Clinical trials: Strain
DENV-3 Controlled Human Infection Model
A Study to Evaluate the Safety and Efficacy of AV-1 Against Dengue Virus 3 (DENV-3) Infection
The goal of this clinical trial is to determine the prophylactic and therapeutic effect of AV-1 in healthy adults using a DENV-3 controlled human infection model (CHIM)
- Trial name
- NCT06799741
- Testing
- AV-1 100 mg, AV-1 300 mg, AV-1 900 mg
- Where
- 3 sites in United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- AbViro LLC
Exercise, Heat Strain
Effect of Exercise and Heat Stress on Acute Cardiometabolic Adaptations in Healthy Young Adults
Life in space is completely void of physical and environmental stress. It is well known that living things need regular physical stress (e.g. exercise) to remain strong, functional and healthy.
- Conditions
- Exercise, Heat Strain, Control Condition
- Trial name
- NCT06872762
- Testing
- Exercise, Heat strain
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Northern Arizona University
Influenza Vaccine
Effect of a Multi-strain Probiotic Formulation on Immune Response to Influenza Vaccination
Randomized clinical trial to determine whether a probiotic formulation containing 4 probiotic strains which belong to Lactiplantibacillus plantarum and Pediococcus acidilactici species can boost the immune response to influenza…
- Trial name
- FLUVAC21 (NCT05157425)
- Testing
- Food Supplement
- Where
- 5 sites in Spain
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- AB Biotics, SA
Chronic Obstructive Pulmonary Disease (COPD), Heat Stress
Indoor Overheating and Physiological Strain in Older Adults With COPD
During warm weather, homes without air conditioning can stay hot for long periods, and most heat-related health problems in Canada happen indoors rather than outdoors.
- Trial name
- NCT07852910
- Testing
- Simulated indoor thermal environment
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- University of Ottawa
Travelers' Diarrhea
Safety and Efficacy of Bovine Milk Immunoglobulin Against CS17 and CsbD
This is a Phase II, randomized, double-blind, placebo-controlled study designed to investigate whether hyperimmune bovine milk IgG products specific for CsbD and CS17, protect subjects against diarrhea upon challenge with a…
- Trial name
- BIgGII (NCT00524004)
- Testing
- Anti-CsbD Bovine IgG, Anti-CS17 Bovin IgG
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Antibiotic Resistant Strain
Fecal Microbiome Transplantation (FMT) in Pediatric Patients Colonized With Antibiotic-resistant Pathogens Before Hematopoietic Stem Cell Transplantation (HSCT)
a clinical trial designed to prospectively assess the safety and effectiveness of fecal microbiota transplantation (FMT) prior to allogeneic hematopoietic stem-cell translation (HSCT) in patients contaminated with…
- Trial name
- FMT-HSCT (NCT04593368)
- Testing
- FMT
- Where
- 3 sites in Russia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Hypertrophic Cardiomyopathy
Study of Hypertrophic Cardiomyopathy Under Stress Conditions. Concordance Between Two Complementary Tests: Stress MRI and Exercice Stress Echocardiography
Hypertrophic cardiomyopathy (HCM) is a primitive myocardic disease and the first of genetic cardiac diseases. The definition of HCM is an increase of the myocardial thickness of the left ventricle (LV) wall without any other…
- Trial name
- CMHStress (NCT02500420)
- Testing
- Diagnosis examens
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Montpellier
Seasonal Influenza
Safety and Immunogenicity of Surface Antigen, Inactivated, Influenza Vaccine Using the Strain Composition 2008/2009
Annual trial for registration influenza vaccine with the strain composition for season 2008/2009
- Trial name
- NCT00748813
- Testing
- Influenza Vaccine, Formulation 2008-2009
- Where
- 3 sites in Italy
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Heart Failure
Strain Echo in Acute Heart Failure
The purpose of this project is to evaluate the utility of left ventricular strain as part of the assessment of patients in the emergency department with acute heart failure (HF).
- Trial name
- Strain Echo (NCT02371642)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Wayne State University
Malaria, Falciparum
Re-exposure of Human Volunteers to a Heterologous Strain of P. Falciparum Sporozoites
In a previous study (NL33904.091.10) the investigators challenged 24 volunteers after Chloroquine Prophylaxis Sporozoites (CPS) immunization with 45, 30 or 15 infected mosquito-bites respectively.
- Trial name
- TIP4 (NCT01660854)
- Testing
- Heterologous challenge, Malarone treatment
- Where
- Netherlands
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Poliomyelitis
A Clinical Trial to Evaluate the Immunogenicity and Safety of sIPV in a '1+2' Sequential Schedule With bOPV in Infants
The purpose of this phrase III clinical trial is to evaluate the immunogenicity and safety of Sabin Inactivated Poliovirus Vaccine (Vero cell) in a '1+2' sequential schedule with bivalent oral poliovirus vaccine in 2-month-old…
- Trial name
- NCT03822754
- Testing
- sIPV-bOPV-bOPV vaccination schedule, wIPV-bOPV-bOPV vaccination schedule
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Sinovac Biotech Co., Ltd
Muscle Strain, Multiple Sites, Inflammation
Optimal Treatment of Acute Skeletal Muscle Injury
Acute muscle strain injuries occur both during sports, in leisure time activities and during manual occupation and represent a major clinical challenge and has societal economic costs.
