Clinical trials: Stomatognathic System
Sjogren's Syndrome, Dry Eye
Nasal Spray Study in Sjogren's Dry Eye Disease
This study will investigate how well OC-01 (varenicline) nasal spray can treat the signs and symptoms of dry eye disease in those Sjogren's Syndrome.
- Trial name
- NCT05700422
- Testing
- Varenicline Nasal Spray
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Pennsylvania
Cleft Lip and Palate, Periodontal Pocket
Periodontal Changes Following Mid Maxillary Distraction
To evaluate the health status of the periodontium and dentition at the distraction osteogenesis site in CLP subjects using mid maxillary distraction (MMD).
- Conditions
- Cleft Lip and Palate, Periodontal Pocket, Attachment Loss, Periodontal
- Trial name
- NCT03686761
- Testing
- A Involvement with the osteotomy site of the surgery
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alexandria
Trigeminal Neuralgia
Comparison of Oxcarbazepine Versus Carbamazepine in the Management of Trigeminal Neuralgia
Trigeminal neuralgia is a debilitating neurological condition, affecting quality of life in most affected patients. Carbamazepine has traditionally been used for the management of this condition, but it has a moderate…
- Trial name
- NCT06849219
- Testing
- Oxcarbazepine, Carbamazepine
- Where
- Pakistan
- Volunteers
- 122 people
- Sponsor
- Jinnah Postgraduate Medical Centre
Dry Eye Syndromes, Sjögren Syndrome
Comparison Between Rebamipide 2% Versus Autologous Serum
Two-period, controlled, randomized and open clinical trial. The sample was composed of adult women with moderate to severe hypo secretory dry eye associated with Sjögren's syndrome, who attended the ocular surface office, derived…
- Trial name
- NCT03608761
- Testing
- Rebamipide, autologous serum, autologous serum and rebamipide 2%
- Where
- Argentina
- Volunteers
- 21 people
- Sponsor
- Hospital Nacional Profesor Alejandro Posadas
Periapical Diseases, Root Canal Infection
Comparing Efficacy of a Stainless-steel Rotary File with Two Nickel-titanium Systems on Periapical Lesion Healing
Background: This study used cone-beam computed tomography (CBCT) to compare a stainless-steel Tornado file system with OneShape and WaveOne rotary systems for biomechanical canal preparation as indicated by the healing of…
- Trial name
- NCT06752837
- Testing
- Tornado rotary system, WaveOne rotary system, OneShape rotary system
- Where
- 2 sites in Lebanon
- Volunteers
- 60 people
- Sponsor
- Beirut Arab University
Malocclusion, Abnormalities, Jaw
Personalized Titanium Plates vs CAD/CAM Surgical Splints in Maxillary Repositioning of Orthognathic Surgery
The purpose of this study is to determine whether personalized titanium plates can achieve better accuracy than CAD/CAM surgical splint in maxilla repositioning in orthognathic surgery, and evaluate the feasibility of this…
- Trial name
- NCT02914431
- Testing
- 3D Printing Personalized Titanium Plate
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Candidiasis, Oral, HIV Infections
A Study of Amphotericin B in the Treatment of Fungal Infections of the Mouth in HIV-Infected Patients Who Have Not Had Success With Fluconazole
To assess response and toxicity in patients with fluconazole-resistant oral candidiasis ( thrush ) when given initial induction with amphotericin B oral suspension.
- Trial name
- NCT00001065
- Testing
- Amphotericin B
- Where
- 32 sites in United States, Puerto Rico and 1 more
- Volunteers
- 70 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Allergic Rhinitis, Geographic Tongue
The Relationship Between Allergic Rhinitis and Geographic Tongue
Allergic rhinitis is a complex chronic inflammatory disease, it always presents with nasal obstruction, nasal itching, sneezing and runny nose. Whether in adults or children, rhinitis is a complex disease.
- Trial name
- AR-GT (NCT01454492)
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Bell's Palsy
Prednisone and Acupuncture for the Treatment of Facial Neuritis: a Multiple Center, CER in China
The aim of this study is to compare the effects of prednisolone and staging acupuncture in the recovery of the affected facial nerve, and to verify that whether in combination with staging acupuncture is more effective than…
- Trial name
- NCT01201642
- Testing
- Prednisolone, acupuncture, other treatment
- Where
- China
- Volunteers
- 1,800 people
- Sponsor
- Xijing Hospital
Sjogren's Syndrome
Etanercept Therapy for Sjogren's Syndrome
This study will test the effectiveness of etanercept (Enbrel) for treating Sjogren's syndrome-an autoimmune disease that affects the secreting glands.
