Clinical trials: Stomach Diseases
Colorectal Cancer, Non-Small Cell Lung Cancer
A Phase 1 Study of IM-1617 in Participants With Advanced Cancer
This study will test the safety and effectiveness of a drug called IM-1617 in participants with solid tumors. Participants will have solid tumor cancer that has spread through the body (metastatic) or cannot be removed with…
- Conditions
- Colorectal Cancer, Non-Small Cell Lung Cancer, Breast Cancer, Esophageal Cancer
- Trial name
- NCT07578571
- Testing
- IM-1617
- Where
- 5 sites in United States
- Volunteers
- 200 people
- Sponsor
- Immunome, Inc.
Foreign Body Left During Endoscopic Examination
Efficacy Study of a Low Volume of Water Intake and Mosapride for Endoscopy in Patients With Subtotal Gastrectomy
A low volume of water intake and mosapride will effectively reduce food residue in remnant stomach for patients who had undergone subtotal gastrectomy due to gastric cancer.
- Trial name
- SMW (NCT01284764)
- Testing
- Mosapride
- Where
- South Korea
- Volunteers
- 144 people
- Sponsor
- Inje University
Advanced Cancers
Lenalidomide in Combination With Bevacizumab, Sorafenib, Temsirolimus, or 5-Fluorouracil, Leucovorin, Oxaliplatin (FOLFOX)
The goal of this clinical research study is to find the highest tolerable doses of the combinations of lenalidomide and other drugs that can be given to patients with advanced cancer.
- Trial name
- NCT01183663
- Testing
- Lenalidomide, Bevacizumab, Sorafenib
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- M.D. Anderson Cancer Center
Gastric Disease
PillBot™ - Remotely Controlled Capsule Endoscopy
The PillBot System is an endoscopic capsule imaging system intended for visualization of the stomach. In contrast to currently used passive capsule endoscopy systems, and FDA cleared active magnetic system, the PillBot System…
- Trial name
- NCT06212206
- Testing
- PillBot
- Volunteers
- 20 people
- Sponsor
- Endiatx
Roux-en-y Anastomosis Site, Marginal Ulcer
Marginal Ulcer Healing With Low-Thermal Argon Plasma Endoscopic Treatment
The objective of the study is to investigate the treatment of marginal ulcers with Low Thermal plasma in an endoscopic setting. By a treatment of the ulcerated areas with argon plasma with low power settings (~ 1 W) we…
- Conditions
- Roux-en-y Anastomosis Site, Marginal Ulcer, Marginal Ulcer (Peptic) or Erosion, Ulcer
- Trial name
- AMULET (NCT06543316)
- Testing
- Low Thermal Plasma (LTP) Treatment, Standard of Care Ulcer Treatment (typically PPI Administration)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Christopher C. Thompson, MD, MSc
Gastric Cancer
Response Rate and Side Effects of Preoperative Chemotherapy (TOX Regimen) in Patients With Locally Advanced Operable Gastric Adenocarcinoma
Early stage diagnosis of gastric cancer has ensued different approaches in its resection strategies. In order to increase the proportion of cases that undergo radical resection and reduce the recurrence rate, different…
- Trial name
- TOX (NCT01672333)
- Testing
- TOX
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Milad Hospital
MSI-H, PD-1 Immunotherapy
PD-1 Antibody Adjuvant Therapy for GC Patients With MSI-H After D2 Radical Surgery
Approximately 5% to 10% of gastric cancers have MSI-H/dMMR. According to the results of retrospective analysis of CLASSIC and MAGIC, MSI-H/dMMR was a good prognosis and potential negative predictor of adjuvant chemotherapy for…
- Conditions
- MSI-H, PD-1 Immunotherapy, Gastric Cancer, Adjuvant Therapy
- Trial name
- NCT05468138
- Testing
- SOX, XELOX, PD-1 antibody
- Where
- China
- Volunteers
- 94 people
- Sponsor
- Fudan University
Morbid Obesity
Adjustable Gastric Band Survey Study
Our aim is to complete a survey study of patients who have undergone Adjustable Gastric Band (AGB) surgery at the University of Washington Medical Center (UWMC) and expanded to other bariatric surgical sites outside the…
- Trial name
- AGB (NCT01041534)
- Testing
- Survey
- Where
- United States
- Sponsor
- University of Washington
Carcinoma, Non-Small Cell Lung, Squamous Cell Carcinoma of Head and Neck
A Study of Sigvotatug Vedotin in Advanced Solid Tumors
This trial will look at a drug called sigvotatug vedotin (SGN-B6A) alone and with pembrolizumab, with or without chemotherapy, to find out whether it is safe for people who have solid tumors.
- Conditions
- Carcinoma, Non-Small Cell Lung, Squamous Cell Carcinoma of Head and Neck, HER2 Negative Breast Neoplasms, Esophageal Squamous Cell Carcinoma
- Trial name
- NCT04389632
- Testing
- sigvotatug vedotin, pembrolizumab, cisplatin
- Where
- 158 sites in United States, France and 5 more
- Volunteers
- 1,006 people
- Sponsor
- Seagen, a wholly owned subsidiary of Pfizer
Gastro Intestinal Bleed
Validation of a New Score for UGI Bleeding in the ED: the Study of the TU-GIB Score
We have developed a new reliable, easy and reproducible clinical and biological score to select patients presenting to the emergency department with upper GI bleeding and at high risk of developing complications in order to plan…
- Trial name
- TU-GIBscore (NCT05646433)
- Where
- Tunisia
- Volunteers
- 500 people
- Sponsor
- Hôpital Universitaire Sahloul
Gastric Cancer
Neoadjuvant Chemotherapy for Patients With Advanced Gastric Cancer in ERAS Programs for Radical Gastrectomy
Patients with advanced gastric cancer received neoadjuvant chemotherapy undergo enhanced recovery after surgery (ERAS) programs.
