- Trial name
- NCT07351682
- Testing
- Calcium Hydroxide (Ca(OH)2) Intracanal Medication, Calcium Hydroxide + Iodoform (Metapex), Calcium Hydroxide + Betamethasone
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Medipol University
Dialysis Hypotension
Steroids on Intra-dialytic Hypotension
Symptomatic hypotension during (or immediately following) hemodialysis complicates 5 to 30 percent of all dialysis treatments and is associated with increased morbidity and mortality.
- Trial name
- NCT03465007
- Testing
- Hydrocortisone, Normal saline
- Where
- Jordan
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Jordan
Thyroidectomy, Thyroid Diseases
Preoperative Single-dose Steroid Application for the Treatment of Nausea and Vomiting After Thyroid Surgery
The study is to compare the postoperative recovery, as determined by postoperative nausea and vomiting (PONV) after preoperative application of single-dose dexamethasone versus saline in patients undergoing partial or total…
- Trial name
- tPONV (NCT01189292)
- Testing
- Dexamethasone, NaCl 0.9%
- Where
- Switzerland
- Volunteers
- 152 people
- Sponsor
- Cantonal Hospital of St. Gallen
Rheumatoid Arthritis
The Role of Tofacitinib in Steroid Withdrawal in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a systemic chronic arthritis characterized by systemic inflammation, persistent synovitis and final joint destruction Inflammatory diseases can lead to decreased productivity and impaired…
- Trial name
- NCT04927000
- Testing
- Tofacitinib
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Lumbar Radiculopathy Due to Spinal Nerve Compression
The Effect of Local Anesthetic Injection Depth on Procedural Pain and Discomfort During Fluoroscopically Guided Lumbar Transforaminal Epidural Injections
Lumbar Transforaminal Epidural Injection is helpful for the treatment of lumbosacral radicular pain. But needle handling during the procedure may cause pain and discomfort to the patient.
- Trial name
- NCT03308136
- Testing
- 1ml of local anesthetics (1% Lidocaine) were injected into the subcutaneous layer., 1ml of a local anesthetics (1% idocaine) are first injected into the subcutaneous layer, followed by 3~4ml of local anesthetics to the muscle layer along the expected needle pathway., 1% Lidocaine
- Where
- South Korea
- Volunteers
- 68 people
- Sponsor
- Yonsei University
Steroid Refractory Acute Graft Versus Host Disease
Methoxsalen and Extracorporeal Photopheresis (ECP) for the Treatment of Pediatric Participants With Steroid Refractory Acute Graft Versus Host Disease
This is a single-arm, open-label, multicenter study of the efficacy of UVADEX® (methoxsalen) Sterile Solution in conjunction with THERAKOS® CELLEX® Photopheresis Systems (ECP) in pediatric participants with steroid-refractory…
- Trial name
- NCT02524847
- Testing
- Methoxsalen, Extracorporeal Photopheresis (ECP)
- Where
- 32 sites in United States, Austria and 6 more
- Volunteers
- 29 people
- Sponsor
- Therakos, Inc., a Mallinckrodt Company
Vasculitis, Wegener's Granulomatosis
Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years
The aim of this trial is to lower the morbidity rate in elderly patients affected with systemic necrotizing vasculitides, by reducing mortality and improving global outcome.
- Conditions
- Vasculitis, Wegener's Granulomatosis, Microscopic Polyangiitis, Churg-Strauss Syndrome
- Trial name
- CORTAGE (NCT00307671)
- Testing
- prednisone, methylprednisolone,cyclophosphamides, Cyclophosphamide, Azathioprine,prednisone,methylprednisolone, Mycophenolate mofetil,methotrexate
- Where
- France
- Volunteers
- 108 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pain Management
Intra-articular Pulsed Radiofrequency With Steroids Injection Versus Intra-articular Steroids Injection in Chronic Sacroiliac Joint Arthritis
The sacroiliac joint is Located between the pelvis and base of the spine, the sacroiliac joints are strong, stable joints that allow for little movement.
- Trial name
- NCT03564106
- Testing
- intraarticular radiofrequency + intraarticular methylprednisolone, intraarticular methylprednisolone
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Diabetes, Knee Osteoarthritis
Knee Steroid Injection and Blood Sugar Signatur
A prospective, observational study assessing the relationship between HbA1c level and the post-injection blood glucose signature.
- Trial name
- NCT04317404
- Testing
- 40 mg Triamcinolone acetonide
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Texas Southwestern Medical Center
Recipients of Liver Transplant
Envarsus XL Immunosuppression Following Liver Transplantation
The standard immunosuppressive regimen for liver transplantation includes twice daily tacrolimus (Prograf). In other transplantation models, there are potential benefits to extended release formulations as lower peak…
- Trial name
- NCT03828058
- Testing
- Envarsus XR, Prograf
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Methodist Healthcare - Memphis
Adrenal Hyperplasia, Polycystic Ovarian Syndrome
Adrenal Hyperplasia Among Young People With PCOS
Background: Polycystic ovarian syndrome (PCOS) is a group of disorders related to problems with the secretion of certain hormones, which can lead to reproductive and other issues in women.
- Conditions
- Adrenal Hyperplasia, Polycystic Ovarian Syndrome, Oligomenorrhea, Obesity
- Trial name
- NCT01313455
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Asthma, Osteoporosis, Osteopenia
Long-term Effect of Steroid on Metabolic Diseases in Asthmatics
The goal of this retrospective/observational study is to compare the clinical outcomes between the high-cumulative-dose group and the low- cumulative-dose group of oral/inhaled corticosteroid in the long-term management of asthma…
- Conditions
- Asthma, Osteoporosis, Osteopenia, Osteoporosis Risk, Osteoporotic Fractures
- Trial name
- NCT06279078
- Testing
- Corticosteroid
- Where
- South Korea
- Volunteers
- 19,968 people
- Sponsor
- Ajou University School of Medicine
MDS, Systemic Autoimmune Diseases
A Study of Azacitidine in Myelodysplastic Syndrome (MDS) Associated to Systemic Auto-immune and Inflammatory Disorders
This study is a phase II of effcicacy and tolerance of azacitidine in patients with myelodysplatic syndrome and steroid dependent or resistent systemic auto-immune and inflammatory disorders
- Trial name
- NCT02985190
- Testing
- Azacitidine
- Where
- 59 sites in France
- Volunteers
- 30 people
- Sponsor
- Groupe Francophone des Myelodysplasies
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