Clinical trials: Stomatognathic Disease
Gingival Recession, Generalized, Gingival Recession, Localized
Clinical and Histological Evaluation of Subepithelial Connective Tissue Graft Maturation at Different Healing Timepoints, With and Without Topical Application of a Polynucleotide- and Hyaluronic Acid-Based Gel
This study evaluates whether a 9-week healing interval is sufficient for subepithelial connective tissue graft (SCTG) maturation after palatal harvesting, and whether topical application of a polynucleotide and hyaluronic acid…
- Conditions
- Gingival Recession, Generalized, Gingival Recession, Localized, Wound Healing, Palate; Wound
- Trial name
- NCT07708051
- Testing
- polynucleotide and hyaluronic acid gel, subepithelial connective tissue graft harvesting
- Volunteers
- 15 people
- Sponsor
- University of Sao Paulo
Periodic Fever, Aphthous Stomatitis
Probiotics and Corticosteroids for Treating Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA)
The purpose of study is to see if adding probiotics to corticosteroid treatment for children with PFAPA could improve the health and daily of patients through reduction in febrile period frequency and length, along with…
- Conditions
- Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis
- Trial name
- PFAPA (NCT02535962)
- Testing
- Lactobacillus acidophilus and Bifidobacterium lactis
- Sponsor
- Connecticut Children's Medical Center
Advanced Breast Carcinoma, Advanced Colon Carcinoma
Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH Trial
The dose escalation phase of this trial identifies the safety, side effects and best dose of ceralasertib (AZD6738) when given in combination with trastuzumab deruxtecan (DS-8201a) in treating patients with solid tumors that have…
- Conditions
- Advanced Breast Carcinoma, Advanced Colon Carcinoma, Advanced Colorectal Carcinoma, Advanced Endometrial Carcinoma
- Trial name
- NCT04704661
- Testing
- Biopsy Procedure, Biospecimen Collection, Ceralasertib
- Where
- 23 sites in United States
- Volunteers
- 51 people
- Sponsor
- National Cancer Institute (NCI)
Apical Periodontitis, Post Operative Pain, Acute
Post-operative Pain and Apical Healing After Root Canal (re)Treatment With Laser-activated Irrigation Versus Sonic or no Activation
When a tooth's nerve dies, inflammation can develop at the tip of the tooth's root. Root canal treatment is carried out to allow this inflammation to heal.
- Trial name
- NCT07883486
- Testing
- sonically activated irrigation, laser activated irrigation, conventional needle irrigation
- Where
- 2 sites in Belgium
- Volunteers
- 183 people
- Sponsor
- University Ghent
Periodontitis
Evaluation of Photodynamic Treatment FOTOSAN® Efficacy in Periodontology
Periodontitis are infectious and inflammatory diseases of gum and tooth supporting tissues leading to tooth loss and oral disability.
- Trial name
- NCT02030470
- Testing
- Fotosan®630. LED lamp. Toluidinblue. Photoactivated disinfection
- Where
- France
- Volunteers
- 36 people
- Sponsor
- University Hospital, Strasbourg, France
Endodontically-Treated Teeth
Clinical Success of Onlays Fabricated With Different Types of Resin
Additive manufacturing, also referred to as "3D printing" or "rapid prototyping," is defined as the process of joining materials layer by layer to create an object based on 3D model data.
- Trial name
- NCT06960070
- Testing
- Saremco print resin, Varseosmile Crownplus resin, Varseosmile TriniQ resin
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Mersin University
Tooth Loss, Soft Tissue Deficiency
A Clinical Study to Investigate Collagen Matrix 10808 for Soft Tissue Volume Augmentation Around Single Implants
The objective of this study is to investigate the safety and the function of the collagen Matrix 10808 in humans and to compare it versus the standard therapy, the transplantation of the autologous connective tissue graft.
- Trial name
- NCT02356770
- Testing
- Collagen Matrix 10808, Connective tissue graft
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Geistlich Pharma AG
Tooth Crowding
Effect of Force Magnitude on Canine Retraction and Gingival Crevicular Fluid Proteome
This study aims to examine the effect of force levels in orthodontic treatment during canine retraction. Force levels refer to the pressure applied by the orthodontic devices to move teeth.
- Trial name
- NCT06668194
- Testing
- Light Force (150g Niti Coil), Heavy Force (400 g Niti coil)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- UConn Health
Dental Caries, Tooth Demineralization
Evaluation of Optical Coherence Tomography in Dentistry
Optical coherence tomography (OCT) is a medical diagnostic tool, providing non-invasive, non-radiative and high resolution imaging. OCT has been established since many years in ophthalmology.
- Trial name
- NCT03753256
- Testing
- Transbond XT, Protecto®CaF2Nano, Pro Seal®
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Heidelberg Medical Center
Gingival Recession
Soft Tissue Augmentation Using Deepithelialized Free Gingival Graft Compared to Connective Tissue Graft in Management of Miller Class I and II Gingival Recession.
The aim of this study will be to clinically assess the soft tissue augmentation achieved by the de-epithelialized free gingival graft with coronally advanced flap versus the subepithelial connective tissue graft with coronally…
- Trial name
- NCT03213483
- Testing
- Coronally advanced flap and subepithelial connective tissue graft, Coronally advanced flap and deepithelialized free gingival graft
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Symptomatic Irreversible Pulpitis (SIP), Dental Pain
Local Dexamethasone Administration in Symptomatic Irreversible Pulpitis
Symptomatic irreversible pulpitis is associated with a high incidence of inadequate pulpal anesthesia during endodontic treatment, particularly in mandibular molar teeth.
