Clinical trials: Stomatognathic System
Missing Teeth
Zirconium Dioxide Fixed Dental Prosthesis.
The purpose of this clinical trial is to evaluate and compare bridges to replace one or two missing teeth in the mouth. The bridges will be made of two variants of ceramic material.
- Trial name
- NCT06352983
- Testing
- Fixed dental prosthesis
- Where
- 2 sites in Sweden
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Malmö University
Metastatic Solid Tumors, Non-small Cell Lung Cancer
Study of INBRX-105 and INBRX-105 With Pembrolizumab in Patients With Solid Tumors Including Head and Neck Cancer
This is a first-in-human, open-label, nonrandomized, four-part trial to determine the safety profile and identify the maximum tolerated dose (MTD) and/or recommended Phase 2 dose (RP2D) of INBRX-105 and INBRX-105 in combination…
- Conditions
- Metastatic Solid Tumors, Non-small Cell Lung Cancer, Melanoma, Head and Neck Squamous Cell Carcinoma
- Trial name
- PDL1x41BB (NCT03809624)
- Testing
- INBRX-105 - PDL1x41BB antibody, Pembrolizumab
- Where
- 23 sites in United States
- Volunteers
- 160 people
- Sponsor
- Inhibrx Biosciences, Inc
Intestinal Permeability, Gastrointestinal Irritation
The Effects of Probiotics on Intestinal Permeability in Gastrointestinal Cancer Patients in Chemotherapy
The aim of this study is to test the hypothesis that adjuvant administration of probiotics in cancer patients undergoing chemotherapy can reduce a chemo-induced increased intestinal permeability.
- Conditions
- Intestinal Permeability, Gastrointestinal Irritation, Mucositis
- Trial name
- NCT03704727
- Testing
- Probiotic
- Where
- Denmark
- Volunteers
- 5 people
- Sponsor
- University of Copenhagen
Periodontitis Stage III, Periodontitis Stage IV
Blood Glucose Screening in Patients With Advanced Periodontits: the Role of Specialist Periodontal Care in Identifying Hyperglycaemia and Supporting Patient Centered Treatment
Periodontitis is a chronic inflammatory disease and individuals with advanced periodontitis have an increased risk of hyperglycaemia.
- Conditions
- Periodontitis Stage III, Periodontitis Stage IV, Diabetes (DM), Prediabetes
- Trial name
- NCT07426224
- Testing
- Selective screening of blood glucose/HbA1c
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Folktandvården Stockholms län AB
Periodontitis, Diabetes Mellitus
Efficacy of Hydrogen Peroxide Gel on Periodontitis With Diabetes
Periodontitis is a chronic infectious disease characterized by loss of tooth supporting periodontal structures and alveolar bone. In the U.S. and worldwide, periodontitis is the major cause of tooth loss in adults.
- Trial name
- Peroxide gel (NCT05669560)
- Testing
- PerioProtect ™= plastic tray +1.7% hydrogen peroxide
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Oklahoma
Carotid Stenosis, Mild Cognitive Impairment
Dental Carotid Cognitive Study
Periodontal Disease (PD) is present in 60+% of adults >65 years and is associated with tobacco smoking, diabetes, and atherosclerosis that worsen inflammation, comorbidities common in older people with mild to moderate cognitive…
- Conditions
- Carotid Stenosis, Mild Cognitive Impairment, Periodontitis
- Trial name
- NCT03755362
- Testing
- Standard Treatment, Intensive Treatment
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Maryland, Baltimore
Apical Periodontitis, Necrotic Pulps
A Comparative Evaluation of the Degree of Pain and MMP-9 Expression Following Instrumentation of Necrotic Pulps With Apical Periodontitis in One or Two Visits
This randomized clinical trial compares postoperative pain and MMP-9 levels after root canal treatment of necrotic teeth with apical periodontitis, using either single-visit or two-visit instrumentation.
- Conditions
- Apical Periodontitis, Necrotic Pulps, Single Rooted Teeth
- Trial name
- NCT07101003
- Testing
- single visit instrumentation, multiple visit instrumentation
- Volunteers
- 28 people
- Sponsor
- Marwa Hisham Mohamed Salah Eldin
Orthodontic Treatment, Tooth Crowding
Assessment of the Efficacy of the Aerodentis System
The purpose of this study is to evaluate the efficacy of the Aerodentis System for orthodontic tooth movement in an open label, two-arms, non-inferiority clinical study.
- Conditions
- Orthodontic Treatment, Tooth Crowding, Orthodontics
- Trial name
- NCT03421886
- Testing
- Aerodentis system, Invisalign clear aligner system
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Radiotherapy Induced Mucositis, Head and Neck Cancer
A Randomized Placebo-Controlled Trial of Manuka Honey for Oral Mucositis Due to Radiation Therapy for Cancer
The primary hypothesis of this study is that regular topical oral application of Manuka Honey will reduce the severity and duration of oral mucositis in patients who are undergoing mucotoxic radiation therapy for cancer treatment.
