Clinical trials: Steroid
Pneumonia, Pneumocystis Carinii, HIV Infections
Comparison of Three Treatments for Pneumocystis Pneumonia in AIDS Patients
This study compares three different therapies for treatment of refractory Pneumocystis carinii pneumonia (PCP) in patients with AIDS.
- Trial name
- NCT00000730
- Testing
- Trimetrexate glucuronate, Methylprednisolone, Pentamidine isethionate
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Progesterone, Estrogens
Neural Changes in the Aging Auditory System
The purpose of this study was to determine the effects of hormone replacement therapy (HRT) on hearing in post-menopausal women.
- Conditions
- Progesterone, Estrogens, Hearing, Psychoacoustics
- Trial name
- NCT00264407
- Testing
- Hormone Replacement Therapy - HRT
- Where
- 2 sites in United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Atopic Dermatitis
Efficacy and Steroid Sparing Potential Study of DGLA Cream in Patients With Moderate to Severe Atopic Dermatitis
This study will investigate the steroid sparing potential of DS107E to vehicle in patients with moderate to severe atopic dermatitis.
- Trial name
- NCT03676036
- Testing
- DS107E, Vehicle
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- DS Biopharma
Glenohumeral Osteoarthritis
Osteoarthritis Shoulder Injection Study
The purpose of this study is to determine the most effective intraarticular steroid dose for the treatment of glenohumeral osteoarthritis.
- Trial name
- NCT03586687
- Testing
- Triamcinolone
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Milton S. Hershey Medical Center
Kidney Diseases
Comparison of Sirolimus to Tacrolimus for Long Term Therapy in Kidney Transplant With no Steroids
Kidney transplant patients will be treated with Thymoglobulin (5 days), tacrolimus (Prograf), and mycophenolate mofetil (Cellcept) from the time of transplant.
- Trial name
- NCT00170053
- Testing
- Sirolimus
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- Mayo Clinic
Alcohol Use Disorder
The Role of Neuroactive Steroids in Stress, Alcohol Craving and Alcohol Use in Alcohol Use Disorders
To use pregnenolone (PREG; 300; 500mg) daily versus placebo (PLA) as a probe to assess the role of neuroactive steroids in individuals with alcohol use disorder (AUD).
- Trial name
- NCT03872128
- Testing
- Pregnenolone300, Pregnenolone500
- Where
- 2 sites in United States
- Volunteers
- 91 people
- Sponsor
- Yale University
Asthma
Leukotriene Receptor Antagonists or Steroids in Pre-School Asthma
Explorative comparison of montelukast with inhaled steroids (fluticasone) to estimate responder profiles, in terms of symptom scores, rescue medication, increase of FEV1, in correlation to presence of allergy, bronchial…
- Trial name
- LOS (NCT00543686)
- Testing
- Montelukast, Fluticasone
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Kidney Transplantation
Efficacy and Safety of AEB071 Versus Tacrolimus in Combination With Mycophenolate Acid Sodium, Basiliximab and Steroids in Preventing Acute Rejection After Kidney Transplantation
Efficacy and safety of AEB071 in combination with mycophenolate acid sodium, basiliximab and steroids in preventing acute rejection after kidney transplantation.
- Trial name
- NCT00492869
- Testing
- AEB071
- Where
- 41 sites in United States, Belgium and 5 more
- Volunteers
- 124 people
- Sponsor
- Novartis Pharmaceuticals
Immune Thrombocytopenic Purpura (ITP)
A Study to Assess the Ability of Eltrombopag to Induce Sustained Response Off Treatment in Subjects With ITP
The purpose of this trial was to assess the ability of eltrombopag to induce sustained treatment-free remission in immune thrombocytopenia purpura (ITP) subjects who relapsed or failed to respond to an initial treatment with…
- Trial name
- TAPER (NCT03524612)
- Testing
- eltrombopag
- Where
- 32 sites in United States, Austria and 13 more
- Volunteers
- 105 people
- Sponsor
- Novartis Pharmaceuticals
Systemic Lupus Erythematosus
Safety of Estrogens in Lupus: Hormone Replacement Therapy
Safety of Estrogens in Lupus Erythematosus - National Assessment (SELENA) is a study to test whether postmenopausal women with systemic lupus erythematosus (SLE, or lupus) can safely use the hormone estrogen.
