Clinical trials: Stomatognathic System
Metastatic Tumor, Advanced Solid Tumor
A Clinical Study of Anti-CD70 UCAR-T in Relapsed or Refractory Solid Tumors
This is a single-center, single-arm ，open-label ，dose escalation and dose extension study. In this study we plan to evaluate the safety and efficacy of CD70-targeting UCAR-T cells in the treatment of CD70-positive refractory or…
- Conditions
- Metastatic Tumor, Advanced Solid Tumor, Renal Cell Carcinoma, Ovarian Cancer
- Trial name
- NCT06383507
- Testing
- CHT101
- Volunteers
- 18 people
- Sponsor
- Zhejiang University
Behcet's Disease, Fibromyalgia
Evaluation of Fibromyalgia With Disease Activity and Clinical Findings in Women With Behçet's Disease
In the literature, the relationship between fibromyalgia and disease activity has been assessed in a few studies without discrimination between women and men.In this study, it was aimed to evaluate the relationship between…
- Trial name
- NCT03543709
- Testing
- fibromyalgia 2013 criteria, Behcet's disease current activity form
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Gingival Inflammation in Diabetic Patients
Herbal Periodontal Patch (THPP) for Gingival Inflammation in Diabetics
Diabetes increases the incidence and severity of periodontal inflammation and disease, and periodontal disease causes an increase in the severity of diabetes by worsening glycemic control and increasing insulin resistance.The…
- Trial name
- NCT00731432
- Testing
- Transmucosal Herbal Periodontal Patch (THPP)
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Izun Pharma Ltd
Aphthous Stomatitis
Hyaluronic Acid in Counteracting Aphthous Stomatitis
Oral mucosal ulcers can determine a real worsening of the quality of life. Conventional therapy usually lasts not less than 2-3 weeks, and carries a high risk of serious side effects; furthermore, ulcers often recur.
- Trial name
- NCT04884464
- Testing
- Hyaluronic acid-based gel, Chlorhexidine Gluconate
- Where
- Italy
- Volunteers
- 49 people
- Sponsor
- University of Urbino "Carlo Bo"
Missing Tooth, Osseointegration Failure of Dental Implant
X-space Implants in Post-extraction Sites.
Several recent systematic reviews have highlighted how the macrodesign of dental implants can influence stress distribution and biomechanical and biological behavior in implants immediately inserted in post-extraction sites.
- Trial name
- NCT04492111
- Testing
- post-extraction dental implant
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Bari
Bruxism, Bruxism, Sleep
Repeated Botulinum Toxin Type A Injections on Intramuscular Fat Accumulation in Individuals With Sleep Bruxism.
This study investigates whether repeated botulinum toxin type A (BoNT-A) injections used to manage sleep bruxism lead to structural changes-specifically intramuscular fat accumulation-in the masseter muscle.
- Conditions
- Bruxism, Bruxism, Sleep, Bruxism, Sleep-Related
- Trial name
- NCT07266064
- Testing
- Botilinum Toxin injection
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Melek Volkan Yazici
Cleft Lip and Palate
Tissue Engineered Constructs for Alveolar Cleft Repair
Description of the research question In children undergoing unilateral alveolar cleft reconstruction, would stem cells carried on collagen scaffold provide bone of a good quality and quantity if compared to autogenous bone…
- Trial name
- NCT03563495
- Testing
- tissue engineered group, autogenous bone graft group
- Volunteers
- 10 people
- Sponsor
- Cairo University
Temporomandibular Disorder, Headache Disorders
Validation of the TMD Pain Screener in a Specialized Headache Center
The purpose of the study is to investigate whether a questionnaire can be used to detect whether patients referred to the Danish Headache Center have a painful temporomandibular disorder (TMD).
- Trial name
- NCT04193111
- Testing
- TMD pain screener
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Head and Neck Neoplasms, Deglutition Disorders
EMST in Patients Undergoing CRT for HNCA
This study is a randomized trial examining the impact of expiratory muscle strength training (EMST) on maintenance of safe and efficient oropharyngeal swallow function in persons with cancer of the head and neck (HNCA) undergoing…
- Trial name
- NCT03916809
- Testing
- EMST
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Wisconsin, Milwaukee
Maxillary Neoplasms
Prevalence of Trismus in Patients With Maxillary Cancer With and Without Radiation Therapy in the Egyptian Population.
This study aims at evaluating the prevalence of trismus among maxillary cancer patients in the Egyptian population and the effect of radiotherapy on the occurrence of trismus.
