Clinical trials: Strain
Recurrent Vulvovaginal Candidiasis
Effect of a Lactobacillus Strain on the Prevention of Recurrent Vaginal Candidiasis
The objective of this study is to evaluate the efficacy of the consumption of the one probiotic strain in the prevention of new vaginal candidiasis events in women with recurrent vaginal candidiasis.
- Trial name
- NCT04639544
- Testing
- Lactobacillus strain
- Where
- Spain
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Biosearch S.A.
Poliomyelitis, Polio
A Multi-center, Open-labelled, Randomized, Controlled, Extended Phase Ⅲ Clinical Trial of sIPV Vaccine
This study is designed to study the immunogenicity and safety of sIPV co-administered with other routine infant vaccines. According to the national immunization schedule of Bangladesh and Pakistan, sIPV was administered…
- Trial name
- NCT05850364
- Testing
- Sabin Strain Inactivated Poliovirus Vaccine
- Where
- 3 sites in Bangladesh, Pakistan
- Volunteers
- 1,442 people, healthy volunteers welcome
- Sponsor
- Sinovac Biotech Co., Ltd
Antibiotic Side Effect, Antibiotic-associated Diarrhea
Metagenomic and Metabolomic Reconstitution of Gut Microbiota After Broad Spectrum Antibiotic Therapy
In the United States, healthcare providers prescribe over 270 million antibiotic prescriptions each year. While antibiotics have transformed medicine and methods of treating life-threatening bacterial infection, broad spectrum…
- Conditions
- Antibiotic Side Effect, Antibiotic-associated Diarrhea, Antibiotic-induced Dysbiosis, Antibiotic-induced Epithelial Barrier Disintegrity
- Trial name
- NCT04171466
- Testing
- Ciprofloxacin + Metronidazole, SH-DS01
- Where
- Canada
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Seed Health
Sleep Deprivation, Sleepiness
Shift Hours' Impact on Fatigue and Tracking of Eye Dynamics
The goal of this clinical trial is to learn how night shift-induced sleep debt affects oculomotor patterns, attentional state, and diagnostic performance in emergency radiologists.
- Conditions
- Sleep Deprivation, Sleepiness, Eye-Tracking Technology, Radiologists
- Trial name
- SHIFTED (NCT07192380)
- Testing
- Electroencephalogram, Actigraphy, Eye Tracking
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- IMADIS Technologies et Services
Smallpox
A Long-Term Study of Healthy Adults Vaccinated With One Dose of Smallpox Vaccine (LISTER Strain)
The purpose of this study is to provide long-term follow-up immunogenicity and safety data on participants who were vaccinated with the second-generation smallpox vaccine in Study VVL04 (NCT 00258947).
- Trial name
- NCT00998543
- Where
- 5 sites in France
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Sanofi
Constipation
Effect of L. Paracasei Strain Shirota on Constipation in Healthy US Adults
The objective of this study is to investigate the efficacy of daily consumption of a fermented milk containing LcS in reducing the frequency of bowel movement with hard or lumpy stools in generally healthy U.S.
- Trial name
- NCT06014008
- Testing
- Test product consumption group
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yakult U.S.A. Inc.
Influenza Disease
Support Annual Strain Update, Safety and Immunogenicity of an Inactivated, Adjuvanted Influenza Vaccine, Formulation 2007-2008, When Administered to Subjects 18-64 Years Affected by Chronic Diseases.
This phase II, open label, is designed as a seasonal study to support annual strain update evaluating the safety, clinical tolerability and immunogenicity of the 2007-2008 formulation of Novartis Vaccines' adjuvanted, subunit…
- Trial name
- NCT00522067
- Testing
- Adjuvanted influenza vaccine
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Novartis Vaccines
Respiratory Syncytial Virus Infections
Safety and Efficacy Study of GS-5806 in Healthy Volunteers Infected With Respiratory Syncytial Virus (RSV)
This study is to evaluate the antiviral effect of GS-5806 in healthy adults infected with a strain of Respiratory Syncytial Virus.
- Trial name
- Challenge (NCT01756482)
- Testing
- GS-5806
- Where
- United Kingdom
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Acute Pain From Ankle Sprain or Strain
An Efficacy and Safety Study for the Treatment of Mild to Moderate Acute Pain Associated With Ankle Strain or Sprain.
This is a randomized, double blind, placebo controlled, parallel group study to assess the efficacy and safety of K-103-IP compared with placebo patch for treatment of mild to moderate acute pain associated with ankle strain or…
- Trial name
- NCT02089425
- Testing
- K-103-IP
- Where
- 47 sites in United States
- Volunteers
- 384 people
- Sponsor
- Kowa Research Institute, Inc.
Infant Formula
Supplementation of Infant Formula With Synbiotics
The primary hypothesis is that Lactobacillus paracasei ssp. paracasei strain F19 in an infant formula containing FOS/GOS is safe and tolerable for use in infants from 0 to 6 months.
