Clinical trials: Stimulant Use (Diagnosis)
Methamphetamine Use, Heart Failure
Rural Community Peer Partnerships for Improving Methamphetamine-Associated Heart Failure Screening and Engagement
The goal of PEER-Heart is to implement and assess feasibility and preliminary effectiveness of a community peer-facilitated screening for methamphetamine-associated heart failure (MAHF) and linkage to evidence-based cardiology…
- Trial name
- PEER-Heart (NCT06461962)
- Testing
- Treatment as Usual, Telehealth-Cardiology
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Oregon Health and Science University
HIV (Human Immunodeficiency Virus)
Stimulant and Polysubstance Use, Inflammation, and Sex Effects on Myocardial Disease in HIV
This observational research study is studying how substance use impacts scarring and inflammation of the heart. This study involves one study visit for a cardiac MRI.
- Trial name
- SPISE (NCT07461350)
- Where
- 4 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of California, San Francisco
Methamphetamine Use Disorder, Human Immunodeficiency Virus (HIV)
Psilocybin Therapy for Methamphetamine Use Disorder and HIV
The goal of this clinical trial is to learn whether it is possible to use psilocybin in combination with motivational support therapy to treat moderate-to-severe methamphetamine use disorder (MeUD) in people with HIV who are…
- Trial name
- PRISM (NCT07756736)
- Testing
- Psilocybin 5 mg, Psilocybin 25 mg, Motivational Support
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Nicky Mehtani, MD, MPH
Stimulant Use, Contingency Management
Contingency Management for Stimulant Use Disorders
The invetigators' objective is to implement Medication Assisted Treatment (MAT) and contingency management in patients affected by co-occurring opioid use disorder and stimulant use disorder.
- Trial name
- NCT05097547
- Testing
- Contingency Management
- Volunteers
- 30 people
- Sponsor
- University of Virginia
Opioid Use Disorder, Stimulant Use Disorder
Suvorexant for Opioid/Stimulant Co-use
This study will evaluate whether Suvorexant 20mg reduces drug use and craving, and improves sleep and stress among persons with co-occurring opioid use disorder and stimulant use disorder.
- Trial name
- NCT05546515
- Testing
- Suvorexant (dual orexin receptor antagonist)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Substance Use Disorders
CDP-choline Treatment in ATS Users
This study is a 12-week, randomized, double-blind, placebo-controlled trial of cytidine-5'-diphosphate choline in amphetamine-type stimulants-using adolescents.
- Trial name
- NCT02630069
- Testing
- CDP-choline, Supportive psychotherapy
- Where
- South Korea
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Ewha Womans University Mokdong Hospital
Cocaine Dependence, Substance Use Disorders
Transcranial Magnetic Stimulation for Cocaine Addiction
Background: Cocaine use disorders (CUD) is a complex brain disorder, involving several brain areas and neurocircuits. Effective treatments for CUD are still needed.
- Conditions
- Cocaine Dependence, Substance Use Disorders, Chemical Addiction, Mental Disorder
- Trial name
- BRAINSWITCH (NCT03333460)
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- ITAB - Institute for Advanced Biomedical Technologies
Cocaine Addiction
Vigabatrin Ph 1 Cocaine Interaction Study
This is a Phase 1 safety/tolerably study to determine if there are clinically significant interactions between oral vigabatrin (gamma vinyl-gamma-amino butyric acid; VGB) concurrent with intravenous (IV) cocaine infusions.
- Trial name
- NCT00626834
- Testing
- Vigabatrin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance Use Disorders, Alcohol Use Disorder
A Randomized Controlled Trial of Digital CBT to Treat Addiction: Digital RITch®CBT vs. Standard CBT
Substance Use Disorders continue to increase across the United States with significant adverse effects resulting in more than $700 billion annually (NIDA, 2017) with high co-occurring rates of IPV.
- Conditions
- Substance Use Disorders, Alcohol Use Disorder, Stimulant-Related Disorder
- Trial name
- NCT05943171
- Testing
- Cognitive Behavioral Therapy, Standard CBT
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Attention Deficit Disorder With Hyperactivity, Amphetamine-Related Disorders
Safety, Tolerability and Abuse Liability Study of Intravenous NRP104 in Adults With Stimulant Abuse Histories
This research is being done to evaluate if NRP 104 is a safe drug. The other purpose is to learn if NRP104, when injected into a vein, produces a high and any other effects like amphetamine and other stimulant drugs that are…
- Conditions
- Attention Deficit Disorder With Hyperactivity, Amphetamine-Related Disorders, Substance-Related Disorders
- Trial name
- NCT00247572
- Testing
- NRP104
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- New River Pharmaceuticals
Attention Deficit Disorder With Hyperactivity, Amphetamine-Related Disorders
Study to Evaluate the Likeability, Safety, and Abuse Potential of NRP 104 in Adults With Histories of Stimulant Abuse
This research is being done to evaluate if NRP104 is a safe drug. The other purpose is to learn if NRP104 produces a high and any other effects like amphetamine and other stimulant drugs that are abused.