- Trial name
- NCT05091814
- Testing
- radiotherapy
- Where
- Egypt
- Volunteers
- 360 people
- Sponsor
- Cairo University
Anterior Uveitis (AU), Birdshot Chorioretinitis
Quantification & Classification of Inflammatory Cells in Uveitis Using OCT
The goal of this study is to determine if it's possible to use a high resolution imaging device called optical coherence tomography (OCT) to develop an unbiased, standard method of counting and categorizing the various types of…
- Conditions
- Anterior Uveitis (AU), Birdshot Chorioretinitis, Behcet Disease, Herpes Simplex Virus
- Trial name
- NCT07065747
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Dental Wear, Tooth Wear
Influences of Gingival Cord Retractor in Retention Rate of Non-carious Cervical Lesions Restorations.
The aim of this study is through a randomized clinical trial, double blind, splith-mouth, evaluate the retention rate of restorative protocols of Non-carious cervical lesion.
- Trial name
- NCT02961049
- Testing
- Gingival displacement, Enamel and dentin etched, Selective enamel etched
- Where
- Brazil
- Volunteers
- 55 people
- Sponsor
- Federal University of Uberlandia
Oral Mucositis
Safety and Efficacy of RRx-001 in the Attenuation of Oral Mucositis in Patients Receiving Chemoradiation for the Treatment of Oral Cancers
The purpose of this study is to determine if RRx-001, which is added on to the cisplatin and radiation treatment, reduces the duration or length of severe oral mucositis in patients with head and neck cancers.
- Trial name
- PREVLAR (NCT03515538)
- Testing
- RRx-001, Cisplatin for injection, Radiation Therapy
- Where
- 12 sites in United States
- Volunteers
- 53 people
- Sponsor
- EpicentRx, Inc.
Cleft Lip and Palate
Three Dimensional Facial Growth Analysis
Cleft lip and palate is the most common facial birth defect affecting one in 700 babies, and frequently leads to problems in feeding, breathing, speech and/or hearing, and aesthetic problems often leading to social and…
- Trial name
- NCT03514563
- Testing
- MRI imaging, Optical scan, 3D photography
- Where
- United Kingdom
- Volunteers
- 1 people
- Sponsor
- University of Hull
Teeth Loss, Bone Loss
Maxillary Sinus Elevation With Bio-Oss or Straumann BoneCeramic
The purpose of the study was to test a clinically relevant non-inferiority of Straumann BoneCeramic treatment compared to Bio-Oss treatment 180 to 240 days after sinus grafting procedure.
- Trial name
- NCT00901121
- Testing
- Straumann BoneCeramic, Bio-Oss
- Where
- 8 sites in Italy
- Volunteers
- 48 people
- Sponsor
- Institut Straumann AG
Periodontitis
Metronidazole and Amoxicillin for the Treatment of Type 2 Diabetic Subjects With Periodontitis
Diabetes mellitus (DM) is a widely prevalent disease associated with several major systemic and oral complications, such as periodontitis.
- Trial name
- NCT02135952
- Testing
- SRP, MTZ+AMX
- Where
- Brazil
- Volunteers
- 58 people
- Sponsor
- University of Guarulhos
Sjogren's Syndrome
Assessment of Inflammatory Biomarkers Expressed in a Sjogren's Population: Effect of a Topical Steroid Intervention
The primary purpose of this study is to quantify the change in expression of biomarkers on the ocular surface of Sjogren's Syndrome participants after treatment with Maxidex.
- Trial name
- NCT00631358
- Testing
- Maxidex, No treatment
- Where
- 2 sites in Canada
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Bone Loss, Missing Teeth
The Use of Bio-Oss Collagen for Sinus Augmentation Using the Transcrestal Approach.
To assess vertical bone height gain with Geistlich Bio-Oss Collagen used in conjunction with simultaneous implant installation in transcrestal approach sinus augmentation.
- Trial name
- NCT04581304
- Testing
- Geistlich Bio-Oss® Collagen, Geistlich Bio-Oss® Granules
- Where
- Israel
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Head and Neck Neoplasms, Xerostomia
Evaluation of Treatment Related Toxicity After Radiotherapy for Head and Neck Cancer
Radiotherapy plays an important role in the curative treatment of head and neck cancer. This treatment however is associated with significant acute and late toxicity with xerostomia and dysphagia severely implicating the…
- Conditions
- Head and Neck Neoplasms, Xerostomia, Deglutition Disorders
- Trial name
- NCT01621048
- Where
- Belgium
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Diabetes Mellitus,Type 2, Periodontitis
Effects of a Probiotic on Oral Microbiota and Glycemic Control in Type 2 Diabetics; A Randomized Clinical Trial
The present study evaluated clinically the effects of a probiotic on oral microbiota and glycemic control in T2 diabetic patients with periodontal disease.
- Trial name
- NCT04913909
- Volunteers
- 70 people
- Sponsor
- Istanbul University
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