Clinical trials: Stomatognathic System
Cleft Lip and Palate
Alveolar Cleft Hard- and Soft Tissue Reconstruction With an Autogenous Tooth Derived Particulate Graft
The present study aims at clinical and radiographic evaluation of the safety and efficacy of Bonmaker ATB powder combined with a novel split thickness papilla curtain flap in the treatment of alveolar cleft defects.
- Trial name
- NCT05971914
- Testing
- Autogenous tooth derived particulate graft and a novel split thickness papilla curtain flap
- Where
- Hungary
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Serum HbA1c and Vitamin D, Vitamin B12 Values in Periodontal Diseases
Vitamin D, HbA1c and Vitamin B12 Levels in Patients
Abstract Aim: to compare the serum vitamin D, HbA1c and vitamin B12 levels in patients with gingivitis and four different periodontitis stages diagnosed according to the 2017 Periodontal Disease Classification.
- Trial name
- NCT05745779
- Testing
- HbA1c, Vitamin D, Vitamin B12
- Where
- Turkey (Türkiye)
- Volunteers
- 606 people
- Sponsor
- Hacettepe University
Chronic Periodontitis
Evaluation of Local Doxycycline in Smokers With Chronic Periodontitis
Summary The aim of this study is to evaluate through clinical, microbiological and immunological parameters using PLGA microspheres (lactic-co-glycolic acid polyacid) containing doxycycline in periodontal therapy in smokers with…
- Trial name
- NCT02726646
- Testing
- Doxycycline, Mechanical debridement
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Campinas, Brazil
Hypomineralization Molar Incisor, Hypersensitivity Dentin
Photobiomodulation and New Restorative Material for Teeth With MIH on Control of Hypersensitivity and Longevity
Introduction: Molar incisor hypomineralization (MIH) is a qualitative defect of enamel development that occurs in the mineralization phase. MIH affects one or more permanent molars and, occasionally, permanent incisors.
- Trial name
- NCT06538142
- Testing
- Photobiomodulation + Restoration with Self-cure Composite Resin, Restoration with Self-cure Composite Resin, Photobiomodulation + Restoration with Photopolymerizable Bulk-fill Composite Resin
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Cleft Palate, Hemorrhage
Acid Tranexamic Effectiveness in Reducing the Intraoperative Bleeding in Palatoplasty
Randomized study evaluating the role of tranexamic acid in reducing intraoperative bleeding in palatoplasty.
- Trial name
- NCT02422056
- Testing
- Tranexamic Acid, Saline
- Volunteers
- 66 people
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Inflammatory Arthritis, Scleroderma
Smartphone Mindfulness Meditation for Patients With Rheumatic Diseases
This study will assess the effect of a mindfulness meditation program administered via a smartphone application on health-related quality of life for patients with rheumatic disease.
- Conditions
- Inflammatory Arthritis, Scleroderma, Myositis, Sjogren's Syndrome
- Trial name
- NCT03937856
- Testing
- Calm- Mindfulness Meditation smartphone application
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Johns Hopkins University
Tooth Abnormalities, Tooth Abnormality
Analysis of Tooth Root Number
The aim of this cross-sectional study is to assess the number of roots in permanent teeth. For this reason, researchers will conduct an analysis of CBCT scans.
- Conditions
- Tooth Abnormalities, Tooth Abnormality, Tooth Anatomy, Tooth Development Disorder
- Trial name
- NCT07170956
- Where
- Poland
- Volunteers
- 4,000 people
- Sponsor
- Hospital of the Ministry of Interior, Kielce, Poland
Mucositis
Serum-derived Bovine Immunoglobulin Effect on Mucositis
The purpose of this cancer control clinical research study is to evaluate whether nutritional therapy with Serum-derived bovine immunoglobulin/protein isolate (SBI) might reduce mucositis (a condition caused by cancer treatment…
- Trial name
- NCT04239261
- Testing
- SBI
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- MercyOne Des Moines Medical Center
Congenital Heart Block, Neonatal Lupus
Preventive Approach to Congenital Heart Block With Hydroxychloroquine
Women with antibodies to proteins called SSA/Ro and or SSB/La face a 2% chance of having a child with a life threatening heart condition regardless of whether they have very active lupus, are in remission, or have only vague…
- Conditions
- Congenital Heart Block, Neonatal Lupus, Autoantibody-Associated Heart Block
- Trial name
- PATCH (NCT01379573)
- Testing
- Hydroxychloroquine
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- NYU Langone Health
Healthy, Sicca Syndrome
A Longitudinal, Observational Biomarker Study in Participants With Primary Sjogren's Syndrome
The main objective of the study is to characterize the gene expression in immune and epithelial cells in salivary gland biopsy samples and blood of pSS (primary Sjögren's syndrome) and non-pSS participants including healthy…
- Conditions
- Healthy, Sicca Syndrome, Sjögren's Syndrome
- Trial name
- NCT02422407
- Testing
- Biopsy
- Where
- 4 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Biogen
Gingivitis; Chronic, Smoking
Synbiotic as an Adjunct to Mechanical Treatment of Gingivitis
The aim of this study is to evaluate the efficacy of oral administration of synbiotic tablets on the clinical parameters and the levels of selected inflammatory mediators in gingival crevicular fluid (GCF) in smokers and…
- Trial name
- NCT03455192
- Testing
- Synbiotic Supplement
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Mucositis, Graft-versus-host Disease
Tacrolimus and Mycophenolate Mofetil (MMF) in GVHD Prophylactic Regimen Compared to Tacrolimus and Methotrexate (MTX
A comparative trial where all patients will receive daily doses of tacrolimus (TAC) until day +60 when tapering will begin, in the absence of graft-versus-host disease (GVHD), and discontinued by day +180.
