Clinical trials: Strain
Aortic Valve Disorder
Novel Cardiac Imaging Prognostic Markers of Clinical Outcome in Patients With Chronic Aortic Regurgitation
Severe aortic regurgitation is a common valvular heart disease with prevalence of approximately 1%, affecting rather younger patients.
- Trial name
- MOLLI-GLS-Hx (NCT02910349)
- Where
- 5 sites in Belgium, Czechia
- Volunteers
- 129 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Mitral Valve Disease, Low Cardiac Output Syndrome
Intraoperative Global Longitudinal Strain and Global Longitudinal Strain Rate as Predictors of Unfavorable Outcome in On-Pump Mitral Surgery
The aim of the present study is to assess the best echocardiographic parameters (GLS, GLS rate and standard echocardiographic parameters) predicting LCOS in on-pump mitral surgery.
- Trial name
- Mit-GO (NCT04045340)
- Testing
- Philips QLAB Ultrasound Quantification Software
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Scientific Institute San Raffaele
Study Vasodilatory Effects of C21
Effect of C21 on Forearm Blood Flow
The purpose of this study is to assess the effect of C21 on forearm blood flow by use of strain-gauge venous occlusion plethysmography.
- Trial name
- NCT05277922
- Testing
- C21, Sodium Nitroprusside
- Where
- Sweden
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Vicore Pharma AB
Influenza A H3N2
Dose, Safety, and Pathogenicity of a New Influenza A H3N2 Challenge Strain
An Exploratory Study to Establish the Dose, Safety and Pathogenicity of a New Influenza A H3N2 Challenge Strain in Healthy Participants 18 to 55 Years of Age In Part A, up to 40 participants will be randomly allocated to one of…
- Trial name
- NCT06613737
- Testing
- Influenza A H3N2 virus dose arm 1, Influenza A H3N2 virus dose arm 2, Influenza A H3N2 virus dose arm 3
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Hvivo
Cholesterol Levels
A Clinical Study on the Effectiveness of a Lacticaseibacillus Strain on Blood Cholesterol Levels
This is a 12-week prospective, multicentre, randomised Phase 4 study to evaluate the effect of a wild type strain of Lacticaseibacillus in cholesterol of blood levels.
- Trial name
- NCT06108505
- Testing
- Lacticaseibacillus with oats, Plain oats
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Democritus University of Thrace
Mechanical Ventilation, Clinical Competence
Using Real-Time Lung Visuals to Reduce Mental Strain and Improve Diagnosis Speed
The goal of this clinical simulation study is to learn if a "Digital Twin" graphical lung display reduce the mental workload of clinicians.
- Conditions
- Mechanical Ventilation, Clinical Competence, Education Curriculum, Self Concept
- Trial name
- VERDICT (NCT07511712)
- Testing
- Real-time Graphical Lung Function Visualization (Digital Twin), Standard Ventilator Waveform Monitoring
- Where
- China
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Abdominal Aortic Aneurysm Without Rupture
Non-invasive Aortic Aneurysm Tissue Characterization Using Wall Viscoelasticity
Abdominal aortic aneurysm (AAA) is an abnormal dilatation of the aorta in the abdomen due to a wall weakening caused by atherosclerosis.
- Trial name
- AAA multiphase (NCT04150653)
- Testing
- Multiphase scan CT, non-invasive vascular ultrasound elastography by ultrasound (NIVE)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Myogenous Temporomandibular Disorders (mTMD)
Effects of Soft Tissue Mobilization of Neck Muscles in Individuals With Myogenous Temporomandibular Disorders: Muscle Energy Technique and Strain-counterstrain
This is a prospective case series study.There were 20 individuals with chronic neck pain accompanied by myogenous temporomandibular disorders(mTMD) from Linkou and Taoyuan Chang Gung hospitals, and Chang-Gung university.
- Trial name
- NCT04704102
- Testing
- Muscle energy technique (MET), Strain-counterstrain (SCS)
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Chang Gung University
Cardiovascular Diseases, Cerebrovascular Accident
Job Strain, Ambulatory Blood Pressure and Hypertension
To analyze the association between an objective measure of "job strain" and risk of stroke, and change in ambulatory blood pressure.
- Conditions
- Cardiovascular Diseases, Cerebrovascular Accident, Hypertension, Heart Diseases
- Trial name
- NCT00005472
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Risk of Heat Stress
Occupational Heat Stress on Workers' Productivity
Workplace heat exposure affects billions of people during their everyday work activities. Occupational heat stress impairs workers' health and capacity to perform manual labour.
