Clinical trials: Steroid
Chronic Planter Fascitis
Local Percutaneous Pulsed Radiofrequency Ablation Versus Ultrasound Guided Steroids Injection in Management of Pain in Cases of Chronic Planter Fascitis, Randomised Double Blinded Study
Plantar fasciitis is the one of the most common causes of painful heel in adults. It is assumed to be caused by inflammation and is typically precipitated by biomechanical stress.
- Trial name
- NCT07394894
- Testing
- Local percutaneous pulsed radiofrequency Ablation PRFA, methylprednisolone
- Volunteers
- 122 people
- Sponsor
- Assiut University
Kidney Transplantation
Comparison of Standard Versus Low Dose Advagraf® With or Without Angiotensin-converting Enzyme Inhibitor (ACEi)/Angiotensin Receptor Blocker (ARB) on Histology and Function of Renal Allografts
This is a multicentre study examining the use of Advagraf-minimization strategy and/or the use of an inhibitor of the renin-angiotensin system in reducing chronic rejection in renal allografts.
- Trial name
- NCT00933231
- Testing
- tacrolimus, Simulect, Cellcept
- Where
- 13 sites in Canada
- Volunteers
- 281 people
- Sponsor
- Astellas Pharma Inc
Amenorrhea, Hypoaldosteronism
Ovarian Follicle Function in Patients With Primary Ovarian Failure
No proven therapy to restore ovarian function and fertility is available to patients with karyotypically normal spontaneous premature ovarian failure.
- Conditions
- Amenorrhea, Hypoaldosteronism, Hypogonadism, Infertility
- Trial name
- NCT00001275
- Where
- United States
- Volunteers
- 1,134 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Acute Graft-versus-Host Disease
Universal CNK-UT Therapy for Refractory aGVHD
This is a single arm, open-label, multi-center, pilot studies (Investigator Initiated Trial, IIT) to evaluate the safety, tolerability, efficacy, pharmacokinetics and pharmacodynamics of universal T-cells engineered with chimeric…
- Trial name
- CNK-UT (NCT06750133)
- Testing
- Chimeric Natural Killer Receptor Universal T-cells (CNK-UT)
- Where
- 2 sites in China
- Volunteers
- 23 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Chronic Obstructive Pulmonary Disease (COPD)
Effect of Inhaled Steroids on Gene Expression in the Lungs - 2
The purpose of this study is to assess the effect of inhaled beclomethasone (an inhaled corticosteroid) on the pattern of the lung airway epithelium and alveolar macrophages gene expression of healthy smokers.
- Trial name
- NCT00826748
- Testing
- Beclomethasone
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Severe Atopic Dermatitis
Efficacy of Combining Topical Antibiotic/Steroid/Moisturizer Therapy Compared to Active Comparator in Atopic Dermatitis.
Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease that occurs most commonly during early infancy and childhood.
- Trial name
- NCT03052348
- Testing
- Polyethylene glycol hexadecyl ether & Betamethasone valerate cream 0.1%, Fusidic acid, polyethylene glycol hexadecyl ether & Betamethasone valerate cream 0.1%
- Where
- 3 sites in South Africa
- Volunteers
- 78 people
- Sponsor
- Red Cross War Memorial Childrens Hospital
Nephrotic Syndrome in Children
Steroid Sensitive Nephrotic Syndrome in Children
Idiopathic nephrotic syndrome (INS) is one of the most common glomerular pathologies in children and corticosteroid therapy is its most effective treatment.
- Trial name
- NCT03878914
- Testing
- Corticosteroids
- Where
- 2 sites in United States, China
- Volunteers
- 34 people
- Sponsor
- Wayne State University
Graft Versus Host Disease, Cancer
Extracorporeal Photopheresis for Acute Graft Versus Host Disease
The purpose of this research study is to evaluate the safety and feasibility of extracorporeal photopheresis (ECP) in the treatment of steroid-refractory acute graft-versus-host disease (GVHD) in children.
- Conditions
- Graft Versus Host Disease, Cancer, Stem Cell Transplantation
- Trial name
- NCT00179855
- Testing
- Extracorporeal Photopheresis
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Acute Allograft Rejection in Simultaneous Kidney/Pancreas Transplant Recipients
A Trial of Two Daclizumab Dosing Strategies vs. No Induction Treatment With Tacrolimus, Mycophenolate Mofetil , & Steroids for the Prevention of Acute Allograft Rejection in Simultaneous Kidney/Pancreas Transplant Recipients
The purpose of the study is to determine the safety and efficacy of two dosing regimens of daclizumab in simultaneous kidney/pancreas transplant recipients.
- Trial name
- NCT00363116
- Testing
- Daclizumab
- Where
- 24 sites in United States, Canada
- Volunteers
- 298 people
- Sponsor
- University of Cincinnati
Congenital Adrenal Hyperplasia
Nevanimibe HCl for the Treatment of Classic CAH
This is a multicenter, intra-subject dose-titration open-label study of nevanimibe hydrochloride (HCl) for the treatment of classic congenital adrenal hyperplasia (CAH).