- Trial name
- NCT00001954
- Testing
- Etanercept
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Dental Caries, Teeth Loss
Impact of the Radiographic Examination on Diagnosis and Treatment Decision of Caries Lesions in Primary Teeth
Radiographs have been used to aid dentists in detecting the presence of cavities in the deciduous teeth of children. This procedure is globally recommended because the conventional clinical examination usually overlooks some…
- Conditions
- Dental Caries, Teeth Loss, Quality of Life
- Trial name
- CARDEC-1 (NCT02078453)
- Testing
- Dental treatment
- Where
- Brazil
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Oral Mucositis
RRx-001 for Reducing Oral Mucositis in Patients Receiving Chemotherapy and Radiation for Head and Neck Cancer
The purpose of this study is to determine if RRx-001, which is added on to the cisplatin and radiation treatment, reduces the incidence of severe oral mucositis in patients with head and neck cancers.
- Trial name
- KEVLARx (NCT05966194)
- Testing
- RRx-001, Intensity Modulated Radiation Therapy (IMRT), Cisplatin for injection 100 mg/m2
- Where
- 14 sites in United States
- Volunteers
- 216 people
- Sponsor
- EpicentRx, Inc.
Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma
Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Cancer
This study will examine the combination of pembrolizumab and tadalafil for safety and efficacy in advanced head and neck cancer.
- Conditions
- Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma, Head and Neck Carcinoma, Head and Neck Cancer Stage III
- Trial name
- NCT03993353
- Testing
- Pembrolizumab, Tadalafil
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of California, San Diego
Trigeminal Neuralgia
Research Study to Test Safety and Effectiveness of Investigational Drug in Patients With Trigeminal Neuralgia
This research study will look at the safety (e.g., the occurrence of side effects) and efficacy (how well the drug works in reducing trigeminal neuralgia attacks) of a drug called lamotrigine in adults with trigeminal neuralgia.
- Trial name
- NCT00203229
- Testing
- lamotrigine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Thomas Jefferson University
Peripheral Facial Paralysis, Quality of Life
Validation of a French-language Version of Quality of Life Questionnaires in Patients With Peripheral Facial Palsy
Facial palsy is a serious and disabling disease whose drudgery and sensation are probably underestimated. Psychological, social and economic issues have major impacts although vital prognosis is not engaged in this pathology.
- Trial name
- PFQDV (NCT03581253)
- Testing
- Facial disability Index" (FDi), "Facial Clinimetric Evaluation" (FaCE)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Myofacial Pain Syndrome
The Effect of Low Level Laser Therapy (LLLT) in Myofacial Pain Syndrome
Temporomandibular disorders (TMDs) are the major cause of non-dental pain in orofacial area. Laser therapy can be considered as one of the most recent treatment approaches in the field of physiotherapy.
- Trial name
- NCT01417637
- Testing
- Low level laser therapy
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Mashhad University of Medical Sciences
Bilateral Complete Cleft Lip And/or Alveolus and Acrylic Splint, and, Maxillary Deficiency
Evaluating the Impact of Prefabricated Acrylic Splints on Premaxillary Stability in Alveolar Cleft Bone Graft Repairs: a Randomized Controlled Trial
Rationale for conducting the research: Bilateral alveolar clefts pose significant management challenges, with current treatments like autogenous bone grafting showing instability in up to 40% of cases within a year, risking graft…
- Conditions
- Bilateral Complete Cleft Lip And/or Alveolus and Acrylic Splint, and, Maxillary Deficiency, Stability
- Trial name
- RCT (NCT06807645)
- Testing
- Clinical Trial Intervention Description General Study Setup Objective: To compare the efficacy of using a custom-made prefabricated acrylic splint versus no splint in maintaining premaxillary stabilit
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Velopharyngeal Insufficiency
Effect of Velopharyngeal Gap Size on Laryngeal Morphology and Vocal Function in Children With VPI
Speech production relies on the precise coordination of the respiratory, phonatory, resonatory, and articulatory systems . The velopharyngeal mechanism is essential in separating the oral and nasal cavities during speech and…
- Trial name
- NCT07832812
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Assiut University
Diabetes Mellitus, Type 2, Pre-diabetes
Regular Use of aPDT in the Management and Prevention of Periodontitis Symptoms in Diabetic Patients
This is an investigator-initiated clinical study to establish easy referral and access for diabetic patients from primary health care to oral health care facilities for preventive oral care, periodontal assessment, and treatment…
- Conditions
- Diabetes Mellitus, Type 2, Pre-diabetes, Periodontal Diseases, Periodontitis
- Trial name
- APDT-T2D (NCT06486012)
- Testing
- Lumoral Treatment, Standard oral hygiene
- Where
- Finland
- Volunteers
- 150 people
- Sponsor
- Wellbeing Services County of Pirkanmaa
Missing Tooth/Teeth
S-TiUltra Implant Study
This prospective clinical study will compare early healing and implant stability between two Nobel Biocare dental implant systems, NobelReplace S-TiUltra and NobelReplace CC TiUnite.
- Trial name
- NCT07911319
- Testing
- NobelReplace S-TiUltra, NobelReplace TiUnite
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Maryland, Baltimore
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