- Trial name
- NCT04160728
- Testing
- Work/ rest scenario, Hydration scenario, Clothing scenario
- Where
- Greece
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- Petros Dinas
Chest Pain
Use of Echocardiography in the Evaluation of Chest Pain in the Emergency Department
Chest pain is one of the most common complaints that brings a patient to the emergency department (ED). The differential diagnosis of chest pain is broad and includes cardiac as well as non-cardiac diseases.
- Trial name
- NCT01125072
- Testing
- Echocardiography with strain analysis
- Where
- United States
- Sponsor
- NYU Langone Health
Trapezius Muscle Strain
Evaluation Of Peripheral Muscle Oxygenation In Individuals With Muscular Idiopathic Pain With Myofascial Release
Introduction: Neck Pain (NP) is considered a common idiopathic disorder in the general population. Oriented from incorrect executions during daily activities the DPO compromises the trapezius muscle that has a viscoelastic…
- Trial name
- NCT03882515
- Testing
- Myofascial Release, Continuous Surface Slip Technique, Without intervention
- Where
- Brazil
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of the State of Santa Catarina
Calf Muscle Pulled
Kinesiology Taping on Calf Tightness
This study aims to determine the effect of combined facilitatory Kinesiology and inhibitory Kinesiology taping on balance and ROM in university students with calf tightness.
- Trial name
- NCT05434780
- Testing
- Kinesiology taping
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shalamar Institute of Health Sciences
Coronary Artery Disease, Ischemic Heart Disease (IHD)
Verona Coronary Physiology Interventional Registry
The Verona Coronary Physiology Interventional Registry (VR-CP) is an observational study that collects information on patients with suspected coronary artery disease who underwent coronary angiography with a functional assessment…
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease (IHD), Coronary Heart Disease (CHD)
- Trial name
- VR-CP (NCT07186582)
- Testing
- Coronary physiology assessment using Fractional Flow Reserve (FFR) as per standard of care and angiography-derived FFR
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Influenza
Elderly Influenza Vaccine Immunogenicity Substudy
The body's immune system (fights infection) is known to decline during the aging process, resulting in an increased risk of catching infections.
- Trial name
- NCT00170482
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pneumothorax
Pleurostrain: Interest of Strain Ultrasound in the Diagnosis of Pneumothorax
The objective of this study is to investigate whether the use of strain ultrasound can improve the lung ultrasound accuracy for the diagnosis of pneumothorax, particularly for inexperienced physicians.
- Trial name
- NCT03907150
- Testing
- Strain ultrasound
- Where
- 4 sites in France
- Volunteers
- 122 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Gastrointestinal Discomfort, Bloating
Multi-strain Probiotic Supplement for Digestive Comfort and Well-being in Healthy Women
This study looks at whether a daily probiotic supplement can help improve mild-to-moderate stomach and digestive symptoms, such as gas and bloating, in women who also experience symptoms commonly associated with hormonal…
- Trial name
- NCT07831317
- Testing
- Active: Multi-strain probiotic dietary supplement
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Daily Nouri
Low Cardiac Output Syndrome After Adult Cardiac Surgery
Peak Systolic Global Longitudinal Strain and Low Cardiac Output Syndrome After Cardiac Surgery
This is a retrospective observational study to assess the relationship between peak systolic global longitudinal strain measured on pre-cardiopulmonary bypass trans-esophageal echo images predicts post-operative low cardiac…
- Trial name
- NCT02771080
- Testing
- Cardiac surgery
- Volunteers
- 275 people
- Sponsor
- University of Liege
Hyperthermia, Weather; Heat
Mitigating Heat-induced Physiological Strain and Discomfort in Older Adults Via Lower Limb Immersion and Neck Cooling
The incidence and severity of hot weather and extreme heat events (heat waves) is increasing. As such, there is an urgent need to develop heat-alleviation strategies that can provide targeted protection for older adults who are…
- Conditions
- Hyperthermia, Weather; Heat, Heat Stress, Heat Syncope
- Trial name
- NCT05601713
- Testing
- No cooling (control), Lower limb immersion, Lower limb immersion + neck cooling
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Covid19
COVID-19 SARS-CoV-2 Screening Protocol
The aim of this screening protocol is to assess volunteers for their potential eligibility to participate in a dose finding human experimental infection study in healthy subjects using a GMP-produced SARS-CoV-2 wild type strain
- Trial name
- NCT04740320
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Imperial College London