Clinical trials: Stomatognathic Disease
Dental Anxiety, Dental Pain
Effect of Play Dough, Slime, and Plush Toys on Dental Anxiety and Pain in Children During Dental Treatment
This study aims to evaluate the effectiveness of tactile distraction materials, including play dough, slime, and plush toys, on dental anxiety, pain perception, and physiological stress responses in children undergoing dental…
- Conditions
- Dental Anxiety, Dental Pain, Behavioral Management
- Trial name
- PLAY-DENT (NCT07445594)
- Testing
- Play Dough Distraction, Slime Distraction, Plush Toy Distraction
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Sjogren's Syndrome, Interstitial Lung Disease
Sjogren's Lung Study
Lung involvement in Sjögren's syndrome is common and causes reduced quality of life and increased mortality. Sjögren's syndrome-related lung diseases (SS-RLD) are classified and treated as the primary lung diseases they resemble.
- Conditions
- Sjogren's Syndrome, Interstitial Lung Disease, Primary Pulmonary Lymphoma (Disorder), Chronic Bronchiolitis
- Trial name
- NCT04843345
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Stanford University
Edentulous Mouth
Real-life Evaluation of the Safety and Performance of EUROTEKNIKA Dental Implants
Real-life evaluation of the safety and performance of EUROTEKNIKA dental implants
- Trial name
- NCT05375045
- Testing
- dental implantation
- Where
- France
- Volunteers
- 868 people
- Sponsor
- Euroteknika
Periodontitis, Aggressive
Clinical and Radiographic Evaluation of Guided Tissue Regeneration With Radiation-sterilized Allogenic Bone Grafts or Xenogenic Grafts for the Treatment of Intrabony Defects in Aggressive Periodontitis
The treatment of intrabony defects in patients with aggressive periodontitis remains a challenging procedure and novel therapeutic strategies are sought.
- Trial name
- NCT03340012
- Testing
- GTR + radiation-sterilize allogenic bone graft, GTR + xenogenic graft
- Where
- Poland
- Volunteers
- 20 people
- Sponsor
- Medical University of Warsaw
Gingival Recession
Clinical Evaluation of Single-stage Advanced Versus Rotated Flaps in the Treatment of Gingival Recessions
BACKGROUND: Several procedures have been reported for the surgical correction of gingival recession (GR), including the laterally positioned flap (LPF) and the coronally advanced flap (CAF), performed as single or two-stage…
- Trial name
- NCT02433912
- Testing
- Test - Laterally positioned flap, Control-Coronally positioned flap, 750 mg paracetamol
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Dental Caries, Periodontal Diseases
Xylitol Chewing-gums: Concentration in Saliva and Antibacterial Effect
a double-blind cross-over in vivo study was performed to measure the salivary concentration of Xylitol released from the two chewing gums containing different amount of the polyol.
- Trial name
- NCT03971981
- Testing
- 100% Xylitol Gum, 22% Xylitol Gum
- Where
- Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Università degli Studi di Sassari
Wisdom Tooth, Dental Impaction
Efficacy and Safety of Articaine and Lidocaine in Extraction of Wisdom Teeth of Upper and Lower Jaws
Local anesthesia drugs and anesthesia technique play an imperative role in dental treatment. The purpose of this study was to compare the efficacy and safety of different dental local anesthetics drugs and brands in clinical use…
- Trial name
- NCT05804630
- Testing
- Different dental anesthetic agents during wisdom tooth surgery (Orabloc®, Octocaine®, and Xylestesin-A®)
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Dental Caries
the NMFACT Caries Index
the NMFACT is a new caries index to overcome the drawbacks of DMF cries index the ''N'' is for non carious lesion, the ''M''for missed teeth,the ''F''for filled teeth,the''C''for carious teeth,the ''A''for alignment and the…
- Trial name
- NCT04330794
- Testing
- NMFACT, DMF index
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Obesity, Dental Erosion
Salivary Function and Dental Changes During GLP-1 Therapy
People who use glucagon-like peptide-1 (GLP-1) receptor agonists, such as semaglutide and tirzepatide, may experience changes in their oral health.
- Conditions
- Obesity, Dental Erosion, Saliva Collection, Saliva Altered
- Trial name
- NCT07720466
- Testing
- Unstimulated Whole Saliva Collection, Salivary Analysis, Oral Examination and BEWE Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Bilecik Seyh Edebali Universitesi
Dental Caries
Fluoride in Saliva After Use of Fluoride Toothpastes Followed by Fluoride Mouthrinses
This study will evaluate fluoride (F) bioavailability in saliva when using an over-the-counter mouthrinse of 226 ppm F, immediately after brushing with an over-the-counter toothpaste of 1,100 ppm F or a prescription toothpaste of…
- Trial name
- NCT05601154
- Testing
- Crest Cavity Protection toothpaste, Crest Cavity Protection toothpaste followed by Act Mint Fluoride Rinse, Colgate PreviDent 5000+ toothpaste
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Peridontal Disease, Rheumatic Arthritis
Nonsurgical Periodontal Treatment Combined With Anti-TNF-α in Patients With Rheumatoid Arthritis and Periodontitis
Periodontitis is a multifactorial disease of the periodontium that can lead to destruction of the alveolar bone and supporting connective tissue and subsequent tooth loss.