- Trial name
- NCT03669549
- Testing
- Nevanimibe hydrochloride
- Where
- 11 sites in Brazil, Czechia and 3 more
- Volunteers
- 15 people
- Sponsor
- Millendo Therapeutics US, Inc.
Spinal Cord Injury
Acute and Chronic Effects of Inhaled Steroids on Pulmonary Function in Persons With Spinal Cord Injury
Individuals with chronic cervical SCI are known to have a restrictive ventilatory defect due to complete or partial loss of respiratory muscle innervation which is dependent upon the level and completeness of injury [2].
- Trial name
- NCT01353599
- Testing
- Mometasone furoate
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Heart Transplantation
Withdrawal of Steroids, Cyclosporine A Dose Reduction and Switch to Mycophenolatmofetile After Heart Transplantation
The purpose of this study is first to improve or save renal function and second to decrease cardiac risk factors by optimising the immunosuppressive regimen by withdrawing steroids and reducing the Cyclosporine A dose.
- Trial name
- NCT00359658
- Testing
- prednisolon, Mycophenolatmofetile, Cyclosporin A
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Hannover Medical School
Alcohol Consumption, Healthy
Dose-response Effect of Alcohol Ingestion on Steroid Profile
The aim of the clinical trial is to study the intra-individual variation of steroid profile parameters after experimental administration of different doses of ethanol in Caucasian women.
- Trial name
- PROFETHYL/2 (NCT02869763)
- Testing
- 10 g ethanol, 20 g ethanol, Water
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Hepatitis Immune
Steroid Sparing in Immune Related Hepatitis (irH)
A multi-centre, randomized, non-inferiority trial in patients with irH, randomized to receive either close surveillance with corticosteroid rescue therapy or early high dose corticosteroids.
- Trial name
- NCT05345847
- Testing
- Active Surveillance, Early initiation
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- AHS Cancer Control Alberta
CHRONIC POST-TRAUMATIC NEUROPATHIC PAIN IN ANKLE AND FOOT
Pilot RCT of Efficacy of Perineural Local Anesthetics and Steroids for Chronic Post-traumatic Ankle and Foot Pain
Injections of local anesthetics (freezing) and steroids are often performed around injured nerves in individuals with nerve injury-related pain.
- Trial name
- PREPLANS (NCT02680548)
- Testing
- 0.9% saline, 0.25% bupivacaine hydrochloride injectable suspension USP, 4mg/cc methylprednisolone acetate injectable suspension USP
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University Health Network, Toronto
Acne Vulgaris
The Effects of Systemic Isotretinoin Treatment on Adrenal Steroid and Sex Hormones Level in Severe Acne Vulgaris
Acne vulgaris is a chronic inflammatory skin disease involving the pilosebaceous unit, affecting approximately 95% of adolescents and young adults.
- Trial name
- NCT05903716
- Testing
- Hormone, Isotretinoin
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Marmara University
Carpal Tunnel Syndrome
Local Injection of Steroid VS.Glucose 5% in Carpal Tunnel Syndrome
To assess pain relief and quality of life among patients with carpal tunnel syndrome after local steroid vs. glucose 5% injection.
- Trial name
- NCT05496764
- Testing
- Dexamethasone, Glucose Injection
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Assiut University
Chronic Shoulder Pain
The Effect of Mesotherapy and Intra-articular Steroid Injection in Shoulder Pain
Patients with chronic shoulder pain will be divided randomly into mesotherapy and intra-articular steroid injection groups. Pain severity, range of motion and functional impairment will evaluated before treatment, 30 minutes and…
- Trial name
- Mesotherapy (NCT06610032)
- Testing
- Mesotherapy, Intra-articular steroid injection
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Haydarpasa Numune Training and Research Hospital
Vestibular Schwannoma, Facial Nerve Paralysis
Steroids for Facial Nerve Function Protection in Post-surgical Vestibular Schwannoma Patients
The purpose of this study is to evaluate the efficacy and safety of steroids treatment compared with placebo in preserving facial nerve function after craniotomy in patients with vestibular schwannoma who have not received…
- Trial name
- SAF-NRVS (NCT07116811)
- Testing
- Steroids therapy
- Where
- China
- Volunteers
- 364 people
- Sponsor
- Beijing Tiantan Hospital
Osteoarthritis, Knee, Diabete Type 2
Increased Blood Glucose Levels After Steroid Injection
a sample of 600 patients diagnosed as Knee osteoarthritis injected with 40 mg triamcinolone, recorded their morning fasting blood glucose levels for 7 days before injection used as the baseline blood glucose level, which was…
- Trial name
- NCT06228911
- Testing
- steroid (triamcinolone)
- Where
- Syria
- Volunteers
- 600 people
- Sponsor
- Syrian Private University
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