Clinical trials: Stomatognathic System
Periodontal Diseases, Chronic Periodontitis
Effect of Switching From Cigarette Smoking to the Use of IQOS on Periodontitis Treatment Outcome
The purpose of this study was to demonstrate in patients with generalized chronic periodontitis that switching from cigarette smoking to using IQOS improves the response to periodontal therapy and the overall oral health status…
- Conditions
- Periodontal Diseases, Chronic Periodontitis, Periodontal Pocket, Tooth Mobility
- Trial name
- NCT03364751
- Testing
- IQOS, Cigarette
- Where
- 26 sites in Japan
- Volunteers
- 179 people
- Sponsor
- Philip Morris Products S.A.
Cleft Lip, Unilateral
Comparative Study Between Millard and Tennison Randall Techniques in Complete and Incomplete Cleft Lip Repair.
"the investigators will compare the quantitative and qualitative (functional and aesthetic outcomes) of these two surgical approaches for repair of the unilateral cleft lip using an evaluation protocol developed many years ago by…
- Trial name
- NCT06166238
- Testing
- Millard and Tension Randal Technique
- Volunteers
- 30 people
- Sponsor
- Assiut University
Atherosclerosis Cardiovascular Disease, Atherosclerosis of Artery
Oral Microbiome in Carotid Atherosclerosis
The goal of this observational study, called OMICA (Oral Microbiome in Carotid Atherosclerosis), is to learn how bacteria living in the mouth may influence the development and stability of plaques in the carotid arteries, which…
- Conditions
- Atherosclerosis Cardiovascular Disease, Atherosclerosis of Artery, Carotid Artery Plaque, Periodontitis
- Trial name
- OMICA (NCT07296965)
- Testing
- Sample Collection
- Where
- Hungary
- Volunteers
- 200 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Teeth, Impacted
Bupivacaine in the Treatment of Postoperative Pain of Impacted Third Molar Extraction
The third molars are the teeth that are most frequently included and impacted, extraction is one of the most performed treatments by maxillofacial surgeons in their clinical practice.
- Trial name
- NCT03950700
- Testing
- Bupivacaine-epinephrine, Saline Solution
- Where
- Colombia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- CES University
Cystic Fibrosis
Oral Health Status of Cystic Fibrosis Patients. An Online Survey in Collaboration With the Vaincre la Mucoviscidose Patient Association.
Cystic Fibrosis (CF) is a rare hereditary disease with autosomal recessive transmission, affecting 1 in 4700 births in France. Numerous studies have explored the links between oral health and CF, predominantly focusing on a…
- Trial name
- E-MUCODENT (NCT06356246)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Facial Nerve Injuries, Mandibular Fractures
Safety-zone Approach and Facial Nerve Preservation in Transbuccal-accessed Fixation of Mandibular Fractures
The goal of this study is to investigate the efficacy of a safety-zone that is anatomically landmarked on the face of patients with mandibular fractures that are approached transbuccally (through cheek) on postoperative…
- Conditions
- Facial Nerve Injuries, Mandibular Fractures, Surgical Incision
- Trial name
- NCT07807813
- Testing
- Landmarking Safety-zone
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Delta University for Science and Technology
Behcet's Syndrome, Intestinal Type
Pathogenesis of Intestinal Behcet's Syndrome
There is a direct interaction between food, intestinal flora and the intestinal barrier composed of intestinal epithelial cells and mucosal immunity, whose composition and functional alterations are theorized to be closely…
- Trial name
- NCT06026020
- Testing
- Biological samples collection
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Inferior Alveolar Nerve Injuries, Root Canal Treatment
The Need Of Root Canal Treatment After Coronectomy In Mandibular Third Molars
The study included 24 patients with written and verbal consent Results with close proximity to IAN diagnosed based on radiographs and evaluation on the criteria of Howe, and Poyton were selected and divided into two groups by…
- Conditions
- Inferior Alveolar Nerve Injuries, Root Canal Treatment, Paresthesia, Third Molar
- Trial name
- NCT05744882
- Testing
- coronectony, root canal treatment
- Where
- Pakistan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Altamash Institute of Dental Medicine
Cleft Palate
Comparison of Different Feeding Appliances for Cleft Palate Babies
This study will compare flexible , rigid feeding plates and a special feeding bottle for children with cleft palate.
- Trial name
- NCT06103162
- Testing
- flexible feeding plate
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tanta University
Benign Essential Blepharospasm, Hemifacial Spasm
Effects of DaxibotulinumtoxinA for Blepharospasm and Hemifacial Spasm
The goal of this clinical trial is to test the effects of DaxibotulinumtoxinA-Lanm (Daxxify) in patients with benign essential blepharospasms (BEB) and hemifacial spasms (HFS). The main questions to answer: 1.
