Clinical trials: Stomatognathic System
Pain and Anxiety in Children With MIH
Preemptive Analgesia for Pain and Anxiety Control in Children With MIH
This randomized, triple-blinded clinical trial aims to evaluate the effect of preemptive analgesia using ibuprofen on pain perception and anxiety during restorative treatment of first permanent molars in children diagnosed with…
- Trial name
- NCT07374354
- Testing
- ibuprofen 100mg/ml oral suspension syrup
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- October University for Modern Sciences and Arts
Systemic Lupus Erythematosus, Idiopahic Inflammatory Myopathies
A Study of CD19 UCAR-T Cells in Subjects With Autoimmune Diseases
The purpose of this study is to assess the safety and efficacy of CD19 UCAR-T cell therapy in Subjects with autoimmune diseases.
- Conditions
- Systemic Lupus Erythematosus, Idiopahic Inflammatory Myopathies, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Sjögren's Syndrome
- Trial name
- ET-902-AID01 (NCT07212322)
- Testing
- CD19 UCAR-T cells
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Hemifacial Spasm
Microvascular Decompressive Surgery for Hemifacial Spasm
Review the clinical outcomes of Micro vascular decompression of Hemi facial Spasm. Assess safety and efficacy of Micro vascular decompression. Improve the outcome of these patients and decease rate of recurrence and complications.
- Trial name
- NCT04474977
- Testing
- Microvascular Decompressive Surgery
- Volunteers
- 30 people
- Sponsor
- Assiut University
Primary Sjögren's Syndrome
Safety, Pharmacokinetics and Preliminary Efficacy Study of CFZ533 in Patients With Primary Sjögren's Syndrome
This study did evaluate the safety,tolerability and preliminary therapeutic efficacy of multiple doses of intravenous infusion of CFZ533 monoclonal antibody in patients with primary Sjögren's syndrome(pSS)
- Trial name
- NCT02291029
- Testing
- CFZ533 active - Cohort 1, CFZ533 active - Cohort 2, CFZ533 active -Cohort 3
- Where
- 9 sites in United States, Germany and 3 more
- Volunteers
- 69 people
- Sponsor
- Novartis Pharmaceuticals
Sjogren's Syndrome
A Prospective Pilot Study to Explore Efficacy and Safety of Baricitinib in Active Primary Sjogren's Syndrome Patients
Primary Sjogren's syndrome (pSS) is a systemic autoimmune disease characterized by dysfunction of the exocrine glands, which results in sicca symptoms in affected patients.
- Trial name
- NCT04916756
- Testing
- Baricitinib 2 MG
- Where
- China
- Volunteers
- 11 people
- Sponsor
- Peking Union Medical College Hospital
Dental Caries
Investigation of Glass Carbomer Performance
The aim of this in vivo study was to evaluate the clinical 1 year follow-up of silica and flouroapatite reinforced glass carbomer filling material.
- Trial name
- NCT04127929
- Testing
- Restoration of cavities using glass carbomer material (GCP Dental), Restoration of cavities using nanocomposite resin (Tokuyama Estelite Posterior)
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Okan University
Blepharospasm, Hemifacial Spasm
Testing the Effect of Zinc Supplementation to Improve the Treatment Effect of Botulinum Toxin for Oculofacial Spasm
The purpose of this study is to determine whether zinc supplements are effective in enhancing the treatment of oculofacial spasm disorders with botulinum toxin.
- Trial name
- NCT01546805
- Testing
- Zinc Supplement, Sugar pill
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Gastroesophageal Reflux Disease, Severity
Association Between Gastroesophageal Reflux Disease (GERD) Severity and Dental Caries
This study aimed to assess the relationship between gastroesophageal reflux disease (GERD) severity (based on upper gastrointestinal endoscopy) and dental caries severity.
- Conditions
- Gastroesophageal Reflux Disease, Severity, Dental Caries
- Trial name
- NCT07108751
- Testing
- Endoscopy
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tanta University
Molar Hypomineralization, Incisor
Comparison of the Long-Term Success of Different CAD-CAM Blocks Used as Indirect Restorations in Molar Incisor Hypomineralized Teeth: A Split Mouth Study
This study is about the long-term survival success of different, externally prepared fillings (Indirect restoration, CAD-CAM blocks) used in teeth with reduced mineral structure, namely Molar Incisor Hypomineralization (MIH)…
- Trial name
- NCT07144605
- Testing
- CAD-CAM, indirect restorations
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Sjogren Syndrome
Intra-Nasal Mechanical Stimulation (INMEST) as a Potential Treatment Method for Sjogren's Syndrome (SS)
The purpose of the study is to investigate the effect and safety of the Walther System delivering INMEST (intranasal mechanical stimulation) on people with Sjogren\'s syndrome.
