Clinical trials: Strain
Lung Transplant Infection, Pneumonia, Bacterial
Antimicrobial Therapeutic Drug Monitoring During Lung Transplant Perioperative Phase
Background: Post-LUTX pneumonia represents a leading cause of death along the first month after LUTX. Donor-derived transmission of pathogenic species occurs up to 25% of recipients receiving a graft with a positive BAL culture…
- Conditions
- Lung Transplant Infection, Pneumonia, Bacterial, Antibiotic Resistant Strain
- Trial name
- NCT06583642
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Policlinico Hospital
Collateral Ligament, Knee; Sprain (Strain), Medial, Anterior Cruciate Ligament Injuries
Medial Collateral Ligament Reconstruction With Anteromedial Reinforcement for Medial and Anteromedial Rotatory Knee Instability
The aim of this study is to assess the outcomes of the combined quadriceps tendon-bone (QTB) ACLR and MCLR with anteromedial reinforcement performed as described in the published technique: K. Malinowski, K. Hermanowicz, A.
- Trial name
- NCT05489627
- Testing
- Medial Collateral Ligament Reconstruction With Anteromedial Reinforcement
- Where
- Poland
- Volunteers
- 17 people
- Sponsor
- Artromedical Konrad Malinowski Clinic
DENV-3 Controlled Human Infection Model
A Study to Evaluate the Safety and Efficacy of AV-1 Against Dengue Virus 3 (DENV-3) Infection
The goal of this clinical trial is to determine the prophylactic and therapeutic effect of AV-1 in healthy adults using a DENV-3 controlled human infection model (CHIM)
- Trial name
- NCT06799741
- Testing
- AV-1 100 mg, AV-1 300 mg, AV-1 900 mg
- Where
- 3 sites in United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- AbViro LLC
Influenza Disease
Support Annual Strain Update, Safety and Immunogenicity of an Inactivated, Adjuvanted Influenza Vaccine, Formulation 2007-2008, When Administered to Subjects 18-64 Years Affected by Chronic Diseases.
This phase II, open label, is designed as a seasonal study to support annual strain update evaluating the safety, clinical tolerability and immunogenicity of the 2007-2008 formulation of Novartis Vaccines' adjuvanted, subunit…
- Trial name
- NCT00522067
- Testing
- Adjuvanted influenza vaccine
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Novartis Vaccines
Obesity, Abdominal Obesity
Study of Safety and Efficacy of a Probiotic and Postbiotic in Overweight Individuals
Investigate the effect of a probiotic (live bacteria) and postbiotic (heat-treated bacteria) strains in overweight individuals.
- Trial name
- KOBI (NCT05428137)
- Testing
- Probiotic, Postbiotic
- Where
- South Korea
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- The Archer-Daniels-Midland Company
Thermal Discomfort
S&B Heat Stress Pilot Protocols
The purpose of this study is to develop a heat stress program for the construction industry and evaluate its feasibility and appeal.
- Trial name
- NCT06094764
- Testing
- Group A, Group B
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- The University of Texas Health Science Center, Houston
Disorder of Upper Gastrointestinal Tract, Pancreatic Nodule
Tissue Characterisation by Endoscopic GI-elastography
In this single centre study we study the use of endoscopic ultrasonography (EUS) combined with elastography in order to separate malignant tissue from benign tissue in and adjacent to the upper gastrointestinal tract.
- Conditions
- Disorder of Upper Gastrointestinal Tract, Pancreatic Nodule, Secondary and Unspecified Malignant Neoplasm of Retroperitoneal Lymph Nodes, Secondary Malignant Neoplasm of Lymph Node
- Trial name
- NCT01360411
- Where
- Norway
- Volunteers
- 137 people
- Sponsor
- Haukeland University Hospital
Type2 Diabetes, Obesity
Probiotic Supplementation and Pancreatic β-Cell Function in Type 2 Diabetes
Probiotics have beneficial effect on obesity related disorders in animal models. Current understanding for the beneficial effects of probiotics in type 2 diabetes strictly relies on animal and clinical data, which mainly focus on…
- Conditions
- Type2 Diabetes, Obesity, Insulin Resistance, Obesity, Abdominal
- Trial name
- NCT05765292
- Testing
- Probiotic
- Where
- 4 sites in Ukraine
- Volunteers
- 68 people
- Sponsor
- Bogomolets National Medical University
Acute Myocardial Infarction
Prognostic Value of Right Ventricular Myocardial Strain in Patients With Acute Myocardial Infarction
For a long time, the right ventricle has been the "forgotten chamber", but with the deepening of people's understanding of the disease, right ventricular dysfunction has become an important factor to evaluate the disease…
- Trial name
- NCT05404555
- Testing
- two-dimensional speckle tracking echocardiography
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Total Hip Arthroplasty (THA), Impaction
Automated V Manual Impactor Study
This study investigates the use of an automated impactor device in total hip arthroplasty versus manual malleting method and the physiological strain on the surgeon.
