Clinical trials: Stomatognathic Diseases
Periodontitis
Oral Gel Containing PHTALOX® as an Adjuvant in the Treatment of Periodontal Disease
Periodontitis, a chronic inflammatory condition of the periodontal tissues, impacts not only the patient's oral and systemic health but also has significant social and economic implications.
- Trial name
- NCT06731777
- Testing
- Scaling and root planing plus PHTALOX® oral gel vehicle, Scaling and root planing plus 0.12% chlorhexidine oral gel, Scaling and root planing plus PHTALOX® oral gel
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Universidade Federal de Alfenas
Temporomandibular Joint Disorders
Effects of Platelet-rich Plasma Prolotherapy of Temporomandibular Joint Subluxation
The aim of this study is to clinically assess the efficacy of PRP prolotherapy for treatment of TMJ subluxation
- Trial name
- NCT03655275
- Testing
- PRP prolotherapy, Saline prolotherapy
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Abdelrahman Soliman Alateyh
Lysosomal Storage Disease, Lung Diseases
Biomarker for Maroteaux-Lamy Disease (BioMaroteaux)
Development of a new MS-based biomarker for the early and sensitive diagnosis of Maroteaux-Lamy disease from blood
- Conditions
- Lysosomal Storage Disease, Lung Diseases, Obstructive Sleep Apnoea, Macroglossia
- Trial name
- BioMaroteaux (NCT01458613)
- Where
- 5 sites in Egypt, Germany and 2 more
- Sponsor
- CENTOGENE GmbH Rostock
Carcinogenesis, Oral Cancer
Study on the Carcinogenesis of Gα12 in Oral Cancer, and the Treatment of Oral Cancer Using Ga12 Inhibitor.
Study on the carcinogenesis of Gα12 in oral cancer, and chemopreventive possibility for the treatment of oral cancer using Ga12 inhibitor.
- Trial name
- NCT01919580
- Where
- Taiwan
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Dental Caries, Gingivitis
Domiciliary Professional Oral Care for Dependent Elderly
Today's increase of dentate elderly, many of them dependent, is a challenge, both according to the personal daily oral hygiene and dentistry.
- Trial name
- NCT02669979
- Testing
- Intervention
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Karolinska Institutet
Tooth Loss
Influence of Healing Time on the Outcomes of Alveolar Ridge Preservation in Periodontally Compromised Extraction Sockets
The goal of this clinical trial is to histologically, clinically, and radiographically evaluate the healing sequelae of periodontally compromised extraction sockets grafted with Bio-Oss Collagen® at 3 and 6 months following tooth…
- Trial name
- NCT06654141
- Testing
- Alveolar ridge preservation
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Head and Neck Squamous Cell Carcinoma, Stage IVA Oropharyngeal Carcinoma AJCC v7
Combination Chemotherapy With or Without Veliparib in Treating Patients With Stage IV Head and Neck Cancer
This partially randomized phase I/II trial studies the side effects and best dose of veliparib when given together with combination chemotherapy and to see how well they work in treating patients with stage IV head and neck…
- Conditions
- Head and Neck Squamous Cell Carcinoma, Stage IVA Oropharyngeal Carcinoma AJCC v7, Stage IVB Oropharyngeal Carcinoma AJCC v7
- Trial name
- NCT01711541
- Testing
- Carboplatin, Cisplatin, Fluorouracil
- Where
- 5 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute (NCI)
Xerostomia, Salivary Gland Diseases
Efficacy Study of a Ginger and Cardamom Gelatin for Xerostomy in Terminally Ill Patients
Xerostomia or dry mouth is the subjective feeling that there is not enough saliva in your mouth. It's a frequent symptom in terminally ill patients receiving palliative care, reducing their quality of life and comfort.
- Conditions
- Xerostomia, Salivary Gland Diseases, Mouth Diseases
- Trial name
- NCT01915966
- Testing
- Cardamom, ginger and orange juice gelatin, Camomile infusion with lemon juice
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Fundacio Salut i Envelliment UAB
Peri-Implantitis and Peri-implant Mucositis
The Use of Adjunct Oxygen High-Level Laser Therapy on the Clinical and Microbiological Outcomes of Peri-implant Disease
The goal of this clinical trial is to learn whether using a special light-activated treatment called photodynamic therapy, or more specifically, its modified version called oxygen high-level laser therapy, using a high-powered…
- Trial name
- NCT07287956
- Testing
- Oxygen high-level laser therapy (Diode laser and hydrogen peroxide), Diode laser therapy
- Where
- Jordan
- Volunteers
- 16 people
- Sponsor
- King Abdullah University Hospital
Nasopharyngeal Carcinoma
Nedaplatin Versus Cisplatin in Treatment for Nasopharyngeal Carcinoma
To compare the effectiveness and toxicity of nedaplatin versus cisplatin in induction chemotherapy combined with concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma.
