Clinical trials: Strain
Microbial Colonization
Investigating the Impact of Humiome B2 (Colon Delivered Riboflavin) and Riboflavin-overproducer Probiotic Strain Limosilactobacillus Reuteri AMBV339 on Intestinal and Vaginal Microbiome and Health of Healthy Adult Women (The VIAB2L Project)
The goal of this clinical trial is to learn if the probiotic strain Limosilactobacillus reuteri AMBV339 or colon-delivered riboflavin or their combination can change the gut and vaginal microbiome and metabolomics.
- Trial name
- VIAB2L (NCT06425081)
- Testing
- Limosilactobacillus reuteri AMBV339, Humiome B2, Limosilactobacillus reuteri AMBV339 + Humiome B2
- Where
- Belgium
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Heart Failure
Early Detection of Heart Problems in Cancer Patients Receiving Chemotherapy
Subjects will include patients diagnosed with breast cancer or hematological cancer who are planned for chemotherapy treatment with anthracycline or trastuzumab; and who have one or more risk factors for cardiovascular disease.
- Trial name
- NCT04413487
- Testing
- Extra echocardiogram
- Sponsor
- The Guthrie Clinic
Body Temperature Changes, Heat Stress
Working in the Heat at Simulated Altitude: Effects of Normobaric Hypoxia on Physiological Strain
Extreme heat events are becoming more frequent, intense, and prolonged, increasing the risk of heat-related illness among workers performing physically demanding work in hot environments.
- Conditions
- Body Temperature Changes, Heat Stress, Heat Exposure, Heat Fatigue
- Trial name
- NCT07664462
- Testing
- Simulated Occupational heat exposure under normoxic conditions, Simulated Occupational heat exposure under hypoxic conditions
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Ottawa
Respiratory Syncytial Virus Infections
Inpatient Challenge Study of rRSV A/Maryland/001/11, a Human Respiratory Syncytial Virus Challenge Strain, Administered to Healthy Adult Volunteers
The purpose of this study is to evaluate the safety, infectivity and replication, and immunogenicity of a recombinant respiratory syncytial virus (rRSV A/Maryland/001/11) challenge virus administered intranasally to healthy…
- Trial name
- NCT03624790
- Testing
- rRSV A/Maryland/001/11
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Patellofemoral Pain Syndrome
Strain Counterstrain Versus Graston Technique for Patellofemoral Pain Syndrome
This clinical trial compares the effects of Strain Counterstrain technique versus Graston Technique on pain and range of motion in patients with patellofemoral pain syndrome.
- Trial name
- SCS-GRAS-PFPS (NCT07589933)
- Testing
- Strain Counterstrain, Graston Technique
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Green International University
Bacterial Vaginosis, Candidosis Vaginal
Lacticaseibacillus Rhamnosus CA15 (DSM 33960) Strain as a New Driver in Restoring the Normal Vaginal Microbiota
The aim of the present randomized double-blind placebo-controlled trial is to evaluate the efficacy of a probiotic formulation, containing the probiotic strain Lacticaseibacillus rhamnosus CA15 (DSM 33960), in the treatment of…
- Conditions
- Bacterial Vaginosis, Candidosis Vaginal, Urinary Tract Infections
- Trial name
- NCT05796921
- Testing
- Lacticaseibacillus rhamnosus CA15 (DSM 33960) probiotic strain
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Agnese Maria Chiara Rapisarda
Septic Shock, Cardiomyopathy
Effects of Levosimendan, Milrinone and Norepinephrine on Left and Right Ventricular Function in Septic Shock
The aim of this study is to investigate the effects milrinon and levosimandan on n heart function in septic cardiomyopathy and how norepinephrine affects the left and right ventricular function in patients with septick shock…
- Trial name
- SCLM (NCT02640846)
- Testing
- Norepinephrine, Milrinone, Levosimendan
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Sahlgrenska University Hospital
Oral Health
L. Brevis CD2 Strain Persistence in Oral Cavity
The aim of this study is to select the optimal conditions for quantification in the oral cavity of Lactobacillus brevis CD2, a probiotic strain contained in a commercially available dietary supplement and to assess its…
- Trial name
- NCT01782079
- Testing
- L. brevis
- Where
- Italy
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Mild-to-Moderate Stress
Prebiotic Effects on Anxiety, Cortisol, and Emotional Processing in Mild-to-Moderately Stressed Adults
The levels of stress that we experience as a population are continuing to rise due to financial, social and work pressures, particularly in mid-life where additional factors such as family and career often compound these issues.
- Trial name
- PEACE (NCT06991023)
- Testing
- Prebiotic (Bimuno®)
- Where
- United Kingdom
- Volunteers
- 55 people
- Sponsor
- University of Reading
Atrial Fibrillation
Left Atrial Function After Pulsed Field Ablation of Atrial Fibrillation
Introduction: Pulsed field ablation (PFA) has emerged in routine clinical practice as a new promising technology in catheter-based treatment of atrial fibrillation (AF).
