Clinical trials: Stomatognathic Disease
Xerostomia, COVID-19
The Use of Photobiomodulation in the Treatment of Oral Complaints of Long COVID-19.A Randomized Controlled Trial.
Coronavirus (COVID-19) is a newly emerging zoonotic agent that emerged in December 2019 in China (2019-nCoV) as a Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV -2).
- Conditions
- Xerostomia, COVID-19, Long COVID, Persistent COVID-19
- Trial name
- NCT05760092
- Testing
- Institutional standard treatment for xerostomia and Long Covid, Photobiomodulation Therapy
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- University of Nove de Julho
Inflammation Gum, Cardiac Surgery
Impact of Teeth Extraction on Inflammation Marker's Levels in Patients Who Undergoing Cardiac Surgery
The aim of this study is to examine effects of dental treatments, surgical (extractions) and non-surgical procedures (non-surgical periodontal therapy), on serum levels for PCR, WBCs and PCT in patients needing a dental…
- Trial name
- NCT04626011
- Testing
- Tooth extractions
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- University of Trieste
Root Canal Therapy
Clinical Applicability of PBSCIMMO as a Single Material in Endodontic Obturations
A randomized, interventional, prospective, unicentric clinical study, 86 patients will be submitted to endodontic treatment of necrotic teeth.
- Trial name
- PBSCIMMO (NCT03514264)
- Testing
- Gutta Percha and AHPLUS cement (group A), PBS CIMMO cement (group B)
- Where
- Brazil
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universidade do Vale do Sapucai
Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma, Recurrent Metastatic Squamous Neck Cancer With Occult Primary
Saracatinib in Treating Patients With Recurrent or Metastatic Head and Neck Cancer
This phase II trial is studying the how well saracatinib works in treating patients with metastatic or recurrent head and neck cancer.
- Conditions
- Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma, Recurrent Metastatic Squamous Neck Cancer With Occult Primary, Recurrent Squamous Cell Carcinoma of the Hypopharynx, Recurrent Squamous Cell Carcinoma of the Larynx
- Trial name
- NCT00513435
- Testing
- saracatinib, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- National Cancer Institute (NCI)
Oral Cancer, Recurrence
Validation of DNA Methylation Biomarkers for Oral Cancer Detection
The purpose of this study is to investigate the correlation between DNA methylation and the treatment and recurrence of oral cancer.
- Trial name
- NCT02648789
- Where
- Taiwan
- Volunteers
- 46 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Dental Caries, Reversible Pulpitis
Assessment of Pain and Anxiety During Infiltration Anesthesia Using Dental Anesthesia Injector Versus Conventional Syringe in Pediatric Patients
This randomized controlled trial is conducted on pediatric dental patients to compare the effectiveness of local anesthesia administered using a dental anesthesia injector device versus the traditional syringe method.
- Trial name
- NCT07101068
- Testing
- Dental Anesthesia Injector, conventional syringe
- Where
- 2 sites in Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Oral Mucositis
Benefits of Immunonutrition in Patients With Head and Neck Cancer Receiving Chemoradiation
This study evaluated the benefits of immunonutrition regarding the prevention of severe mucositis. Patients with head and neck cancer (HNC) undergoing definitive concurrent chemoradiation including 3-week cycles of cisplatin were…
- Trial name
- NCT05101889
- Testing
- Oral Impact®
- Volunteers
- 110 people
- Sponsor
- Prince of Songkla University
Ectopic Tooth Eruption, Palatal Expansion Technique
The Effectiveness of Early Intervention to Correct the Position of PDC:s
Approximately 2-3% of children will have problems with one or both of their permanent or 'adult' canine teeth in the upper jaw. These canine teeth sometimes fail to erupt properly, because they are displaced into the roof of the…
- Conditions
- Ectopic Tooth Eruption, Palatal Expansion Technique, Randomized Clinical Trial
- Trial name
- PDC (NCT06267989)
- Testing
- Extraction of the primary canine teeth, Expansion
- Where
- 3 sites in Germany, Sweden and 1 more
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Dry Mouth, Xerostomia.Hyaluronic Acid, Xylitol
CLINICAL EVALUATION OF THE EFFICACY OF AN INTRA ORAL SPRAY FOR PATIENTS WITH XEROSTOMIA
This cross-over group, double-blind, randomized, single center, study will enroll 26 subjects to target at least 24 subjects completing the study.Following an initial 3-5 minute evaluation of resting salivary flow, subjects will…
- Trial name
- NCT04719091
- Testing
- Lubricity
- Volunteers
- 26 people
- Sponsor
- You First Services
Dental Caries
Occlusal-proximal ART Restorations in Primary Molars Using 2 Different Kinds of GIC
The aim of this research is to investigate the survival rate and cost effectiveness of two brands of GIC as occlusal-proximal ART restorations. Also the survival rate of the tooth will be investigated.
