Clinical trials: Strabismus, open to volunteers
Strabismus, Nystagmus, Congenital
Genetic Studies of Strabismus, Nystagmus, and Associated Disorders
Strabismus (misalignment of the eyes) often runs in families. In this study, the investigators are looking for genetic variants associated with strabismus and nystagmus.
- Trial name
- NCT04770519
- Testing
- whole genome sequencing or whole exome sequencing
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Boston Children's Hospital
Exotropia Equal or More Than 50 Prism Diopter
A Comparative Study Between Three Surgical Techniques in Large Angle Exotropia
This is a randomized comparative interventional study that aims to compare the surgical outcomes of correcting large angle exotropia (≥50 prism diopter) by three different surgical techniques including: 1/ bilateral lateral…
- Trial name
- NCT07143032
- Testing
- Extropia squint surgery
- Volunteers
- 60 people
- Sponsor
- Sohag University
Strabismic Deviation, Strabismus
Botulinum Toxin for Strabismus Treatment
The bacterial species Clostridium botulinum produces a class of neurotoxins known as botulinum toxin. At the neuromuscular junction, botulinum toxin A prevents acetylcholine from being released.
- Trial name
- Botox Squint (NCT07180394)
- Testing
- Botox injection into extraocular muscles
- Where
- Pakistan
- Volunteers
- 127 people
- Sponsor
- Foundation University Islamabad
Exercise Training, Intermittent Exotropia
Exercise Training on a Mirror for Intermittent Exotropia Control Post Strabismus Surgery
The study aims to explore the impact of mirror therapy on exodeviation control, near and far strabismus angles, and quality of life in intermittent exotropia control post strabismus surgery, as well as its effects on near and far…
- Conditions
- Exercise Training, Intermittent Exotropia, Strabismus
- Trial name
- NCT06762067
- Testing
- mirror therapy, traditional therapy
- Volunteers
- 40 people
- Sponsor
- Cairo University
Presbyopia, Esotropia
Accommodation-Related Visual Training Combined with Transcranial Electrical Stimulation Versus Visual Training Alone for the Treatment of Accommodation Dysfunction
This is a single-center, randomized controlled trial to compare the effectiveness of transcranial electrical stimulation combined with visual training with visual training alone for the treatment of accommodation disorder…
- Trial name
- NCT06714890
- Testing
- Transcranial Electrical Stimulation, Visual Training
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Esotropia
Vision Therapy Versus Prism Treatment in Small-angle Acute Acquired Concomitant Esotropia
This prospective, single-center, nonrandomized comparative study evaluates 6-month ocular alignment and binocular visual function outcomes following combined accommodation and fusional training or prism correction in patients…
- Trial name
- NCT06622044
- Testing
- Vision therapy group, Prism
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Eye & ENT Hospital of Fudan University
Strabismus Surgery
Efficacy of Oxalidine and Sufentanil in Strabismus Correction
The purpose of this study is to compare the anesthetic effect of oxalidine and sufentanil in strabismus surgery through a non inferiority test, including analgesic efficacy, intraoperative hemodynamic stability, postoperative…
- Trial name
- strabismus (NCT07112157)
- Testing
- Oliceridine, Sulfentanil
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Henan Provincial People's Hospital
Ocular Motility Disorders, Strabismus
Clinical Validation of AI-Based Quantitative Eye Movement Analysis From Smartphone 9-Gaze Videos (Glandy EOM)
This prospective, multicenter, multinational observational study evaluates the clinical validity of an AI-based quantitative eye movement analysis system (Glandy EOM) that analyzes smartphone-recorded 9-gaze videos.
- Conditions
- Ocular Motility Disorders, Strabismus, Extraocular Muscle Dysfunction, Thyroid Eye Disease
- Trial name
- GLANDY-EOM-VAL (NCT07623837)
- Testing
- Glandy EOM (AI-based quantitative eye movement analysis software)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- THYROSCOPE INC.
Squint Anaesthesia
Comparative Study Between Using Combined Propofol Sedation With subTenon's Infusion as Local Anaesthsia to the Eye Versus General Anesthesia for Strabismus Surgery in Adults
in this study investigators compare two type of anesthetic technique for squint surgery in adult patient first is general anesthesia versus local anesthesia using subtenon injection of local anesthetic.
- Trial name
- squint anaesth (NCT07504354)
- Testing
- sedation with subtenon injection of local anesthetic, General Anesthesia (control group)
- Volunteers
- 60 people
- Sponsor
- Sohag University
Amblyopia
Establishing New Treatment Approaches for Amblyopia: Perceptual Learning and Video Games
Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast.
