Clinical trials: Stomatognathic Diseases
Periodontitis, Smoking Habit
Effects of Smoking on Clinical and Microbiological Response in Individuals With Periodontitis
This study aimed to compare the distribution of subgingival periodontal pathogens following non-surgical periodontal therapy in smoking and non-smoking people with periodontitis.
- Conditions
- Periodontitis, Smoking Habit, Subgingival Plaque
- Trial name
- NCT06383455
- Testing
- Non-surgical periodontal therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Trakya University
Cancer
Gene Therapy in Treating Patients With Cancer
RATIONALE: Inserting a gene that has been created in the laboratory into a person's white blood cells may make the body build an immune response to kill cancer cells.
- Trial name
- NCT00004178
- Testing
- therapeutic autologous lymphocytes
- Where
- United States
- Sponsor
- Roger Williams Medical Center
Jaw, Edentulous, Partially
Evaluation of B+ Surface on Early Loading
The trial is designed as a consecutive enrollment prospective one-center study. A minimum of 30 patients will be included in the study.
- Trial name
- NCT03059108
- Testing
- Early Loading, Conventional Loading
- Where
- Spain
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Gingival Recession
A Randomized Controlled Clinical Trial to Evaluate Safety and Effectiveness of CAF + Mucograft® Compared to CAF Alone in Patients With Gingival Recessions
The purpose of this multi-center study is to determine the efficacy and safety of Mucograft® in combination with the coronally advanced flap (CAF) for the treatment of gingival recessions.
- Trial name
- MCT-Recession (NCT00902876)
- Testing
- Mucograft, Coronally advanced flap (CAF)
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- Geistlich Pharma AG
Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Neoplasm in the Lung
Nivolumab and Ipilimumab and Stereotactic Body Radiation Therapy in Treating Patients With Salivary Gland Cancers
This phase I/II trial studies the side effects and how well nivolumab and ipilimumab works when given together with stereotactic body radiation therapy (SBRT) in treating patients with salivary gland cancers.
- Conditions
- Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Neoplasm in the Lung, Salivary Gland Carcinoma, Stage IV Major Salivary Gland Cancer AJCC v8
- Trial name
- NCT03749460
- Testing
- Nivolumab, Ipilimumab, Stereotactic Body Radiation Therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Washington
Palatal Expansion Technique, Posterior Crossbite
Miniscrew-assisted Rapid Palatal Expansion With and Without Corticopuncture
Rapid palatal expansion aims at skeletally correcting the transverse maxillary deficiency by applying forces to separate the mid-palatal suture.
- Conditions
- Palatal Expansion Technique, Posterior Crossbite, Maxillary Hypoplasia, Malocclusion
- Trial name
- NCT05543460
- Testing
- MARPE with Corticopunctures, MARPE
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Alexandria University
Head and Neck Cancers, Oral Mucositis
Comparison of the Effectiveness of Three Different Gargates in Radiotherapy-Associated Oral Mucositis
This study was conducted to compare the effectiveness of thyme honey, saline and sodium bicarbonate solution in the management of oral mucositis in patients with head and neck cancer receiving radiotherapy.
- Trial name
- NCT05648682
- Testing
- Salin, Sodium bicarbonate, Thyme honey
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Saglik Bilimleri Universitesi Gulhane Tip Fakultesi
Behçet Disease, Behcet Syndrome
Erectile Dysfunction in Patients With Non Ocular Behçet's Disease
It was aimed to demonstrate whether erectile dysfunction is affected by BH pathogenesis and whether there is a relationship between erectile dysfunction and BD pathogenesis by assessing both sexual function and retinal…
- Conditions
- Behçet Disease, Behcet Syndrome, Erectile Dysfunction
- Trial name
- NCT04386824
- Testing
- Erectil dysfunction
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Antalya Training and Research Hospital
Metastatic Solid Tumors, Non-small Cell Lung Cancer
Study of INBRX-105 and INBRX-105 With Pembrolizumab in Patients With Solid Tumors Including Head and Neck Cancer
This is a first-in-human, open-label, nonrandomized, four-part trial to determine the safety profile and identify the maximum tolerated dose (MTD) and/or recommended Phase 2 dose (RP2D) of INBRX-105 and INBRX-105 in combination…
- Conditions
- Metastatic Solid Tumors, Non-small Cell Lung Cancer, Melanoma, Head and Neck Squamous Cell Carcinoma
- Trial name
- PDL1x41BB (NCT03809624)
- Testing
- INBRX-105 - PDL1x41BB antibody, Pembrolizumab
- Where
- 23 sites in United States
- Volunteers
- 160 people
- Sponsor
- Inhibrx Biosciences, Inc
Gingivitis
A Clinical Study to Evaluate the Efficacy of a Range of Dental/Denture Products for Improved Oral Health in Partial Denture Wearers
The purpose of this study is to investigate the effectiveness of usage of a range of oral products (toothpaste, mouth rinse, denture cleanser) on the oral health of partial denture wearers compared to existing oral hygiene…
- Trial name
- NCT04290624
- Testing
- Experimental Dentifrice: Stannous Fluoride, COREGA Denture Foaming Cleanser, Mouth rinse: Sodium Fluoride
- Where
- United Kingdom
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- HALEON
Immunity, Measles
The Influence of Probiotics on the Immunologic Response to Vaccinations in Infants
Background: It is well established that the presence of bacteria in the intestine has a profound influence on health. Probiotics, ("beneficial bacteria") have shown ameliorating effects on various infectious diseases.
