Clinical trials: Stomach Diseases
Stomach Neoplasms
Premedication With Simethicone or Simethicone Plus N-acetylcysteine in Improving Visibility During Upper Endoscopy
The purpose of this study is to determine whether premedication with Simethicone or Simethicone plus N-acetylcysteine are effective improving visibility during Upper endoscopy compared with use of water or no preparation.
- Trial name
- PRUE (NCT01653171)
- Testing
- Simethicone, N-acetylcysteine 500 mg, N-acetylcysteine 1000 mg
- Where
- Chile
- Volunteers
- 230 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Gastroesophageal Varices, Liver Cirrhosis
Gastric Variceal Ligation Versus Gastric Variceal Obturation for Secondary Prophylaxis of Gastric Varices
The investigators establish a randomized controlled clinical trial, comparing the efficacy and prognosis of GVL and GVO in secondary prevention of GVs, especially in patients with portosystemic shunting, and exploring the…
- Trial name
- NCT03729921
- Testing
- gastric variceal ligation, gastric variceal obturation
- Volunteers
- 166 people
- Sponsor
- Shanghai Zhongshan Hospital
Gastric Cancer Stage, Gastric Cancer Patients Undergoing Gastrectomy
AI-Assisted Detection and Staging of Gastric Cancer Using Contrast-Enhanced CT
Accurate preoperative assessment of gastric cancer stage guides eligibility for endoscopic resection, extent of gastrectomy and lymphadenectomy, selection for neoadjuvant therapy, and use of staging laparoscopy.
- Trial name
- NCT07250347
- Testing
- CT scan
- Where
- China
- Volunteers
- 8,000 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Type 2 Diabetes, Morbid Obesity
Type 2 Diabetes After Sleeve Gastrectomy and Roux-en-Y Gastric Bypass: A Randomised Single Centre Study
Glycaemia, insulin secretion and action in morbidly obes subjects with type 2 diabetes after sleeve gastrectomy ond Roux-en-Y gastric bypass: A randomised single centre study.
- Trial name
- OSEBERG (NCT01778738)
- Testing
- Bariatric surgery, either gastric bypass surgery or sleeve gastrectomy, Sleeve gastrecomy, Bastric bypass
- Where
- Norway
- Volunteers
- 125 people
- Sponsor
- Sykehuset i Vestfold HF
Lung Cancer, Solid Tumor
Open-Label, Dose-Escalation Study of Pemigatinib in Subjects With Advanced Malignancies - (FIGHT-101)
The purpose of this study will be to evaluate the safety, tolerability, and pharmacological activity of pemigatinib in subjects with advanced malignancies.
- Conditions
- Lung Cancer, Solid Tumor, Gastric Cancer, Urothelial Cancer
- Trial name
- NCT02393248
- Testing
- Pemigatinib, Gemcitabine, Pembrolizumab
- Where
- 20 sites in United States, Denmark
- Volunteers
- 201 people
- Sponsor
- Incyte Corporation
Vomit Aspiration, Anxiety
Preoperative Oral Carbohydrate on Gastric Emptying
The current preoperative fasting guidelines recommend, applying preoperative carbohydrate solution 2 hours before the operation to minimize prolonged fasting time potential negative effects and improve patient comfort.
- Trial name
- NCT06289543
- Testing
- Preoperative carbohydrate solution
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Biomarkers
Chilean Gastric Cancer Task Force (FORCE 1)
Background. Gastric cancer (GC) is the world's second leading cause of neoplastic mortality. Genetic alterations, response to treatments and mortality rates are highly heterogeneous across different regions.
- Trial name
- FORCE-1 (NCT03158571)
- Where
- Chile
- Volunteers
- 116 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Gastric Cancer (Diagnosis)
Screening and Validation of Serum Protein Biomarkers for Early Diagnosis of Gastric Cancer
This study focuses on the discovery of protein biomarkers for the early diagnosis of gastric cancer and the development of corresponding detection methods.
- Trial name
- NCT07096752
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Oncology Epidemiology, Risk Factors
Prevalence of H. Pylori in Stomach Cancers in the West Indies
The incidence and mortality of stomach cancer are higher in the French West Indies than in mainland France. The prevalence of H. pylori infection associated with this cancer remains unknown in these populations.
- Trial name
- PyloCaGe (NCT07233447)
- Where
- 2 sites in Guadeloupe
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Adenocarcinoma of the Gastroesophageal Junction, Esophageal Cancer
Symptom Control With or Without Docetaxel in Treating Patients With Relapsed Esophageal Cancer or Stomach Cancer
RATIONALE: Analgesics, antiemetics, steroids, and radiation therapy are effective in helping to control symptoms caused by cancer.