- Trial name
- NCT04437329
- Testing
- Docetaxel, nedaplatin, fluorouracil, Docetaxel, cisplatin, fluorouracil, Nedaplatin
- Where
- China
- Volunteers
- 352 people
- Sponsor
- Affiliated Cancer Hospital & Institute of Guangzhou Medical University
Gingivitis, Oral Health
Frequency of Oral Hygiene
The purpose of this study is to evaluate the frequency of oral hygiene in the maintenance of gingival health in patients with an adequate method of oral hygiene.
- Trial name
- NCT01630837
- Testing
- frequency of oral hygiene
- Where
- Brazil
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Santa Maria
Anesthesia, Local, Intubation, Intratracheal
The Effect of Local Anesthetic Techniques on Hemodynamic Response and Postoperative Sore Throat in Double-Lumen Tubes
This clinical trial aims to determine if different local anesthetic application techniques can reduce postoperative sore throat (POST) and manage hemodynamic responses in adult patients undergoing elective thoracic surgery with…
- Conditions
- Anesthesia, Local, Intubation, Intratracheal, Double-lumen Tube, Sore Throat
- Trial name
- NCT06705595
- Testing
- Tracheo-Spray, Lidocaine Spray on DLT
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- V.K.V. American Hospital, Istanbul
Periodontitis
Effects of Prebiotic Oral Healthcare Products as an Adjunct to Non-surgical Periodontal Therapy
The aim of this study is to determine the impact of a prebiotic toothpaste and mouthrinse in periodontitis patients as an adjunct to scaling and rootplaning.
- Trial name
- NCT02520375
- Testing
- Prebiotic, Control
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Nasopharyngeal Carcinoma (NPC), CTIT-Chemotherapy Induced Thrombocytopenia
A Clinical Study of Hetrombopag for Prevention of Thrombocytopenia Induced by Gemcitabine Plus Cisplatin in the Treatment of Nasopharyngeal Carcinoma
This study is a single-arm, exploratory, self-controlled clinical trial for the prevention of thrombocytopenia induced by gemcitabine plus cisplatin in the treatment of nasopharyngeal carcinoma.
- Trial name
- NCT07252375
- Testing
- herombopag olamine tablets
- Volunteers
- 35 people
- Sponsor
- Fujian Cancer Hospital
Tooth Loss, Bone Graft; Complications
Patient-reported Outcome Measures After Implant Placement With Contour Augmentation Procedure
Maintaining the general health and well-being of patients is the main goal of dental therapy. However, tooth extraction is indicated when teeth cannot be maintained in a status compatible with health, adequate esthetics…
- Conditions
- Tooth Loss, Bone Graft; Complications, Patient Satisfaction, Patient Acceptance of Health Care
- Trial name
- NCT05890170
- Testing
- Patient Reported Outcomes Measures
- Where
- Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Bern
Head and Neck Cancer, Precancerous Condition
Induction Chemotherapy Followed By Cetuximab and Radiation in HPV-Associated Resectable Stage III/IV Oropharynx Cancer
RATIONALE: Drugs used in chemotherapy, such as paclitaxel and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT01084083
- Testing
- cetuximab, intensity-modulated radiation therapy (IMRT), Paclitaxel
- Where
- 121 sites in United States
- Volunteers
- 90 people
- Sponsor
- Eastern Cooperative Oncology Group
Dental Research, Orthodontics
Treatment of the Mandibular Dental Crowding With and Without Corticotomy Surgery
The use of corticotomy surgery in addition to orthodontic standard treatment could accelerate the treatment. Corticotomy involves vertical interdental incisions of the gingiva and the bone with a very low thickness.
- Conditions
- Dental Research, Orthodontics, Surgery, Oral, Maxillofacial Surgery
- Trial name
- CORTICO (NCT03967002)
- Testing
- Test group with corticotomy surgery
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ardentis Cliniques Dentaires
Apical Periodontitis
Association Between Apical Periodontitis and Psoriasis Vulgaris
The aim of the present cross-sectional study is to assess the presence of AP and caries in psoriasis vulgaris individuals and to examine whether these medications influence these oral conditions.
- Trial name
- NCT06436339
- Where
- Italy
- Volunteers
- 152 people
- Sponsor
- University of Siena
Herpes Labialis
Safety Study of ME-609 for Treatment of Herpes Simplex Labialis in Adolescents
The Purpose of this study is to evaluate the safety of ME-609 for the treatment of recurrent herpes labialis in adolescents.
- Trial name
- NCT00375570
- Testing
- ME-609
- Volunteers
- 254 people
- Sponsor
- Medivir
Dental Caries
Early Childhood Caries Prevention at a Pediatric Clinic
This purpose of this study was to evaluate effectiveness of a risk-based dental caries prevention program conducted by dental personnel at an urban pediatric primary care clinic serving largely low-income residents of Baltimore…
- Trial name
- NCT00497029
- Testing
- fluoride varnish, patient education
- Where
- United States
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
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