- Trial name
- SIPDEX (NCT07672873)
- Testing
- Saline (0.9%, sterile, for infusion), Dexamethasone
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Marmara University
Tooth Demineralization, White Spot Lesion
Comparison of a 3-step Bonding System (Transbond™ XT) and a 2-step System (GC Ortho Connect™) on Demineralization Around Maxillary Orthodontic Brackets
White spot lesions (WSLs) are one of the most common adverse effects of fixed orthodontic treatments, affecting up to 97% of patients treated with labial appliances.
- Conditions
- Tooth Demineralization, White Spot Lesion, Demineralization, Orthodontic Appliance Complication
- Trial name
- ORTHOCOLLAGE (NCT07355322)
- Testing
- Transbond™ XT bonding procedure, GC Ortho Connect™ bonding procedure
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Montpellier
Oral Health, Parkinson Disease
Preliminary Study of the Quality of the Oral Flora in Parkinson's Patients
This is a prospective interventional clinical study whose main objective is to determine the impact of oral hygiene guidance on the oral health status of patients with Parkinson disease
- Trial name
- PARKIDENT (NCT03827551)
- Testing
- Delivery of oral hygiene advices
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Bordeaux
Alveolar Bone Atrophy
Titanium Mesh vs Customized PEEK Mesh for Horizontal Maxillary Ridge Augmentation: A Randomized Clinical Trial
Background: Reconstruction of the deficient maxillary ridge in three dimensions is crucial for the successful placement of implants.
- Trial name
- NCT07002931
- Testing
- Prebent titanium mesh augmentation, Customized PEEK mesh augmentation
- Where
- Egypt
- Volunteers
- 14 people
- Sponsor
- Basma Alsheikh
Temporomandibular Disorders (TMD), Functional Limitation
Functionality and Clinical Correlates in TMD
Temporomandibular disorders (TMD) are among the most common causes of orofacial pain and refer to structural and functional impairments related to the masticatory muscles, surrounding soft tissues, and/or the temporomandibular…
- Conditions
- Temporomandibular Disorders (TMD), Functional Limitation, Pain Severity, Neck Disability
- Trial name
- NCT06937502
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Istinye University
Gingivitis, Periodontal Inflammation
Influence of Probiotics on Clinical Parameters, the Oral Microbiome and the Immune System During an Orthodontic Treatment in Adult Patients
Orthodontic treatment with fixed appliances can be necessary to correct malocclusions in adolescence or adulthood. It its known that orthodontic treatment induces aseptic pseudo-inflammatory reactions.
- Conditions
- Gingivitis, Periodontal Inflammation, Orthodontic Appliance Complication
- Trial name
- NCT04606186
- Testing
- Lactobacillus reuteri Prodentis®-lozenges (DSM 17938, ATCC PTA 5289)
- Where
- Germany
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg
Periodontitis
Impact of Periodontal Therapy on Function and Quality of Life in Stage III Periodontitis
Stage III, Grade B periodontitis is a severe form of gum disease that damages the tissues and bone supporting the teeth. It can cause loose teeth, difficulty chewing, and reduced quality of life.
- Trial name
- NCT07450573
- Testing
- non-surgical periodontal treatment, surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ankara Medipol University
Herpes Labialis
Monoclonal Antibody Therapy Against Chronic Herpes Simplex Virus 1 Infection
This is a phase II, double-blind, randomised, controlled, multicentre trial of topical HDIT101 versus placebo. HSV-1-positive patients with at least 6 orolabial herpes lesions in the last 12 months can be included.
- Trial name
- MATCH-1 (NCT04539483)
- Testing
- HDIT101 (blinded therapy), Photo documentation of orolabial herpes lesions, Completion of questionnaires (patient-reported outcomes)
- Where
- 5 sites in Germany
- Volunteers
- 761 people
- Sponsor
- Heidelberg ImmunoTherapeutics GmbH
Nasopharyngeal Carcinoma, Leucogen
A Multi-center, Randomized, Double-blind, Phase III Clinical Trial of Leucogen Versus Placebo on Leukocyte and Platelet Whole-course Management Assisted by PFLL Chemotherapy in the Treatment of Stage IV, Recurrent or Metastatic NPC
Toxic and side effects during and after chemoradiotherapy for nasopharyngeal carcinoma seriously affect patients' treatment compliance and long-term quality of life.
- Conditions
- Nasopharyngeal Carcinoma, Leucogen, Chemotherapy, Myelosuppression
- Trial name
- NCT05780294
- Testing
- 5-fu, Lobaplatin, leucogen
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Sun Yat-sen University
Molar Incisor Hypomineralization
Zirconia Versus Lithium Di-silicate Overlays for Restoring Hypomineralized Molars Affected With MIH
the study evaluate the clinical outcome of zirconia versus lithium disilicate overlays restorations for restoring vital young permanent first molar teeth affected with moderate form of molar Incisor hypomineralization: randomized…
- Trial name
- NCT05529329
- Testing
- overlay
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Al-Azhar University
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