Clinical trials: Stimulant Use
PrEP Uptake, Stimulant Abuse
Pepped on Pre-exposure Prophylaxis (PrEP): A Counseling and Problem-Solving PrEP Adherence Intervention for Stimulant Using Men Who Have Sex With Men (MSM).
Pepped on PrEP is an innovative pilot RCT designed by an interdisciplinary team to develop a counseling and problem-solving PrEP adherence intervention with a Behavioral Activation (BA) approach that aims to re-engage…
- Conditions
- PrEP Uptake, Stimulant Abuse, Adherence, Medication
- Trial name
- NCT03137342
- Testing
- Pepped on PrEP Package
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Brown University
Stimulant Use & Co-occuring Opioid Use Disorders
Stimulant Oxytocin Study
This study will investigate the effects of intranasal administration of oxytocin, a social neuropeptide, on reducing stimulant use, enhancing therapeutic engagement, and susceptibility to stress-induced relapse in Veterans with…
- Trial name
- SOS (NCT03016598)
- Testing
- Intranasal oxytocin
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- VA Office of Research and Development
Substance Related Disorders
Testing Implementation Strategies to Scale-up a Multicomponent Continuum of Service Intervention for Families Involved in Systems With Parental Opioid and Methamphetamine Use
This study will explore how to expand the Just Care for Families (JCFF) program beyond its current sites in Oregon, while addressing two main challenges: the developer team cannot provide ongoing support to every new program, and…
- Trial name
- NCT07365293
- Testing
- Just Care for Families (JCFF), Just Care for Families (JCFF) App, Just Care for Families (JCFF) App Feedback
- Where
- United States
- Volunteers
- 254 people
- Sponsor
- Chestnut Health Systems
Amphetamine Use Disorders
Individualized Neuromodulation for the Core Clinical Features of Drug Addiction
Using specific EEG biomarkers in methamphetamine-dependent individuals, this study systematically probes closed-loop tACS based on brain states, assessing dosage, neurologic and behavioral effects, while comparing its efficacy…
- Trial name
- NCT06165198
- Testing
- Closed-loop tACS stimulation based on addiction-induced states
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Shanghai Mental Health Center
Methamphetamine Abuse
Field Study of a Digital Therapeutic Platform to Facilitate Treatment for Methamphetamine-Primary Stimulant Use Disorder
The overall purpose of the observational, investigational pilot study is to assess the clinical utility of the Affect digital health platform (the Affect® "app") as part of the Affect program of treatment for…
- Trial name
- NCT05266716
- Testing
- Affect Methamphetamine Treatment Program
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Affect Therapeutics, Inc.
Parkinson's Disease
Caffeine for Motor Manifestations of Parkinson's Disease
Numerous epidemiological studies have linked lifelong use of caffeine to a lower risk of Parkinson's disease (PD) - prospective studies have estimated that non-coffee drinkers have an approximately 1.7-2.5 fold increased risk of…
- Trial name
- NCT01190735
- Testing
- Caffeine alkaloid
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- Ron Postuma
Accidental Overdose of Opiate
Remote Intervention to Prevent Overdose
This Type 1 hybrid effectiveness-implementation randomized controlled trial, A Remote Intervention to Prevent Overdose among People who Use Stimulants and/or Opioids, aims to address the United States opioid crisis driven by…
- Trial name
- NCT07128485
- Testing
- Overdose prevention resources, Overdose prevention education
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Alabama at Birmingham
Cocaine Dependence
Efficacy of Caffeine, With and Without Biperiden, as a Maintenance Treatment for Cocaine Dependence
The aim of this study is to assess the efficacy of caffeine compared to placebo as a maintenance treatment for cocaine dependence. Caffeine potentiation with biperiden will be also studied.
- Trial name
- NCT00495183
- Testing
- caffeine, Biperiden
- Where
- Spain
- Volunteers
- 108 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Methamphetamine Use Disorder
Behavioral Effects of Drugs (Inpatient): 40 [Methamphetamine, Methylphenidate, Duloxetine]
This study will evaluate the behavioral effects of methamphetamine during maintenance on placebo, duloxetine, methylphenidate and duloxetine combined with methylphenidate using sophisticated human laboratory methods.
- Trial name
- NCT04178993
- Testing
- Methamphetamine, Methylphenidate, Duloxetine
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Craig Rush
Stimulants Use Disorder
Add-on Low Dose Dextromethorphan and Memantine in Patients With Amphetamine-type Stimulants Use Disorder
The current study will investigate whether add-on dextromethorphan (DM) and memantine (MM) is able to improve the treatment outcomes for ATSUD, and be associated with improvement in inflammatory markers, neurotrophic factors and…
- Trial name
- NCT03729128
- Testing
- dextromethorphan and memantine (DM+MM)
- Where
- Taiwan
- Volunteers
- 85 people
- Sponsor
- Tzu-Yun Wang
Obesity, Methamphetamine Use Disorder
An Open-Label Tirzepatide Trial for Comorbid Obesity and Stimulant Use Disorder
This open label pilot study will assess the feasibility and preliminary efficacy of tirzepatide which will be prescribed under its FDA approved weight management indication in adults with moderate or severe methamphetamine…
- Conditions
- Obesity, Methamphetamine Use Disorder, Cocaine Use Disorder, Stimulant Use Disorders
- Trial name
- TRI-MR (NCT07693608)
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Texas Southwestern Medical Center
Methamphetamine Use, Heart Failure
Rural Community Peer Partnerships for Improving Methamphetamine-Associated Heart Failure Screening and Engagement
The goal of PEER-Heart is to implement and assess feasibility and preliminary effectiveness of a community peer-facilitated screening for methamphetamine-associated heart failure (MAHF) and linkage to evidence-based cardiology…
- Trial name
- PEER-Heart (NCT06461962)
- Testing
- Treatment as Usual, Telehealth-Cardiology
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Oregon Health and Science University
Substance Use Disorders
CDP-choline Treatment in ATS Users
This study is a 12-week, randomized, double-blind, placebo-controlled trial of cytidine-5'-diphosphate choline in amphetamine-type stimulants-using adolescents.
- Trial name
- NCT02630069
- Testing
- CDP-choline, Supportive psychotherapy
- Where
- South Korea
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Ewha Womans University Mokdong Hospital