Clinical trials: Steroid
Pre-diabetes, Impaired Fasting Glucose
Effect of Sitagliptin on Short-Term Metabolic Dysregulation of Oral Glucocorticoid Therapy
The investigators hypothesize that sitagliptin will significantly reduce impairments in insulin secretion and insulin resistance resulting from short-term oral glucocorticoid therapy.
- Conditions
- Pre-diabetes, Impaired Fasting Glucose, Impaired Glucose Tolerance
- Trial name
- NCT01488279
- Testing
- Dexamethasone 2.5 mg and Sitagliptin 100 mg
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Trigger Finger Disorder
Pain With Trigger Finger Injection: A Comparison of Steroid Alone Versus Steroid/Lidocaine Mixture
This research is being done to compare pain relief and efficacy of trigger finger injection using a combination of lidocaine/corticosteroid versus corticosteroid injection alone versus corticosteroid/saline combination.
- Trial name
- NCT02421419
- Testing
- Dexamethasone Sodium Phosphate, Xylocaine, Sodium Chloride
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Kenneth Taylor, M.D.
Transplant, Intraocular Pressure
Anecortave Acetate Injection to Treat Steroid-responsive Intraocular Pressure Increase in Cornea Transplant Patients
This study will investigate the use of anecortave acetate injection to reduce intraocular pressure (IOP) in corneal transplant recipients who are experiencing steroid-associated pressure control problems.
- Trial name
- NCT00884039
- Testing
- anecortave acetate, 30 mg anecortave acetate
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Cornea Research Foundation of America
Knee Osteoarthritis
Cingal Study for Knee Osteoarthritis
The purpose of this study is to see if a single injection of Cingal into the knee provides safe relief of pain caused by osteoarthritis.
- Trial name
- NCT01891396
- Testing
- Hyaluronic Acid and TH (Cingal®), Hyaluronic Acid (Monovisc®), Saline
- Where
- 27 sites in Bulgaria, Canada and 3 more
- Volunteers
- 368 people
- Sponsor
- Anika Therapeutics, Inc.
Sjogren's Syndrome
Assessment of Inflammatory Biomarkers Expressed in a Sjogren's Population: Effect of a Topical Steroid Intervention
The primary purpose of this study is to quantify the change in expression of biomarkers on the ocular surface of Sjogren's Syndrome participants after treatment with Maxidex.
- Trial name
- NCT00631358
- Testing
- Maxidex, No treatment
- Where
- 2 sites in Canada
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Psoriasis Vulgaris
A Plaque Test Comparing the Anti-psoriatic Effect of Marketed Products for Topical Use for Psoriasis Vulgaris
The purpose of the study is to compare the anti-psoriatic effect of marketed products with Daivobet® ointment in a plaque test
- Trial name
- NCT00845481
- Testing
- Daivobet® ointment, Betnovat® ointment, Diprosalic ointment
- Where
- France
- Volunteers
- 24 people
- Sponsor
- LEO Pharma
Graft-Versus-Host Disease (GVHD) Acute on Chronic
Alpha 1 Anti-Trypsin (AAT) in Treating Patients With Acute Graft-Versus-Host Disease GVHD)
This phase I/II trial evaluates the efficacy and adverse effects of alpha 1 anti-trypsin (AAT) for the treatment of acute graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation.
- Trial name
- NCT01523821
- Testing
- Alpha 1-Proteinase Inhibitor, Human 1 MG [Glassia]
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Fred Hutchinson Cancer Center
Congestive Heart Failure
Post Approval Registry of Corox OTW, Endocardial, Left Ventricular Steroid Lead, Bipolar
The objective of this study is to confirm the long-term safety and reliability of the Corox OTW BP left ventricular (LV) pacing lead.
- Trial name
- CELESTIAL (NCT00810264)
- Testing
- CRT Therapy - LV Lead Registry
- Where
- 86 sites in United States
- Volunteers
- 2,499 people
- Sponsor
- Biotronik, Inc.
Sinusitis
Rates of Middle Meatus Synechiae Formation Post Endoscopic Sinus Surgery
Endoscopic sinus surgery (ESS) is the gold standard surgical intervention for chronic rhinosinusitis that is not adequately controlled with maximal medical therapy.
- Trial name
- NCT02627794
- Testing
- Restora™ Steroid eluting spacer, Silastic Silicone Spacer
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Cedars-Sinai Medical Center
Multiple Sclerosis
Study to Evaluate Intravenous and Oral Steroids for Multiple Sclerosis Attacks
This clinical trial compares the relative efficacy of treating acute exacerbations of relapsing forms of Multiple Sclerosis with equivalent doses of oral and intravenous (IV) methylprednisolone.