- Trial name
- NCT00000419
- Testing
- Premarin and Provera
- Where
- 16 sites in United States
- Volunteers
- 350 people
- Sponsor
- NYU Langone Health
Pericarditis
Therapeutic Approach in Colchicine-resistant Recurrent pEricarditis in Children
The purpose of this study is to demonstrate that anakinra provides more rapid disease control than steroids in the first month of treatment in the event of recurrent pericarditis and is more effective in preventing further…
- Trial name
- CREATE (NCT05805930)
- Testing
- Anakinra, Prednisone
- Volunteers
- 48 people
- Sponsor
- Istituto Giannina Gaslini
Hypogonadism, Hypogonadism, Male
A Randomized, Double-blinded, Clinical, Placebo-controlled Trial on the Effects of Therapy With Letrozole and hUman Choriongonadotropin in Male Hypogonadism Induced by Illicit Use of Anabolic Androgenic Steroids- The LUCAS Trial
The overall objective of this randomized trial is to investigate the effects of treatment of AAS- induced male hypogonadism with combined therapy of letrozole and hCG compared with placebo on reproductive hormone levels…
- Conditions
- Hypogonadism, Hypogonadism, Male, Hypogonadotropic Hypogonadism
- Trial name
- NCT05205837
- Testing
- Letrozole 2.5mg, hCG
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Congenital Adrenal Hyperplasia
Congenital Adrenal Hyperplasia: Calcium Channels as Therapeutic Targets
This study will test the ability of extended release nifedipine (Procardia XL), a blood pressure medication, to permit a decrease in the dose of glucocorticoid medication children take to treat congenital adrenal hyperplasia…
- Trial name
- NCT00000102
- Testing
- Nifedipine
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Chronic Rhinosinusitis, Nasal Polyps
Adjunctive Treatment for Chronic Rhinosinusitis With Nasal Polyposis
This is a research study to find out if an off-label use of carboxymethylcellulose foam (CMC), an absorbable nasal packing, combined with triamcinolone acetonide, a steroid, is more comfortable postoperatively for participants…
- Trial name
- NCT03607175
- Testing
- Triamcinolone-impregnated CMC foam, Propel Stent
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Marina Boruk
Oral Lichen Planus
Dexamethasone to Treat Oral Lichen Planus
This study will evaluate the effectiveness of dexamethasone 0.01% solution in treating pain associated with oral lichen planus, a chronic disease that causes painful ulcers inside the mouth.
- Trial name
- NCT00111072
- Testing
- dexamethasone 0.01% solution
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Graft vs Host Disease
A Phase 1/2 Trial of Donor Regulatory T-cells for Steroid-Refractory Chronic Graft-versus-Host-Disease
Phase 1/2 clinical study for the treatment of steroid-refractory chronic graft versus host disease after an allogeneic transplant of hematopoietic progenitors with donor CliniMACS-selected regulatory T cells
- Trial name
- TREGeneration (NCT02385019)
- Testing
- Donor regulatory T cell adoptive immunotherapy in chronic graft versus host disease
- Where
- 3 sites in Portugal
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Instituto de Medicina Molecular João Lobo Antunes
Alcoholic Hepatitis
Fecal Microbiota Therapy in Steroid Ineligible Alcoholic Hepatitis
Alcoholic hepatitis, the most florid form of alcoholic liver disease, has a very high short-term mortality of up to 50% and no specific therapies are available other than steroids.
- Trial name
- NCT05285592
- Testing
- Fecal Transplantation, Standard Medical Treatment
- Where
- India
- Volunteers
- 84 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Post-operative Edema, Steroid Use
Prospective Evaluation of Perioperative Steroid Dosing on Postsurgical Edema in Orthognathic Surgery
The current standard of care at the Oral and Maxillofacial Department at the CDHA is the use of one gram of methylprednisolone administered intravenously prior to orthognathic surgery. This is largely based on the work of Habal.
- Trial name
- NCT03190642
- Testing
- Methylprednisolone
- Where
- Canada
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Jean Charles Doucet
Analgesia, Epidural
Correlation of Intravascular Injection Rate and Severity of Cervical Neural Foraminal Stenosis
This study evaluates whether there is a correlation between intravascular injection rate and severity of cervical foraminal stenosis during cervical transforaminal epidural steroid injection
- Trial name
- NCT04071483
- Testing
- Cervical transforaminal epidural steroid injection
- Where
- South Korea
- Volunteers
- 126 people
- Sponsor
- Kyungpook National University Hospital
Pulmonary Sarcoidosis
Randomized Controlled Trial of Hydroxychloroquine Combined With Low-dose Corticosteroid in Pulmonary Sarcoidosis
"The reference treatment for pulmonary sarcoidosis is prolonged systemic corticosteroid therapy, which improves dyspnea, fatigue and respiratory function.
- Trial name
- QUIDOSE (NCT05247554)
- Testing
- Hydroxychloroquine + low-dose prednisone, Prednisone
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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