Clinical trials: Steroid
Osteoarthritis
Intraarticular Platelet-rich Plasma Injections Versus Corticosteroid Injections in Primary Knee Osteoarthritis
Aim: To study and compare the clinical effects of platelet-rich plasma (PRP) injections and intra-articular (IA) corticosteroid injections in patients with primary osteoarthritis (OA) of the knee.
- Trial name
- NCT01923909
- Testing
- Intra-articular platelet-rich plasma, Intra-articular corticosteroid injections
- Where
- Bahrain
- Sponsor
- King Hamad University Hospital, Bahrain
Nasal Obstruction, Chronic Rhinitis
Steroid Treatment for Elimination of Rebound Obstruction From Intranasal Decongestants
This prospective, virtually administered trial conducted throughout the United States aims to evaluate a standardized protocol including the serial dilution of topical decongestants with concurrent topical steroids…
- Trial name
- STEROID (NCT07168148)
- Testing
- Oxymetazoline + Triamcinolone
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Washington University School of Medicine
Disc Disease
Outcome After Lumbar Epidural Steroid Injection
prospectively validate a fibronectin-aggrecan complex as a biomarker for response to ESI for radiculopathy with HNP
- Trial name
- NCT01079026
- Volunteers
- 26 people
- Sponsor
- Scuderi, Gaetano J., M.D.
Asthma
Inflammation Following Mepolizumab and Oral Corticosteroids in Asthma
The aim of the project is to study the persistence of inflammation after addition of an interleukin-5 (IL-5) blocker in severe eosinophilic asthma as a study of untreated pathways in these patients.
- Trial name
- MAPLE (NCT03610685)
- Testing
- Prednisolone
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Primary Myelofibrosis (PMF), Post Polycythemia Myelofibrosis (PPV MF)
Managed Access Programs for INC424, Ruxolitinib
The purpose of this registration is to list Managed Access Programs (MAPs) related to INC424, Ruxolitinib
- Conditions
- Primary Myelofibrosis (PMF), Post Polycythemia Myelofibrosis (PPV MF), Thrombocythemia Myelofibrosis (PET-MF), Severe/Very Severe COVID-19 Illness
- Trial name
- NCT04745637
- Testing
- Ruxolitinib
- Sponsor
- Novartis Pharmaceuticals
Graft vs Host Disease
Thymoglobulin (ATG) Dose Finding Study
Primary Objective: To determine the response and toxicity rate at day 56 of two different dose levels of thymoglobulin (ATG) [anti-thymocyte globulin (rabbit)] as a treatment of steroid-refractory acute graft versus host disease…
- Trial name
- NCT00409695
- Testing
- Low Dose Thymoglobulin (ATG), High Dose Thymoglobulin (ATG)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- M.D. Anderson Cancer Center
Lumbar Disc Herniation
Impact of Transforaminal Epidural Steroid Injection in Lumbar Disc Prolpse on Micro RNA-155 Serum Level
Chronic pain could be considered a brain disease as it can affect multiple aspects of brain function, chemistry, neural networks and structure. Pain is associated with impaired cognitive function (1).
- Trial name
- NCT05626283
- Testing
- transforaminal epidural injection., micro RNA-155 serum level
- Where
- Egypt
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Ulcerative Colitis
An Observational Follow-up Study for Subjects Receiving Salvage Therapy After Previous Treatment in a Visilizumab Study for Intravenous Steroid-Refractory Ulcerative Colitis
To assess the effects of visilizumab on the safety of subsequent salvage therapies in subjects who experienced disease progression in a previous visilizumab study and subsequently received salvage therapy.
- Trial name
- NCT00355901
- Testing
- Visilizumab (Nuvion®; HuM291)
- Where
- 40 sites in United States, Australia and 12 more
- Volunteers
- 300 people
- Sponsor
- PDL BioPharma, Inc.
Skin Diseases
Observational Study to Assess Safety and Utility Pattern of Topical Steroids
To assess incidence of adverse drug reactions and use pattern of topical steroids among patients who are prescribed or purchase over the counter (OTC) topical steroids for skin conditions in Korea
- Trial name
- NCT02377557
- Testing
- Topical Steroids
- Where
- South Korea
- Volunteers
- 1,175 people
- Sponsor
- Hanyang University
Pulmonary Disease, Chronic Obstructive, Pneumonia, Bacterial
Modulation of Steroid Immunosuppression by Alveolar Efferocytosis
The long-term goals of this study are (a) to understand the biological underpinnings for the increased incidence of community-acquired pneumonia in patients with chronic obstructive pulmonary disease (COPD) who are treated with…
- Trial name
- NCT03034642
- Testing
- Bronchoscopy with bilateral bronchoalveolar lavages
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- VA Ann Arbor Healthcare System
Malignant Glioma
High Dose Camptothecin-11 (CPT-11) in Recurrent Unresectable Malignant Glioma
The purpose of this study is to compare the response to treatment and side effects associated with high dose irinotecan in patients with recurrent brain tumors.