- Trial name
- NCT00615420
- Testing
- manuka honey
- Where
- 2 sites in Canada
- Volunteers
- 106 people
- Sponsor
- British Columbia Cancer Agency
Anti-CCP Positive Early Rheumatoid Arthritis
Effect Assessment of Periodontal Prophylaxis on Rheumatoid Arthritis Activity.
The purpose of this study is to assess the impact of an intervention (scaled every 06 months associated with the use of mouthwash with essential oils (toothpaste and Listerine® 2 times / day containing polymer Triclosan (Colgate…
- Trial name
- BHYRRA (NCT01706874)
- Testing
- Periodontal prophylaxis
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Trigeminal Neuralgia, Pain
Clinical Trial of Hyperbaric Oxygen Treatment in Trigeminal Neuralgia Patients
The purpose of this study is to determine whether the hyperbaric oxygen treatment reduces pain and improve the life quality in trigeminal neuralgia patients.
- Trial name
- NCT00866424
- Testing
- Hyperbaric oxygen, Mock hyperbaric chamber
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xijing Hospital
SLE (Systemic Lupus), Systemic Sclerosis
Clinical Study on Targeted CD19 or CD19-BCMA CAR-T Therapy for Autoimmune Diseases
This is an open clinical pharmacological translational Research Study, aiming to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of CD19 or CD19-BCMA CAR-T in patients with active SLE, SSc, AAV…
- Conditions
- SLE (Systemic Lupus), Systemic Sclerosis, ANCA Associated Vasculitis, Idiopathic Inflammatory Myopathies
- Trial name
- NCT06548607
- Testing
- CD19 or CD19-BCMA CAR-T
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Nanjing Bioheng Biotech Co., Ltd.
Lymphoma, Nasopharyngeal Cancer
Applying PET/MR in Oncology - a Prospective Project
Cancer is a global health issue. According to the World Health Organization, Cancer is the second leading cause of death globally, and is responsible for an estimated 9.6 million deaths in 2018.
- Conditions
- Lymphoma, Nasopharyngeal Cancer, Esophageal Cancer, Cervical Cancer
- Trial name
- NCT04158414
- Testing
- PET/MR scan
- Volunteers
- 500 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer
This phase I trial is studying the side effects and best dose of erlotinib hydrochloride when given together with cetuximab and to see how well they work in treating patients with advanced gastrointestinal cancer, head and neck…
- Conditions
- Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum, Advanced Adult Primary Liver Cancer, Carcinoma of the Appendix
- Trial name
- NCT00397384
- Testing
- cetuximab, erlotinib hydrochloride, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- National Cancer Institute (NCI)
Trigeminal Neuralgia
A Study of Patient Reported Outcomes After Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia
The investigators know little about how patients feel following radiosurgery treatment of trigeminal neuralgia. Patient satisfaction may ultimately be one of the most important outcome measures for an individual patient; however…
- Trial name
- NCT01364285
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Stanford University
Facial Paralysis
Microbiologic Findings of Acute Facial Palsy in Children
Objective: Microbiologic etiologies of facial palsy in children were investigated. Study design: Prospective clinical study. Methods: Forty-six children aged 0-16 years with facial palsy comprised the study group.
- Trial name
- NCT01537952
- Volunteers
- 46 people
- Sponsor
- University of Helsinki
Cleft Palate, Jaw Abnormalities
Improving Informed Consent for Cleft Palate Repair
To determine if providing a written document in addition to the standard oral discussion of surgical risks improves risk recall for the parents/guardians of a child seen in consultation for cleft palate surgery, and if this has…
- Conditions
- Cleft Palate, Jaw Abnormalities, Maxillofacial Abnormalities, Mouth Abnormalities
- Trial name
- NCT02595307
- Testing
- Pamphlet
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- IWK Health Centre
Candidiasis, Oral, HIV Infections
A Study of Amphotericin B in the Treatment of Fungal Infections of the Mouth in HIV-Infected Patients Who Have Not Had Success With Fluconazole
To assess response and toxicity in patients with fluconazole-resistant oral candidiasis ( thrush ) when given initial induction with amphotericin B oral suspension.
- Trial name
- NCT00001065
- Testing
- Amphotericin B
- Where
- 32 sites in United States, Puerto Rico and 1 more
- Volunteers
- 70 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Molar, Fourth, Extracting Own Teeth
Effects of the Application of a Hyper-oxygenated Gel After Oral Surgery
The goal of this clinical trial is to evaluate whether the topical application of Novox® Drop on surgical wounds after the extraction of lower third molars can have a clinical advantage.
- Conditions
- Molar, Fourth, Extracting Own Teeth, Edema Face, Pain
- Trial name
- NCT06458478
- Testing
- Hyper-oxygenated gel, glycerin based gel
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- Azienda Ospedaliera di Perugia
Cancer, Mucositis
Effect of Topical Morphine (Mouthwash) on Oral Pain Due to Chemo- and/or Radiotherapy Induced Mucositis
Introduction: Oral pain due to mucosal lesion is quite frequent in oncology, geriatric as well as palliative care settings. The oncology patient is mainly suffering from radio- and/or chemotherapy induced oral mucositis.
- Trial name
- NCT00613743
- Testing
- mouth wash with morphine
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
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