- Trial name
- NCT03238404
- Testing
- NAC group, Surgery alone group
- Where
- China
- Volunteers
- 88 people
- Sponsor
- JIANG Zhi-Wei
Fish Oils, Perfusion; Complications
Effects of Omega-3 Fish Oil Fat Emulsion on Rehabilitation and Immune Function After Radical Surgery Combined With Intraperitoneal Hyperthermic Infusion Chemotherapy in Patients With Locally Advanced Gastric Cancer
The purpose of this study was to investigate the effects of omega-3 fish oil fat emulsion on peripheral blood C-reactive protein, total lymphocyte count, plasma albumin and immune function after radical surgery combined with…
- Conditions
- Fish Oils, Perfusion; Complications, Stomach Neoplasms, Nutrition Aspect of Cancer
- Trial name
- NCT06047158
- Testing
- Omega-3 fish oil fat emulsion
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Diabetes Mellitus, Type 2
The Effect of Combination of Mosapride and DPP-4 Inhibitor on Plasma Concentration of Incretin Hormones
The aim of this study is to investigate the effects of combined administration of mosapride as modulator of gastrointestinal motility and DPP-4 inhibitor on secretion of gut hormone such as glucagon-like peptide-1 (GLP-1) and…
- Trial name
- NCT02180334
- Testing
- Mosapride citrate, Linagliptin, Acetaminophen (paracetamol)
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Seoul National University Hospital
Gastroesophageal Reflux Disease With Esophagitis
PPI Dosing Per CYP2C19 Genotype
This study is being done to determine if the dosing of proton pump inhibitor (PPI) medication based on CYP2C19 genotype-derived phenotype leads to improved healing of erosive esophagitis compared to conventional PPI medication…
- Trial name
- NCT07843264
- Testing
- CYP2C19 based dosing Proton Pump Inhibitors, Conventional proton pump inhibitor dose
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Florida
Acute Coronary Syndrome, Myocardial Infarction
Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1)
The purpose of the COGENT-1 clinical trial is to determine whether CGT-2168 (clopidogrel and omeprazole) compared to clopidogrel is safe and effective in reducing the incidence of gastrointestinal bleeding and symptomatic ulcer…
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- COGENT-1 (NCT00557921)
- Testing
- CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin, Plavix (clopidogrel 75 mg) and aspirin
- Where
- 491 sites in United States, Australia and 14 more
- Volunteers
- 5,000 people
- Sponsor
- Cogentus Pharmaceuticals
Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
ctDNA-MRD Monitoring After Neoadjuvant Therapy in Gastric Cancer With pCR or MPR
This prospective observational study will enroll adults with gastric or gastroesophageal junction adenocarcinoma who achieve pathological complete response or major pathological response after neoadjuvant therapy and R0…
- Trial name
- NCT07799649
- Testing
- Tumor-Informed ctDNA-MRD Monitoring, Clinician-Selected Standard-of-Care Postoperative Treatment
- Where
- China
- Volunteers
- 150 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Gastric Neoplasms
Clinical Impact of Second-look Endoscopy After Endoscopic Submucosal Dissection of Gastric Neoplasm
Gastroenterologists often follow up second look endoscopy after endoscopic submucosal dissection(ESD) of gastric neoplasms because they want to prevent bleeding of procedure sites.
- Trial name
- SLEGD (NCT02005809)
- Testing
- second look endoscopy
- Where
- South Korea
- Volunteers
- 268 people
- Sponsor
- Kosin University Gospel Hospital
NSCLC, Gastric Cancer
A Study of PEGylated Recombinant Human Hyaluronidase (PEGPH20) With Pembrolizumab in Participants With Selected Hyaluronan High Solid Tumors
This is a Phase 1b study evaluating a combination of PEGPH20 and pembrolizumab in hyaluronan-high (HA-high) participants with relapsed/refractory non-small cell lung cancer (NSCLC) and HA-high participants with…
- Trial name
- NCT02563548
- Testing
- PEGPH20, Pembrolizumab
- Where
- 28 sites in United States
- Volunteers
- 56 people
- Sponsor
- Halozyme Therapeutics
Esophagitis, Reflux Esophagitis
The Role of HIF-2a in the Pathogenesis of Reflux Esophagitis
The purpose of this study is to determine the role of hypoxia inducible factor (HIF)-2a on the production of inflammatory cytokines that lead to reflux esophagitis.
- Conditions
- Esophagitis, Reflux Esophagitis, Gastroesophageal Reflux Disease
- Trial name
- NCT01733810
- Testing
- Cessation of Acid Suppressing Medications
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Dallas VA Medical Center
Gastroenteropancreatic Neuroendocrine Tumor, Lung Neuroendocrine Neoplasm
Clinical Utility Assay as a Biomarker for Gastroenteropancreatic and Lung Neuroendocrine Tumors
The purpose of this study is to evaluate how well an investigational blood test performs. The study will look at the sensitivity and specificity of a blood-based multitranscriptome assay (NETest).
- Trial name
- NCT02948946
- Testing
- NETest
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
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