- Conditions
- Adenocarcinoma of the Gastroesophageal Junction, Esophageal Cancer, Gastric Cancer, Nausea and Vomiting
- Trial name
- NCT00978549
- Testing
- docetaxel, steroid therapy, questionnaire administration
- Where
- 8 sites in United Kingdom
- Volunteers
- 320 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Early Gastric Cancer
Pure Single Incision Laparoscopic Distal Gastrectomy (SIDG) Versus Totally Laparoscopic Distal Gastrectomy (TLDG)
1. Compare the immune response and postoperative complications between pure SIDG (single-incision laparoscopic distal gastrectomy) and TLDG (totally laparoscopic distal gastrectomy) for early gastric cancer (EGC) 2.
- Trial name
- NCT01938326
- Testing
- Approach Method
- Where
- South Korea
- Volunteers
- 86 people
- Sponsor
- Seoul National University Bundang Hospital
Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
Pathological Response to Perioperative FLOT in Gastric Adenocarcinoma
Perioperative chemotherapy with the FLOT regimen (5-fluorouracil, leucovorin, oxaliplatin and docetaxel) is a standard treatment for resectable gastric and gastroesophageal junction adenocarcinoma.
- Conditions
- Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Stomach Neoplasms
- Trial name
- NCT07859254
- Testing
- FLOT Chemotherapy
- Where
- Colombia
- Volunteers
- 90 people
- Sponsor
- Fundación Santa Fe de Bogota
Solid Tumor, Colorectal Cancer
Phase 1a/1b Study of TPST-1495 as a Single Agent and in Combination With Pembrolizumab in Subjects With Solid Tumors
This is a first-in-human Phase 1a/1b, multicenter, open-label, dose-escalation, dose and schedule optimization, and expansion study of TPST-1495 as a single agent and in combination with pembrolizumab to determine its maximum…
- Conditions
- Solid Tumor, Colorectal Cancer, Non Small Cell Lung Cancer, Squamous Cell Carcinoma of Head and Neck
- Trial name
- NCT04344795
- Testing
- TPST-1495 twice daily, TPST-1495 once daily or on intermittent schedule, Pembrolizumab
- Where
- 11 sites in United States
- Volunteers
- 89 people
- Sponsor
- Tempest Therapeutics
The Prevalence of Surgery for Small Bowel Obstruction After LGBP Procedure.
Internal Hernia After Laparoscopic Gastric Bypass
To see if closing the mesenteric defects created at a Laparoscopic Gastric Bypass is better than leaving them open.
- Trial name
- NCT01137201
- Testing
- Suturing of mesenteric defects
- Where
- Sweden
- Volunteers
- 2,507 people
- Sponsor
- Region Örebro County
Gastric Cancer
A Biomarker Study for Predicting the Efficacy of Neoadjuvant Sintilimab Plus SOX for Gastric Adenocarcinoma.
Recently, a number of clinical studies were carried out to evaluate the therapeutic effects of PD-1 antibodies combined with chemotherapy as preoperative neoadjuvant therapy of gastric cancer (GC) worldwide.
- Trial name
- NCT05594381
- Testing
- Sintilimab
- Volunteers
- 90 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Gastroparesis
Gastric Per-Oral Endoscopic Myotomy (G-POEM) for the Treatment of Gastroparesis
Gastric Per-Oral Endoscopic Myotomy (G-POEM) is a procedure for the Treatment of Gastroparesis.
- Trial name
- G-POEM (NCT04434781)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Indiana University
Gastrointestinal Motility Disorder, Gastroparesis
IVIG for Drug and Device Refractory Gastrointestinal Auto-Immune Neuropathy
Patients with the symptoms of generalized GI dysmotility, including gastroparesis, are sometimes refractory to available medications, devices and other interventions/ Some of these patients have serologic and/or endo organ…
- Conditions
- Gastrointestinal Motility Disorder, Gastroparesis, Neuropathy
- Trial name
- GAIN (NCT04208828)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Louisville
Gastric Cancer
Confocal Laser Endomicroscopy for in Vivo Molecular Imaging of Gastric Cancer by Targeting MG7-Ag
The study aims to: 1. Achieve molecular imaging of MG7 antigen in patients with gastric cancer in vivo using confocal laser endomicroscopy. 2.
- Trial name
- NCT01366586
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Shandong University
Obesity
MGB/OAGB Versus RYGB After Failed Sleeve
Sleeve Gastrectomy is the most performed bariatric procedure worldwide. But a growing number of data documents that some patients have to be surgical revised due to weight regain or gastro-esophageal reflux disease.
- Trial name
- NCT03526783
- Testing
- Roux en Y gastric bypass, Mini/One anastomosis gastric bypass
- Where
- Germany
- Volunteers
- 55 people
- Sponsor
- Sana Klinikum Offenbach
Obesity, Morbid, Endoscopy
Endoscopic Gastric Reduction of Gastric Mucosa in Obesity
In the stomach, the ghrelin-containing cells are more abundant in the fundus than in the pylorus originally termed X/A-like cells.
- Trial name
- ETO (NCT06231251)
- Testing
- upper gastrointestinal endoscopy
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Zagazig University
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