- Trial name
- NCT06818045
- Testing
- Non Surgical Periodontal Treatment, Periodontal measurements will be performed, biochemical measurements
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Hatice Yemenoğlu
Chronic Periodontitis
Effect of Periodontal Treatment on Salivary Biomarkers
The investigators plan to recruit 40 healthy patients referred to the unit of Periodontology, diagnosed with generalized moderate - severe chronic periodontitis.
- Trial name
- NCT02159781
- Testing
- periodontal treatment - scaling and root planning
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Baruch Padeh Medical Center, Poriya
Nasopharyngeal Carcinoma (NPC)
Toripalimab, Induction Chemotherapy, Radiation Therapy With Omega-3 for Locally Advanced Nasopharyngeal Carcinoma
The aim of this study is to evaluate the efficacy, adverse reactions, nutritional status analysis, and quality of life analysis of Toripalimab Plus Induction Chemotherapy Followed by Radiation Therapy Combined with Omega-3 in the…
- Trial name
- NCT07136519
- Testing
- Toripalimab, Omega-3, radiotherapy
- Where
- 3 sites in China
- Volunteers
- 30 people
- Sponsor
- Affiliated Hospital of Guangdong Medical University
Class II Division 1 Malocclusion
Study to Measure the Effect of Part Time Versus Full Time Orthodontic Appliance Wear
The aim of this study is to assess skeletal (bone) and dental (teeth) changes occurring following wear of a twin block functional appliance (removable brace which postures the lower jaw forward to improve a discrepancy between…
- Trial name
- NCT02190630
- Testing
- Modified Clark Twin Block
- Where
- United Kingdom
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Oral Cancer, Chatbot
Enhancing Oral Cancer Awareness
To evaluate the impact of AI-powered chatbot interactions versus traditional educational handouts on increasing participants' knowledge of oral cancer and its prevention
- Conditions
- Oral Cancer, Chatbot, Patient Education, Prevention
- Trial name
- NCT06682494
- Testing
- Traditional Education, AI-powered Chatbox
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Oroantral Communication
Inverted Periosteal Flap vs Buccal Advancement Flap for Oroantral Communication Closure
This randomized controlled clinical study will evaluate the effectiveness of the inverted buccal periosteal flap in closing recent post-extraction oroantral communications and compare it with the conventional buccal advancement…
- Trial name
- NCT07630701
- Testing
- Inverted Buccal Periosteal Flap, Buccal Advancement Flap
- Where
- Syria
- Volunteers
- 24 people
- Sponsor
- Arab International University
Nasopharyngeal Carcinoma (NPC), Minimal Residual Disease
Integrating Allogeneic NK Cells in High-risk Advanced Stage III-IV Nasopharyngeal Cancer Patients
This clinical trial aims to determine whether Natural Killer (NK) cell therapy administered in combination with concurrent chemoradiotherapy (CRT) can reduce recurrence in patients with advanced nasopharyngeal cancer (NPC), and…
- Conditions
- Nasopharyngeal Carcinoma (NPC), Minimal Residual Disease, Recurrent Nasopharyngeal Carcinoma, Maximum Tolerated Dose
- Trial name
- AlloNK1 (NCT07247201)
- Testing
- Allogenic expanded Natural Killer Cells (AlloNK1)
- Where
- Singapore
- Volunteers
- 31 people
- Sponsor
- Singapore General Hospital
TPF, Immunotherapy
A Phase II Study of TPF With PD-1 Inhibitor Induction Therapy for Locally Advanced Nasopharyngeal Carcinoma
NPC is one of the most common malignant tumors in the head and neck region of China. Currently, the main treatment regimen for LA-NPC is radical concurrent chemoradiotherapy combined with induction or adjuvant chemotherapy.
- Conditions
- TPF, Immunotherapy, Nasopharyngeal Carcinoma, Phase II Clinical Study
- Trial name
- NCT06781112
- Testing
- albumin paclitaxel (200mg/m2), cisplatin (60mg/m2, infused over 3 days), 5-fluorouracil (3000mg/m2, continuously intravenously pumped for 120 hours), and tislelizumab ( 200mg).
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Weiwei Zhang
Root Canal Treatment, Intracanal Medicament
The Success of Root Canal Treatments Performed Using Two Different Intracanal Medicaments
Previously untreated, asymptomatic, single-rooted maxillary anterior teeth with periapical lesions <5 mm, no fractures, resorption, calcification, or recent antibiotic use will performed two-visit root canal treatment.
- Conditions
- Root Canal Treatment, Intracanal Medicament, Post Operative Pain, Apical Periodontitis
- Trial name
- NCT07210177
- Testing
- Bio-C Temp Intracanal Medication, Metapaste Intracanal Medication
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ege University
Velopharyngeal Insufficiency
Effect of Velopharyngeal Gap Size on Laryngeal Morphology and Vocal Function in Children With VPI
Speech production relies on the precise coordination of the respiratory, phonatory, resonatory, and articulatory systems . The velopharyngeal mechanism is essential in separating the oral and nasal cavities during speech and…
- Trial name
- NCT07832812
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Assiut University
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