- Conditions
- Total Hip Arthroplasty (THA), Impaction, Physiological Strain
- Trial name
- NCT06903767
- Testing
- Automated Impaction (HAMMR), Manual Malleting
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Coronavirus Infections
Study of Tixagevimab/Cilgavimab and Regdanvimab Efficacy for Treatment of COVID-19
Study hypothesis: the viral neutralizing monoclonal antibodies Tiksagevimab/Cilgavimab and Regdanvimab have high neutralizing activity against SARS-CoV-2 coronavirus, including Omicron strain, and may be effective in treating…
- Trial name
- NCT05982704
- Testing
- tixagevimab/cilgavimab 150+150 mg, tixagevimab/cilgavimab 300+300 mg, regdanvimab
- Where
- Russia
- Volunteers
- 82 people
- Sponsor
- City Clinical Hospital No.52 of Moscow Healthcare Department
Acute Respiratory Distress Syndrome
Strain and Blood Inflammatory Markers as Prognostic Tools for ARDS AMIS (ARDS - Markers of Inflammation - Strain)
The objective is determine the strain measured at the bedside could be a dynamic prognostic marker of during Acute respiratory Distress Syndrome (ARDS).
- Trial name
- AMIS (NCT02003326)
- Testing
- Inflammatory markers
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Ankle Sprain Strain
Plaster Cast Versus DJO Walker in Paediatric Ankle Injuries
Present treatment of children with stable ankle and foot injuries very often involves a period in plaster cast(s). In the last decade in adult patients this has been superceded in many instances by the use of a removable foot…
- Trial name
- NCT04230538
- Testing
- DJO Walker, Traditional plaster cast
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Sheffield Children's NHS Foundation Trust
Infant Development, Safety Issues
Safety of Bifidobacterium Breve PS1 for Infants
The objective of this work was the characterization of the probiotic potential of Bifidobacterium breve PS1, a strain originally isolated from human milk.
- Trial name
- NCT05973812
- Testing
- Infant formula supplemented with Bifidobacterium breve PS1, Infant formula NOT supplemented with Bifidobacterium breve PS1
- Where
- 3 sites in Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Heart Failure With Reduced Ejection Fraction (HFrEF)
Correlation of Typical LBBB Mechanical Activation Pattern by 2D Strain Echocardiography With Acute GWE Improvement in Patients Receiving LBBp or Conventional BiVp for Cardiac Resynchronization Therapy (Echo LBBp)
The present study is a multicenter interventional non randomised study in patients requiring an implantable device for cardiac resynchronization therapy.
- Trial name
- ECHO-LBBp (NCT06689111)
- Testing
- Left bundle branch pacing lead, CRT with the standard method through cs
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University Hospital of Patras
Muscle Tightness, Muscle Strain
Changes in the Quadriceps Muscle After Dry Needling Treatment
The present study aims to examine the mechanical changes following dry needling of the quadriceps muscle. To this end, structural and mechanical changes in quadriceps muscle activity will be measured using M-mode ultrasound.
- Trial name
- NCT06396741
- Testing
- The quadriceps muscle will be punctured with ultrasound control
- Where
- Spain
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Daniel Pecos Martín
Food Hypersensitivity, Probiotic
Colonization and Persistence Capacity of a Multi-strain Probiotics in Pediatric Food Allergy to Milk or Egg.
This study evaluates the addition of three probiotics (Bifidobacterium longum, Bifidobacterium breve and Bifidobacterium infantis) in the treatment of pediatric food allergic children to milk or egg.
- Trial name
- NCT03639337
- Testing
- Multi-strain probiotic
- Where
- Italy
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Bambino Gesù Hospital and Research Institute
COVID-19
Correlation Study of Isotype Switching and Neutralizing Capacity to the COVID-19 Variants Strain
The level of neutralizing antibody was detected by using the constructed pseudovirus covid-19 variant at baseline , 1 month , 6 months and 12 months after primary vaccination, within 15 days after booster immunization at 12…
- Trial name
- NCT05087277
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention, China
Lumbar Disc Herniation
A Biomechanical Study of the Lumbar Intervertebral Disc by Lever Positioning Manipulation
Purpose of Study: The purpose of this clinical trial is the clinical efficacy of different trigger modes of lever positioning manipulation (LPM) for the treatment of lumbar disc herniation (LDH).
- Trial name
- NCT06872918
- Testing
- Lever positioning manipulation, Cluster of pseudo-manipulators, Mechanics and kinematics data acquisition of unilateral wrenching patterns in lever positioning manipulation
- Where
- China
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Covid19
Evaluation of a Probiotic Supplementation in the Immune Response of Participants With COVID-19 (Coronavirus Disease).
An interventional, randomized, double-blind, placebo-controlled study will be conducted to investigate the effect of a probiotic strain on the immune response in participants positive for SARS-CoV-2 infection.
- Trial name
- PROVID (NCT04937556)
- Testing
- Probiotic: Lactobacillus salivarius + Vit D + Zinc
- Where
- Spain
- Volunteers
- 41 people
- Sponsor
- ProbiSearch SL