- Conditions
- Attention Deficit Disorder With Hyperactivity, Amphetamine-Related Disorders, Substance-Related Disorders
- Trial name
- NCT00248092
- Testing
- NRP104
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- New River Pharmaceuticals
Stimulant Use (Diagnosis)
Implementing Contingency Management for Stimulant Use in Specialty Addiction Treatment Organizations
Stimulants constitute a new and deadly fourth wave of the opioid epidemic. Contingency management is the most effective intervention for stimulant use and is an evidence-based adjunct to medication for opioid use disorder.
- Trial name
- MIMIC2 (NCT05702021)
- Testing
- Science to Service Laboratory
- Where
- 9 sites in United States
- Volunteers
- 76 people
- Sponsor
- Northwestern University
Drug Use Disorders, PrEP Uptake
Reducing Co-occurring Substance Use and HIV Risk Among Stimulant-using Men at High Risk for HIV in the United States of America.
This intervention will focus on stimulant-using men at high risk for HIV who are in need of tailored behavioral interventions to mitigate co-occurring stimulant use and HIV risk in the era of pre-exposure prophylaxis (PrEP).
- Conditions
- Drug Use Disorders, PrEP Uptake, PrEP Adherence, HIV Risk Behavior
- Trial name
- NCT07281378
- Testing
- Tailored Positive Affect Intervention, Contingency Management
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Florida
Stimulant Dependence, Methamphetamine-dependence
Pilot TMS for Methamphetamine Use Disorder
This is a pilot study to test the feasibility of a recruitment strategy and study protocol to examine the effects of a dual target transcranial magnetic stimulation treatment in methamphetamine use disorder.
- Conditions
- Stimulant Dependence, Methamphetamine-dependence, Addiction, Drug
- Trial name
- NCT04449055
- Testing
- Transcranial Magnetic Stimulation--DPFC first, MPFC second, Transcranial Magnetic Stimulation--MPFC first, DPFC second
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Ryan M. Carnahan
Opioid Use Disorder, Injection Related Infections
Continuum of Care in Hospitalized Patients With Opioid/Stimulant Use Disorder and Infectious Complications From Drug Use
This is a two-group randomized controlled trial conducted at five hospitals across the U.S. designed to test the effectiveness of an Integrated infectious diseases/Substance Use Disorder outpatient clinic (IC) compared to…
- Conditions
- Opioid Use Disorder, Injection Related Infections, Stimulant Use Disorder
- Trial name
- CHOICE-STAR (NCT06513156)
- Testing
- Integrated Infectious Diseases and Substance Use Disorder Clinic (IC)
- Where
- 4 sites in United States
- Volunteers
- 304 people
- Sponsor
- Elana Rosenthal
Methamphetamine Abuse, Substance Use Disorders
rTMS for Craving in Methamphetamine Use Disorder
The primary aim of this project is to use a randomized single-blind sham-controlled study to investigate if high frequency repetitive transmagnetic stimulation (HF-rTMS) can modulate cue-induced craving in adult methamphetamine…
- Conditions
- Methamphetamine Abuse, Substance Use Disorders, Stimulant Dependence, Methamphetamine-dependence
- Trial name
- NCT03470480
- Testing
- Real Repetitive transcranial magnetic stimulation, Methamphetamine visual cues, Neutral visual cues
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Oregon Health and Science University
Prescription Drug Abuse (Not Dependent)
Examining Expectancy Challenges to Prevent Nonmedical Prescription Stimulant Use
Nonmedical prescription stimulant use (NPS) is commonly reported among college students for cognitive enhancement purposes, though it is associated with numerous negative psychological and physical consequences.
- Trial name
- NCT03648684
- Testing
- Caffeine-Based Expectancy Challenge
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- University of Wyoming
Obesity, Methamphetamine Use Disorder
An Open-Label Tirzepatide Trial for Comorbid Obesity and Stimulant Use Disorder
This open label pilot study will assess the feasibility and preliminary efficacy of tirzepatide which will be prescribed under its FDA approved weight management indication in adults with moderate or severe methamphetamine…
- Conditions
- Obesity, Methamphetamine Use Disorder, Cocaine Use Disorder, Stimulant Use Disorders
- Trial name
- TRI-MR (NCT07693608)
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Texas Southwestern Medical Center
Drug Abuse
Stimulant Abuser Groups to Engage in 12-Step
The purpose of this study is to determine whether a combined group and individual 12-Step facilitative (TSF) intervention, Stimulant Abuser Groups to Engage in 12 -Step (STAGE-12), improves substance -related outcomes.
- Trial name
- STAGE-12 (NCT00573183)
- Testing
- STAGE-12, Treatment as Usual
- Where
- 10 sites in United States
- Volunteers
- 471 people
- Sponsor
- University of Washington
Stimulant Use Disorder
PEX010-Assisted Therapy for Stimulant Use Disorder: A Safety, Feasibility and Efficacy Study
The goal of this clinical trial is to learn if PEX010 is effective for the treatment of Stimulant Use Disorder in adults. The study will also assess the safety and feasibility of administering PEX010 to this population.
- Trial name
- PATSUD (NCT06666010)
- Testing
- PEX010-Assisted Therapy, PEX010(01)
- Volunteers
- 86 people
- Sponsor
- Filament Health Corp.