- Trial name
- NCT02267720
- Testing
- Occlusal-proximal ART restorations - Ketac Molar, Occlusal-proximal ART restorations - Vitro Molar
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Bone Fragile, Bisphosphonate-Associated Osteonecrosis
Efficacy and Safety on the Use of Bisphosphonates in Paediatrics
The investigators suppose that the impact of bisphosphonate therapy is beneficial on the bone during the growth period with few adverse events.
- Conditions
- Bone Fragile, Bisphosphonate-Associated Osteonecrosis, Children, Adverse Events
- Trial name
- Bisphosphonate (NCT04012320)
- Testing
- No intervention, observational study
- Where
- France
- Volunteers
- 99 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Caries, Periodontitis
The Effect of Miswak Chewing Sticks on the Oral Helicobacter Pylori Infection
To elucidate the relationship of chewing miswak sticks on the H. Pylori infection in the oral cavity.The study would be conducted at the Faculty of Dentistry, Kuwait University.
- Trial name
- Miswak (NCT02418520)
- Testing
- Miswak
- Where
- Kuwait
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kuwait University
Periodontitis, Acute-Phase Response
Relationship Between LRG and Periodontal Disease
This study aimed to investigate gingival crevicular fluid (GCF) and serum levels of LRG, interleukin (IL)-6 and tumor necrosis factor (TNF)-α in patients with periodontitis before and after non-surgical periodontal treatment.
- Conditions
- Periodontitis, Acute-Phase Response, Inflammation
- Trial name
- NCT04383561
- Testing
- Non-surgical periodontal treatment, Oral hygiene instructions
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Periodontitis, Pocket, Periodontal
Adjunctive Effect of Erythritol on Pocket Closure Rates
This clinical trial is studying whether using erythritol powder during non-surgical periodontal treatment (deep cleaning) helps improve gum health in people with severe periodontitis.
- Conditions
- Periodontitis, Pocket, Periodontal, Pocket, Gingival
- Trial name
- NCT06958874
- Testing
- Non-surgical periodontal therapy + sub-gingival air polishing, Non-surgical periodontal therapy alone
- Where
- Italy
- Volunteers
- 56 people
- Sponsor
- University of L'Aquila
Gingival Recession
Treatment of Single Maxillary Gingival Recession With Loss of Inter-dental Attachment. A Randomized Controlled Clinical Trial
Background: The aim of this randomized clinical trial (RCT) was to evaluate the adjunctive benefit of Connective Tissue Graft (CTG) to Coronally Advanced Flap (CAF) for the treatment of gingival recession associated with…
- Trial name
- NCT05460182
- Testing
- CAF+CTG, CAF
- Where
- Italy
- Volunteers
- 29 people
- Sponsor
- University of Florence
Nasopharyngeal Carcinoma
Induction Chemotherapy in Patients With Locoregionally Advanced Nasopharyngeal Carcinoma
The purpose of this study is to compare induction chemotherapy (docetaxel+cisplatin+fluorouracil) plus concurrent chemoradiotherapy with concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal…
- Trial name
- NCT01245959
- Testing
- Docetaxel, cisplatin and fluorouracil, Concurrent chemoradiotherapy
- Where
- China
- Volunteers
- 476 people
- Sponsor
- Sun Yat-sen University
Xerostomia, End of Life
A Mouth Education Program for Dry Mouth
The goal of this cluster based intervention trial is to evaluate the effect of a nurse-led patient education program on dry mouth in patients with a life-limiting condition or frailty.
- Conditions
- Xerostomia, End of Life, Frailty, Dry Mouth
- Trial name
- MEP (NCT05964959)
- Testing
- Mouth Educational Program, Care as Usual
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- Leiden University Medical Center
Periimplantitis, Periimplant Diseases
Non-surgical Treatment of Peri-implantitis Using Chitosan Brush and Tetracycline Slurry
Aim: The aim of this prospective, randomized, parallel arm, blind clinical trial is to compare the clinical and radiographic outcomes following non-surgical treatment of mild peri-implant defects using Labrida Bioclean with or…
- Trial name
- NCT06695559
- Testing
- Labrida Bioclean, Tetracycline slurry
- Where
- Greece
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Oral Mucositis
Study to Evaluate the Efficacy and Safety of Three Different Doses of SCV 07 in Attenuating Oral Mucositis in Subjects With Head and Neck Cancer
This is a phase 2b, double-blind, placebo-controlled, 4-arm, adaptive-design trial, initially stratified by cisplatin regimen, and then randomized 1:1:1:1.
- Trial name
- NCT01247246
- Testing
- SCV-07
- Where
- 49 sites in United States
- Volunteers
- 160 people
- Sponsor
- SciClone Pharmaceuticals
Non-Hodgkin's Lymphoma, Multiple Myeloma
PROMPT - Palifermin in Reduction of Oral Mucositis in PBSC Transplantation
This is an open-label, single-arm, multicentre study conducted in Spain to estimate the effectiveness of palifermin administered at a dose of 60 mg/kg/day IV for 3 consecutive days before the start of the conditioning regimen and…
- Trial name
- NCT00352703
- Testing
- Kepivance (Palifermin)
- Volunteers
- 145 people
- Sponsor
- Swedish Orphan Biovitrum
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