Clinical trials: Stomatognathic Diseases
Advanced Solid Tumors, Genital Neoplasm, Female
A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors
This is an open label, multicenter, phase 1/2 study to assess the safety/tolerability and preliminary clinical activity of STAR0602 as a single agent and in combination with chemotherapy administered intravenously in participants…
- Conditions
- Advanced Solid Tumors, Genital Neoplasm, Female, Urogenital Neoplasms, Lung Neoplasm
- Trial name
- START-001 (NCT05592626)
- Testing
- STAR0602, Irinotecan (Camptosar), Docetaxel (Taxotere)
- Where
- 19 sites in United States, Canada and 2 more
- Volunteers
- 366 people
- Sponsor
- Marengo Therapeutics, Inc.
Rheumatoid Arthritis, Osteoarthritis
Periodontal Disease and P. Gingivalis in Rheumatoid Arthritis
Periodontitis (PD) has been postulated to be a risk factor for the onset and progression of rheumatoid arthritis (RA). Recent reports suggest that infection with Porphyromonas gingivalis (P.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Periodontal Disease
- Trial name
- NCT01156155
- Testing
- Digital xray of jaw and teeth, Blood draw, questionnaires
- Where
- United States
- Volunteers
- 617 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Root Resorption
A Comparative CT Evaluation of the Amount of Root Resorption in Self-ligating Versus Conventional Brackets
Aim: The aim of the study was to evaluate and compare the extent of root resorption in the maxillary and mandibular anterior teeth during orthodontic treatment with the use of different types of brackets.
- Trial name
- NCT03613285
- Testing
- conventional brackets, smart clip passive self ligating brackets, Empower active self ligating brackets
- Where
- India
- Volunteers
- 21 people
- Sponsor
- Institute of Dental Science and Technologies
Nasopharyngeal Carcinoma
Safety and Efficacy Study of Icotinib With Intensity-modulated Radiotherapy in Nasopharyngeal Carcinoma
Nasopharyngeal carcinoma (NPC) is a prevalent disease in southeast of China. Radiation therapy with or without chemotherapy is a standard therapy for nasopharyngeal cancer.
- Trial name
- NCT01534585
- Testing
- Icotinib, intensity-modulated radiotherapy, Paclitaxel and Cisplatin
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Taizhou Hospital
Myofascial Pain - Dysfunction Syndrome of TMJ
Dry Needling Vs Transcutaneous Electrical Nerve Stimulation in Management of Myofascial Pain Dysfunction Syndrome
Myofascial pain dysfunction syndrome (MPDS) is the most common form of temporomandibular disorders. Because of the multifactorial nature of the problem, its management is still not definite.
- Trial name
- NCT06583915
- Testing
- TENS, Dry Needle
- Volunteers
- 26 people
- Sponsor
- Cairo University
Migraine Disorders
TREXIMA and RELPAX Gastric Scintigraphy Inside and Outside a Migraine
An evaluation of tablet disintegration and absorption and gastric transit of sumatriptan and naproxen sodium from a TREXIMA tablet and eletriptan from a RELPAX 40mg tablet.
- Trial name
- NCT00385008
- Testing
- Combination Product (sumatriptan succinate / naproxen sodium), RELPAX(eletriptan) 40mg Tablet
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- GlaxoSmithKline
Tooth Decay
The Proximal Contact Tightness and Location in Class II Composite Restorations
This study aims to investigate consecutive biological changes in proximal contact tightness using digital force gauge and evaluate proximal contact location using cone beam computed tomography between class II direct composite…
- Trial name
- NCT05749640
- Testing
- Precontoured sectional matrix EZ COAT, PerForm™, AdDent Trimax™
- Where
- Egypt
- Volunteers
- 18 people
- Sponsor
- karim mohamed
Chronic Periodontitis
Effects of Scaling and Root Planing With and Without Er:YAG Laser in Chronic Periodontitis Patients
Dental bacterial plaque is the most frequent modifiable finding in patients with periodontal (gum) diseases. Many studies have provided evidence that mechanical removal of dental plaque is critical for improving the periodontal…
- Trial name
- NCT03003689
- Testing
- Scaling and Root Planing, Er:YAG Laser
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Tufts University School of Dental Medicine
Sialorrhea
Botulinum Toxin-A for Sialorrhoea Treatment in Asian Adults With Neurological Diseases
The efficacy of Botulinum toxin A (BoNT-A) in Asian population has not been properly studied and there is no literature available on the most efficacious dose of BoNT-A for sialorrhoea treatment.
- Trial name
- NCT02425176
- Testing
- Botulinum toxin A (BoNT-A) 50U, Botulinum toxin A (BoNT-A) 100U, Botulinum toxin A (BoNT-A) 200U
- Where
- Malaysia
- Volunteers
- 30 people
- Sponsor
- University of Malaya
Periodontal Diseases
A Randomized, Double-blind, Controlled Study to Evaluate the Safety and Feasibility of a Intraoral Electrotherapy Device
A parallel-armed, sham-controlled, and participant-blind pilot study will be conducted to determine the safety and effectiveness of use of a noninvasive intraoral electrotherapy device to treat periodontal disease.
