Clinical trials: Stomatognathic Disease
Measles, Mumps
Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Combined Measles-mumps-rubella (MMR) Vaccine in Children in Their Second Year of Life
The purpose of this study is to evaluate end of shelf-life potency in terms of the immunogenicity and safety of GSK Biologicals' trivalent MMR vaccine, by comparing it to Merck \& Co., Inc.'s MMR vaccine, which is approved for…
- Conditions
- Measles, Mumps, Rubella, Measles-Mumps-Rubella Vaccine
- Trial name
- NCT01681992
- Testing
- Priorix, M-M-R II, Varivax
- Where
- 81 sites in United States, Czechia and 5 more
- Volunteers
- 4,538 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Periodontal Disease
Genetics of Periodontal Diseases in Chinese (Taiwan)
A retrospective case control study to validate the association between Interleukin-1 gene variations and adult chronic periodontal disease in Chinese (Taiwan).
- Trial name
- NCT01675336
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University
Gingival Diseases
Brief Title: a Clinical Study to Assess Gingivitis
The objective of this learning clinical study is to evaluate the effects of formulation chemistry on gingivitis.
- Trial name
- NCT06659471
- Testing
- 0.76% Sodium Monofluorophosphate Dentifrice, 0.454% Stannous Fluoride Dentifrice
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Procter and Gamble
Class II Malocclusion
Evaluation of the Levels of Pain, Discomfort, and Functional Impairment With Two Techniques of Retraction
Thirty-eight patients requiring extraction of maxillary first premolars will participate in the study. They will be divided randomly into two groups: an en-masse retraction group and a two-step group.
- Trial name
- NCT05652244
- Testing
- Mini-implants, Transpalatal arche (TPA)
- Where
- Syria
- Volunteers
- 38 people
- Sponsor
- Damascus University
Alveolar Process Atrophy
Ridge Preservation With Provisional Ovoid Pontic
A prospective randomized controlled trial of 30 patients from the Faculty of Dentistry of the UFJF was conducted. It was included patients who presented indication of extraction of premolars, canines or incisors.
- Trial name
- NCT03166475
- Testing
- Surgical procedures
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federal University of Juiz de Fora
Periodontal Disease (PD), Cardio Vascular Disease
PMPR and Chlorhexidine on Periodontal Disease and Vascular Function
Gum inflammation is called gingivitis. Gum disease, known as periodontal disease, is a long-term inflammation of the gums and bone around teeth, leading to tooth loss.
- Conditions
- Periodontal Disease (PD), Cardio Vascular Disease, Oral-Systemic Link, Vascular Dysfunction
- Trial name
- CHX-PMPR-PERIV (NCT07311512)
- Testing
- Chlorhexidine (0.2%) mouthwash
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Mahdi Mutahar
Periodontitis, Type 2 Diabetes
Inflammatory Response and Gingival iNOS Levels in Diabetic vs. Non-Diabetic Periodontitis Patients
This study investigates the relationship between Type 2 diabetes mellitus (T2DM), glycemic control, and periodontal disease. Researchers analyzed the levels of inducible nitric oxide synthase (iNOS) and proinflammatory cytokines…
- Conditions
- Periodontitis, Type 2 Diabetes, Glycemic Control
- Trial name
- NCT06803836
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Head and Neck Squamous Cell Carcinoma, Oral Mucositis
MIT-001 for Prevention of CCRT-Induced OM in HNSCC Patients
The proposed study in patients with previously untreated locally advanced head and neck squamous cell carcinoma (HNSCC) is designed to evaluate the efficacy and safety of three different doses of MIT-001 compared to the placebo…
- Trial name
- MIT-001 (NCT04651634)
- Testing
- MIT-001 plus CCRT
- Where
- 16 sites in United States, South Korea
- Volunteers
- 60 people
- Sponsor
- MitoImmune Therapeutics
Oral Mucositis Due to Chemotherapy, Hematolymphoid Malignancies
Phase II Single Arm Open Label Study Evaluating the Feasibility and Safety of Photobiomodulation as an Adjunct to Standard Supportive Care for Chemotherapy Induced Oral Mucositis in Pediatric Patients With Hematolymphoid Malignancies
Chemotherapy induced oral mucositis is a common and debilitating complication in pediatric patients receiving chemotherapy for hematolymphoid malignancies.
- Trial name
- BEAM (NCT07605234)
- Testing
- Photobiomodulation Therapy
- Volunteers
- 46 people
- Sponsor
- Tata Memorial Hospital
Quality of Life
Effects Of Different Periodontal Treatments On Quality Of Life In Patients With Periodontitis
In this study, the quality of life of patients with stage 3 grade C periodontitis who underwent surgical and non-surgical periodontal treatments was evaluated.
- Trial name
- NCT06539364
- Testing
- Quality of life surveys were conducted
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Izmir Katip Celebi University
Periodontal Diseases
The Use of Biorepair Peribioma Toothpaste and Mousse for Home Oral Care in Patients Undergoing Periodontal Therapy
This is a split-mouth randomized clinical trial in which a new domiciliary oral care protocol with Biorepair Peribioma Toothpaste and Mousse is evaluated in periodontal patients.