- Trial name
- NCT00360685
- Testing
- Tac+MTX, TAC + MMF
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Encephalitis, Herpes Simplex
Structure of the Herpes Simplex Virus Receptor
This study will examine the structure of the receptor molecule for the herpes simplex virus (HSV) and determine if the receptor's structure is related to susceptibility to infection with the virus.
- Conditions
- Encephalitis, Herpes Simplex, Keratitis, Mouth Disease
- Trial name
- NCT00001648
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Parotid Neoplasms, Facial Paralysis
Post-parotidectomy Facial Paresis: Intraoperative and Postoperative Factors
This is a protocol to govern the prospective trial of facial nerve monitoring in patients undergoing parotidectomy with an eye towards interpreting if the facial nerve monitor provides useful information to operating surgeons and…
- Trial name
- NCT02527226
- Testing
- Facial exercises
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- Mayo Clinic
Bell Palsy
Kabat Rehabilitation Versus Mime Therapy on Facial Disability and Synkinesis in Patients of Bell's Palsy
Bell's palsy, also called idiopathic facial paralysis, is a common cause of unilateral facial paralysis. It is one of the most common neurological disorders of the cranial nerves.
- Trial name
- NCT06029855
- Testing
- Kabat Therapy, Mime Therapy
- Where
- Pakistan
- Volunteers
- 85 people
- Sponsor
- University of Lahore
Deglutition Disorders, Oropharynx Cancer
Physiological Flow of Liquids in Head and Neck Cancer Patients: A Pilot Study
This study is part of a larger grant, for which the overall goal is to collect measurements of liquid flow through the oropharynx (i.e., mouth and throat) during swallowing.
- Trial name
- NCT04112940
- Testing
- Starch-based Thickened Liquids, Xanthan-gum Thickened Liquids
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University Health Network, Toronto
Fibromyalgia, Irritable Bowel Syndrome
Efficacy of Transcranial Magnetic Stimulation (TMS) in Chronic Idiopathic Pain Disorders
Objectives : To investigate the analgesic effects of repeated sessions of unilateral rTMS in patients with chronic pain syndrome due to fibromyalgia, IBS or burning mouth syndrome. Primary outcome will be numerical pain scores.
- Conditions
- Fibromyalgia, Irritable Bowel Syndrome, Burning Mouth Syndrome
- Trial name
- NCT00374673
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hospital Ambroise Paré Paris
Dental Pain and Sensation Disorder, Anesthesia, Local
Impact of Tramadol Addiction On Dental Anesthesia Success
The aim is to investigate and to find a correlation between tramadol addiction misuse among Algerian males and Dental Local Anesthesia success while performing dental care and oral surgeries.
- Conditions
- Dental Pain and Sensation Disorder, Anesthesia, Local, Addiction, Opioid
- Trial name
- NCT05908305
- Testing
- articaine@ (4% 1:100000 epinephrine) dental anesthesia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Algiers
Cleft Lip and Cleft Palate, Cleft Lip Palate
Early Intervention in Infants With Unrepaired Cleft Palate: Language, Palatal Function, and Articulation.
The goal of this clinical trial is to learn if teaching speech skills to infants with cleft palates, prior to palate repair, will help them to develop speech and language skills.
- Conditions
- Cleft Lip and Cleft Palate, Cleft Lip Palate, Cleft Lip and/or Palate, Cleft Palate
- Trial name
- NCT07219901
- Testing
- Early intervention for language, articulation and palatal function skills
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Old Dominion University
Taste, Altered, Xerostomia
An Investigation Into Taste Problems Associated With Xerostomia in Patients With Advanced Cancer
Taste problems and xerostomia (dry mouth) are common among patients with advanced cancer. These symptoms can affect the pleasure of eating and drinking, reduce dietary intake, cause low mood, and a lower quality of life.
- Conditions
- Taste, Altered, Xerostomia, Neoplasms
- Trial name
- NCT06287294
- Where
- Ireland
- Volunteers
- 120 people
- Sponsor
- Our Lady's Hospice and Care Services
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