- Trial name
- NCT00283556
- Testing
- Irinotecan (Camptosar, CPT-11)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kentuckiana Cancer Institute
Smith-Lemli-Opitz Syndrome
SLOS: The Effect of Simvastatin in Patients Receiving Cholesterol Supplementation
The purpose of this study is to determine if simvastatin improves development and behavior in patients with Smith Lemli-Opitz syndrome (SLOS) receiving dietary cholesterol supplementation.
- Trial name
- NCT01434745
- Testing
- Simvastatin, Lactose
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Oregon Health and Science University
Chronic Postoperative Pain, Chest Pain
The Effectiveness of Thoracal Epidural Steroid and Local Anesthetic Injection
The primary objective was to evaluate the effectiveness of thoracic interlaminar epidural injections in alleviating pain and enhancing function in patients suffering from chronic mid and/or upper back pain.
- Conditions
- Chronic Postoperative Pain, Chest Pain, Back Pain
- Trial name
- NCT06507995
- Testing
- thoracic interlaminar epidural injection
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ankara University
Surgical Wound Infection, Surgery, Colon
The Effects of Hypercapnia, Supplemental Oxygen, and Dexamethasone on Surgical Wound Infection
The investigators will test the hypotheses that mild hypercapnia and supplemental oxygen reduce wound infection risk in patients undergoing colon resection.
- Trial name
- NCT00273377
- Testing
- Mild intraoperative hypercapnia (50 mmHg vs. 30 mmHg), Supplemental oxygen (80% vs. 30%), Dexamethasone
- Where
- 4 sites in United States, Austria and 1 more
- Volunteers
- 2,000 people
- Sponsor
- The Cleveland Clinic
Rheumatic Diseases, Rheumatic Disorder
Exploring and Measuring the Impact of Steroids in Children and Young People
Assessing the impact of glucocorticoids in children and young people with rheumatic conditions, to develop a patient reported outcome measure (PROM).
- Conditions
- Rheumatic Diseases, Rheumatic Disorder, Rheumatologic Conditions (JRA,Lupus)
- Trial name
- NCT07350395
- Where
- 3 sites in United Kingdom
- Volunteers
- 70 people
- Sponsor
- University of the West of England
Fractures, Bone, Fractures, Closed
Distal Radius Steroid
The primary goal of this study is to compare functional outcomes (range of motion [flexion, extension, supination, pronation], return to work, of patients with distal radius fractures who receive intraoperative glucocorticoids to…
- Conditions
- Fractures, Bone, Fractures, Closed, Radius Fracture Distal
- Trial name
- NCT05655130
- Testing
- Dexamethasone, Methylprednisolone, Standard of Care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Indiana Hand to Shoulder Center
Morton Neuroma
Morton's Neuroma: Manipulation Versus Steroid Injection
This study compares manipulative therapy to steroid injection in the treatment of Morton's Neuroma.
- Trial name
- NCT05707572
- Testing
- methylprednisolone, manual manipulation
- Where
- United Kingdom
- Volunteers
- 62 people
- Sponsor
- Dundee Podiatry Clinic
Cardiovascular Diseases, Heart Diseases
Sex Steroid Hormones and Risk of CHD in Women
To investigate the relationship between endogenous estrogen and androgen levels and risk of coronary heart disease among postmenopausal women in the Women's Health Initiative-Observational Study (WHI-OS).
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Postmenopause
- Trial name
- NCT00006407
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Eustachian Tube Dysfunction, Endolymphatic Hydrops
Refractory Eustachian Tube Dysfunction: Are the Symptoms Related to Endolymphatic Hydrops
The purpose of this study is to evaluate the benefit of treatment of refractory Eustachian tube dysfunction with standard treatment for endolymphatic hydrops.
- Trial name
- NCT01661777
- Testing
- Nasal steroid, Myringotomy tube placement, Diuretic
- Where
- United States
- Sponsor
- Vanderbilt University
Acquired Hemophilia A
Trial of Acquired Haemophilia With Steroid Combined With Cyclophosphamide Versus Steroid Combined With Rituximab
Purpose: To evaluate the efficacy when administering steroid combined with single dose rituximab to eliminate the antibody in acquired hemophilia A patients compared to treatment using steroid with cyclophosphamide.
- Trial name
- NCT03384277
- Testing
- Steroid, Rituximab, Cyclophosphamide
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
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