- Trial name
- NCT01625273
- Testing
- Lactobacillus paracasei paracasei strain F19
- Where
- Poland
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Arla Foods
Acute Pain
Diclofenac Patch for the Treatment of Acute Pain Due to Mild to Moderate Wrist Sprain, Strain or Contusion
The purpose of the study is to assess the effectiveness of once daily application of a diclofenac sodium topical patch in reducing acute pain due to mild to moderate wrist sprain, strain or contusion when applied to the painful…
- Trial name
- WIND (NCT00869063)
- Testing
- Diclofenac Sodium Patch
- Where
- United States
- Volunteers
- 214 people
- Sponsor
- Cerimon Pharmaceuticals
Digital Eye Strain (DES)
Lactic Acid Bacteria for Reducing Blue Light-Induced Eye Fatigue
With the widespread use of digital devices and prolonged screen exposure, digital eye strain (DES), also known as computer vision syndrome, has become a global public health concern.
- Trial name
- NCT07737938
- Testing
- BL531_low dose, BL531_high dose, LR1349_low dose
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Synbio Tech Inc.
Eye Strain, Eye Strain of Both Eyes
Study of Non-inferiority Between Manzanilla Sophia® and Meticel Ofteno® 0.5% for Providing a Soothing Sensation to the Eyes.
This is a phase IV clinical study to demonstrate the non-inferiority of Manzanilla Sophia® compared to Meticel Ofteno® 0.5% in providing restful sensation to the eyes.
- Trial name
- NCT06373653
- Testing
- Manzanilla Sophia®, Meticel Ofteno®
- Volunteers
- healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
SARS CoV-2 Infection, Elderly
Effect of the Consumption of a Lactobacillus Strain on the Incidence of Covid-19 in the Elderly
The objective of this trial is to evaluate the effect of the consumption of a probiotic strain on the incidence and severity of COVID-19 in elderly population living in a nursing home.
- Trial name
- NCT04756466
- Testing
- Lactobacillus
- Where
- 3 sites in Spain
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Biosearch S.A.
Covid19
Evaluation of a Probiotic Supplementation in the Immune Response of Participants With COVID-19 (Coronavirus Disease).
An interventional, randomized, double-blind, placebo-controlled study will be conducted to investigate the effect of a probiotic strain on the immune response in participants positive for SARS-CoV-2 infection.
- Trial name
- PROVID (NCT04937556)
- Testing
- Probiotic: Lactobacillus salivarius + Vit D + Zinc
- Where
- Spain
- Volunteers
- 41 people
- Sponsor
- ProbiSearch SL
Reduction of Small Intestinal Ulceration Risk
The Effect of a Probiotic Strain on Ibuprofen-induced GI Damage
To investigate if a daily dose of minimum 15 billion CFU of Bif195 reduces the risk of small-intestinal tissue damage in an Ibuprofen challenge model as assessed by video capsule endoscopy in a healthy US population.
- Trial name
- PIP-I (NCT04447924)
- Testing
- Bif195
- Where
- United States
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Chr Hansen
Influenza
Immunogenicity and Tolerability Study of FluvalAB FL-K-004 Trivalent Influenza Vaccine
This is a single blind, reference drug controlled, one center viral immunogenicity and tolerability study of FluvalAB FL-K-004 Trivalent Influenza Vaccine with 6 μg HA/strain/dos antigen content to assess immunogenicity and…
- Trial name
- NCT00778297
- Testing
- Vaccination with FluvalAB FL-K-004 trivalent flu vaccine, Vaccination with FluvalAB trivalent influenza vaccine
- Where
- Hungary
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- Fluart Innovative Vaccine Ltd, Hungary
Pain
Japanese IP-TN Trial
This is an open-label, single-group, multi-centre trial to confirm the safety and efficacy of loxoprofen sodium/methocarbamol ( IP-TN) when administered orally for 2 weeks to patients with low back pain, scapulohumeral…
- Trial name
- NCT02831569
- Testing
- Loxoprofen sodium, Methocarbamol
- Where
- 3 sites in Japan
- Volunteers
- 80 people
- Sponsor
- Boehringer Ingelheim
Breast Milk Expression
Effect of Consuming a Combination of Probiotic Strains and a Combination of Plant Extracts and a Probiotic Strain on the Production and Nutritional Composition of Breast Milk
The objective of this trial is to evaluate the effect of the consumption of a combination of probiotic strains (Prob-milk) and of a combination of plant extracts plus an inactivated probiotic strain (VoluntasProb) on the…
- Trial name
- NCT04639232
- Testing
- Prob-milk, Voluntas-Prob
- Where
- Spain
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Biosearch S.A.
Reduction of Small Intestinal Ulceration Risk
The Effect of a Probiotic Strain on Aspirin-induced GI Damage
The primary objective of this trial is to investigate if a daily dose of minimum 50 billion CFU of Bif195 reduces the risk of small-intestinal tissue damage in an acetylsalicylic acid challenge model as assessed by video capsule…
- Trial name
- PIP-L (NCT03910322)
- Testing
- Bif195
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chr Hansen