- Trial name
- A-SS-001 (NCT06626477)
- Testing
- Intra nasal mechanical stimulation treatment (INMEST)
- Where
- Sweden
- Volunteers
- 26 people
- Sponsor
- Abilion Medical Systems AB
Dentine Hypersensitivity, Dental Pain
Dose Response of a Tubule Occlusion Agent
To evaluate the efficacy of two different concentrations of a tubule occlusion agent - calcium sodium phosphosilicate in treatment of dentine hypersensitivity
- Trial name
- NCT01075256
- Testing
- 5% calcium sodium phosphosilicate toothpaste, 7.5% calcium sodium phosphosilicate toothpaste
- Where
- United States
- Volunteers
- 195 people
- Sponsor
- GlaxoSmithKline
Sjogren's Syndrome
EVADRY® in the Treatment of Xerostomia in Sjögren's Syndrome
Xerostomia is a common and very bothersome manifestation that impairs the quality of life in Sjogren's syndrome. Symptomatic therapeutic alternatives for this syndrome are limited in Tunisia.
- Trial name
- DRYLESS (NCT06313905)
- Testing
- EVADRY
- Volunteers
- 180 people
- Sponsor
- University Tunis El Manar
Polio, Measles
the Five-year Antibody Persistence After Immunization With IPV, MMR and HepA-L Vaccines
This study evaluated the antibody persistence of Chinese children five years after they received four doses of sIPV, two doses of MMR vaccine and one dose of HepA-L vaccine.
- Conditions
- Polio, Measles, Rubella, Mumps
- Trial name
- NCT07338851
- Where
- 6 sites in China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- China National Biotec Group Company Limited
Sjogren's Syndrome
A Study of Nipocalimab in Adults With Primary Sjogren's Syndrome (pSS)
The purpose of this study is to evaluate the efficacy and safety of nipocalimab in participants with primary Sjogren's syndrome (pSS) versus placebo.
- Trial name
- NCT04968912
- Testing
- Nipocalimab, Standard of Care Treatment
- Where
- 69 sites in United States, France and 8 more
- Volunteers
- 163 people
- Sponsor
- Janssen Research & Development, LLC
Cleft Lip
Silicone Gel in the Treatment of Cleft Lip Scars
Cleft lip / palate is the most common craniofacial anomaly in humans. Lip repair is one of the most important reconstructions for these patients, and is performed at around 3 months of age.
- Trial name
- NCT03314090
- Testing
- Silicone Gels
- Where
- Taiwan
- Volunteers
- 33 people
- Sponsor
- Chang Gung Memorial Hospital
Maxillary Deficiency
Maxillary Expansion: Leaf Expander Versus Hyrax Expander
The aim of the current study was to evaluate maxillary and mandibular arch widths' response to five different appliances and clinical protocols (Rapid maxillary expander RME, Leaf Expander 450g, Leaf Expander 900g, Self-expander…
- Trial name
- LEAF (NCT05135962)
- Testing
- orthodontic - rapid maxillary expansion, orthodontic - slow maxillary expansion with leaf expander, orthodontic - slow maxillary expansion with self leaf expander
- Volunteers
- 200 people
- Sponsor
- University of Genova
Nasopharyngeal Carcinoma (NPC)
Validation of the 9th AJCC Staging System for NPC in Non-High-Incidence Areas in China
Background: Nasopharyngeal carcinoma (NPC) is a malignancy with marked geographic variation, with over 80% of global cases found in Southeast and East Asia.
- Trial name
- NCT07088861
- Volunteers
- 1,401 people
- Sponsor
- Lirong Wu
Periodontal Pocket
Comparative Evaluation of Bromelain-Quercetin Gel With Chlorhexidine Gel as Subgingival Local Drug Delivery Following Scaling and Root Planing In Stage I /II and Grade B Periodontitis - Randomized Control Clinical Trail
Comparative Evaluation of Bromelain-Quercetin Gel With Chlorhexidine Gel as Subgingival Local Drug Delivery Following Scaling and Root Planing In Stage I /II and Grade B Periodontitis - Randomized Control Clinical Trail
- Trial name
- NCT06775392
- Testing
- bromelain-quercetin gel, chlorhexidine gel, SRP
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Diabetes, Periodontitis
Hyperbaric Oxygen Therapy as Adjunctive Therapy to Scaling and Root-planing in the Management of Periodontitis in Patients With Type 2 Diabetes
Diabetes and Periodontitis are both prevalent diseases affecting millions of Americans. Periodontitis is prevalent among Diabetics.
- Trial name
- NCT02671136
- Testing
- Hyperbaric Oxygen therapy, Conventional Wound Therapies
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Loma Linda University
Sjogren's Syndrome, Digestive System Abnormalities
Evaluation of the Prevalence of Functional Digestive Disorders During Primary Sjögren Gougerot Syndrome
the investigators propose to carry out a prospective study consisting of a systematic research of digestive symptoms in patients with SGSp with the validated Global symptom score (GSS) questionnaire, which allowed to grades…
- Trial name
- GASTRO-SGS (NCT03157011)
- Testing
- Global symptom score (GSS) questionary
- Where
- France
- Volunteers
- 151 people
- Sponsor
- University Hospital, Limoges