- Trial name
- NCT06478342
- Testing
- ablation
- Volunteers
- 50 people
- Sponsor
- Charles University, Czech Republic
Coronary Artery Disease Progression, Radial Wall Strain
Natural History of Coronary Atherosclerosis
The present study sought to explore the predictive value of radial wall strain (RWS, derived solely from angiograms) for coronary artery lesion progression compared with lesion vulnerability assessed by optical coherence…
- Conditions
- Coronary Artery Disease Progression, Radial Wall Strain, Atherosclerotic Lesion, Optical Coherence Tomography
- Trial name
- NASCENT (NCT06040073)
- Where
- China
- Volunteers
- 125 people
- Sponsor
- China National Center for Cardiovascular Diseases
Gastrointestinal, Microbiota
Open-Label Clinical Trial Evaluating the Impact of a Multi-Strain Commensal Probiotic Dietary Supplement on Gastrointestinal Microbiota Composition, Functional Gastrointestinal Markers, and Gastrointestinal Symptoms
A single-arm, open-label prospective study will be conducted evaluating the impact of 8 weeks of supplementation at the manufacturer-recommended dose of Complete Commensal Probiotic™ on the GI-MAP stool test panel (Diagnostic…
- Trial name
- NCT07720362
- Testing
- Complete Commensal Probiotic
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- OvationLab
Eye Strain, Eye Fatigue
The Effects of Blackcurrant Supplementation on Eye Health
The purpose of this study is to evaluate the potential for supplementation with black currant to support eye health among otherwise healthy adult women who spend 6+ hours per day using digital screens.
- Trial name
- NCT04775654
- Testing
- Blackcurrant
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Nutraceuticals Research Institute
Achilles Tendinopathy, Ankle Strain
A Study Examining Changes in Pain After Manual Therapy in People With Achilles Tendon Pain
The purpose of this research is to find out how pain sensation may change in the Achilles tendon after the use of manual physical therapy.
- Conditions
- Achilles Tendinopathy, Ankle Strain, Achilles Tendon Pain, Achilles Tendonitis
- Trial name
- NCT06134856
- Testing
- Ankle mobilization
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Philadelphia College of Osteopathic Medicine
Hand Muscle Strain
Effects of Parenteral Protein Concentrations in Critically Ill Patients
Sixty patients who need Parenteral nutrition for more than 48h will be assigned into two groups .Group A (n=30) patient will receive 1g/kg/day protein and group B n=30) patient will receive 2g /kg/day.
- Trial name
- NCT04961866
- Testing
- parenteral protein 1 g/kg, Parenteral nutrition 2 g/kg
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Minia University
Chagas Cardiomyopathy, Speckle Tracking Echocardiography
Cardiac Mechanics by Speckle Tracking as a Prognostic Predictor in Patients With Chagas Cardiomyopathy
This study aims to evaluate the prognostic value of myocardial mechanics parameters, including global longitudinal strain (GLS) and mechanical dispersion (MD), assessed through speckle tracking echocardiography, in patients with…
- Conditions
- Chagas Cardiomyopathy, Speckle Tracking Echocardiography, Arrythmias, Sudden Death
- Trial name
- ST-Chagas (NCT06806722)
- Where
- Brazil
- Volunteers
- 153 people
- Sponsor
- University of Sao Paulo
Alzheimer's Type Dementia, Cognitive Decline
The Effectiveness of Global Postural Reeducation on Alzheimer Disease Patients
This research study is developed on an experimental design with randomized controlled intervention were participated 135 subjects with AD including 45 of the control group.
- Conditions
- Alzheimer's Type Dementia, Cognitive Decline, Postural; Strain
- Trial name
- GPR (NCT03732053)
- Testing
- GPR Intervention Research group
- Volunteers
- 135 people
- Sponsor
- Universidad Católica San Antonio de Murcia
Urosepsis, Bladder Cancer
Antibiotic Prophylaxis in Transurethral Prostate Resection (TURP) and Transurethral Bladder Tumour Resection (TURB)
To investigate the use of antibiotic prophylaxis in patients undergoing TURP and TURB. The investigators set up a prospective, randomized controlled trial in which (after exclusion of risk factors) patients will be randomized in…
- Conditions
- Urosepsis, Bladder Cancer, Prostate Hyperplasia, Antibiotic Resistant Strain
- Trial name
- Prophylaxis001 (NCT04212403)
- Testing
- Levofloxacin
- Where
- Belgium
- Volunteers
- 1,350 people
- Sponsor
- Jessa Hospital
Muscle Strain, Multiple Sites
Nutritional Strategies After Muscle Strain Injuries
Muscle strain injuries are a particularly frequent type of sports injury in soccer, athletics, badminton/ tennis and cross-fit fitness, thereby affecting a broad range of popular leisure time activities.
- Trial name
- NCT04100161
- Testing
- Protein supplementation, Carbohydrate supplementation, Active rehabilitation
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Healthy Volunteer
Human Challenge Model Refinement With Enterotoxigenic Escherichia Coli Strain B7A
The purpose of this study is to determine the safe and optimal dose and regimen (fasting duration) for administering the challenge ETEC strain B7A, a CS6 expressing ETEC strain.
- Trial name
- NCT02773446
- Testing
- ETEC strain B7A (O148:H28 CS6+ LT+ST+) (Lot 0481) in Buffer
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health