- Trial name
- NCT05522972
- Testing
- Video Game Vision Training, Perceptual Learning, Occlusion Therapy
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Exotropia, Exophoria
A-eyedrops on Ocular Alignment and Binocular Vision
Atropine is a non-selective muscarinic acetylcholine (M) receptor antagonist that paralyzes the ciliary muscle, dilates the pupil, and reduces the power of accommodation.
- Conditions
- Exotropia, Exophoria, Myopia
- Trial name
- NCT05379855
- Testing
- 0.01% atropine eye drops, 0.05% atropine eye drops
- Where
- China
- Volunteers
- 339 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Myopia, Strabismus
Evaluation of a County-Based Eye Health Service Model in Rural Chinese Children
This project proposes to conduct a prospective, multicenter registry study in rural China to evaluate, under real-world conditions, the implementation effectiveness of an integrated child eye health service model centered at the…
- Conditions
- Myopia, Strabismus, Eye Health
- Trial name
- NCT07547748
- Testing
- School-based Eye Health Screening
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Intermittent Strabismus, Exotropia Intermittent
Visual Therapy for Intermittent Strabismus
Intermittent strabismus is a condition in which the eyes occasionally become misaligned, affecting binocular vision, depth perception, and quality of life.
- Conditions
- Intermittent Strabismus, Exotropia Intermittent, Esotropia Intermittent
- Trial name
- ViT(I)S (NCT07563959)
- Testing
- Visual Therapy
- Volunteers
- 30 people
- Sponsor
- Universitat Politècnica de Catalunya
Anisometropic Amblyopia, Strabismic Amblyopia
3D Movie Viewing vs Occlusion for Treating Amblyopia in Children
Amblyopia is a common childhood visual disorder that affects vision in one eye and can also impair depth perception (stereopsis).
- Trial name
- VISTA3D (NCT07563946)
- Testing
- 3D Movie Viewing, Occlusion Therapy
- Volunteers
- 56 people
- Sponsor
- Universitat Politècnica de Catalunya
Macular Holes, Epiretinal Membrane
Intraoperative OCT Guidance of Intraocular Surgery II
The overall five-year goals of the project are to develop novel technology to provide actionable new information through provision of live volumetric imaging during surgery, improving surgical practice and outcomes.
- Conditions
- Macular Holes, Epiretinal Membrane, Diabetic Retinopathy, Retinal Detachment
- Trial name
- MIOCT (NCT03713268)
- Testing
- Microscope integrated optical coherence tomography
- Where
- United States
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Duke University
Exotropia
Comparative Study of Muscle Transplantation Versus Y Splitting Recession Technique in Treatment of Large Angle Exotropia
This study is designed to correct large-angle exotropia by monocular surgery. It compares two augmented recession techniques, which are recession with muscle transplantation and recession with Y splitting.
- Trial name
- NCT07350330
- Testing
- muscle transplantation, Y splitting
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Esotropia
A Randomized Trial of Botulinum Toxin A vs Strabismus Surgery for Esotropia >10 to ≤30PD
Childhood esotropia (ET) is a common cause of visual disability, and its early management is critical for optimal visual and developmental outcomes.
- Trial name
- ETS4 (NCT07470164)
- Testing
- Botulinum toxin A, bilateral medial rectus recession
- Volunteers
- 244 people
- Sponsor
- Jaeb Center for Health Research
Ametropia, Myopia; Refractive Error
The Objective of This Study is to Evaluate the Perfomance of a Photorefraction Device for Screening Ametropia in Children. Eligible Participants Will Undergo Multiple Refractive Error Measurements, Visual Acuity and Strabismus Assessments During a Single Evaluation Visit.
The goal of this clinical trial is to evaluate the performance of a photorefraction screener in terms of sensibility, sensitivity and accuracy on children aged 3 to 8 y.o.
- Conditions
- Ametropia, Myopia; Refractive Error, Myopia; Astigmatism
- Trial name
- NCT06882408
- Testing
- Photorefraction device under investigation, Comparator device, Tabletop auto-refractometer, Comparator device, portable photorefraction device
- Where
- 2 sites in France
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Essilor International
Amblyopia, Strabismus
VISION-3D: Visual Skills Improvement With On-screen 3D Movies.
This clinical study investigates whether watching 3D films can help improve the vision of children with residual amblyopia (lazy eye), that is, those children who, despite having undergone usual treatments such as glasses or…
- Trial name
- VISION3D (NCT07301645)
- Testing
- Stereoscopic (3D) Movie Viewing, 2D Movie Viewing
- Volunteers
- 40 people
- Sponsor
- Universitat Politècnica de Catalunya
Strabismus Surgery
Refractive and Topographic Changes After Strabismus Surgery
Strabismus, characterized by a misalignment of the eyes, is a common condition that can result in functional and cosmetic issues, often affecting vision and binocular coordination.
- Trial name
- NCT06929130
- Volunteers
- 60 people
- Sponsor
- Assiut University