Clinical trials: Stomatognathic Disease
Nasopharyngeal Carcinoma
Effect of Triple Combination of Induction, Concurrent and Adjuvant Chemotherapy in High Risk Nasopharyngeal Carcinoma
The investigators aim to evaluate the survival benefit from triple combination of induction, concurrent and aduvant chemotherapy versus concurrent chemotherapy alone for high risk locoregionally advanced nasopharyngeal carcinoma…
- Trial name
- NCT02621970
- Testing
- Cisplatin 1, Cisplatin 2, Docetaxel
- Where
- China
- Volunteers
- 534 people
- Sponsor
- Sun Yat-sen University
Dental Caries, Class II Dental Caries
5-year Clinical Follow-up of Restorative Materials
Materials to be used as permanent filling materials in Class II restorations are still an essential field of study. This study aims to evaluate the 5-year clinical performance of Class II restorations performed with different…
- Trial name
- NCT06393270
- Testing
- Modified US Public Health Service (USPHS) criteria
- Where
- Turkey (Türkiye)
- Volunteers
- 192 people
- Sponsor
- Selcuk University
Metastatic Oral Cavity Carcinoma, Recurrent Oral Cavity Carcinoma
Methotrexate, Erlotinib, and Celecoxib for the Treatment of Recurrent/Metastatic Head and Neck Cancer in a Rural Midwest United States Population
This phase II trial gathers information on the feasibility, safety, and effect of giving methotrexate, erlotinib, and celecoxib in treating head and neck cancer that has come back after a period of improvement (recurrent) or that…
- Conditions
- Metastatic Oral Cavity Carcinoma, Recurrent Oral Cavity Carcinoma, Stage IVC Lip and Oral Cavity Cancer AJCC v8, Head and Neck Cancer
- Trial name
- NCT06997068
- Testing
- Celecoxib, Erlotinib Hydrochloride, Imaging Procedure
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Mayo Clinic
Class III Malocclusion, Facemask
Evaluation of Treatment Outcomes of Interceptive Orthodontic Intervention for Class Iii Malocclusion Using Inclined Plane Appliance Combined With Variable Bracket Placement
Study Title: Evaluation of Treatment Outcomes of Interceptive Orthodontic Intervention for Class III Malocclusion Using Inclined Plane Appliance Combined With Variable Bracket Placement Objective: To evaluate the clinical and…
- Conditions
- Class III Malocclusion, Facemask, Inclined Plane Appliance
- Trial name
- NCT07581990
- Testing
- Inclined Plane Appliance Combined With Variable Bracket Placement
- Where
- Vietnam
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Can Tho University of Medicine and Pharmacy
Periodontitis
Alb-PRF as an Adjunct to Nonsurgical Periodontal Therapy
Periodontitis is an inflammatory disease that damages the tissues supporting the teeth. Nonsurgical periodontal therapy is the standard initial treatment, but deep periodontal pockets may remain after treatment.
- Trial name
- NCT07794046
- Testing
- Nonsurgical Periodontal Therapy, Albumin Platelet-Rich Fibrin
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Halil Ata BIÇAKÇIOĞLU
Oropharyngeal Cancer, Oral Cancer
Trismus Trial of Therabite vs Wooden Spatula in Head and Neck Cancer Patients
The trial will compare exercises using Therabite® versus wooden spatulas to prevent or relieve trismus in patients with stage 3 and 4 oral/oropharyngeal cancer.
- Trial name
- NCT01733797
- Testing
- Wooden spatula, Therabite
- Where
- 5 sites in United Kingdom
- Volunteers
- 71 people
- Sponsor
- Brynn Chappell
Jaw, Edentulous, Partially
Evaluation of Marginal Bone Loss and Associated Factors Around Ziacom Dental Implants With Different Prosthetic Connection
Dental implants may suffer from bone loss around them, particularly at the upper portion where the prosthesis starts. The connection between both parts of the tooth restoration is key for avoiding micromovement during chewing…
- Trial name
- NCT05859113
- Testing
- Ziacom Galaxy dental implant with internal connical prosthetic connection, Ziacom Zinic dental implant with internal hexagonal prosthetic connection
- Where
- Spain
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Gingivitis
A Controlled Clinical Study to Determine the Gingivitis Benefit of Flossing
This is a randomized, controlled, examiner-blind, parallel group, four week clinical study comparing brushing plus flossing to brushing alone in 60 healthy adults with pre-existing gingivitis.
- Trial name
- NCT00964860
- Testing
- Glide dental floss
- Where
- Guatemala
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Tooth Impaction, Impacted Canine, Dental Anomalies
This Systematic Review Aims to Synthesize Available Evidence Regarding the Prevalence, Anatomical Distribution, Etiological Determinants, and Diagnostic Assessment of Permanent Canine Impaction. A Systematic Search of PubMed, PubMed Central, and ScienceDirect Was Conducted for Studies Published Betw
This systematic review aimed to synthesize current evidence regarding the prevalence, anatomical distribution, etiological determinants, and diagnostic assessment of permanent canine impaction.
- Trial name
- PCI (NCT07509320)
- Where
- Romania
- Sponsor
- Dimitrie Cantemir University
Tooth Loss and Rehabilitation With Telescopic Crown Prostheses
Rigid Versus Non-Rigid Digitally Fabricated Telescopic Double Crown Prosthesis
This study aims to compare the clinical and patient satisfaction outcomes of rigid versus non-rigid digitally fabricated telescopic double crown prostheses supported by teeth and implants.