- Trial name
- NCT04793048
- Testing
- a noninvasive intraoral electrotherapy device
- Volunteers
- 30 people
- Sponsor
- Shanghai Keku Medical Technology Co., Ltd.
Temporomandibular Joint Disorder
Study of Etanercept and Celecoxib to Treat Temporomandibular Disorders (Painful Joint Conditions)
This 2-part study will evaluate the effectiveness and side effects of two anti-inflammatory drugs for relieving pain and improving jaw function in patients with temporomandibular disorder (TMD).
- Trial name
- NCT00001955
- Testing
- Etanercept, Celecoxib
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Class II Malocclusion, Division 1
Pain, Discomfort, and Acceptance During Using Electrical Stimulation to Accelerate Orthodontic Teeth Movement
Forty patients with class II division 1 malocclusion who will require extraction of the upper first premolars as a part of the orthodontic treatment plan will be invited to participate in the study.
- Trial name
- NCT05920525
- Testing
- Electrical stimulation, Traditional retraction of the front upper teeth
- Where
- Syria
- Volunteers
- 40 people
- Sponsor
- Damascus University
Peripheral Facial Paralysis
Lengthening Temporalis Myoplasty and Improvement of Primary Swallowing Disorders in Facial Paralysis
The facial paralysis is a frequent disease causing important functionals swallowing dysfunctions. The purpose of our study was to evaluate the improvement of the swallowing disorders after surgery by lengthening temporalis…
- Trial name
- MATPF (NCT03284125)
- Testing
- Swallowing disorders evaluation
- Where
- France
- Volunteers
- 13 people
- Sponsor
- University Hospital, Tours
Class III Malocclusion
Mandibular Sequential Distalization Versus Class III Elastics With Clear Aligners in Class III Patients
Distalizing mandibular molars may be indicated for patients with minor skeletal Class III discrepancies or in Class III subjects with mild crowding.
- Trial name
- NCT06859606
- Testing
- Lower molar distalization, Class III elastics
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Saint Camillus International University of Health Sciences
Nasopharyngeal Cancers, Lung Cancer (NSCLC)
The Clinical Application Value of CAIX-Targeted PET Hypoxia Imaging in Malignant Tumors
This project involves conducting integrated PET/MR or PET/CT imaging using a CAIX-targeted PET tracer (e.g., [68Ga]Ga-DOTA-CAIX peptide) in clinically diagnosed malignant tumor patients, aiming to achieve the following…
- Conditions
- Nasopharyngeal Cancers, Lung Cancer (NSCLC), Esophageal Cancer, Glioma
- Trial name
- NCT07890038
- Testing
- Specific PET Imaging Agent Targeting CAIX
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Black Staining
Comparison of Erythritol Air-Polishing and Conventional Polishing Following Ultrasonic Scaling on the Relapse of Chromogenic Tooth Staining in Children
The goal of this randomized clinical trial is to compare the effect of erythritol air-polishing and conventional polishing following ultrasonic scaling on the relapse of chromogenic tooth staining in children aged 4-13 years…
- Trial name
- NCT07730658
- Testing
- Guided Biofilm Therapy with erythritol, Conventional Polishing
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Marmara University
Gingival Pocket
Gingival Displacement by Polytetrafluoroethylene & Conventional Retraction Cord
To achieve harmony between restoration and surrounding periodontium, soft tissue management plays a pivotal role. Various Gingival displacement techniques show varying results in achieving the goals of displacement.
- Trial name
- NCT04087226
- Testing
- PTFE Retraction Cord
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Nasopharyngeal Carcinoma
18F-FMISO PET Guided Dose Escalation in Nasopharyngeal Carcinoma - a Feasibility and Planning Study
This study aims to investigate the use of 18F-FMISO PET in identifying hypoxic subvolume for dose escalation radiotherapy in nasopharyngeal cancer and thus improve local control without significant increase in toxicities.
- Trial name
- NCT04995185
- Testing
- (18)F-fluoromisonidazole (FMISO)
- Where
- 2 sites in Singapore
- Volunteers
- 9 people
- Sponsor
- National Cancer Centre, Singapore
Periodontitis, Periodontitis (Stage 3)
Evaluation of Albumin Platelet-Rich Fibrin Following SRP in Patients With Periodontitis
The study aims to investigate whether application of albumin platelet-rich fibrin (Alb-PRF) into the gum pockets after scaling and root planing (SRP) can improve healing in patients with Stage III Grade B periodontitis.
- Trial name
- NCT07363135
- Testing
- Albumin platelet-rich fibrin, Sterile saline (0.9%)
- Where
- Turkey (Türkiye)
- Volunteers
- 23 people
- Sponsor
- Saglik Bilimleri Universitesi
Facial Palsy
Relationship Between Facial Palsy and Psychological Distress
The goal of this observational cross-sectional study is to investigate whether the severity of facial dysfunction is associated with psychological distress in patients with unilateral facial palsy.
- Trial name
- FNP-Psy (NCT07511140)
- Where
- Egypt
- Volunteers
- 85 people
- Sponsor
- Cairo University
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