- Conditions
- Immunity, Measles, Mumps, Rubella
- Trial name
- NCT00645996
- Testing
- Probiotics (L.acidophilus and B.lactis), Cornflor
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Bruxism, Self-management
Impact of Self-Management Strategies in Self-Reported Bruxism
This study aim to evaluate the effects of a 6-week self-management program on pain, muscle stiffness, and temporomandibular joint (TMJ) functions in sedentary individuals aged 18-40 with bruxism.
- Conditions
- Bruxism, Self-management, Pain, Proprioception
- Trial name
- NCT06914388
- Testing
- Self-Management Strategies
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Cyprus International University
Positive Regulation of Oxidative Stress Process
A Clinical Trial to Study the Effect of Lycopene in Patients With Gum Disease and type2 Diabetes Mellitus
This study was performed to assess the efficacy of systemic lycopene (8 mgms Daily for two months) as an adjunct to scaling and root planing in chronic periodontitis patients with type 2 diabetes mellitus.
- Trial name
- "SLSRPD" (NCT02263352)
- Testing
- Lycored soft gels Jagsonpal Pharma, Systemic 8mgms/day, Scaling and root planing
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Space Maintenance, Tooth Loss / Rehabilitation
3D-Printed Versus Band-and-Loop Versus Denovo Space Maintainers in Primary Dentition.
Purpose of the Study When a child loses a "baby" molar early due to a cavity or injury, the surrounding teeth can shift into the empty space. This often blocks the permanent adult tooth from growing in correctly.
- Trial name
- NCT07613658
- Testing
- 3D-Printed Custom Space Maintainer, Conventional Band-and-Loop Space Maintainer, Denovo Chairside Space Maintainer
- Where
- Saudi Arabia
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Murad Alrashidi
Operation Site Inflammation, Pain, Postoperative
Efficacy of Ibuprofen Chronotherapy in Healing After Surgical Extraction of the Mandibular Third Molar
Clinical and preclinical studies have demonstrated encouraging results of non-steroidal anti-inflammatory drug (NSAID) chronotherapy in the management and treatment of inflammatory diseases such as rheumatoid arthritis.
- Conditions
- Operation Site Inflammation, Pain, Postoperative, Teeth, Impacted
- Trial name
- NCT03789058
- Testing
- Ibuprofen 400 mg
- Where
- Jordan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Erythema Migrans
Inflammatory Responses in Solitary and Multiple Erythema Migrans
The investigators will evaluate differences in host immune responses (levels of cytokines and chemokines, representative of innate, Th1, and Th17 immune responses) in acute sera from adult patients with solitary or multiple…
- Trial name
- NCT03980015
- Testing
- antibiotic treatment
- Where
- Slovenia
- Volunteers
- 134 people
- Sponsor
- University Medical Centre Ljubljana
Anal Carcinoma, Bladder Carcinoma
Determining the Biodistribution of an Imaging Tracer (68Ga-FAPi-46) in Patients With Solid Tumors or Hematologic Cancers
This phase I trial is evaluating a new imaging tracer (68Ga-FAPi-46) with positron emission tomography (PET)/computed tomography (CT) to determine where and to which degree the tracer (68Ga-FAPi-46) accumulates in normal and…
- Conditions
- Anal Carcinoma, Bladder Carcinoma, Breast Carcinoma, Cervical Carcinoma
- Trial name
- NCT07118176
- Testing
- Computed Tomography, Fludeoxyglucose F-18, Gallium Ga 68 FAPi-46
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Nasopharyngeal Carcinoma
Induction and Concurrent Chemoradiotherapy With Cetuximab for Patients With Locally Advanced Nasopharyngeal Carcinoma
Standard of care for treatment of nasopharyngeal carcinoma is chemoradiation with concurrent cisplatin. Addition of a second agent, cetuximab, which targets nasopharyngeal carcinoma cells with high EGFR protein expression, may…
- Trial name
- NCT01230476
- Testing
- Cetuximab
- Where
- Malaysia
- Volunteers
- 3 people
- Sponsor
- University of Malaya
Alveolar Process Atrophy
Evaluation of a Combined Ridge Expansion Technique With Simultaneous Dental Implant Placement
Patients with long span, narrow edentulous ridge in the posterior mandible underwent piezotomed ridge splitting and osseodensification with simultaneous implant placement.
- Trial name
- NCT05685576
- Testing
- Piezotomed ridge splitting and osseodensification
- Where
- Egypt
- Volunteers
- 8 people
- Sponsor
- Lydia Nabil
Dental Caries
DPBRN Reasons for Replacement or Repair of Dental Restorations
The purpose of this study was to document the reasons for replacement or repair of defective restorations ("fillings") and to record the restorative material of the failed restoration and the material used in the replacement…
- Trial name
- NCT01201876
- Where
- 7 sites in United States, Denmark
- Volunteers
- 6,368 people, healthy volunteers welcome
- Sponsor
- Dental Practice-Based Research Network
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