- Trial name
- NCT06274151
- Testing
- Naproxen 500 Mg, Rehabilitation
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Musculoskeletal Injury, Pediatrics
Topical Diclofenac vs.Oral Ibuprofen for MSK Pain in Children
The TOP-MAP pilot trial has multiple goals. The first goal of this pilot clinical trial is to find out if it will be possible to carry out a study at multiple pediatric emergency department sites (Peds ED) comparing Non-Steroidal…
- Conditions
- Musculoskeletal Injury, Pediatrics, Sprain and Strain of Ankle, Sprain Knee
- Trial name
- TOP-MAP (NCT07145645)
- Testing
- Voltaren Topical Gel, Ibuprofen Oral Suspension 100 mg/5mL, ORA-Blend Oral Suspension
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University of Calgary
Treatment of Acute Yellow Fever Virus Infection
Safety and Tolerability of an Antibody Against Yellow Fever Virus (TY014) in Humans
Yellow Fever is an acute viral hemorrhagic disease caused by the Yellow Fever Virus (YFV), a re-emerging arbovirus transmitted by the same mosquito vector (Aedes aegypti) that transmits Dengue virus (DENV) and Zika virus (ZIKV).
- Trial name
- NCT03776786
- Testing
- TY014, 0.9% Saline
- Where
- Singapore
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Tysana Pte Ltd
Diabetic Cardiomyopathies
Diabetic Cardiomyopathy
Diabetes represents one of the 10 leading causes of death in the world and concerns 5% of the French population (> 3.3 million patients). About 30% of diabetic patients will develop heart failure.
- Trial name
- CarDiab (NCT04593173)
- Where
- France
- Volunteers
- 77 people
- Sponsor
- University Hospital, Strasbourg, France
Covid19
Evaluation of a Probiotic Supplementation in the Immune Response of Participants With COVID-19 (Coronavirus Disease).
An interventional, randomized, double-blind, placebo-controlled study will be conducted to investigate the effect of a probiotic strain on the immune response in participants positive for SARS-CoV-2 infection.
- Trial name
- PROVID (NCT04937556)
- Testing
- Probiotic: Lactobacillus salivarius + Vit D + Zinc
- Where
- Spain
- Volunteers
- 41 people
- Sponsor
- ProbiSearch SL
Myofascial Pain Syndromes, Myofascial Trigger Point Pain
Kinesio Taping for Upper Trapezius Myofascial Trigger Points
Myofascial pain syndrome is one of the most common causes of musculoskeletal pain, and the upper trapezius is the muscle most frequently affected in the neck and shoulder region.
- Conditions
- Myofascial Pain Syndromes, Myofascial Trigger Point Pain, Neck Pain
- Trial name
- NCT07790042
- Testing
- Kinesio Taping (muscle inhibition technique)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Pamukkale University
SVT, Vagal Bradycardia
Testing of a Valsalva Assist Device (VAD) in Healthy Volunteers Performing a Valsalva Manoeuvre
A prototype for a Valsalva Assist Device (VAD), which provides resistance to exhalation, has been developed and is ready for testing in healthy volunteers.
- Trial name
- NCT03298880
- Testing
- Supine VM VAD, Supine VAD manometer, Modified VM VAD
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Rotator Cuff Tendinosis, Supraspinatus Strain
The Effects of Platelet-Rich Plasma Versus Prolotherapy On Rotator Cuff Tendinopathy: A Randomized Controlled Trial.
Rotator cuff tendinopathy is the common cause of shoulder pain in the working-age group and the elderly (1). The condition reported takes an average of 10 months or longer to recover.
- Conditions
- Rotator Cuff Tendinosis, Supraspinatus Strain, PRP
- Trial name
- NCT04640662
- Testing
- Platelet-Rich Plasma, Prolotherapy
- Where
- Malaysia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Diabetic Foot, Amputation
Predictors of Foot Amputation in Diabetic Foot Ulcers
Diabetes affects 463 million population of the world. Diabetic foot is one of the complications of uncontrolled diabetes which can lead to amputation in 5- 24% of non-healing diabetic foot ulcers.
- Conditions
- Diabetic Foot, Amputation, Antibiotic Resistant Strain, Diabetic Foot Ulcer
- Trial name
- NCT05551988
- Testing
- Retrospective observational study of diabetic foot ulcer
- Where
- Pakistan
- Volunteers
- 110 people
- Sponsor
- Bolan Medical Complex Hospital Quetta Pakistan