- Trial name
- NCT00418145
- Testing
- megadose oral methylprednisolone, IV methylprednisolone
- Where
- 10 sites in United States
- Volunteers
- 16 people
- Sponsor
- Fred Lublin
Kidney Diseases, Kidney Transplantation
Steroid-Free Versus Steroid-Based Immunosuppression in Pediatric Renal (Kidney) Transplantation
Over the last 40 years, corticosteroids (steroids) have been an important part of drug regimens used to prevent organ rejection and to maintain the immune health of individuals who have received organ transplants.
- Conditions
- Kidney Diseases, Kidney Transplantation, Kidney Transplant, Renal Transplantation
- Trial name
- NCT00141037
- Testing
- Daclizumab, Mycophenolate mofetil (MMF), Prednisone
- Where
- 12 sites in United States
- Volunteers
- 130 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Thrombotic Thrombocytopenic Purpura
Safety Study of Danazol With Plasma Exchange and Steroids for the Treatment of Thrombotic Thrombocytopenic Purpura (TTP)
The purpose of the study is to find out if administration of danazol with plasma exchange and corticosteroids will reduce the number of plasma exchanges required to control Thrombotic Thrombocytopenic Purpura (TTP).
- Trial name
- TTP (NCT00953771)
- Testing
- Danazol
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Ovarian Granulosa Cell Tumor, Ovarian Gynandroblastoma
Paclitaxel and Carboplatin or Bleomycin Sulfate, Etoposide Phosphate, and Cisplatin in Treating Patients With Advanced or Recurrent Sex Cord-Ovarian Stromal Tumors
This randomized phase II trial studies paclitaxel and carboplatin to see how well they work compared with bleomycin sulfate, etoposide phosphate, and cisplatin in treating patients with sex cord-ovarian stromal tumors that have…
- Conditions
- Ovarian Granulosa Cell Tumor, Ovarian Gynandroblastoma, Ovarian Sertoli-Leydig Cell Tumor, Ovarian Sex Cord Tumor With Annular Tubules
- Trial name
- NCT01042522
- Testing
- Bleomycin Sulfate, Carboplatin, Cisplatin
- Where
- 219 sites in United States
- Volunteers
- 63 people
- Sponsor
- GOG Foundation
Asthma
BI 671800 ED in Steroid-naive Asthmatic Patients
This is a 6 week study to investigate the effectiveness and safety of BI 671800 ED in patients with asthma who do not take inhaled corticosteroids.
- Trial name
- NCT01092143
- Testing
- BI 671800, Fluticasone propionate
- Where
- 92 sites in United States, Australia and 8 more
- Volunteers
- 389 people
- Sponsor
- Boehringer Ingelheim
Chronic Sinusitis
Safety and Efficacy of the Propel Mini and Propel Nova Steroid-Eluting Sinus Implant in Frontal Sinus
The objective of the PROGRESS Study is to assess the safety and efficacy of the Propel Mini and Propel Nova steroid-eluting Sinus Implants when placed in the frontal sinus opening following frontal sinus surgery in patients with…
- Trial name
- PROGRESS (NCT02266810)
- Testing
- PROPEL Mini Sinus Implant., Sinus Surgery alone, Propel Nova Sinus Implant
- Where
- 10 sites in United States
- Volunteers
- 160 people
- Sponsor
- Intersect ENT
TMJ, Osteoarthritis
Efficacy of PRGF Supplementation After TMJ Arthrocentesis in Patients With TMJ Osteoarthritis
Temporomandibular joint (TMJ) osteoarthritis (OA) affects articulating tissues secondary to inflammation resulting in intracapsular pain.
- Trial name
- NCT04731233
- Testing
- Plasma Rich in Growth Factor (PRGF) Supplementation, Triamcinolone Acetonide
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Florida
Pain, Postoperative
Opioid & Steroid Use Following Tonsillectomy in Pediatric Patients
The purpose of this study is to determine if a post-operative course of oral dexamethasone affects opioid usage in pediatric patients undergoing tonsillectomy.
- Trial name
- NCT04541147
- Testing
- Dexamethasone, Analgesics
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Duke University
Apparent Mineralocorticoid Excess (AME)
The Role of Mineralocorticoid Receptors in Vascular Function
The purpose of this study is to figure out how decreasing the activity of 11-beta hydroxysteroid dehydrogenase (11-beta HSD) will affect your blood vessel function.
- Trial name
- NCT00759525
- Testing
- Glycyrrhetic Acid
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Liver Cirrhosis, Liver Transplant Disorder
Steroid Free Immunosuppression in Liver Transplantation
The purpose of this study is to determine whether steroid-related complications can be avoided by using steroid-free immuno-suppressive drug regimen after liver transplantation.
- Trial name
- NCT00296244
- Testing
- Steroids, Basiliximab, Tacrolimus
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Thomas Jefferson University
Glenohumeral Osteoarthritis
Osteoarthritis Shoulder Injection Study
The purpose of this study is to determine the most effective intraarticular steroid dose for the treatment of glenohumeral osteoarthritis.
- Trial name
- NCT03586687
- Testing
- Triamcinolone
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Milton S. Hershey Medical Center