- Trial name
- NCT07682623
- Testing
- Rigid telescopic double crown prosthesis, Non-rigid telescopic double crown prosthesis
- Volunteers
- 10 people
- Sponsor
- Mansoura University
Molar Incisor Hypomineralization, Dental Caries
Silver Diamine Fluoride and Papain-Based Gel for Management of MIH-affected Molar in Paediatric Patients
Molar incisor hypomineralization (MIH) is a developmental defect of enamel affecting the first permanent molar and frequently the incisors with a prevalence of 16-16.9% in Malaysia.
- Conditions
- Molar Incisor Hypomineralization, Dental Caries, Hypomineralization of Enamel
- Trial name
- NCT04710927
- Testing
- Silver Diamine Fluoride, Papain-Based Gel, High Viscosity Glass Ionomer Cement (HVGIC)
- Where
- Malaysia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Temporomandibular Joint Internal Derangement, Temporomandibular Joint Disorders
Arthrocentesis-PRF Versus Botulinum Toxin for Management of ADDwR
Temporomandibular joint (TMJ) internal derangement is a common cause of temporomandibular disorders and is often associated with pain, restricted mandibular movement, joint sounds, and functional limitations during mastication…
- Conditions
- Temporomandibular Joint Internal Derangement, Temporomandibular Joint Disorders, Temporomandibular Disorders (TMD), TMJ Pain
- Trial name
- NCT07385742
- Testing
- Injectable Platelet-Rich Fibrin (I-PRF) Injection, Botulinum Toxin Type A (BOTOX) Injection
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Suez Canal University
Gingival Recession
Guided Creeping Technique (GCT) in Treating Gingival Recession
A novel minimally invasive guided creeping technique (GCT) is suggested to treat gingival recessions.
- Trial name
- NCT05101642
- Testing
- Guided Creeping Technique (GCT)
- Where
- Egypt
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- October 6 University
Periodontitis Stage II, Gingival Pocket
Use of Injectable Extended Platelet-Rich Fibrin as a Local Drug Delivery in the Treatment of Stage II Periodontitis Patients
The objective of the present study is to assess the clinical effectiveness of local delivery of injectable extended platelet-rich fibrin in subgingival application when used in conjunction with scaling and root planing (SRP) in…
- Trial name
- NCT07080294
- Testing
- extended platelet rich fibrin injection in pocket, albumin injection in pocket, scaling and root planing
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Mansoura University
Dental Caries, Restorative Material
Evaluate the Effectiveness of an Experimental Urethane Dimethacrylate Resin Based Dental Composite Material
This double blind randomized controlled prospective clinical trial will compare the clinical success of two tooth colored resin composite dental filling materials - TPH3 (Dentsply Caulk) and an experimental urethane…
- Trial name
- NCT02018822
- Testing
- urethane dimethacrylate, TPH3, Esthet-X HD
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Nasopharyngeal Carcinoma
Concurrent Chemoradiation and Durvalumab for Locoregionally Advanced Nasopharyngeal Carcinoma
The investigators propose a phase II randomized-controlled study on using durvalumab in combination with induction chemotherapy followed by concurrent chemoradiation and adjuvant durvalumab, compared to induction chemotherapy…
- Trial name
- NCT04447612
- Testing
- Durvalumab, Cisplatin, Gemcitabine
- Where
- Hong Kong
- Volunteers
- 118 people
- Sponsor
- The University of Hong Kong
Nasopharyngeal Carcinoma
Chemoradiation Plus Weekly c225 Against Locoregionally Advanced Nasopharyngeal Carcinoma (NPC)
The investigators will add weekly cetuximab (c225) to the standard care of chemoradiation against locoregionally advanced Nasopharyngeal Carcinoma (NPC), and evaluate the toxicity and efficacy of this new regimen.
- Trial name
- NCT01712919
- Testing
- Intensity-modulated radiotherapy, Concurrent chemotherapy with paclitaxel and nedaplatin, Cetuximab
- Where
- China
- Volunteers
- 61 people
- Sponsor
- Jiangsu Cancer Institute & Hospital
Muscle Pain, Feedback, Psychological
Evaluation of Biofeedback Therapy Efficiency in Masticatory Muscles Pain Management
This study evaluates beneficial effects of biofeedback therapy in reducing pain and increased tension of muscles occurring in patients with temporomandibular disorders (TMD).
- Conditions
- Muscle Pain, Feedback, Psychological, Craniomandibular Disorders, Temporomandibular Disorder
- Trial name
- NCT03421028
- Testing
- Electromyography Biofeedback, Classic treatment for myogenous TMD
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Wroclaw Medical University
Oral Cancers
Diagnosis of Oral Precancers and Cancers Using Optic Coherence Tomography
Diagnosis of oral precancers and cancers using optic coherence tomography
- Trial name
- NCT00172965
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Caries,Dental
Clinical Performance of Thermoviscous Bulk Fill Resin Composites in Comparison to Conventional Packable Bulk Fills
This clinical trial will be conducted to compare the clinical performance of the thermo-viscous preheated bulk fill composite in the management of carious lesions in posterior teeth in adult patients over 12 months.
- Trial name
- NCT05276154
- Testing
- thermoviscous bulkfill composite (Viscalor)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Minia University
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