- Trial name
- NCT04809831
- Testing
- Domiciliary oral care with Biorepair Peribioma Toothpaste + Mousse, Domiciliary oral care with Curasept Toothpaste (chlorhexidine 0,2%)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Cancer
Supersaturated Calcium Phosphate Oral Rinse (Caphosol®) For the Prevention of Oral Mucositis in Children Undergoing Chemotherapeutic Treatments
Prospective double-blinded randomized clinical study. Aim of the study is to compare the effectiveness of Caphosol mouth rinses in prevention of oral mucositis as compared to 0.9% NaCl rinses.
- Trial name
- NCT02807337
- Testing
- Caphosol, 0,9% NaCl
- Where
- 3 sites in Finland
- Volunteers
- 47 people
- Sponsor
- Tampere University Hospital
Head and Neck Cancer, Radiation Toxicity
Salivary Gland Surgery Before Radiation Therapy in Preventing Radiation-Caused Xerostomia in Patients With Head and Neck Cancer
RATIONALE: Moving a salivary gland out of the area that will undergo radiation therapy may protect the gland from side effects of radiation therapy and may prevent xerostomia (dry mouth).
- Conditions
- Head and Neck Cancer, Radiation Toxicity, Xerostomia
- Trial name
- NCT00068237
- Testing
- salivary gland transfer, Post-operative radiation therapy
- Where
- 12 sites in United States, Canada
- Volunteers
- 49 people
- Sponsor
- Radiation Therapy Oncology Group
Malocclusion, Clear Aligner Appliance
Impact of Aligner Replacement Protocols on Predictability of Planned Dental Movements: Evaluation of Double Aligner
The study will evaluate the impact of replacing aligners after 7 days with new aligners made of different materials on the predictability of planned dental movements.
- Conditions
- Malocclusion, Clear Aligner Appliance, Orthodontics, Tooth Movement
- Trial name
- NCT06882395
- Testing
- Group 1: FLX aligners for 10 days, Group 3: FLX aligners for 7 days, followed by new FLX aligners for 3 days., Group 2: FLX aligners worn for 7 days, followed by FLX35 aligners for 3 days.
- Where
- Brazil
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Neodent
Dental Caries
Decision Aids for the Management of Suspicious Occlusal Caries Lesions
The study will determine whether clinicians who use a diagnostic device treat suspicious occlusal carious lesions (SOCL) surgically more often, with the same frequency, or less frequently, than dentists not relying on a…
- Trial name
- SOCL (NCT02340767)
- Testing
- Spectra Device, DIAGNOdent
- Where
- 6 sites in United States
- Volunteers
- 3,085 people, healthy volunteers welcome
- Sponsor
- The National Dental Practice-Based Research Network
Xerostomia, Diabetes Mellitus
Photobiomodulation In Treatment Of Xerostomia In Type Ii Diabetic Patients
Xerostomia is a major oral health problem that if not recognized and treated can have a significant effect on a patient's quality of life. It leads to difficulties with speech, swallowing and taste alteration.
- Trial name
- NCT06703372
- Testing
- Diode Laser 980 nm, 0.2W
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Hams Hamed Abdelrahman
Temporomandibular Disorders (TMD)
Journaling Intervention for Temporomandibular Disorder (TMD) and Chronic Overlapping Pain
The goal of this clinical trial is to learn whether a 2-week gratitude journaling activity is feasible and acceptable for individuals with Temporomandibular Disorder (TMD) and chronic overlapping pain.
- Trial name
- NCT06977100
- Testing
- Gratitude, General Wellness
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Florida
Oral Mucositis, Nausea
ZeroTolerance Mucositis: Managing Oral and Alimentary Mucositis With High Potency Sucralfate - ProThelial
RATIONALE: Polymerized (cross-linked) sucralfate malate paste (ProThelial) may be an effective single therapy approach for the management of chemoradiation mucositis, treating and preventing its occurrence in the oral cavity…
- Conditions
- Oral Mucositis, Nausea, Vomiting, Diarrhea
- Trial name
- NCT02016807
- Testing
- ProThelial
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Ashley Downs Bioscience
Mandibular Diseases, Guided Surgery
Computer Guided Split Thickness Versus Full Thickness Flap Buccal Bone Lid Approach in Hard Mandibular Pathosis
Full thickness Buccal bone lid approach is well known and well reported technique with a superiority on preserving bone volume and better bone healing especially when done using piezoelectrical devices when compared to…
- Conditions
- Mandibular Diseases, Guided Surgery, Guided Surgery Accuracy
- Trial name
- NCT07338136
- Testing
- computer guided split thickness flap for buccal bone lid approuch
- Volunteers
- 26 people
- Sponsor
- Cairo University
Periodic Fever, Aphthous Stomatitis
Probiotics and Corticosteroids for Treating Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA)
The purpose of study is to see if adding probiotics to corticosteroid treatment for children with PFAPA could improve the health and daily of patients through reduction in febrile period frequency and length, along with…
- Conditions
- Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis
- Trial name
- PFAPA (NCT02535962)
- Testing
- Lactobacillus acidophilus and Bifidobacterium lactis
- Sponsor
- Connecticut Children's Medical Center
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