- Trial name
- NCT06195241
- Testing
- DaxibotulinumtoxinA
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Montefiore Medical Center
Hemifacial Spasm, Microvascular Decompression
Determination of Target of Adequate Partial Neuromuscular Blockade for Electrophysiologic Monitoring During Microvascular Decompression Surgery
There have been reports of monitoring LSR during MVD surgery helps predicting the clinical outcome of MVD.However, there have been no evidence of which degree of partial neuromuscular blockade should be performed or no…
- Conditions
- Hemifacial Spasm, Microvascular Decompression, Lateral Spread Response Monitoring
- Trial name
- NCT01598961
- Testing
- TOF count-guided partial NMB, T1/Tc guided partial NMB, No NMB
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Samsung Medical Center
Maxillofacial Deformity, Maxillofacial Abnormalities
a Comparative Analysis of Subspinal and Conventional Le Fort I Osteotomy on Nasolabial Soft Tissues
Following surgical operations, patients have aesthetic expectations as well as functional ones. To minimize undesirable aesthetic results after surgery and to increase the effectiveness of the surgery, the surgical method used…
- Conditions
- Maxillofacial Deformity, Maxillofacial Abnormalities, Maxillo-facial Surgery
- Trial name
- NCT07549659
- Testing
- conventional le fort I osteotomy type, subspinal le fort I osteotomy type
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Sialorrhea
Open-Label and Single-Arm Study of MYOBLOC® in the Treatment of Troublesome Sialorrhea in Adults
Multicenter, open-label, outpatient study of the safety and effectiveness of repeated doses of MYOBLOC over a 1-year duration in adult subjects with troublesome sialorrhea.
- Trial name
- OPTIMYST (NCT02610868)
- Testing
- MYOBLOC
- Where
- 35 sites in United States, Belarus and 1 more
- Volunteers
- 187 people
- Sponsor
- Solstice Neurosciences, LLC, a subsidiary of US WorldMeds, LLC
Premature Infants, Pierre Robin Sequence
Comparison of Sucking in Premature Infants and Infants With Pierre Robin Sequence
The NUTROBIN study aims to analyze sucking in two populations of vulnerable children who require intensive and prolonged care, and whose treatment has an impact on the subsequent development of oral function.
- Conditions
- Premature Infants, Pierre Robin Sequence, Feeding Disorder
- Trial name
- NUTROBIN (NCT07604818)
- Testing
- Succiometry
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Hospices Civils de Lyon
Trigeminal Neuralgia
Pregabalin as an add-on Therapy to Carbamazepine in Trigeminal Neuralgia Patients
Trigeminal neuralgia is a very painful condition associated with paroxysmal severe episodes of pain. Carbamazepine has been the first line of drug for Trigeminal Neuralgia.
- Trial name
- NCT06357260
- Testing
- Pregabalin and Carbamazepine, Carbamazepine
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Facial Paralysis
Effects of Mindfulness Meditation on Facial Paralysis Patients
Currently, physicians have several options in addressing the anatomic and physiologic sequela of facial paralysis. However, strategies to address the psychologic and coping ability for patients have not been investigated.
- Trial name
- NCT03622697
- Testing
- Mindfulness Meditation Phone Application
- Where
- 2 sites in United States
- Sponsor
- Johns Hopkins University
Type II Diabetes, Periodontal Disease
Periodontal Treatment Response in Type II Diabetic Patients
Diabetes mellitus affects > 171 million people worldwide, with type II diabetes being the most prevalent, affecting 85-95% of the diabetic population.
- Trial name
- NCT01881074
- Testing
- Triclosan containing toothpaste, Non-triclosan containing toothpaste
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Florida
Molar Incisor Hypomineralization, Asthma in Children
Prevalence of Molar Incisor Hypomineralization Among Children Treated With Asthmatic Drugs Early in Their Lives
The aim of this study is to assess the prevalence of molar incisor hypo mineralization among children who have been treated with asthmatic drugs during the first three years of life.
- Trial name
- NCT04103710
- Where
- Egypt
- Volunteers
- 167 people
- Sponsor
- Cairo University
Acute Rhinitis, Nasal Obstruction
Performance and Safety Assessment of the Mechanical Decongestant Seawater Spray Enriched With Essential Oils From Laboratoires Gilbert in Patient With Acute Rhinitis Associated With Nasal Obstruction
The purpose of this post-market clinical investigation is to assess the performance and the safety of the mechanical decongestant seawater spray enriched with essential oils from Laboratoires Gilbert.
- Conditions
- Acute Rhinitis, Nasal Obstruction, Rhinosinusitis, Rhinopharyngitis
- Trial name
- DEMECA (NCT06580210)
- Where
- 3 sites in France
- Volunteers
- 114 people
- Sponsor
- Laboratoires Gilbert
Human Papilloma Virus, Cervical Cancer
M7824 in Subjects With HPV Associated Malignancies
Background: In the United States, each year there are more than 30,000 cases of human papillomavirus (HPV) associated cancers. Some of these cancers are often incurable and are not improved by standard therapies.
- Conditions
- Human Papilloma Virus, Cervical Cancer, Oropharyngeal Cancer, Anal Cancer
- Trial name
- NCT03427411
- Testing
- M7824
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- National Cancer Institute (NCI)